EA200200048A1 - Новые соединения циклогептена, способ их получения и содержащие их фармацевтические композиции - Google Patents
Новые соединения циклогептена, способ их получения и содержащие их фармацевтические композицииInfo
- Publication number
- EA200200048A1 EA200200048A1 EA200200048A EA200200048A EA200200048A1 EA 200200048 A1 EA200200048 A1 EA 200200048A1 EA 200200048 A EA200200048 A EA 200200048A EA 200200048 A EA200200048 A EA 200200048A EA 200200048 A1 EA200200048 A1 EA 200200048A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- compounds
- cyclogepten
- new
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Соединения формулы (I)где Х представляет собой связь или алкиленовую, СО, S(O), -S(O)-A-, -CO-A-, -A-S(O)-A'- или -A-CO-A'- группу,Y представляет собой арильную, гетероарильную, циклоалкильную или гетероциклоалкильную группу, каждая из которых незамещена или замещена,R, R, Rи R, каждый независимо от других, представляют собой атом водорода или арильную, гетероарильную, циклоалкильную или гетероциклоалкильную группу, каждая из которых незамещена или замещена, или R, R, Rи R, взятые попарно, вместе образуют связь или образуют слитое бензольное кольцо или слитый ароматический или частично ненасыщенный гетероцикл,Т представляет собой группу -CH(R)-, -N(R)- или -N(R)CO-,V представляет собой атом водорода или незамещенную или замещенную арильную или гетероарильную группу,Aпредставляет собой группу [С(R)(R')],Rи Rимеют значения, указанные в описании,Лекарственные препараты.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0100641A FR2819509B1 (fr) | 2001-01-18 | 2001-01-18 | Nouveaux composes cycloheptene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200048A1 true EA200200048A1 (ru) | 2002-08-29 |
| EA004859B1 EA004859B1 (ru) | 2004-08-26 |
Family
ID=8858954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200048A EA004859B1 (ru) | 2001-01-18 | 2002-01-17 | Новые соединения циклогептена и содержащие их фармацевтические композиции |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6638962B2 (ru) |
| EP (1) | EP1225170A3 (ru) |
| JP (1) | JP2002265448A (ru) |
| KR (1) | KR100483360B1 (ru) |
| CN (1) | CN1166641C (ru) |
| AR (1) | AR034015A1 (ru) |
| AU (1) | AU781680B2 (ru) |
| BR (1) | BR0200114A (ru) |
| CA (1) | CA2367306C (ru) |
| EA (1) | EA004859B1 (ru) |
| FR (1) | FR2819509B1 (ru) |
| HK (1) | HK1048471A1 (ru) |
| HU (1) | HUP0200204A3 (ru) |
| MX (1) | MXPA02000529A (ru) |
| NO (1) | NO322100B1 (ru) |
| NZ (1) | NZ516684A (ru) |
| PL (1) | PL351732A1 (ru) |
| ZA (1) | ZA200200471B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210008084A1 (en) | 2017-10-16 | 2021-01-14 | Tsinghua University | Mevalonate pathway inhibitor and pharmaceutical composition thereof |
| CN114573501A (zh) * | 2022-03-02 | 2022-06-03 | 河南阿尔法医药科技有限公司 | 一种可规模化生产2,2′:6′,2″-三联吡啶-4′-甲醛的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117580A0 (en) * | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| US5710171A (en) * | 1995-05-24 | 1998-01-20 | Merck & Co., Inc. | Bisphenyl inhibitors of farnesyl-protein transferase |
| US6028201A (en) * | 1996-01-30 | 2000-02-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1997036606A1 (en) | 1996-03-29 | 1997-10-09 | The Trustees Of The University Of Pennsylvania | Constrained cd4 peptides and methods of using the same |
| CA2250936A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU715202B2 (en) * | 1996-04-03 | 2000-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1997036890A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5922883A (en) * | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU717190B2 (en) * | 1996-04-03 | 2000-03-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1999010329A1 (en) * | 1997-08-27 | 1999-03-04 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6410539B1 (en) * | 1997-10-22 | 2002-06-25 | Astrazenca Uk Limited | Imidazole derivatives and their use as farnesyl protein transferase inhibitors |
-
2001
- 2001-01-18 FR FR0100641A patent/FR2819509B1/fr not_active Expired - Fee Related
-
2002
- 2002-01-15 MX MXPA02000529A patent/MXPA02000529A/es active IP Right Grant
- 2002-01-16 US US10/050,666 patent/US6638962B2/en not_active Expired - Fee Related
- 2002-01-16 EP EP02290101A patent/EP1225170A3/fr not_active Withdrawn
- 2002-01-16 PL PL02351732A patent/PL351732A1/xx not_active Application Discontinuation
- 2002-01-17 NZ NZ516684A patent/NZ516684A/xx unknown
- 2002-01-17 NO NO20020262A patent/NO322100B1/no unknown
- 2002-01-17 BR BR0200114-4A patent/BR0200114A/pt not_active IP Right Cessation
- 2002-01-17 EA EA200200048A patent/EA004859B1/ru not_active IP Right Cessation
- 2002-01-17 CA CA002367306A patent/CA2367306C/fr not_active Expired - Fee Related
- 2002-01-17 CN CNB021020426A patent/CN1166641C/zh not_active Expired - Fee Related
- 2002-01-18 AR ARP020100173A patent/AR034015A1/es unknown
- 2002-01-18 JP JP2002009645A patent/JP2002265448A/ja active Pending
- 2002-01-18 ZA ZA200200471A patent/ZA200200471B/xx unknown
- 2002-01-18 HU HU0200204A patent/HUP0200204A3/hu unknown
- 2002-01-18 KR KR10-2002-0002972A patent/KR100483360B1/ko not_active IP Right Cessation
- 2002-01-18 AU AU11937/02A patent/AU781680B2/en not_active Ceased
-
2003
- 2003-01-07 HK HK03100156A patent/HK1048471A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL351732A1 (en) | 2002-07-29 |
| FR2819509B1 (fr) | 2004-04-16 |
| MXPA02000529A (es) | 2004-11-01 |
| NO20020262L (no) | 2002-07-19 |
| EA004859B1 (ru) | 2004-08-26 |
| HK1048471A1 (en) | 2003-04-04 |
| JP2002265448A (ja) | 2002-09-18 |
| EP1225170A2 (fr) | 2002-07-24 |
| US6638962B2 (en) | 2003-10-28 |
| HUP0200204A2 (hu) | 2002-12-28 |
| HU0200204D0 (en) | 2002-03-28 |
| NO322100B1 (no) | 2006-08-14 |
| FR2819509A1 (fr) | 2002-07-19 |
| CA2367306C (fr) | 2006-07-11 |
| CN1166641C (zh) | 2004-09-15 |
| US20020156113A1 (en) | 2002-10-24 |
| NO20020262D0 (no) | 2002-01-17 |
| CA2367306A1 (fr) | 2002-07-18 |
| AR034015A1 (es) | 2004-01-21 |
| NZ516684A (en) | 2003-06-30 |
| ZA200200471B (en) | 2002-07-22 |
| CN1365973A (zh) | 2002-08-28 |
| KR20020062212A (ko) | 2002-07-25 |
| AU781680B2 (en) | 2005-06-09 |
| KR100483360B1 (ko) | 2005-04-15 |
| EP1225170A3 (fr) | 2002-08-28 |
| BR0200114A (pt) | 2002-10-22 |
| AU1193702A (en) | 2002-07-25 |
| HUP0200204A3 (en) | 2003-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |