EA200600441A1 - TRANS-4 - ((1R, 3S) -6HLOR-3-PHENYLINDAN-1-IL) -1,2,2-TRIMETHYL-PYPERASINE SUCTION AND MALONATE SALTS - Google Patents

TRANS-4 - ((1R, 3S) -6HLOR-3-PHENYLINDAN-1-IL) -1,2,2-TRIMETHYL-PYPERASINE SUCTION AND MALONATE SALTS

Info

Publication number
EA200600441A1
EA200600441A1 EA200600441A EA200600441A EA200600441A1 EA 200600441 A1 EA200600441 A1 EA 200600441A1 EA 200600441 A EA200600441 A EA 200600441A EA 200600441 A EA200600441 A EA 200600441A EA 200600441 A1 EA200600441 A1 EA 200600441A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenylindan
pyperasine
6hlor
trimethyl
trans
Prior art date
Application number
EA200600441A
Other languages
Russian (ru)
Other versions
EA014641B1 (en
Inventor
Хейди Лопес Де Диего
Оле Нильсен
Лоне Мюнк Ринггар
Хенрик Сване
Аллан Карстен Даль
Марк Хауэллз
Бенни Бан-Андерсен
Ларс Оле Люнгсе
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Priority claimed from PCT/DK2004/000545 external-priority patent/WO2005016900A1/en
Publication of EA200600441A1 publication Critical patent/EA200600441A1/en
Publication of EA014641B1 publication Critical patent/EA014641B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Гидросукцинат или гидромалонат 4-((1R,3S)-6-хлор-3-фенилиндан-1-ил)-1,2,2-триметилпиперазина, фармацевтические композиции, содержащие указанные соли, и их применение в медицине, включая применение для лечения шизофрении и других психотических заболеваний. Описаны также способы получения 4-((1R,3S)-6-хлор-3-фенилиндан-1-ил)-1,2,2-триметилпиперазина и виды его применения в медицинских целях.Hydrosuccinate or hydromalonate 4 - ((1R, 3S) -6-chloro-3-phenylindan-1-yl) -1,2,2-trimethylpiperazine, pharmaceutical compositions containing these salts, and their use in medicine, including the use for treatment schizophrenia and other psychotic illnesses. Methods for preparing 4 - ((1R, 3S) -6-chloro-3-phenylindan-1-yl) -1,2,2-trimethylpiperazine and its uses for medical purposes are also described.

EA200600441A 2003-08-18 2004-08-18 Succinate and malonate salt of trans-4-((ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament EA014641B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301180 2003-08-18
DKPA200301305 2003-09-11
PCT/DK2004/000545 WO2005016900A1 (en) 2003-08-18 2004-08-18 Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament

Publications (2)

Publication Number Publication Date
EA200600441A1 true EA200600441A1 (en) 2006-08-25
EA014641B1 EA014641B1 (en) 2010-12-30

Family

ID=58707237

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200600441A EA014641B1 (en) 2003-08-18 2004-08-18 Succinate and malonate salt of trans-4-((ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament
EA200600443A EA200600443A1 (en) 2003-08-18 2004-08-18 TRANS-1- (6-HLOR-3-PHENYLINDAN-1-IL) -3,3-DIMETHILPIPERAZIN

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200600443A EA200600443A1 (en) 2003-08-18 2004-08-18 TRANS-1- (6-HLOR-3-PHENYLINDAN-1-IL) -3,3-DIMETHILPIPERAZIN

Country Status (16)

Country Link
KR (2) KR101227789B1 (en)
CN (1) CN101935305B (en)
AR (2) AR045278A1 (en)
AT (1) ATE552247T1 (en)
DK (1) DK1658277T3 (en)
EA (2) EA014641B1 (en)
ES (1) ES2383369T3 (en)
HK (2) HK1096089A1 (en)
IS (1) IS8264A (en)
ME (1) MEP2408A (en)
MY (2) MY154535A (en)
PT (1) PT1658277E (en)
RS (3) RS20060083A (en)
SG (2) SG148183A1 (en)
SI (1) SI1658277T1 (en)
TW (2) TWI403505B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453198B (en) * 2005-02-16 2014-09-21 Lundbeck & Co As H Process for making the trans-1-( (1r , 3s)- 6-chloro - 3 -phenylindan-1- yl ) - 3 , 3 - dimethylpiperazine and salts thereof and for making 4 -((1r , 3s )-6- chloro- 3- phenylindan -1- yl )-1, 2 , 2 -trimethylpiperazine and salts thereof
PL2720989T3 (en) 2011-06-20 2017-05-31 H. Lundbeck A/S Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50867B1 (en) * 1980-02-29 1986-08-06 Kefalas As Indane derivatives
DK55192D0 (en) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindene derivatives

Also Published As

Publication number Publication date
EA014641B1 (en) 2010-12-30
ATE552247T1 (en) 2012-04-15
HK1096089A1 (en) 2007-05-25
MY154535A (en) 2015-06-30
AR045278A1 (en) 2005-10-19
KR101227789B1 (en) 2013-01-30
IS8264A (en) 2006-01-26
SI1658277T1 (en) 2012-10-30
CN101935305A (en) 2011-01-05
KR20060066094A (en) 2006-06-15
RS20060121A (en) 2008-09-29
ES2383369T3 (en) 2012-06-20
AR045279A1 (en) 2005-10-19
RS20060083A (en) 2008-08-07
MY149089A (en) 2013-07-15
TWI403505B (en) 2013-08-01
SG148183A1 (en) 2008-12-31
TW201111351A (en) 2011-04-01
HK1152699A1 (en) 2012-03-09
EA200600443A1 (en) 2006-08-25
TW200519098A (en) 2005-06-16
DK1658277T3 (en) 2012-06-18
KR20060066104A (en) 2006-06-15
PT1658277E (en) 2012-05-25
MEP2408A (en) 2010-02-10
RS53369B (en) 2014-10-31
CN101935305B (en) 2013-04-10
SG145723A1 (en) 2008-09-29
TWI388550B (en) 2013-03-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU