EA199900914A1 - Treatment or prophylaxis of prostate cancer and benign prostatic hyperplasia with selective modulators of estrogen receptors - Google Patents
Treatment or prophylaxis of prostate cancer and benign prostatic hyperplasia with selective modulators of estrogen receptorsInfo
- Publication number
- EA199900914A1 EA199900914A1 EA199900914A EA199900914A EA199900914A1 EA 199900914 A1 EA199900914 A1 EA 199900914A1 EA 199900914 A EA199900914 A EA 199900914A EA 199900914 A EA199900914 A EA 199900914A EA 199900914 A1 EA199900914 A1 EA 199900914A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- prostate cancer
- benign prostatic
- prostatic hyperplasia
- prophylaxis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Abstract
Данное изобретение предлагает способ лечения или профилактики доброкачественной гиперплазии простаты или рака простаты у пациента, нуждающегося в таком лечении, включающий в себя введение селективно модулирующего рецепторы эстрогена соединения формулы (I)где Rи Rнезависимо представляют собой гидрокси и алкокси, содержащий от одного до четырех атомов углерода, Rи Rнезависимо представляют собой метил или этил, или Rи R, взятые вместе с атомом азота, к которому они присоединены, образуют пирролидиновое, метилпирролидиновое, диметилпирролидиновое, пиперидиновое, морфолиновое или гексаметилениминовое кольцо.Международная заявка была опубликована вместе с отчетом о международном поиске.This invention provides a method of treating or preventing benign prostatic hyperplasia or prostate cancer in a patient in need of such treatment, including administering estrogen receptor modulatory estrogen receptor compounds of formula (I) , R and R independently represent methyl or ethyl, or R and R, taken together with the nitrogen atom to which they are attached, form pyrrolidine, methyl pyrrolidine, dimethyl pyrrolide new, piperidino, morpholino or geksametileniminovoe koltso.Mezhdunarodnaya application was published together with the international search report.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4322397P | 1997-04-09 | 1997-04-09 | |
PCT/US1998/007274 WO1998045288A1 (en) | 1997-04-09 | 1998-04-07 | Treatment or prophylaxis of prostatic cancer and benign prostatic hyperplasia with selective estrogen receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199900914A1 true EA199900914A1 (en) | 2000-04-24 |
Family
ID=21926126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900914A EA199900914A1 (en) | 1997-04-09 | 1998-04-07 | Treatment or prophylaxis of prostate cancer and benign prostatic hyperplasia with selective modulators of estrogen receptors |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0975629A4 (en) |
JP (1) | JP2001518900A (en) |
KR (1) | KR20010006218A (en) |
CN (1) | CN1259944A (en) |
AU (1) | AU6966198A (en) |
BR (1) | BR9808515A (en) |
CA (1) | CA2286204A1 (en) |
EA (1) | EA199900914A1 (en) |
HU (1) | HUP0003589A3 (en) |
ID (1) | ID24358A (en) |
IL (1) | IL132277A0 (en) |
NO (1) | NO994903L (en) |
PL (1) | PL336205A1 (en) |
TR (1) | TR199902701T2 (en) |
WO (1) | WO1998045288A1 (en) |
ZA (1) | ZA982819B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
US6653479B1 (en) | 1999-07-29 | 2003-11-25 | Eli Lilly And Company | Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride |
US6610706B1 (en) | 1999-07-29 | 2003-08-26 | Eli Lilly And Company | Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride |
US7425565B2 (en) * | 2002-05-09 | 2008-09-16 | Cedars-Sinai Medical Center | Use of benzothiopenes to treat and prevent prostate cancer |
EP1392304A1 (en) * | 2001-05-10 | 2004-03-03 | Cedars Sinai Medical Center | Use of benzothiophenes to treat and prevent prostate cancer |
BRPI0712103A2 (en) * | 2006-05-22 | 2012-01-17 | Hormos Medical Corp | method of treating chronic non-bacterial prostatitis and to prevent the progression of benign prostatic hyperplasia (bph) or prostate cancer in men |
NZ585389A (en) | 2007-10-16 | 2011-10-28 | Repros Therapeutics Inc | Trans-clomiphene for metabolic syndrome |
MX2014009322A (en) | 2012-02-29 | 2014-11-10 | Repros Therapeutics Inc | Combination therapy for treating androgen deficiency. |
PT2958907T (en) | 2013-02-19 | 2018-03-23 | Novartis Ag | Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
WO2017081171A1 (en) | 2015-11-10 | 2017-05-18 | Paracrine Therapeutics Ab | Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5429922A (en) * | 1988-03-09 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for distinguishing virulent and non-virulent toxoplasma infections |
IL132952A (en) * | 1995-02-28 | 2002-02-10 | Lilly Co Eli | Benzothiophene derivatives |
US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
US5731342A (en) * | 1996-02-22 | 1998-03-24 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
-
1998
- 1998-04-02 ZA ZA9802819A patent/ZA982819B/en unknown
- 1998-04-07 TR TR1999/02701T patent/TR199902701T2/en unknown
- 1998-04-07 IL IL13227798A patent/IL132277A0/en unknown
- 1998-04-07 KR KR1019997009298A patent/KR20010006218A/en not_active Application Discontinuation
- 1998-04-07 HU HU0003589A patent/HUP0003589A3/en unknown
- 1998-04-07 ID IDW991188A patent/ID24358A/en unknown
- 1998-04-07 AU AU69661/98A patent/AU6966198A/en not_active Abandoned
- 1998-04-07 WO PCT/US1998/007274 patent/WO1998045288A1/en not_active Application Discontinuation
- 1998-04-07 CN CN98805956A patent/CN1259944A/en active Pending
- 1998-04-07 PL PL98336205A patent/PL336205A1/en unknown
- 1998-04-07 EP EP98915488A patent/EP0975629A4/en not_active Withdrawn
- 1998-04-07 EA EA199900914A patent/EA199900914A1/en unknown
- 1998-04-07 BR BR9808515-8A patent/BR9808515A/en not_active Application Discontinuation
- 1998-04-07 CA CA002286204A patent/CA2286204A1/en not_active Abandoned
- 1998-04-07 JP JP54316898A patent/JP2001518900A/en active Pending
-
1999
- 1999-10-08 NO NO994903A patent/NO994903L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1259944A (en) | 2000-07-12 |
ZA982819B (en) | 1999-10-04 |
JP2001518900A (en) | 2001-10-16 |
WO1998045288A1 (en) | 1998-10-15 |
ID24358A (en) | 2000-07-13 |
PL336205A1 (en) | 2000-06-05 |
HUP0003589A3 (en) | 2002-02-28 |
NO994903D0 (en) | 1999-10-08 |
KR20010006218A (en) | 2001-01-26 |
CA2286204A1 (en) | 1998-10-15 |
EP0975629A4 (en) | 2001-03-21 |
HUP0003589A2 (en) | 2002-01-28 |
TR199902701T2 (en) | 2000-02-21 |
IL132277A0 (en) | 2001-03-19 |
NO994903L (en) | 1999-12-09 |
AU6966198A (en) | 1998-10-30 |
EP0975629A1 (en) | 2000-02-02 |
BR9808515A (en) | 2001-06-19 |
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