EA040374B1 - METHOD FOR TREATMENT OR ALLEVIATION OF METABOLIC DISORDERS USING GASTRIC INHIBITOR PEPTIDE RECEPTOR (GIPR) BINDING PROTEINS IN COMBINATION WITH GLP-1 AGONISTS - Google Patents

Description

Field of invention

The present invention relates to the treatment or elimination of metabolic disorders such as type 2 diabetes, elevated glucose, elevated insulin, obesity, non-alcoholic steatohepatitis, or cardiovascular disease using an antigen-binding protein specific for the gastric inhibitory peptide receptor (GIPR).

State of the art

Glucose-dependent insulinotropic polypeptide (GIP) is a single 42-amino acid peptide isolated from K cells in the small intestine (duodenum and jejunum). Human GIP is produced by processing proGIP, a 153 amino acid precursor that is encoded by a gene located on chromosome 17q (Inagaki et al., Mol. Endocrinol. 1989; 3:1014-1021; Fehmann et al. Endocr. Rev. 1995; 16:390 -410). GIP was formerly referred to as gastric inhibitory polypeptide.

GIP secretion is induced by food intake. GIP has a number of physiological effects in tissues, including promoting fat accumulation in adipocytes and promoting islet β-cell function and glucose-dependent insulin secretion. GIP and glucagon-like polypeptide-1 (GLP-1) are known as insulinotropic factors (incretins). Intact GIP is rapidly degraded by dipeptidyl peptidase IV (DPPIV) to an inactive form. The insulinotropic effect of GIP is lost in patients with type 2 diabetes, while the effect of GLP-1 incretin remains intact (Nauck et al. J. Clinc. Invest. 1993; 91:301-307).

The GIP receptor (GIPR) is a member of the secretin-glucagon family of G protein-coupled receptors (GPCRs) having an extracellular N-terminus, seven transmembrane domains, and an intracellular C-terminus. The N-terminal extracellular domains of this family of receptors are typically glycosylated and form the recognition and binding domain of the receptor. GIPR is highly expressed in a number of tissues including the pancreas, intestine, adipose tissue, heart, pituitary, adrenal cortex and brain (Usdin et al., Endocrinology, 1993, 133:2861-2870). Human GIPR contains 466 amino acids and is encoded by a gene located on chromosome 19q13.3 (Gremlich et al., Diabetes. 1995; 44:1202-8; Volz et al., FEBS Lett. 1995, 373:23-29). Research suggests that alternative mRNA splicing results in the production of GIP receptors of varying length in humans, rats, and mice.

GIPR knockout (Gipr' ^/_ ) mice are resistant to high fat diet-induced weight gain and have improved insulin sensitivity and lipid spectra. (Yamada et al., Diabetes. 2006, 55:S86; Miyawaki et al., Nature Med. 2002, 8:738-742). In addition, the novel small molecule GIPR antagonist SKL-14959 prevents obesity and insulin resistance (Diabetologia, 2008, 51:S373, ^44th EASD Annual meeting poster).

Glucagon-like peptide-1 (GLP-1) is a 31 amino acid peptide derived from the proglucagon gene. It is secreted by intestinal L cells and released in response to food intake to induce insulin secretion from pancreatic β cells (Diabetes, 2004, 53:S3, 205214). In addition to the effects of incretin, GLP-1 also reduces glucagon secretion, delays gastric emptying, and reduces caloric intake (Diabetes Care, 2003, 26(10):2929-2940). GLP-1 exerts its effects by activating the GLP-1 receptor, which belongs to the B class of G protein-coupled receptors (Endocrinology, 1993, 133(4):1907-10). The function of GLP-1 is limited by rapid degradation by the DPP-IV enzyme resulting in a half-life of approximately 2 minutes. Recently, long-acting GLP-1 receptor agonists such as exenatide, liraglutide, dulaglutide have been developed and are currently used to improve glycemic control in patients with type 2 diabetes. In addition, GLP-1 receptor agonists also promote weight loss as well as lower blood pressure and plasma cholesterol levels in patients (Bioorg. Med. Chem. Lett. 2013, 23:4011-4018).

Taken together, these associations with obesity and insulin resistance imply that GIPR inhibition is a useful approach for therapeutic intervention, either alone or in combination with GLP-1.

The essence of the invention

In one aspect, the invention provides a method of treating a subject with a metabolic disorder comprising administering to the subject a therapeutically effective amount of an antigen-binding protein that specifically binds to a protein having an amino acid sequence that has at least 90% amino acid sequence identity with the amino acid sequence of GIPR. In one aspect, the invention relates to a method of treating a subject with a metabolic disorder comprising administering to the subject a therapeutically effective amount of a GLP-1 receptor agonist and a therapeutically effective amount of a GIPR antagonist that specifically binds to a protein having an amino acid sequence having at least 90% amino acid identity. sequences with the amino acid sequence GIPR. In one embodiment, the metabolic disorder is a disorder of glucose metabolism. In another embodiment, disorders of glucose metabolism include hyperglycemia and administration of an antigen-binding protein lowers plasma glucose levels. In another embodiment, the disorder of glucose metabolism includes hyperinsulinemia and administration of an antigen-binding protein decreases plasma insulin levels. In another embodiment, the impaired glucose metabolism includes glucose intolerance and administration of an antigen binding protein reduces the increasing glucose tolerance. In another embodiment, the impairment of glucose metabolism includes insulin resistance and administration of an antigen-binding protein reduces insulin resistance. In another embodiment, the disorder of glucose metabolism includes diabetes mellitus. In another embodiment, the subject is obese. In another embodiment, administration of an antigen-binding protein reduces body weight in an obese subject. In another embodiment, administration of an antigen-binding protein reduces weight gain in an obese subject. In another embodiment, administration of an antigen-binding protein reduces fat mass in an obese subject. In another embodiment, the impaired glucose metabolism includes insulin resistance, and administration of an antigen-binding protein reduces insulin resistance in an obese subject. In another embodiment, administration of an antigen-binding protein reduces hepatic steatosis in an obese subject having increased hepatic steatosis. In another embodiment, administration of an antigen-binding protein reduces liver fat in an obese subject having elevated liver fat.

In one aspect, the invention relates to a method of treatment comprising administering to a subject a therapeutically effective amount of at least one GLP-1 receptor agonist in combination with administering at least one GIPR antagonist which, when administered to a subject with metabolic symptoms, provides sustained beneficial effects.

In one embodiment, administration of at least one GLP-1 receptor agonist in combination with administration of at least one GIPR antagonist provides sustained beneficial effects for at least one symptom of a metabolic disorder.

In one embodiment, a therapeutically effective GLP-1 and a GIPR antagonist are combined prior to administration to a subject.

In one embodiment, the therapeutically effective GLP-1 and the GIPR antagonist are administered sequentially to the subject.

In one embodiment, a therapeutically effective amount of an agonist amount of an agonist of a receptor receptor agonist

GLP-1 and the GIPR antagonist are synergistically effective amounts.

In one embodiment, the molar ratio of GLP-1 receptor agonist to GIPR antagonist is about 1:1 to 1:110, 1:1 to 1:100, 1:1 to 1:75, 1:1 to 1: 50, 1:1 to 1:25, 1:1 to 1:10, 1:1 to 1:5, and 1:1.

In one embodiment, the molar ratio of GIPR antagonist to GLP-1 receptor agonist is about 1:1 to 1:110, 1:1 to 1:100, 1:1 to 1:75, 1:1 to 1: 50, 1:1 to 1:25, 1:1 to 1:10, and 1:1 to 1:5.

In one embodiment, a GLP-1 receptor agonist is used in combination with a GIPR antagonist in therapeutically effective molar ratios between about 1:1.5 to 1:150, preferably 1:2 to 1:50.

In one embodiment, the GLP-1 receptor agonist and GIPR antagonist are present at doses that are at least about 1.1 to 1.4, 1.5, 2, 3, 4, 5, 6, 7, 8, 9 or 10 times lower than the doses of each individual compound needed to treat the pathology and/or disease.

In one embodiment, the GLP-1 receptor agonist is GLP-1(7-37) or a GLP-1(7-37) analogue.

In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of essenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semiglutide, and taspoglutide.

In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of:

GLP-1(7-37) (SEQ ID NO: 3184);

GLP-1(7-36)-NH ₂ (SEQ ID NO: 3185);

liraglutide; albiglutide; taspoglutide; dulaglutide, semaglutide; LY2428757;

desamino-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (N ^ε -(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) (core peptide described as SEQ ID NO: 3222);

deamino-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (Nε-octanoyl)-GLP-1(7-37) (SEQ ID NO: 3223);

Arg ^26.34 , Lys ³⁸ (N ^ε -(ω-carboxypentadecanoyl))-GLP-1(7-38) (SEQ ID NO: 3224);

Arg ^26.34 , Lys ³⁶ (N ^ε -(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-36) (core peptide described as SEQ ID NO: 3225);

Aib ⁸ ' ³⁵ , Arg ²⁶ ' ³⁴ , Phe ³¹ -GLP-1(7-36)) (SEQ ID NO: 3186);

HXaa ₈ EGTFTSDVSSYLEXaa ₂₂ Xaa ₂₃ AAKEFIXaa ₃₀ WLXaa ₃₃ Xaa ₃₄ GXaa ₃₆ Xaa ₃₇ ; wherein Xaa ₃ is A, V, or G; Xaa ₂₂ is G, K or E; Xaa ₂₃ is Q or K; Xaa ₃₀

- 2 040374 is A or E; Xaa ₃₃ is V or K; Xaa ₃₄ is K, N, or R; Xaa ₃₆ is R or G; and Xaa ₃₇ is G, H, P, or absent (SEQ ID NO: 3187);

Arg ³⁴ -GLP-1(7-37) (SEQ ID NO: 3188); Glu ³⁰ -GLP-1(7-37) (SEQ ID NO: 3189);

Lys ²² -GLP-1(7-37) (SEQ ID NO: 3190); Gly ⁸³⁶ ,Glu ²² -GLP-1(7-37) (SEQ ID NO: 3191);

Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1(7-37) (SEQ ID NO: 3192);

Gly ⁸ ' ³⁶ ,Glu ²² ,Lys ³³ ,Asn ³⁴ -GLP-1(7-37) (SEQ ID NO: 3193);

Val ⁸ ,Glu ²² ,Lys ³³ ,Asn ³⁴ ,Gly ³⁶ -GLP-1(7-37) (SEQ ID NO: 3194);

Gly ⁸ ' ³⁶ ,Glu ²² ,Pro ³ 7-GLP-1(7-37) (SEQ ID NO: 3195);

Val ⁸ ,Glu ²² ,Gly ³⁶ Pro ³⁷ -GLP-1(7-37) (SEQ ID NO: 3196);

Gly ⁸ ' ³⁶ , Glu ²² , Lys ³³ , Asn ³⁴ , Pro ³ 7-GLP-1(7-37) (SEQ ID NO: 3197);

Val ⁸ , Glu ²² , Lys ³³ , Asn ³⁴ , Gly ³⁶ , Pro ³⁷ -GLP-1(7-37) (SEQ ID NO: 3198);

Gly ⁸³⁶ ,Glu ²² -GLP-1(7-36) (SEQ ID NO: 3199);

Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1(7-36) (SEQ ID NO: 3200);

Val ⁸ ,Glu ²² ,Asn ³⁴ ,Gly ³⁶ -GLP-1(7-36) (SEQ ID NO: 3201) and

Gly ⁸ ' ³⁶ ,Glu ²² ,Asn ³⁴ -GLP-1(7-36) (SEQ ID NO: 3202).

In another embodiment, the subject is a mammal. In another embodiment, the subject is a human. In another embodiment, the GIPR is human GIPR. In another embodiment, administration is by parenteral injection. In another embodiment, administration is by subcutaneous injection.

In another aspect, the invention provides an antigen-binding protein that specifically binds to a human GIPR polypeptide and inhibits GIPR activation by a GIP ligand. In one embodiment, the antigen binding protein inhibits the binding of a GIP ligand to GIPR. In another embodiment, the antigen-binding protein is a human antigen-binding protein. In another embodiment, the antigen binding protein is a human antibody. In another embodiment, the antigen binding protein is a monoclonal antibody.

In another aspect, this invention provides a pharmaceutical composition comprising at least one antigen-binding protein according to any of the above embodiments.

In another aspect, the invention provides a nucleic acid molecule encoding an antigen-binding protein according to any of the above embodiments.

In another aspect, the invention provides a vector comprising a nucleic acid molecule encoding an antigen-binding protein according to any of the above embodiments.

In another aspect, the invention provides a host cell comprising a nucleic acid molecule encoding an antigen-binding protein according to any of the above embodiments, or a vector comprising a nucleic acid molecule encoding an antigen-binding protein according to any of the above embodiments. In another aspect, the invention provides an antigen-binding protein that specifically binds to a human GIPR polypeptide that is expressed by the vector. In another aspect, the invention provides a method for producing an antigen-binding protein according to any of the above embodiments, the method comprising expressing the antigen-binding protein in a host cell that secretes the antigen-binding protein, and then purifying the antigen-binding protein from the cell culture medium. In another aspect, the invention provides an antigen-binding protein that specifically binds to a human GIPR polypeptide isolated from a host cell. In another aspect, the present invention provides an antigen binding protein of any of the above embodiments or a pharmaceutical composition of any of the above embodiments for use in therapy.

Brief description of graphic materials

Fig. 1. Mouse pharmacodynamic assay for anti-GIPR antibody testing - Study design.

Fig. 2. Antibody 2.63.1 to GIPR antagonizes GIP-induced insulin secretion.

Fig. 3. Chronic treatment of diet-induced obese mice with anti-GIPR antibody 2.63.1 - Study design.

Fig. 4. Antibody 2.63.1 to GIPR leads to a decrease in body weight gain.

Fig. 5. Antibody 2.63.1 to GIPR leads to a decrease in fat mass.

Fig. 6. Antibody 2.63.1 to GIPR leads to a decrease in the mass of epididymal white adipose tissue.

Fig. 7. Antibody 2.63.1 to GIPR leads to a decrease in fasting glucose levels.

Fig. 8. Antibody 2.63.1 to GIPR leads to a decrease in insulin levels.

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Fig. 9. Antibody 2.63.1 to GIPR results in improved glucose tolerance.

Fig. 10. Antibody 2.63.1 to GIPR leads to a decrease in total cholesterol and triglycerides in serum.

Fig. 11. Antibody 2.63.1 to GIPR leads to a decrease in microvesicular changes in hepatocytes and the corresponding lipid accumulation.

Fig. 12. Antibody 2.63.1 to GIPR leads to a decrease in liver weight and triglyceride content.

Fig. 13. Reduced inflammation and reduced number of adipocytes surrounded by infiltrated macrophages in epididymal white adipose tissue as a result of treatment with GIPR antibody 2.63.1.

Fig. 14A-14Q. The graph summarizes the calculated dissociation rate constant (1/s) for test samples binding to huGIPR ECD, as well as IC60 values for inhibition of GIP binding to huGIPR ECD.

Fig. 15. Binding of the 16H1 family to huGIPR ECD. The 200 nM huGIPR ECD coupled to the goat anti-huFc antibody was captured by the 6H1 family anti-huGIPR antibody.

Fig. 16. Mouse pharmacodynamic assay for anti-GIPR antibody testing - Study design.

Fig. 17. Antibody 5G12.006 to GIPR antagonizes GIP-induced insulin secretion.

Fig. 18. Chronic treatment of diet-induced obese mice with anti-GIPR antibody 5G12.006 - Study design.

Fig. 19. Antibody 5G12.006 to GIPR leads to a decrease in body weight gain

Fig. 20. GIPR antibody 5G12.006 results in improved glucose tolerance.

Fig. 21. Antibody 5G12.006 to GIPR leads to a decrease in glucose and insulin levels.

Fig. 22. Antibody 5G12.006 to GIPR leads to a decrease in liver weight.

Fig. 23. Antibody 5G12.006 to GIPR leads to a decrease in total cholesterol levels.

Fig. 24. Treatment of mice with anti-GIPR 2.63.1 in combination with liraglutide - Study design.

Fig. 25. Weight loss in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 26. Significant loss of fat mass in mice treated with anti-GIPR 2.63.1 in combination with liraglutide

Fig. 27. Food intake in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 28. Liver, epididymal fat and inguinal fat masses in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 29. Glucose tolerance in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 30. Blood glucose levels in mice treated with anti-GIPR 2.63.1 in combination with liraglutide

Fig. 31. Plasma insulin levels in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 32. Serum total cholesterol levels in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 33. Serum leptin levels in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 34. Serum triglycerides in mice treated with anti-GIPR 2.63.1 in combination with liraglutide.

Fig. 35. Study with mice treated with anti-GIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 36. Weight loss in mice treated with anti-GIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 37. Fat and lean mass in mice treated with anti-GIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 38. Food intake in mice treated with anti-GIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 39. Insulin, glucose and glucose tolerance in mice treated with antiGIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 40. Total cholesterol and plasma triglycerides in mice treated with antiGIPR 2.63.1 in combination with liraglutide, dulaglutide or exendin IV.

Fig. 41 Anti-GIPR Treatment of Mice Pretreated with GLP-1 Analog - Study Design. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lira) daily; and 2) vehicle or anti-GIPR antibody (Ab) weekly. The overall design of the study is divided into two stages: Stage 1 consisted of the introduction of two doses of liraglutide. Step 2 consisted of administering GIPR Ab in addition to liraglutide to dosed mice from Step 1. During Steps 1 and 2, a group of mice were simultaneously injected with liraglutide and GIPR Ab to ensure maximum percentage weight loss.

Fig. 42. A) Body masses - combined graphs and B) Body masses - separate graphs. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lira) daily and 2) vehicle or anti-GIPR antibody (Ab) weekly, and the daily percent change in body weight was calculated. The study was divided into two stages: Stage 1 assessed the percentage change in body weight in response to two doses of liraglutide. In Stage 2, the percentage change in body weight as a result of Ab GIPR in addition to liraglutide in the dosed mice from Stage 1 was assessed. During Stages 1 and 2, a group of mice were simultaneously injected with liraglutide and Ab GIPR to ensure the maximum percentage weight loss.

Fig. 43. Food intake. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lira) daily and 2) vehicle or anti-GIPR antibody (Ab) weekly, and food intake was measured over three separate periods. The study was divided into two stages: Stage 1 evaluated the change in food intake at the beginning of the introduction of two doses of liraglutide. In Stage 2, the change in food intake at the beginning and at the end of the administration of Ab GIPR in addition to liraglutide in the dosed mice from Stage 1 was assessed. During Stages 1 and 2, a group of mice was simultaneously injected with liraglutide and Ab GIPR to ensure the maximum percentage weight loss.

Fig. 44. Insulin. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lira) daily and 2) vehicle or anti-GIPR antibody (Ab) weekly, and insulin was measured over three separate periods. The study was divided into two stages: Stage 1 assessed insulin levels prior to the administration of two doses of liraglutide. In Stage 2, insulin levels were assessed before administration of GIPR Ab in addition to liraglutide in dosed mice from Stage 1 and at the completion of Stage 2. During Stages 1 and 2, a group of mice were simultaneously administered liraglutide and GIPR Ab to ensure maximum percent weight loss.

Fig. 45. (A) Biochemistry - liver enzymes. (B) Biochemistry - cholesterol and triglycerides. (C) Biochemistry - non-esterified fatty acids and glucose. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lyra) daily and 2) GIPR transporter or antibody (Ab) weekly, and measured liver enzymes, lipid levels, glucose, and non-esterified fatty acids over three separate periods. The study was divided into two stages: Stage 1 assessed the levels of clinical chemistry prior to the introduction of two doses of liraglutide. In Stage 2, biochemistry was assessed prior to the administration of GIPR Ab in addition to liraglutide in dosed mice from Stage 1 and at the completion of Stage 2. During Stages 1 and 2, a group of mice were simultaneously administered liraglutide and GIPR Ab to ensure maximum percent weight loss.

Fig. 46. Masses of tissues. Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lyra) daily and 2) vehicle or anti-GIPR antibody (Ab) weekly, and tissues were weighed at final tissue collection. The overall design of the study is divided into two stages: Stage 1 consisted of the introduction of two doses of liraglutide. Stage 2 consisted of administering Ab GIPR in addition to liraglutide to dosed mice from Stage 1 and at the conclusion of Stage 2. During Stages 1 and 2, a group of mice were simultaneously administered liraglutide and Ab GIPR to ensure maximum percent weight loss.

Fig. 47. (A) Plasma hormones. (B) Plasma hormones (continued). Diet-induced obesity (DIO) mice were dosed with a combination of: 1) nat. solution or liraglutide (Lira) daily and 2) vehicle or anti-GIPR antibody (Ab) weekly, and hormonal parameters of mice were measured using blood collected after euthanasia. The overall design of the study is divided into two stages: Stage 1 consisted of the introduction of two doses of liraglutide. Stage 2 consisted of administering Ab GIPR in addition to liraglutide to dosed mice from Stage 1 and at the conclusion of Stage 2. During Stages 1 and 2, a group of mice were simultaneously administered liraglutide and Ab GIPR to ensure maximum percent weight loss.

Fig. 48. Study design for chronic treatment with anti-GIPR Ab in spontaneously obese cynomolgus monkeys.

Fig. 49. 2G10 causes weight loss in spontaneously obese cynomolgus monkeys with or without dulaglutide.

Fig. 50. 2G10 alone induces weight loss in spontaneously obese cynomolgus monkeys (baseline reset on day 15 prior to treatment with 2G10).

Fig. 51. 2G10 prevents rise in insulin levels and reduces triglyceride levels with or without dulaglutide in spontaneously obese cynomolgus monkeys on overnight fasting (% change from baseline).

Fig. 52. 2G10 prevents rise in insulin levels and reduces triglyceride levels with or without dulaglutide in spontaneously obese cynomolgus monkeys on overnight fasting (not

- 5 040374 processed data), after the treatment stage (day 45).

Fig. 53. 2G10 does not worsen OGTT in spontaneously obese cynomolgus monkeys, fasted overnight, with or without dulaglutide post-treatment (day 49).

Fig. 54. 2G10 does not affect total cholesterol, LDL-C, and HDL-C levels in spontaneously obese cynomolgus monkeys, fasted overnight, post-treatment (day 45).

Fig. 55. 2G10 does not affect glucose levels in normoglycemic obese cynomolgus monkeys, fasted overnight, post-treatment (day 45).

Fig. 56. 2G10 does not affect liver enzymes in spontaneously obese cynomolgus monkeys fasted overnight at the post-treatment stage (day 45).

Fig. 57. General structure of the huGIPR-Fab 2G10 complex. A) Two pairs of complexes are packed against each other within an asymmetric unit. Fab 2G10 molecules are shown schematically and are colored white and blue-green or wheaten and dark green for their respective combination of light chain and heavy chain. The huGIPR domain is shown in magenta and orange, respectively. B) Close-up of one huGIPR-Fab 2G10 complex. Molecules are colored as in panel A.

Fig. 58. Binding interface. A) A close-up of the binding interface, illustrating the CDR loops of Fab 2G10 in more detail. The heavy chain and light chain of Fab 2G10 are shown in blue-green and white. The heavy chain and light chain CDR loops are colored as follows: CDR1: red (HC) or light red (LC); CDR2: green (HC) or light green (LC); and CDR3: blue (HC) or cyan (LC). Magenta shows huGIPR. B) A close-up of the binding interface, illustrating the huGIPR remnants in more detail. Magenta shows huGIPR and residues that interact with Fab 2G10 are colored blue.

Fig. 59. General structure of the huGIPR-Fab 2C2 complex. A) Two pairs of complexes adopt an antiparallel conformation in an asymmetric unit. Fab 2C2 molecules are shown schematically and are colored white and blue-green or wheaten and dark green for their respective combination of light chain and heavy chain. The huGIPR domain is shown in magenta and orange. B) Close-up of one huGIPR-Fab 2C2 complex. Molecules are colored as in panel A.

Fig. 60. Binding interface. A) A close-up of the binding interface, illustrating Fab 2C2 CDR loops in more detail. The heavy chain and light chain of Fab 2C2 are shown in blue-green and white. The heavy chain and light chain CDR loops are colored as follows: CDR1: red (HC) or light red (LC); CDR2: green (HC) or light green (LC); and CDR3: blue (HC) or cyan (LC). Magenta shows huGIPR. B) A close-up of the binding interface, illustrating the huGIPR remnants in more detail. Magenta shows huGIPR and residues that interact with Fab 2C2 are colored blue.

Fig. 61. General structure of the huGIPR-Fab 6H1 complex. The Fab molecule is shown schematically, and is colored white and blue-green for the combination of light chain and heavy chain. The huGIPR domain is shown in magenta.

Fig. 62. Binding interface. A) A close-up of the binding interface, illustrating Fab 6H1 CDR loops in more detail. The heavy chain and light chain of Fab 6H1 are shown in blue-green and white. The heavy chain and light chain CDR loops are colored as follows: CDR1: red (HC) or light red (LC); CDR2: green (HC) or light green (LC); and CDR3: blue (HC) or cyan (LC). Magenta shows huGIPR. B) A close-up of the binding interface, illustrating the huGIPR remnants in more detail. Magenta shows huGIPR and residues that interact with Fab 6H1 are colored blue.

Fig. 63. General structure of the huGIPR-Fab 17H11 complex. The Fab molecule is shown schematically and is colored white and blue-green for the combination of light chain and heavy chain. The huGIPR domain is shown in magenta.

Fig. 64. Binding interface. A) Close-up of the binding interface, illustrating the CDR loops of Fab 17H11 in more detail. The heavy chain and light chain of Fab 17H11 are shown in blue-green and white. The heavy chain and light chain CDR loops are colored as follows: CDR1: red (HC) or light red (LC); CDR2: green (HC) or light green (LC); and CDR3: blue (HC) or cyan (LC). Magenta shows huGIPR. B) A close-up of the binding interface, illustrating the huGIPR remnants in more detail. Magenta shows huGIPR and residues that interact with Fab 17H11 are colored blue.

Fig. 65. Surface image of an antibody epitope. The ECD GIPR domain is shown in pink in the surface image. The epitope for four antibodies: A) 2G10, B) 2C2, C) 6H1 and D) 17H11, is highlighted in blue, green, blue-green and orange, respectively. The epitope for Gipg013 (PDB: 4JH0) is highlighted in red in panel E.

Detailed Description of the Invention

The present invention provides a method for treating a metabolic disorder such as a disorder of glucose metabolism (e.g. type 2 diabetes, elevated glucose levels, elevated insulin levels, dyslipidemia, metabolic syndrome (Syndrome X or Insulin Resistance Syndrome), glycosuria, metabolic acidosis , type 1 diabetes, obesity and pathology,

- 6 040374 aggravated by obesity) by blocking or interfering with the biological activity of GIP. In one embodiment, a therapeutically effective amount of an isolated human GIPR binding protein is administered to a subject in need thereof. Methods of administration and delivery are also provided. As used herein, methods for producing a recombinant polypeptide and nucleic acid, including those in the examples, are generally those specified in Sambrook et al., Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, 1989) or Current Protocols in Molecular Biology (Ausubel et al., eds., Green Publishers Inc. and Wiley and Sons 1994), each of which is incorporated herein by reference for all purposes. The section headings used in this document are for organizational purposes only and should not be construed as limiting the subject matter being described.

Unless otherwise defined herein, scientific and technical terms used in connection with an application for this invention will have the meanings commonly understood by those skilled in the art. Also, unless otherwise provided by the context, singular terms will include their plural, and plural terms will include their singular.

In general, the terminology used in relation to cell and tissue culture, molecular biology, immunology, microbiology, genetics, and protein and nucleic acid chemistry, and hybridization, as well as methods related to all of the above described in this document, are well known and commonly used in the art. Methods and methods according to this invention, as a rule, are carried out in accordance with traditional methods, well known in the art and described in various general and more specific references, which are given and discussed throughout the description of this invention, unless otherwise indicated. See, for example, Sambrook et al., Molecular Cloning: A Laboratory Manual, ^3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (2001), Ausubel et al., Current Protocols in Molecular Biology, Greene Publishing Associates (1992) and Harlow and Lane Antibodies: A Laboratory Manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1990), which are incorporated herein by reference. Enzymatic reactions and purification methods are performed in accordance with the manufacturer's instructions, usually carried out in the art or as described in this document. The terminology used in relation to analytical chemistry, chemistry of organic synthesis, and medical and pharmaceutical chemistry, as well as related laboratory techniques and methods described in this document, is well known and commonly used in the art. For chemical synthesis, chemical analysis, preparation, preparation and delivery of pharmaceuticals, as well as treatment of patients, standard methods can be used.

It should be understood that this invention is not limited to the particular methodology, protocols and reagents, etc. described herein, and thus is subject to change. The terminology used herein is for the purpose of describing certain embodiments only and is not intended to limit the scope of this invention, which is defined solely by the claims.

Except for the working examples, or unless otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein are to be understood as modified in all examples by the term about. The term about, when used in relation to percentages, can mean ±1%. By convention, as used herein, the singular of a noun means one or more, unless specifically stated otherwise.

As used herein, the terms amino acid and residue are used interchangeably and, when used in the context of a peptide or polypeptide, refer to both naturally occurring and synthetic amino acids, as well as amino acid analogs, amino acid mimetics, and non-naturally occurring amino acids that are chemically similar. to naturally occurring amino acids. A naturally occurring amino acid is an amino acid that is encoded by the genetic code, as well as those amino acids that are encoded by the genetic code that are modified after synthesis, such as hydroxyproline, γ-carboxyglutamate, and O-phosphoserine. a naturally occurring amino acid, eg α-carboxylic, which is attached to hydrogen, a carboxyl group, an amino group and an R group, eg homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (eg, norleucine) or modified peptide backbones, but will retain the same basic chemical structure as the naturally occurring amino acid.

An amino acid mimetic is a chemical compound that has a structure that differs from the general chemical structure of an amino acid, but that functions similarly to a naturally occurring amino acid. Examples include methacryloyl or acryloyl amide derivative, β-, γ-, δ-amino acids (eg, piperidine-4-carboxylic acid), and the like.

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A non-naturally occurring amino acid is a compound that has the same basic chemical structure as a naturally occurring amino acid, but is not incorporated into the growing polypeptide chain via a translation complex. A non-naturally occurring amino acid also includes, but is not limited to: amino acids that are modified (e.g., through post-translational modifications) variants of a naturally occurring amino acid (including but not limited to the 20 standard amino acids), but which are themselves in nature are not built into the growing polypeptide chain through the translation complex. A non-limiting list of examples of non-naturally occurring amino acids that may be included in the polypeptide sequence or substituted for a wild-type residue in the polypeptide sequence include β-amino acids, homoamino acids, cyclic amino acids, and amino acids with derivatized side chains. Examples include (in L-form or D-form; abbreviated as in brackets) citrulline (Cit), homocitrulline (hCit), Na-methylcitrulline (NMeCit), Na-methylhomocitrulline (Na-MeHoCit), ornithine (Orn) , Na-methylornithine (Na-MeOrn or NMeOrn), sarcosine (Sar), homolysin (hLys or hK), homoarginine (hArg or hR), homoglutamine (hQ), Na-methylarginine (NMeR), Na-methylleucine (Na-MeL or NMeL), N-methylhomolizine (NMeHoK), Na-methylglutamine (NMeQ), norleucine (Nle), norvaline (Nva), 1,2,3,4-tetrahydroisoquinoline (Tic), octahydroindole-2-carboxylic acid (Oic) , 3-(1-naphthyl)alanine (1-Nal), 3-(2-naphthyl)alanine (2-Nal), 1,2,3,4-tetrahydroisoquinoline (Tic), 2-indanylglycine (IgI), paraiodine -phenylalanine (pI-Phe), para-aminophenylalanine (4AmP or 4-Amino-Phe), 4-guanidinophenylalanine (Guf), glycillisine (abbreviated as K(Nε-glycyl) or K(glycyl) or K(gly)), nitrophenylalanine (nitrophe), aminophenylalanine (aminophe or Amino-Phe), benzylphenylalanine (benzylphe), γ-carboxyglutamic acid (γ-carboxyglu), hydroxyproline (hydroxypr o), p-carboxyl-phenylalanine (Cpa), α-aminoadipic acid (Aad), Na-methyl valine (NMeVal), N-a-methylleucine (NMeLeu), Na-methylnorleucine (NMeNle), cyclopentylglycine (Cpg), cyclohexylglycine (Chg ), acetylarginine (acetylarg), α,β-diaminopropionic acid (Dpr), α,γ-diaminobutyric acid (Dab), diaminopropionic acid (Dap), cyclohexylalanine (Cha), 4-methyl-phenylalanine (MePhe), β,β -diphenyl-alanine (BiPhA), aminobutyric acid (Abu), 4-phenyl-phenylalanine (or biphenylalanine; 4Bip), α-aminoisobutyric acid (Aib), beta-alanine, beta-aminopropionic acid, piperidic acid, aminocaprioic acid, aminoheptanoic acid, amino pimelic acid, desmosine, diaminopimelic acid, N-ethylglycine, N-atlasparagine, hydroxylysine, allo -hydroxylysine, isodesmosine, allo-isoleucine, N-methylglycine, N-methylisoleucine, N-methylvaline, 4-hydroxyproline (Hyp), γ-carboxyglutamate, ε-N,N.N-trimethyllysine, ε-N-acetyllisine, O-phosphoserine, N-acetylserine, N-formylmethionine, 3-methylhistidine, 5-hydroxylysine, ω-methylarginine, 4-amino-O-phthalic acid (4APA) and other similar amino acids and derivatized forms of any of these.

The term isolated nucleic acid molecule refers to a single- or double-stranded polymer of deoxyribonucleotides or ribonucleotides read from the 5' to 3' end (e.g., the GIPR nucleic acid sequence provided herein), or an analogue thereof, that has been separated from at least 50% polypeptides, peptides, lipids, carbohydrates, polynucleotides, or other substances with which the nucleic acid is naturally found when all of the nucleic acid is isolated from the source cells. Preferably, the isolated nucleic acid molecule is substantially free of any other contaminating nucleic acid molecules or other molecules found in the natural environment of the nucleic acid that interfere with its use in polypeptide production or its therapeutic, diagnostic, prophylactic, or research uses.

The term isolated polypeptide refers to a polypeptide (e.g., the GIPR polypeptide sequence proposed herein or the antigen-binding protein of the present invention) that has been separated from at least 50% of the polypeptides, peptides, lipids, carbohydrates, polynucleotides, or other substances with which the polypeptide is naturally found, when isolated from source cells. Preferably, the isolated polypeptide is substantially free of any other contaminating polypeptides or other contaminants found in its natural environment that interfere with its therapeutic, diagnostic, prophylactic, or research use.

The term encoding refers to a polynucleotide sequence encoding one or more amino acids. The term does not require the presence of a start or stop codon.

