MY112949A - Benzo-thiaphene estrogen agonists to treat prostatic hyperplasia - Google Patents
Benzo-thiaphene estrogen agonists to treat prostatic hyperplasiaInfo
- Publication number
- MY112949A MY112949A MYPI95003850A MYPI19953850A MY112949A MY 112949 A MY112949 A MY 112949A MY PI95003850 A MYPI95003850 A MY PI95003850A MY PI19953850 A MYPI19953850 A MY PI19953850A MY 112949 A MY112949 A MY 112949A
- Authority
- MY
- Malaysia
- Prior art keywords
- thiaphene
- benzo
- estrogen agonists
- prostatic hyperplasia
- treat prostatic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
BENZOTHIOPHENES AND RELATED COMPOUNDS OF THE FORMULA ARE ESTROGEN AGONISTS WHICH ARE USEFUL FOR TREATING PROSTATIC AND DISEASES, OBESITY AND BONE LOSS IN MALE ANIMALS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/356,011 US5589482A (en) | 1994-12-14 | 1994-12-14 | Benzo-thiophene estrogen agonists to treat prostatic hyperplasia |
Publications (1)
Publication Number | Publication Date |
---|---|
MY112949A true MY112949A (en) | 2001-10-31 |
Family
ID=23399729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI95003850A MY112949A (en) | 1994-12-14 | 1995-12-13 | Benzo-thiaphene estrogen agonists to treat prostatic hyperplasia |
Country Status (12)
Country | Link |
---|---|
US (1) | US5589482A (en) |
EP (1) | EP0716855A2 (en) |
JP (1) | JPH08231540A (en) |
KR (1) | KR100190724B1 (en) |
CN (1) | CN1130063A (en) |
AU (1) | AU696573B2 (en) |
CA (1) | CA2165012C (en) |
IL (1) | IL116283A (en) |
MX (1) | MX9505249A (en) |
MY (1) | MY112949A (en) |
NZ (1) | NZ280667A (en) |
ZA (1) | ZA9510592B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0801066A1 (en) * | 1996-03-12 | 1997-10-15 | Eli Lilly And Company | Heterocyclic substituted benzothiophenes and pharmaceutical compositions |
CA2218756A1 (en) * | 1996-10-25 | 1998-04-25 | Kristin Sue Marron | Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators |
US6271227B1 (en) | 1997-04-30 | 2001-08-07 | Eli Lilly And Company | Antithrombotic Agents |
GB2324726A (en) * | 1997-05-01 | 1998-11-04 | Merck & Co Inc | Combination Therapy for the Treatment of Osteoporosis |
CA2304138A1 (en) * | 1997-09-23 | 1999-04-01 | Eli Lilly And Company | Benzothiophenes |
BR9812944A (en) | 1997-10-20 | 2000-08-08 | Hoffmann La Roche | Bicyclic kinase inhibitors |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
CN1615873A (en) | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | Azaindoles compound |
DE60124616T2 (en) * | 2000-05-08 | 2007-09-13 | Pfizer Products Inc., Groton | Enzymatic cleavage of selective modulators of the estrogen receptor |
CA2412462A1 (en) | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 6,5-fused bicyclic heterocycles |
DE60108710T2 (en) * | 2000-11-30 | 2006-05-04 | Pfizer Products Inc., Groton | Estrogen agonist antagonist and testosterone-containing composition for the treatment of decreasing testosterone levels |
AU781168B2 (en) * | 2001-01-26 | 2005-05-12 | Pfizer Products Inc. | Method of treating certain cancers using an estrogen agonist/antagonist |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
MXPA06014471A (en) | 2004-06-09 | 2007-03-21 | Glaxo Group Ltd | Pyrrolopyridine derivatives. |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2006019831A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
JP2008507518A (en) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス,インコーポレーテッド | Thienopyridine for treating hepatitis C |