The terms identical and percent identity in the context of two or more nucleic acids or polypeptide sequences refers to two or more sequences or subsequences that are the same. Percent identity means the percentage of identical residues between amino acids or nucleotides in the compared molecules and is calculated based on the size of the smallest of the molecules to be compared. In these calculations, gaps in alignments (if any) can be accounted for using a specific mathematical model or computer program (eg, algorithm). Ways that can be applied

- 8 040374 for calculating the identity of aligned nucleic acids or polypeptides, include methods that are described in Computational Molecular Biology, (Lesk, A.M., ed.), (1988), New York: Oxford University Press; Biocomputing Informatics and Genome Projects, (Smith, D.W., ed.), 1993, New York: Academic Press; Computer Analysis of Sequence Data, Part I, (Griffin, A.M., and Griffin, H.G., eds.), 1994, New Jersey: Humana Press; von Heinje, G., (1987), Sequence Analysis in Molecular Biology, New York: Academic Press; Sequence Analysis Primer, (Gribskov, M. and Devereux, 1, eds.), 1991, New York: M. Stockton Press; and Carillo et al., (1988), SIAM J. Applied Math. 48:1073.

When calculating percent identity, compared sequences are aligned in a manner that gives the greatest match between sequences. The computer program used to determine percent identity is the GCG software package, which includes GAP (Devereux et al., 1984, Nucl. Acid Res. 12:387; Genetics Computer Group, University of Wisconsin, Madison, Wisconsin). The GAP computer algorithm is used to align two polypeptides or polynucleotides for which percent sequence identity is to be determined. The sequences are aligned to obtain an optimal match for their respective amino acids or nucleotides (a range of matching as determined by this algorithm). Gap opening penalty (which is calculated as three times the average diagonal, with the average diagonal being the average of the diagonal of the applied comparison matrix; the diagonal is the score or number assigned to each complete amino acid match according to the defined comparison matrix) and gap length penalty ( which is typically 1/10 of the gap opening penalty), as well as a comparison matrix such as PAM 250 or BLOSUM 62 is used with the algorithm. In some embodiments, this algorithm also uses a standard comparison matrix (see Dayhoff et al., 1978, Atlas of Protein Sequence and Structure 5:345-352 for the PAM 250 comparison matrix; Henikoff et al., 1992, Proc. Natl. Acad Sci U.S.A. 89:10915-10919 for the comparison matrix BLOSUM 62).

The recommended parameters for determining percent polypeptide or nucleotide sequence identity using the GAP program are as follows:

Algorithm: Needleman et al., 1970, J. Mol. Biol. 48:443-453.

Comparison matrix: BLOSUM 62 from Henikoff et al., 1992, see above.

Space Penalty: 12 (but no trailing space penalty).

Penalty for space length: 4.

Similarity Threshold: 0.

As a result of applying some alignment schemes to align two amino acid sequences, only a short section of these two sequences can be matched, and this small aligned section can have very high sequence identity even if there is no significant relationship between these two full-length sequences. Accordingly, the selected alignment method (GAP program) can optionally be adapted to provide an alignment that spans at least 50 contiguous amino acids of the target polypeptide.

The terms GIPR polypeptide and GIPR protein are used interchangeably and refer to a naturally occurring wild-type polypeptide expressed in a mammal, such as a human or mouse, and includes naturally occurring alleles (e.g., naturally occurring allelic forms of the human GIPR protein). For the purposes of this disclosure, the term GIPR polypeptide can be used interchangeably to refer to any full-length GIPR polypeptide, for example SEQ ID NO: 3141, which consists of 466 amino acid residues and which is encoded by the nucleotide sequence of SEQ ID NO: 3142 or SEQ ID NO: 3143, which consists of 430 amino acid residues and which is encoded by the nucleotide sequence of SEQ ID NO: 3144 or SEQ ID NO: 3145, which consists of 493 amino acids and which is encoded by the nucleotide sequence of SEQ ID NO: 3146 or SEQ ID NO: 3147, which consists of 460 amino acid residues and which is encoded by the nucleotide sequence of SEQ ID NO: 3148 or SEQ ID NO: 3149, which consists of 230 amino acid residues and which is encoded by the nucleic acid sequence of SEQ ID NO: 3150.

The term GIPR polypeptide also includes a GIPR polypeptide in which a naturally occurring GIPR polypeptide sequence (eg, SEQ ID NO: 3141, 3143, or 3145) has been modified. Such modifications include, but are not limited to, one or more amino acid substitutions, including substitutions for non-naturally occurring amino acids, non-naturally occurring amino acid analogs, and amino acid mimetics.

In various embodiments, the GIPR polypeptide contains an amino acid sequence that is at least 85% identical to a naturally occurring GIPR polypeptide (eg, SEQ ID NO: 3141, 3143, or 3145). In other embodiments, the GIPR polypeptide comprises an amino acid sequence that is at least about 90% or about 95%, 96%, 97%, 98%, or 99% identical to the naturally occurring amino acid sequence of the GIPR polypeptide (e.g., SEQ ID NO: 3141, 3143, or 3145). Such GIPR polypeptides are preferably

- 9 040374 optionally have at least one wild-type GIPR polypeptide activity, such as the ability to bind GIP. The invention also encompasses nucleic acid molecules encoding such GIPR polypeptide sequences.

The term GIPR activity assay (also referred to as GIPR functional assay) means an assay that can be used to measure the activity of GIP or GIP binding protein in a cellular environment. In one embodiment, the activity assay (or functional assay) can be a cAMP assay in cells expressing GIPR, in which GIP can induce a cAMP signal, and the activity of the GIP/GIPR binding protein can be measured in the presence/absence of a GIP ligand, in which there can be obtained IC50/EC50 and degree of inhibition/activation (Biochemical and Biophysical Research Communications (2002), 290:1420-1426). In another embodiment, the activity assay (or functional assay) can be an insulin secretion assay in pancreatic beta cells, in which GIP can induce glucose-dependent insulin secretion and GIP/GIPR binding protein activity can be measured in the presence/absence of a GIP ligand, in which can be obtained IC50/EC50 and the degree of inhibition/activation (Biochemical and Biophysical Research Communications (2002), 290:1420-1426).

The term GIPR binding assay means an assay that can be used to measure the binding of GIP to GIPR. In one embodiment, the GIPR binding assay can be an FMAT or FACS assay that measures the binding of fluorescently labeled GIP to cells expressing GIPR, and the activity of the GIP/GIPR binding protein can be measured by displacement of fluorescently labeled GIP from cells expressing GIPR. In one embodiment, the GIPR binding assay can be an assay that measures the binding of radioactively labeled GIP to cells expressing GIPR, and the activity of the GIP/GIPR binding protein can be measured by displacement of radioactively labeled GIP from cells expressing GIPR (Biochimica et Biophysica Acta ( 2001), 1547:143-155).

The terms GIP, gastric inhibitory polypeptide, glucose-dependent insulinotropic peptide, and GIP ligand are used interchangeably and refer to a naturally occurring wild-type polypeptide expressed in a mammal, such as a human or mouse, and includes naturally occurring alleles (e.g., naturally occurring allelic forms human GIP protein). For the purposes of this disclosure, the term GIP may be used interchangeably to refer to any mature GIP polypeptide. The 42 amino acid sequence of mature human GIP is: YAEGTFISDY SIAMDKIHQQ DFVNWLLAQK GKKNDWKHNI TQ (SEQ ID NO: 3151) and is encoded by the DNA sequence:

tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcatcagcag gattttgtga actggctgct ggcgcagaaa ggcaaaaaaa acgattggaa acataacatt acccag (SEQ ID NO: 3152).

The 42 amino acid sequence of mature mouse GIP is YAEGTFISDY SIAMDKIRQQ DFVNWLLAQR GKKSDWKHNI TQ (SEQ ID NO: 3153) and is encoded by the DNA sequence:

tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcgccagcag gattttgtga actggctgct ggcgcagcgc ggcaaaaaaa gcgattggaa acataacatt acccag (SEQ ID NO: 3154).

The 42 amino acid sequence of mature rat GIP is YAETGTFISDY SIAMDKIRQQ DFVNWLLAQK GKKNDWKHNL TQ (SEQ ID NO: 3155) and is encoded by the DNA sequence:

tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcgccagcag gattttgtga actggctgctg gcgcagaaag gcaaaaaaaa cgattggaaa cataacctga cccag (SEQ ID NO: 3156).

The term antigen-binding protein, as used herein, refers to any protein that specifically binds a particular target antigen, such as a GIPR polypeptide (e.g., a human GIPR polypeptide, such as that provided in SEQ ID NO: 3141, 3143, or 3145). The term also encompasses intact antibodies that contain at least two full-length heavy chains and two full-length light chains, as well as derivatives, variants, fragments, and mutations thereof. Examples of antibody fragments include Fab, Fab', F(ab') ₂ , Fv fragments. The antigen binding protein also includes domain antibodies such as nanobodies and scFvs, as further described below.

In general, an anti-GIPR antigen-binding protein is generally said to specifically bind its GIPR target antigen when the antigen-binding protein exhibits substantially background binding to non-GIPR molecules. An antigen-binding protein that specifically binds GIPR may also cross-react with GIPR polypeptides from different species. Typically, antigen-binding protein to GIPR specifically binds human GIPR when the dissociation constant (KD) is <^10'7 M as measured by surface plasmon resonance (e.g., BIACore, GE-Healthcare Uppsala, Sweden) or kinetic exclusion assay ( KinExA, Sapidyne, Boise, Idaho). GIPR antigen-binding protein specifically binds human GIPR to

- 10 040374 high affinity when KD is <5x10-9 M, and very high affinity when KD is <5x10'10 M, as measured using the methods described above.

An antigen-binding region means a protein or region of a protein that specifically binds a specific antigen. For example, that portion of an antigen-binding protein that contains amino acid residues that interact with an antigen and provide an antibody with its specificity and affinity for the antigen is called the antigen-binding region. The antigen binding region typically includes one or more complementary binding regions (CDRs) of an immunoglobulin, a single chain immunoglobulin, or a camel antibody. Some antigen binding regions also include one or more framework regions. CDR is an amino acid sequence that contributes to antigen-binding specificity and affinity. Framework regions can help maintain the proper CDR conformation to facilitate binding between the antigen-binding region and the antigen.

A recombinant protein, including a recombinant GIPR antigen-binding protein, is a protein obtained using recombinant techniques, i.e. by expressing the recombinant nucleic acid described herein. Methods and methods for obtaining recombinant proteins are well known in the art.

The term antibody refers to an intact immunoglobulin of any isotype, or antigen-binding fragment thereof, that can compete with an intact antibody for specific binding to a target antigen, and includes, for example, chimeric, humanized, and fully human and bispecific antibodies. An antibody, as such, is a type of antigen-binding protein. An intact antibody will typically contain at least two full length heavy chains and two full length light chains. different portions of an antibody can be generated from two different antibodies, as further described below. Antigen-binding proteins, antibodies, or binding fragments can be generated in hybridomas using recombinant DNA techniques or by enzymatic or chemical cleavage of intact antibodies.

The term light chain, as applied to an antibody or fragments thereof, includes a full length light chain and fragments thereof having a variable region sequence sufficient to provide binding specificity. The full length light chain includes a variable region domain, VL, and a constant region domain, CL. The light chain variable region domain is located at the amino terminus of the polypeptide. Light chains include kappa chains and lambda chains. The term heavy chain, as applied to an antibody or fragments thereof, includes a full length heavy chain and fragments thereof having a variable region sequence sufficient to provide binding specificity. The full length heavy chain includes a variable region domain, VH, and three constant region domains, CH1, CH2 and CH3. The VH domain is located at the amino terminus of the polypeptide, and the CH domains are located at the carboxyl terminus, with CH3 located closest to the carboxyl terminus of the polypeptide. Heavy chains can be of any isotype, including IgG (including the IgG1, IgG2, IgG3, and IgG4 subtypes), IgA (including the IgA1 and IgA2 subtypes), IgM, and IgE.