KR101319675B1 (en) * | 2008-09-29 | 2013-10-22 | 일라이 릴리 앤드 캄파니 | Selective estrogen repector modulator for the treatment of osteoarthritis |
EP2503188B1 (en) * | 2011-03-25 | 2015-01-21 | NAF Neunkirchener Achsenfabrik AG | Switching cylinder for a drive device, in particular for a self-propelled work machine, drive device, work machine and method for operating a work machine |
BR112015018882B1 (en) | 2013-02-19 | 2021-09-14 | Novartis Ag | BENZOTHOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTOGEN RECEPTOR DEGRADATORS |
JP6549735B2 (en) | 2015-06-09 | 2019-07-24 | アッヴィ・インコーポレイテッド | Nuclear receptor modulator |
KR102542698B1 (en) * | 2022-04-05 | 2023-06-14 | 주식회사 베노바이오 | Novel benzothiophene derivatives and use as BET inhibitors |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
EP0062503A1 (en) * | 1981-04-03 | 1982-10-13 | Eli Lilly And Company | Benzothiophene compounds and process for preparing them |
US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
IL65378A (en) * | 1981-04-03 | 1986-02-28 | Lilly Co Eli | Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes |
GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
US4859585A (en) * | 1986-04-17 | 1989-08-22 | Trustees Of Tufts College | In-vitro methods for identifying compositions which are agonists and antagonists of estrogens |
US4970237A (en) * | 1987-03-20 | 1990-11-13 | Yale University | Use of clomiphene to increase bone mass in premenopausal women |
US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
DE4117512A1 (en) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-PHENYLBENZO (B) FURANES AND THIOPHENES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
JP3157882B2 (en) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | New benzothiophene derivatives |
US5196435A (en) * | 1991-11-21 | 1993-03-23 | Eli Lilly And Company | Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma |
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US8135386B2 (en) * | 2008-07-09 | 2012-03-13 | Telefoanktebolaget L M Ericsson (Publ) | Method and apparatus for instance identifier based on a unique device identifier |
-
1994
- 1994-12-14 US US08/356,011 patent/US5589482A/en not_active Expired - Fee Related
-
1995
- 1995-12-07 IL IL11628395A patent/IL116283A/en not_active IP Right Cessation
- 1995-12-08 EP EP95308923A patent/EP0716855A2/en not_active Withdrawn
- 1995-12-12 CA CA002165012A patent/CA2165012C/en not_active Expired - Fee Related
- 1995-12-13 MX MX9505249A patent/MX9505249A/en unknown
- 1995-12-13 AU AU40412/95A patent/AU696573B2/en not_active Ceased
- 1995-12-13 CN CN95118879A patent/CN1130063A/en active Pending
- 1995-12-13 ZA ZA9510592A patent/ZA9510592B/en unknown
- 1995-12-13 MY MYPI95003850A patent/MY112949A/en unknown
- 1995-12-13 KR KR1019950049171A patent/KR100190724B1/en not_active IP Right Cessation
- 1995-12-13 NZ NZ280667A patent/NZ280667A/en unknown
- 1995-12-14 JP JP7325329A patent/JPH08231540A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0716855A3 (en) | 1996-07-10 |
AU4041295A (en) | 1996-06-20 |
US5589482A (en) | 1996-12-31 |
AU696573B2 (en) | 1998-09-10 |
CA2165012A1 (en) | 1996-06-15 |
IL116283A (en) | 2002-02-10 |
CA2165012C (en) | 1999-03-16 |
EP0716855A2 (en) | 1996-06-19 |
CN1130063A (en) | 1996-09-04 |
KR100190724B1 (en) | 1999-06-01 |
IL116283A0 (en) | 1996-03-31 |
MX9505249A (en) | 1997-01-31 |
KR960021020A (en) | 1996-07-18 |
ZA9510592B (en) | 1997-06-13 |
NZ280667A (en) | 2000-08-25 |
JPH08231540A (en) | 1996-09-10 |
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