As used herein, the term immunologically functional fragment (or simply fragment) of an antibody or immunoglobulin chain (heavy or light chain) is an antigen-binding protein containing a portion (regardless of how that portion was made or synthesized) of an antibody in which missing at least some of the amino acids present in the full-length chain, but which is able to specifically bind to the antigen. Such fragments are biologically active because they specifically bind to the target antigen and can compete with other antigen-binding proteins, including intact antibodies, for specific binding to a given epitope. These biologically active fragments can be obtained using recombinant DNA technologies or can be obtained, for example, by enzymatic or chemical cleavage of antigen-binding proteins, including intact antibodies. Immunologically functional immunoglobulin fragments include, but are not limited to, Fab, Fab', F(ab') ₂ fragments. In another embodiment, the Fvs, domain antibodies and scFvs can be derived from an antibody of the invention.

Additionally, it is contemplated that a functional portion of the antigen-binding proteins disclosed herein, e.g., one or more CDRs, can be covalently linked to a second protein or small molecule to create a target-specific therapeutic agent in the body that has bifunctional therapeutic properties. or having a prolonged serum half-life.

The Fab fragment consists of one light chain and CH1 and variable regions of one heavy chain. The heavy chain of a Fab molecule cannot form a disulfide bond with another heavy chain molecule.

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The Fc region contains two heavy chain fragments containing the CH2 and CH3 domains of the antibody. The two heavy chain fragments are held together by two or more disulfide bonds and through hydrophobic interactions of the CH3 domains.

A Fab' fragment containing one light chain and part of one heavy chain contains a VH domain and a CH1 domain, as well as a region between the CH1 and CH2 domains, so that an interchain disulfide bond can form between the two heavy chains of the two Fab' fragments to form an F( ab')2.

The F(ab') ₂ fragment contains two light chains and two heavy chains containing a portion of the constant region between the CH1 and CH2 domains so that an interchain disulfide bond is formed between the two heavy chains. Thus, the F(ab') ₂ fragment consists of two Fab' fragments that are held together by a disulfide bond between the two heavy chains.

The Fv region contains both heavy and light chain variable regions, but no constant regions.

Single chain antibodies or scFvs are Fv molecules in which the variable regions of the heavy and light chains are connected by a flexible linker to form a single polypeptide chain, resulting in an antigen binding region. scFvs are discussed in detail in International Patent Application Publication No. WO 88/01649 and in US Pat. Nos. 4,946,778 and 5,260,203, the disclosures of which are incorporated by reference.

A domain antibody or single chain immunoglobulin is an immunologically functional fragment of an immunoglobulin containing only a heavy chain variable region or a light chain variable region. Examples of domain antibodies include Nanobodies®. In some cases, two or more VH regions are covalently linked by a peptide linker to create a bivalent domain antibody. The two VH regions of the bivalent domain antibody may be targeted by the same or different antigens. A bivalent antigen-binding protein or bivalent antibody contains two antigen-binding regions. In some cases, two antigen-binding regions have the same antigenic specificity. Bivalent antigen-binding proteins or bivalent antibodies can be bispecific (see below).

A multispecific antigen binding protein or multispecific antibody is one that targets more than one antigen or epitope.

A bispecific, dual specificity, or bifunctional antigen-binding protein or antibody is a hybrid antigen-binding protein or antibody, respectively, having two different antigen-binding sites. Bispecific antigen-binding proteins and antibodies are a kind of multispecific antigen-binding protein or multispecific antibody and can be produced by a number of methods, including, but not limited to, fusion of hybridomas or joining of Fab' fragments. See, for example, Songsivilai and Lachmann, 1990, Clin. Exp. Immunol. 79:315-321; Kostelny et al., 1992, J. Immunol. 148:1547-1553. The two binding sites of a bispecific antigen-binding protein or antibody will bind two different epitopes, which may be located on the same or different target proteins. The term compete, when used in the context of antigen-binding proteins (eg, antibodies), means competition between antigen-binding proteins, as determined by an assay in which the antigen-binding protein of interest (eg, an antibody or immunologically functional fragment thereof) prevents or inhibits specific binding of a reference antigen-binding protein. with a common antigen (for example, GIPR or its fragment). A wide variety of competitive binding assays can be used, such as solid phase direct or indirect radioimmunoassay (RIA), solid phase direct or indirect enzyme immunoassay (ELISA), competitive sandwich assay (see e.g. Stahli et al., 1983, Methods in Enzymology, 9:242253); solid phase direct ELISA with biotin and avidin (see, for example, Kirkland et al., 1986, J. Immunol. 137:3614-3619), solid phase direct labeled assay, solid phase direct labeled sandwich assay (see, for example, Harlow and Lane, 1988, Antibodies, A Laboratory Manual, Cold Spring Harbor Press); solid phase direct RIA with labeling using the label I-125 (see, for example, Morel et al., 1988, Molec. Immunol. 25:7-15); solid-state direct ELISA with biotin and avidin (see, for example, Cheung, et al., 1990, Virology, 176:546-552) and direct RIA with labeling (Moldenhauer et al., 1990, Scand. J. Immunol. 32: 77-82). Typically, such an assay involves the use of purified antigen bound to a solid surface or cells expressing the antigen, an unlabeled antigen-binding protein of interest, and a labeled control antigen-binding protein. Competitive inhibition is measured by determining the amount of solid surface-bound label or cells in the presence of the antigen-binding protein of interest. Typically, the antigen-binding protein of interest is present in excess. Additional details regarding methods for determining competitive binding are given in this document in the examples. Typically, if the competing antigen-binding protein is present in excess, it will inhibit specific binding of the control antigen-binding protein to the total antigen by at least 40%, 45%, 50%, 55%, 60%, 65%, 70%, or 75%. In some cases

- 12 040374 binding is inhibited by at least 80%, 85%, 90%, 95% or 97% or more.

The term antigen refers to a molecule or portion of a molecule that a selective binding agent, such as an antigen-binding protein (including, for example, an antibody) is capable of binding, and that can additionally be used to produce antibodies in an animal body that are capable of binding to that antigen. An antigen may contain one or more epitopes that are capable of interacting with different antigen-binding proteins, such as antibodies.

The term epitope refers to the portion of a molecule that is bound by an antigen-binding protein (eg, an antibody). The term includes any determinant capable of specifically binding to an antigen-binding protein, such as an antibody. An epitope may be contiguous or non-contiguous (discontinuous) (for example, these are amino acid residues in a polypeptide that are not contiguous to each other in the polypeptide sequence, but are bound within the molecule by an antigen-binding protein). A conformational epitope is an epitope that exists in the conformation of the active protein but is not present in the denatured protein. In certain embodiments, epitopes may be mimetic in the sense that they have a similar three-dimensional structure to the epitope used to produce the antigen-binding protein, but do not contain or contain only some of the amino acid residues found in the epitope used to produce the antigen-binding protein. . Most often, epitopes are found on proteins, but in some cases they can be found on other types of molecules, such as nucleic acids. Epitopic determinants may include reactive surface groups of molecules such as amino acids, sugar side chains, phosphoryl or sulfonyl groups, and may have specific three-dimensional structural and/or specific charge characteristics. In general, in general, antigen-binding proteins specific for a particular target antigen preferentially recognize an epitope on the target antigen in a complex mixture of proteins and/or macromolecules.

As used herein, essentially pure means that the species of the molecule being described is present as the predominant species, ie. in molar content it is more numerous than any other single species in the same mixture. In some embodiments, the substantially pure molecule is a composition in which the target species is at least 50% (by molar content) of all macromolecular species present. In other embodiments, the substantially pure composition will contain at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% of all macromolecular species present in the composition. In other embodiments, the target species is purified to a substantially homogeneous state, wherein conventional detection methods cannot detect contaminant species in the composition, and the composition consists of a single detectable macromolecular species.

The term treatment refers to any indication of success in treating or repairing an injury, pathology, or condition, including any objective or subjective parameter such as relief of pain or symptom severity; remission; ameliorating symptoms or promoting better tolerance of the injury, pathology or condition in the patient; slowing down the rate of degeneration or deterioration; contributing to a less severe course of the final stage of degeneration; improving the patient's physical or mental health. Treatment or relief of symptoms may be based on objective or subjective parameters; including the results of a medical examination, neuropsychiatric examinations and / or psychiatric examination. For example, some of the methods provided herein successfully treat cardiovascular disease such as atherosclerosis by reducing the incidence of cardiovascular disease, inducing remission of cardiovascular disease, and/or improving a symptom associated with cardiovascular disease.

The term effective amount is generally an amount sufficient to reduce the severity and/or frequency of symptoms, eliminate symptoms and/or underlying cause, prevent the onset of symptoms and/or underlying cause, and/or ameliorate or eliminate the lesion resulting from or associated with a pathological condition (eg, diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels, or diabetic nephropathy). In some embodiments, the effective amount is a therapeutically effective amount or a prophylactically effective amount. A therapeutically effective amount is an amount sufficient to correct the condition (e.g., atherosclerosis) or symptoms, in particular the condition or symptoms associated with the condition, or otherwise prevent, hinder, slow or reverse the progression of the condition or any other undesirable symptom, associated with disease in any form. A prophylactically effective amount is the amount of a pharmaceutical composition that, when administered to a subject, will have an intended prophylactic effect, such as preventing or delaying the occurrence (or recurrence) of a condition or reducing the likelihood of occurrence

- 13 040374 (or recurrence) of a pathological condition or associated symptoms. The full therapeutic or prophylactic effect does not necessarily result from the administration of a single dose and may only occur after a series of doses has been administered. Thus, a therapeutically or prophylactically effective amount may be administered in one or more administrations.

The terms therapeutically effective dose and therapeutically effective amount, as used herein, refer to the amount of GIPR binding protein that elicits a biological or drug response in a tissue system, animal, or human that is sought by a researcher, physician, or other clinician, which includes facilitation or improvement in the symptoms of the disease or pathology being treated, i. e. the amount of GIPR binding protein that maintains the observed level of one or more of the desired biological or drug response, such as lowering blood glucose, insulin, triglycerides, or cholesterol; weight loss or increased glucose tolerance, energy expenditure, or insulin sensitivity. The term polynucleotide or nucleic acid includes both single-stranded and double-stranded nucleotide polymers. The nucleotides that make up the polynucleotide may be ribonucleotides or deoxyribonucleotides, or a modified form of any of these types of nucleotides. Modifications include base modifications such as bromuridine and inosine derivatives, ribose modifications such as 2',3'-dideoxyribose, and internucleotide linkage modifications such as phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoranilinothioate, phoshoranyladate, and phosphoramidate.

The term oligonucleotide means a polynucleotide containing 200 or fewer nucleotides. In some embodiments, the implementation of the length of the oligonucleotides is from 10 to 60 bases. In other embodiments, the oligonucleotides are 12, 13, 14, 15, 16, 17, 18, 19, or 20 to 40 nucleotides in length. Oligonucleotides may be single or double stranded, for example, for use in the construction of a mutant gene. Oligonucleotides can be sense or antisense oligonucleotides. The oligonucleotide may contain a label, including a radiolabel, a fluorescent label, a hapten label, or an antigenic label, for use in detection methods. The oligonucleotides can be used, for example, as PCR primers, cloning primers or hybridization probes. An isolated nucleic acid molecule means genomic DNA or RNA, mRNA, cDNA, or synthetic origin, or some combination thereof, that is not associated with all or part of a polynucleotide in which the isolated polynucleotide is found in nature, or is associated with a polynucleotide with which it is not naturally associated . For the purposes of this disclosure, it should be understood that a nucleic acid molecule containing a particular nucleotide sequence does not span intact chromosomes. Isolated nucleic acid molecules containing certain nucleotide sequences may include, in addition to said sequence, coding sequences for up to ten or even up to twenty other proteins or parts thereof, or may contain operably linked regulatory sequences that direct the expression of the coding regions of said nucleotide sequences, and/or may contain vector sequences.

Unless otherwise indicated, the left end of any single stranded polynucleotide sequence discussed herein is the 5' end; the left direction of double-stranded polynucleotide sequences is called the 5' direction. The 5' to 3' direction in which nascent RNA transcripts build up is called the transcriptional direction; regions of the DNA strand sequence having the same sequence as the RNA transcript that are located 5' to the 5' end of the RNA transcript are called upstream sequences; portions of a DNA chain sequence having the same sequence as the RNA transcript that are located 3' to 3' end of the RNA transcript are called downstream sequences.

The term regulatory sequence refers to a polynucleotide sequence that can influence the expression and processing of the coding sequences to which it is ligated. The nature of such regulatory sequences may depend on the host organism. In specific embodiments, regulatory sequences for prokaryotes may include a promoter, a ribosome binding site, and a transcription termination sequence. For example, regulatory sequences for eukaryotes may include promoters containing one or more transcription factor recognition sites, transcription enhancer sequences, and transcription termination sequences. The regulatory sequences may include leader sequences and/or fusion partner sequences. The term vector refers to any molecule or entity (eg, nucleic acid, plasmid, bacteriophage, or virus) used to transfer protein-coding information into a host cell.

The term expression vector or expression construct refers to a vector that is suitable for transformation of a host cell and contains nucleotide sequences that direct and/or regulate (together with the host cell) the expression of one or more

- 14,040,374 heterologous coding regions operably linked to them. An expression construct may include, but is not limited to, sequences that affect or regulate transcription, translation and, if introns are present, affect RNA splicing of the coding region operably linked to them.

As used herein, operably linked means that the components to which the term refers are in a relationship that allows them to perform their inherent functions under appropriate conditions. For example, a regulatory sequence in a vector that is operably linked to a protein coding sequence is ligated such that expression of the protein coding sequence is achieved under conditions compatible with the transcriptional activity of the regulatory sequences.

The term host cell refers to a cell that has been transformed with a nucleotide sequence and thus expresses a gene of interest. The term includes the progeny of the original cell, whether or not the progeny is identical in morphology or genetic construct to the original parent cell, as long as the gene of interest is present.

The terms polypeptide and protein are used interchangeably herein and refer to a polymer of amino acid residues. Also, these terms apply to amino acid polymers in which one or more amino acid residues is an analog or mimetic of the corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers. The terms may also cover amino acid polymers that have been modified, for example by the addition of carbohydrate residues to form glycoproteins, or phosphorylated. Polypeptides and proteins may be produced by a non-recombinant naturally occurring cell or by a genetically engineered or recombinant cell and may contain molecules having the amino acid sequence of the native protein, or molecules containing deletions, additions and/or substitutions of one or more amino acids of the native sequence . The terms polypeptide and protein specifically encompass anti-GIPR antigen-binding proteins, antibodies, or sequences that contain deletions, additions, and/or substitutions of one or more amino acids of the antigen-binding protein.

The term polypeptide fragment refers to a polypeptide that has an amino-terminal deletion, a carboxy-terminal deletion, and/or an internal deletion compared to a full-length protein. Such fragments may also contain modified amino acids compared to the full length protein. In certain embodiments, the fragments are from about 5 to 500 amino acids in length. For example, fragments may be at least 5, 6, 8, 10, 14, 20, 50, 70, 100, 110, 150, 200, 250, 300, 350, 400, or 450 amino acids long. Suitable polypeptide fragments include immunologically functional antibody fragments, including binding domains.

The term isolated protein means that said protein (1) does not contain at least some of the other proteins with which it is commonly found; (2) substantially free of other proteins from the same source, such as those derived from the same species; (3) expressed by a cell derived from another species; (4) has been separated from at least about 50% of the polynucleotides, lipids, carbohydrates, or other substances to which it is naturally associated, (5) is operably linked (via a covalent or non-covalent interaction) to a polypeptide to which it is not naturally associated , or (6) is not found in nature. Typically, the isolated protein makes up at least about 5%, at least about 10%, at least about 25%, or at least about 50% of a given sample. Such an isolated protein may be encoded by genomic DNA, mRNA cDNA, or other RNA of synthetic origin, or any combination thereof. Preferably, the isolated protein is substantially free of proteins or polypeptides or other contaminants found in its natural environment that would interfere with its therapeutic, diagnostic, prophylactic, research or other uses.

A variant polypeptide (eg, an antigen-binding protein, such as an antibody) contains an amino acid sequence, with one or more amino acid residues inserted into, removed from, and/or substituted in that amino acid sequence compared to another polypeptide sequence. Variants include fusion proteins.

A polypeptide derivative is a polypeptide (eg, an antigen-binding protein, such as an antibody) that has been chemically modified in some manner other than insertion, deletion, or substitution, such as by conjugation to another chemical moiety.

As used throughout the specification, with respect to biological materials such as polypeptides, nucleic acids, host cells, and the like, the term naturally occurring refers to materials that can be found in nature.

The subject or patient, as used herein, may be any mammal. In a typical embodiment, the subject or patient is a human.

As disclosed herein, the GIPR polypeptide described in the disclosure may

- 15 040374 be designed and/or obtained using standard molecular biology methodology. In various embodiments, a nucleotide sequence encoding a GIPR, which may comprise all or part of SEQ ID NO: 1, 3, or 5, can be isolated and/or amplified from genomic DNA or cDNA using suitable oligonucleotide primers. Primers can be designed based on the nucleotide and amino acid sequences provided herein according to standard RT-PCR (reverse transcription polymerase chain reaction) methods. The amplified GIPR nucleic acid can then be cloned into a suitable vector and characterized by DNA sequence analysis.

Oligonucleotides for use as probes to isolate or amplify all or part of the GIPR sequences provided herein can be designed and prepared using standard synthetic techniques, such as automated DNA machine synthesis, or can be isolated from a longer DNA sequence.

The 466 amino acid sequence of human GIPR is (Volz et al., FEBS Lett.

373:23-29 (1995); annotated NCBI sequence: NP_0001555):

MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA CNGFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL

RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA

TLLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILSR DRLLPRPGPY

LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG

SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR

TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV

TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC

RLRRSLGEEQ RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC (SEQ W NO: 3141)

- 16 040374 и кодируется последовательностью ДНК (аннотированная последовательность NCBI: NM_000164): ggcagcggtg gcaggggctg caggagcaag tgaccaggag caggactggg gacaggcctg atcgcccctg cacgaaccag acccttcgcc gccctcacga tgactacctc tccgatcctg cagctgctgc tgcggctctc actgtgcggg ctgctgctcc agagggcgga gacaggctct aaggggcaga cggcggggga gctgtaccag cgctgggaac ggtaccgcag ggagtgccag gagaccttgg cagccgcgga accgccttca ggcctcgcct gtaacgggtc cttcgatatg tacgtctgct gggactatgc tgcacccaat gccactgccc gtgcgtcctg cccctggtac ctgccctggc accaccatgt ggctgcaggt ttcgtcctcc gccagtgtgg cagtgatggc caatggggac tttggagaga ccatacacaa tgtgagaacc cagagaagaa tgaggccttt ctggaccaaa ggctcatctt ggagcggttg caggtcatgt acactgtcgg ctactccctg tctctcgcca cactgctgct agccctgctc atcttgagtt tgttcaggcg gctacattgc actagaaact atatccacat caacctgttc acgtctttca tgctgcgagc tgcggccatt ctcagccgag accgtctgct acctcgacct ggcccctacc ttggggacca ggcccttgcg ctgtggaacc aggccctcgc tgcctgccgc acggcccaga tcgtgaccca gtactgcgtg ggtgccaact acacgtggct gctggtggag ggcgtct acc tgcacagtct cctggtgctc gtgggaggct ccgaggaggg ccacttccgc tactacctgc tcctcggctg gggggccccc gcgcttttcg tcattccctg ggtgatcgtc aggtacctgt acgagaacac gcagtgctgg gagcgcaacg aagtcaaggc catttggtgg attatacgga cccccatcct catgaccatc ttgattaatt tcctcatttt tatccgcatt cttggcattc tcctgtccaa gctgaggaca cggcaaatgc gctgccggga ttaccggctg aggctggctc gctccacgct gacgctggtg cccctgctgg gtgtccacga ggtggtgttt gctcccgtga cagaggaaca ggcccggggc gccctgcgct tcgccaagct cggctttgag atcttcctca gctccttcca gggcttcctg gtcagcgtcc tctactgctt catcaacaag gaggtgcagt cggagatccg ccgtggctgg caccactgcc gcctgcgccg cagcctgggc gaggagcaac gccagctccc ggagcgcgcc ttccgggccc tgccctccgg ctccggcccg ggcgaggtcc ccaccagccg cggcttgtcc tcggggaccc tcccagggcc tgggaatgag gccagccggg agttggaaag ttactgctag ggggcgggat ccccgtgtct gttcagttag catggattta ttgagtgcca actgcgtgcc aggcccagta cggaggacgc tggggaaatg gtgaaggaaa cagaaaaaag gtccctgccc ttctggagat gacaactgag tggggaaaac agaccgtgaa cacaaaacat caagttccac acacgctatg gaatggttat gaagggaagc gagaaggggg cctagg gtgg tctgggaggc gtctccaagg aggtgacact taagccatcc ccgaaagagg tgaaagagat cactttgggg agagctggag aacaggattc taggcggaag cgatagcata ggcaaaggcc cttgggcagg aaggcgctca gccttggctg gagtagaatt aagtcagagc caacaggtgg ggagagacag agaagtgggc aggggcaccc aagttgggat ttcatttcag gtgcattgga gattcttagg agtgtctctt gggggtaata ttttattttt taaaaaatga ggat (SEQ ID NO: 3142).

The 430-amino acid human GIPR isoform (X1 isoform) predicted by automated computer analysis has the sequence (NCBI annotated sequence XP_005258790):

MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSVAA GFVLRQCGSD GQWGLWRDHT QCENPEKNEA FLDQRLILER LQVMYTVGYS LSLATLLLAL LILSLFRRLH CTRNYIHINL FTSFMLRAAAILSRDRLLPR PGPYLGDQAL LHNQALAAC RTAQNYTGAIVSLVSL

LVGGSEEGHF RYYLLLGWGA PALFVIPWVI VRYLYENTQC WERNEVKAIW

WHRTPILMT ILINFLIFIR ILGILLSKLR TRQMRCRDYR LRLARSTLTL VPLLGVHEVV FAPVTEEQAR GALRFAKLGF EIFLSSFQGF LVSVLYCFIN KEVQSEIRRG

WHHCRLRRSL GEEQRQLPER AFRALPSGSG PGEVPTSRGL SSGTLPGPGN

EASRELESYC (SEQ W NO: 3143)

- 17 040374 and is encoded by the DNA sequence:

atgaccacca gcccgattct gcagctgctg ctgcgcctga gcctgtgcgg cctgctgctg cagcgcgcgg aaaccggcag caaaggccag accgcgggcg aactgtatca gcgctgggaa cgctatcgcc gcgaatgcca ggaaaccctg gcggcggcgg aaccgccgag cgtggcggcg ggctttgtgc tgcgccagtg cggcagcgat ggccagtggg gcctgtggcg cgatcatacc cagtgcgaaa acccggaaaa aaacgaagcg tttctggatc agcgcctgat tctggaacgc ctgcaggtga tgtataccgt gggctatagc ctgagcctgg cgaccctgct gctggcgctg ctgattctga gcctgtttcg ccgcctgcat tgcacccgca actatattca tattaacctg tttaccagct ttatgctgcg cgcggcggcg attctgagcc gcgatcgcct gctgccgcgc ccgggcccgt atctgggcga tcaggcgctg gcgctgtgga accaggcgct ggcggcgtgc cgcaccgcgc agattgtgac ccagtattgc gtgggcgcga actatacctg gctgctggtg gaaggcgtgt atctgcatag cctgctggtg ctggtgggcg gcagcgaaga aggccatttt cgctattatc tgctgctggg ctggggcgcg ccggcgctgt ttgtgattcc gtgggtgatt gtgcgctatc tgtatgaaaa cacccagtgc tgggaacgca acgaagtgaa agcgatttgg tggattattc gcaccccgat tctgatgacc attctgatta actttctgat ttttattcgc attctgggca ttctgctgag caaactgcgc acccgccaga tgcgctgccg cgattatcgc ctgcgcctgg cgcgcagcac cctgaccctg gtgccgctgc tgggcgtgca tgaagtggtg tttgcgccgg tgaccgaaga acaggcgcgc ggcgcgctgc gctttgcgaa actgggcttt gaaatttttc tgagcagctt tcagggcttt ctggtgagcg tgctgtattg ctttattaac aaagaagtgc agagcgaaat tcgccgcggc tggcatcatt gccgcctgcg ccgcagcctg ggcgaagaac agcgccagct gccggaacgc gcgtttcgcg cgctgccgag cggcagcggc ccgggcgaag tgccgaccag ccgcggcctg agcagcggca ccctgccggg cccgggcaac gaagcgagcc gcgaactgga aagctattgc (SEQ ID NO: 3144).

The 493 amino acid isoform of human GIPR obtained by alternative splicing has the sequence (Gremlich et al., Diabetes, 44:1202-8 (1995); UniProtKB sequence identifier: P48546-2):

MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLPLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILY DRL

LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR

TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVG RDPAAAPALW

RRRGTAPPLS AIVSQVQSEI RRGWHHCRLR RSLGEEQRQL PERAFRALPS GSGPGEVPTS RGLSSGTLPGPGNEASRELE SYC (SEQ ID NO: 3145)

- 18 040374 and is encoded by the DNA sequence:

atgaccacca gcccgattct gcagctgctg ctgcgcctga gcctgtgcgg cctgctgctg cagcgcgcgg aaaccggcag caaaggccag accgcgggcg aactgtatca gcgctgggaa cgctatcgcc gcgaatgcca ggaaaccctg gcggcggcgg aaccgccgag cggcctggcg tgcaacggca gctttgatat gtatgtgtgc tgggattatg cggcgccgaa cgcgaccgcg cgcgcgagct gcccgtggta tctgccgtgg catcatcatg tggcggcggg ctttgtgctg cgccagtgcg gcagcgatgg ccagtggggc ctgtggcgcg atcataccca gtgcgaaaac ccggaaaaaa acgaagcgtt tctggatcag cgcctgattc tggaacgcct gcaggtgatg tataccgtgg gctatagcct gagcctggcg accctgctgc tggcgctgct gattctgagc ctgtttcgcc gcctgcattg cacccgcaac tatattcata ttaacctgtt taccagcttt atgctgcgcg cggcggcgat tctgagccgc gatcgcctgc tgccgcgccc gggcccgtat ctgggcgatc aggcgctggc gctgtggaac caggcgctgg cggcgtgccg caccgcgcag attgtgaccc agtattgcgt gggcgcgaac tatacctggc tgctggtgga aggcgtgtat ctgcatagcc tgctggtgct ggtgggcggc agcgaagaag gccattttcg ctattatctg ctgctgggct ggggcgcgcc ggcgctgttt gtgattccgt gggtgattgt gcgctatctg tatgaaaaca cccagtgctg ggaacgcaac gaagtgaaag cgatttggtg gattattcgc accccgattc tgatgaccat tctgattaac tttctgattt ttattcgcat tctgggcatt ctgctgagca aactgcgcac ccgccagatg cgctgccgcg attatcgcct gcgcctggcg cgcagcaccc tgaccctggt gccgctgctg ggcgtgcatg aagtggtgtt tgcgccggtg accgaagaac aggcgcgcgg cgcgctgcgc tttgcgaaac tgggctttga aatttttctg agcagctttc agggctttct ggtgagcgtg ctgtattgct ttattaacaa agaagtgggc cgcgatccgg cggcggcgcc ggcgctgtgg cgccgccgcg gcaccgcgcc gccgctgagc gcgattgtga gccaggtgca gagcgaaatt cgccgcggct ggcatcattg ccgcctgcgc cgcagcctgg gcgaagaaca gcgccagctg ccggaacgcg cgtttcgcgc gctgccgagc ggcagcggcc cgggcgaagt gccgaccagc cgcggcctga gcagcggcac cctgccgggc ccgggcaacg aagcgagccg cgaactggaa agctattgct aa (SEQ ID NO: 3146)

The 460 amino acid sequence of mouse GIPR is (NCBI annotated sequence: NP_001074284; uniprotKB/Swiss-Prot Q0P543-1); see Vassilatis et al., PNAS USA 2003, 100:4903-4908.

MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCFINKEVQSEIRQ GWRHRRLRLS LQEQRPRPHQ ELAPRAVPLS SACREAAVGN ALPSGMLHVP GDEVLESYC (SEQ ID NO: 3147)

- 19 040374 and is encoded by the DNA sequence (NCBI annotated sequence: NM_001080815):

atgccgctgc gcctgctgct gctgctgctg tggctgtggg gcctgcagtg ggcggaaacc gatagcgaag gccagaccac caccggcgaa ctgtatcagc gctgggaaca ttatggccag gaatgccaga aaatgctgga aaccaccgaa ccgccgagcg gcctggcgtg caacggcagc tttgatatgt atgcgtgctg gaactatacc gcggcgaaca ccaccgcgcg cgtgagctgc ccgtggtatc tgccgtggtt tcgccaggtg agcgcgggct ttgtgtttcg ccagtgcggc agcgatggcc agtggggcag ctggcgcgat catacccagt gcgaaaaccc ggaaaaaaac ggcgcgtttc aggatcagac cctgattctg gaacgcctgc agattatgta taccgtgggc tatagcctga gcctgaccac cctgctgctg gcgctgctga ttctgagcct gtttcgccgc ctgcattgca cccgcaacta tattcatatg aacctgttta ccagctttat gctgcgcgcg gcggcgattc tgacccgcga tcagctgctg ccgccgctgg gcccgtatac cggcgatcag gcgccgaccc cgtggaacca ggcgctggcg gcgtgccgca ccgcgcagat tatgacccag tattgcgtgg gcgcgaacta tacctggctg ctggtggaag gcgtgtatct gcatcatctg ctggtgattg tgggccgcag cgaaaaaggc cattttcgct gctatctgct gctgggctgg ggcgcgccgg cgctgtttgt gattccgtgg gtgattgtgc gctatctgcg cgaaaacacc cagtgctggg aacgcaacga agtgaaagcg atttggtgga ttattcgcac cccgattctg attaccattc tgattaactt tctgattttt attcgcattc tgggcattct ggtgagcaaa ctgcgcaccc gccagatgcg ctgcccggat tatcgcctgc gcctggcgcg cagcaccctg accctggtgc cgctgctggg cgtgcatgaa gtggtgtttg cgccggtgac cgaagaacag gtggaaggca gcctgcgctt tgcgaaactg gcgtttgaaa tttttctgag cagctttcag ggctttctgg tgagcgtgct gtattgcttt attaacaaag aagtgcagag cgaaattcgc cagggctggc gccatcgccg cctgcgcctg agcctgcagg aacagcgccc gcgcccgcat caggaactgg cgccgcgcgc ggtgccgctg agcagcgcgt gccgcgaagc ggcggtgggc aacgcgctgc cgagcggcat gctgcatgtg ccgggcgatg aagtgctgga aagctattgc taa (SEQ ID NO: 3148)

The 230-amino acid isoform of mouse GIPR obtained by alternative splicing has the sequence (Gerhard et al., Genome Res, 14:2121-2127 (2004); NCBI annotated sequence: AAI20674):

MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA PAILTYD

APTPWNQVLH RLLPGGTKTF PIYFRTFPHH (SEQ ID NO: 3149) и кодируется последовательностью ДНК: atgccgctgc gcctgctgct gctgctgctg tggctgtggg gcctgcagtg ggcggaaacc gatagcgaag gccagaccac caccggcgaa ctgtatcagc gctgggaaca ttatggccag gaatgccaga aaatgctgga aaccaccgaa ccgccgagcg gcctggcgtg caacggcagc tttgatatgt atgcgtgctg gaactatacc gcggcgaaca ccaccgcgcg cgtgagctgc ccgtggtatc tgccgtggtt tcgccaggtg agcgcgggct ttgtgtttcg ccagtgcggc agcgatggcc agtggggcag ctggcgcgat catacccagt gcgaaaaccc ggaaaaaaac ggcgcgtttc aggatcagac cctgattctg gaacgcctgc agattatgta taccgtgggc tatagcctga gcctgaccac cctgctgctg gcgctgctga ttctgagcct gtttcgccgc ctgcattgca cccgcaacta tattcatatg aacctgttta ccagctttat gctgcgcgcg gcggcgattc tgacccgcga tcagctgctg ccgccgctgg gcccgtatac cggcgatcag gcgccgaccc cgtggaacca ggtgctgcat cgcctgctgc cgggcggcac caaaaccttt ccgatttatt ttcgcacctt tccgcatcat taa (SEQ ID NO: 3150).

As used herein, the term GIPR polypeptide encompasses naturally occurring GIPR polypeptide sequences, such as human amino acid sequences of SEQ ID NO: 3141, 3143, or 3145. However, the term GIPR polypeptide also encompasses polypeptides containing an amino acid sequence that is different from the amino acid sequence found in nature of the GIPR polypeptide sequence, for example SEQ ID NO: 3141, 3143, or 3145, with one or more amino acids, such that the sequence is at least 85% identical to SEQ ID NO: 3141, 3143, or 3145. GIPR polypeptides can be obtained by making one or more amino acid substitutions, either conservative or non-conservative, and using naturally occurring and non-naturally occurring amino acids, at specific positions of the GIPR polypeptide.

A conservative amino acid substitution may include substitution of a native amino acid residue (i.e., a residue found at a given position in the wild-type GIPR polypeptide sequence)

- 20 040374 to a non-native residue (ie, a residue that is not found at a given position in the wild-type GIPR polypeptide sequence), so that it has little or no effect on the polarity or charge of the amino acid residue at that position. Conservative amino acid substitutions also encompass non-naturally occurring amino acid residues that are typically introduced by chemical peptide synthesis rather than synthesis in biological systems. They include peptidomimetics and other reversed or inverted forms of amino acid components.

Naturally occurring residues can be divided into classes based on the general properties of the side chain:

(1) hydrophobic: norleucine, Met, Ala, Val, Leu, Ile;

(2) neutral hydrophilic: Cys, Ser, Thr;

(3) acidic: Asp, Glu;

(4) basic: Asn, Gln, His, Lys, Arg;

(5) residues that affect chain orientation: Gly, Pro; and (6) aromatic: Trp, Tyr, Phe.

Additional amino acid groups can also be formulated using the principles described in, for example, Creighton (1984), Proteins: Structure and molecular properties ( ^2nd Ed. 1993), WH Freeman and Company. In some cases, it may be useful to further characterize the substitutions based on two or more of these features (eg, a substitution with a small polar residue, such as a Thr residue, may be a very conservative substitution in the appropriate context).

Conservative substitutions may include replacing a member of one of the given classes with another member of the same class. Non-conservative substitutions may involve replacing a member of one of the given classes with a member of another class.

Synthetic, rare or modified amino acid residues having known physicochemical properties similar to those of the amino acids of the classes described above can be used as a conservative substituent for a particular amino acid residue in the sequence. For example, a D-Arg residue can serve as a replacement for a typical L-Arg residue. It may also be the case that a particular substitution can be described in terms of two or more of the classes described above (e.g., substitution by a small and hydrophobic residue means the replacement of one amino acid by a residue(s) that is in both of the above classes, or other synthetic, rare or modified residues, which are known in the art as having similar physicochemical properties to those residues that meet both characteristics). Nucleotide sequences encoding the GIPR polypeptide provided herein, including those degenerate to SEQ ID NO: 3141, 3143, or 3145, and those encoding variants of the polypeptides of SEQ ID NO: 3141, 3143, or 3145 form other aspects current disclosure of the invention.

In order to express the GIPR nucleotide sequences provided herein, suitable coding sequences, e.g., SEQ ID NO: 3141, 3143, or 3145, can be cloned into a suitable vector, and after introduction into a suitable host, the sequence can be expressed to produce an encoded polypeptide according to by standard cloning and expression methods that are known in the art (for example, as described in Sambrook, J., Fritsh, EF, and Maniatis, T. Molecular Cloning: A Laboratory Manual, ^2nd , ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989). The invention also relates to such vectors which contain the nucleotide sequence according to the invention.

A vector refers to a delivery vehicle that (a) facilitates the expression of a nucleotide sequence encoding a polypeptide; (b) promotes the production of a polypeptide from it; (c) promotes transfection/transformation of target cells; (d) promotes the replication of a nucleotide sequence; (e) contributes to the stability of the nucleic acid; (f) facilitates detection of the nucleic acid and/or transformed/transfected cells; and/or (g) otherwise provides an advantageous biological and/or physicochemical function to the nucleic acid encoding the polypeptide. The vector can be any suitable vector, including chromosomal, non-chromosomal and synthetic nucleotide vectors (a nucleotide sequence containing a suitable set of expression controls). Examples of such vectors include SV40 derivatives, bacterial plasmids, phage DNA, baculovirus, yeast plasmids, vectors derived from combinations of plasmids and phage DNA, and nucleotide (RNA or DNA) viral vectors.

Recombinant expression vectors can be engineered to express the GIPR protein in prokaryotic (eg, E. coli) or eukaryotic cells (eg, insect cells using baculovirus expression vectors, yeast cells, or mammalian cells). In one embodiment, the host cell is a non-human cell from a mammalian host. Exemplary host cells include those commonly used for cloning and expression, including Escherichia coli strains TOP10F', TOP10, DH10B, DH5a,

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HB101, W3110, BL21(DE3) and BL21(DE3) pLysS, BLUESCRIPT (Stratagene), mammalian cell lines CHO, CHO-K1, HEK293, 293-EBNA pIN vectors (Van Heeke & Schuster, J. Biol. Chem. 264 :55035509 (1989) pET vectors (Novagen, Madison Wis) Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using the T7 promoter and T7 polymerase regulatory sequences and an in vitro translation system. a cloning site containing a nucleotide sequence encoding a polypeptide.Examples of promoters that can be turned on and off include the lac promoter, the T7 promoter, the trc promoter, the tac promoter, and the trp promoter.

Thus, this document provides vectors containing a nucleotide sequence encoding GIPR that facilitate the expression of recombinant GIPR. In various embodiments, the vectors contain an operably linked nucleotide sequence that regulates the expression of GIPR. The vector may contain or be associated with any suitable promoter, enhancer, and other elements that facilitate expression. Examples of such elements include strong expression promoters (e.g. human CMV IEV promoter/enhancer, RSV promoter, SV40 promoter, SL3-3 promoter, MMTV promoter or HIV LTR promoter, EF1alpha promoter, CAG promoter), poly(A) sequences termination, an origin of replication for the plasmid product in E. coli, an antibiotic resistance gene as a selection marker, and/or a convenient cloning site (eg, a polylinker). The vectors may also contain an inducible promoter, as opposed to a constitutive promoter such as CMV IE. In one aspect, a nucleic acid is provided comprising a sequence encoding a GIPR polypeptide that is operably linked to a tissue-specific promoter that promotes expression of the sequence in a metabolically appropriate tissue, such as liver or pancreatic tissue.

In another aspect of the current disclosure of the invention, host cells containing the nucleic acids and GIPR vectors disclosed herein are provided. In various embodiments, the vector or nucleic acid is inserted into the genome of the host cell, in other embodiments, the vector or nucleic acid is placed extrachromosomally.

Recombinant cells such as yeast, bacterial (eg, E. coli), and mammalian cells (eg, immortalized mammalian cells) containing such nucleic acid, vector, or combinations of any or both of them are provided. In various embodiments, cells are provided that contain a non-integrated nucleic acid, such as a plasmid, cosmid, phagemid, or linear expression element, that contains a coding sequence for expressing a GIPR polypeptide.

A vector containing a nucleotide sequence encoding a GIPR polypeptide as provided herein can be introduced into a host cell by transformation or transfection. Methods for transforming a cell with an expression vector are well known.

The nucleic acid encoding the GIPR can be placed and/or delivered to a host cell or animal host using a viral vector. As such, any suitable viral vector may be used. The viral vector may contain any number of viral polynucleotides, alone or in combination with one or more viral proteins, which facilitate the delivery, replication and/or expression of the nucleic acid of the invention in the desired host cell. The viral vector can be a polynucleotide containing all or part of the viral genome, a viral protein/nucleic acid conjugate, a virus-like particle (VLP), or an intact viral particle containing viral nucleic acids and a nucleic acid encoding a GIPR polypeptide. The virus vector of the virus particle may contain a wild-type virus particle or a modified virus particle. The viral vector may be a vector that requires another vector or wild-type virus for replication and/or expression (eg, the viral vector may be a helper-dependent virus), such as an adenoviral vector amplicon. Typically, such viral vectors consist of a wild-type virus particle or a virus particle modified in protein and/or nucleic acid content to increase transgenic ability or facilitate transfection and/or nucleic acid expression (examples of such vectors include herpes virus/AAV amplicons) . Typically, the viral vector is similar to and/or derived from a virus that normally infects humans. Suitable viral vector particles in this regard include, for example, adenovirus vector particles (including any virus or derived from Adenoviridae virus), adeno-associated viral vector particles (AAV vector particles) or other parvoviruses and parvovirus vector particles, papillomavirus vector particles, flavivirus vectors , alphavirus vectors, herpes virus vectors, poxvirus vectors, retroviral vectors, including lentiviral vectors. A GIPR polypeptide expressed as described herein can be isolated using standard protein purification techniques. The GIPR polypeptide may be isolated from a cell in which it is naturally expressed, or it may be isolated from a cell that has been engineered to express GIPR, such as a cell that does not naturally express GIPR.

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Protein purification methods that can be used to isolate a GIPR polypeptide, as well as related materials and reagents, are known in the art. Additional purification methods that may be useful for isolating a GIPR polypeptide can be found in references such as Bootcov MR, 1997, Proc. Natl. Acad. sci. USA, 94:11514-9, Fairlie WD, 2000, Gene 254: 67-76.

This document provides antagonistic antigen-binding proteins that bind GIPR, including human GIPR (hGIPR). In one embodiment, the human GIPR has the sequence as set forth in SEQ ID NO: 3141. In another embodiment, the human GIPR has the sequence as set forth in SEQ ID NO: 3143. In another embodiment, the human GIPR has the sequence as set forth in SEQ ID NO: 3143. NO: 3145.

Proposed antigen-binding proteins are polypeptides into which one or more complementarity-determining regions (CDRs) are inserted or fused, as described herein. In some antigen-binding proteins, the CDRs are embedded in a framework that orients the CDRs in such a way that the appropriate antigen-binding properties of the CDRs are achieved. Certain antigen-binding proteins described herein are antibodies or derived from antibodies. In other antigen-binding proteins, CDR sequences are inserted into various types of protein scaffolds. Various structures are further described below.

Antigen binding proteins, which are described in this document, have many uses. Antigen binding proteins, for example, are useful in specific binding assays, GIPR affinity purification, and in screening assays to identify other antagonists of GIPR activity. Other uses of antigen binding proteins include, for example, diagnosis of diseases or pathologies associated with GIPR and screening assays to determine the presence or absence of GIPR. Given that the proposed antigen-binding proteins are antagonists, antigen-binding proteins to GIPR are of value in therapeutic methods in which it is useful to reduce weight gain, even while maintaining or increasing food intake, increasing % mass fat and increasing % non-adipose tissue mass, increasing glucose tolerance by lowering insulin levels, lowering cholesterol and triglycerides. Accordingly, antigen binding proteins are useful in the treatment and prevention of diabetes, such as type 2 diabetes, obesity, dyslipidemia, elevated glucose or elevated insulin levels.

Various selective binding agents have been proposed that are useful in modulating GIPR activity. These agents include, for example, antigen-binding proteins that contain an antigen-binding domain (eg, scFvs, domain-specific antibodies, and antigen-binding region polypeptides) and specifically bind to a GIPR polypeptide, in particular human GIPR. Some of the agents are, for example, useful in enhancing GIPR activity and may activate one or more of the GIPR related activities.

In general, antigen-binding proteins provided generally contain one or more CDRs as described herein (eg, 1, 2, 3, 4, 5, or 6). In some instances, the antigen binding protein comprises (a) a polypeptide structure and (b) one or more CDRs that are inserted into and/or attached to the polypeptide structure. The polypeptide structure can take various forms. For example, it may be or contain the structure of a naturally occurring antibody, or fragment or variant thereof, or may be wholly synthetic in nature. Examples of various polypeptide structures are further described below.

In some embodiments, the implementation of the polypeptide structure of the antigen-binding proteins is an antibody or derived from an antibody. Accordingly, examples of certain proposed antigen-binding proteins include, but are not limited to, monoclonal antibodies, bispecific antibodies, mini-antibodies, domain antibodies such as Nanobodies®, synthetic antibodies (sometimes referred to herein as antibody mimetics), chimeric antibodies , humanized antibodies, human antibodies, antibody hybrids, and portions or fragments of each, respectively. In some instances, the antigen-binding protein is an immunological fragment of a complete antibody (eg, Fab, Fab', F(ab') ₂ ). In other instances, the antigen binding protein is a scFv that uses the CDR from an antibody of the invention.

Antigen binding proteins, as described herein, specifically bind to human GIPR. In a specific embodiment, the antigen binding protein specifically binds to a human GIPR comprising or consisting of the amino acid sequence of SEQ ID NO: 3141. In a specific embodiment, the antigen binding protein specifically binds to a human GIPR containing or consisting of the amino acid sequence of SEQ ID NO: 3143. In a specific embodiment, in an embodiment, the antigen binding protein specifically binds to a human GIPR containing or consisting of the amino acid sequence of SEQ ID NO: 3145.

The proposed antigen-binding proteins are antagonists and typically have one, two, three, four, five, six, seven, or all eight of the following characteristics:

(a) the ability to prevent or reduce GIP binding to GIPR, where levels can be measured, for example, by methods such as a radioactive or fluorescent binding assay

- 23 040374 but-labeled ligand, or using the methods described in this document (for example, cAMP analysis or other functional assays). The reduction may be at least 10%, 25%, 50%, 100% or more relative to pre-treatment levels of SEQ ID NO: 3141, 3143 or 3145 under comparable conditions;

(b) the ability to lower blood glucose levels;

(c) the ability to increase glucose tolerance;

(d) the ability to increase insulin sensitivity;

(e) the ability to reduce body weight or reduce weight gain;

(f) the ability to reduce fat mass or reduce inflammation in adipose tissue;

(g) the ability to lower fasting insulin levels;

(h) the ability to lower blood cholesterol levels;

(i) the ability to reduce circulating triglyceride levels;

(j) the ability to reduce hepatic steatosis or lower hepatic triglyceride levels;

(k) the ability to reduce the levels of ACT, ALT and/or ALF.

In one embodiment, the GIPR antigen-binding protein has one or more of the following activities:

(a) binds human GIPR such that the KD is <200 nM, <150 nM, <100 nM, <50 nM, <10 nM, <5 nM, <2 nM, or <1 nM, e.g., as measured by surface plasma resonance or kinetic exclusion method;

(b) has a human serum half-life of at least 3 days; some proposed antigen-binding proteins have a compound constant (ka) for GIPR of at least 10 ⁴ /M-s, at least 10 ⁵ /M-s, or at least 10 ⁶ /M-s, as measured, for example, as described below . Certain proposed antigen-binding proteins have a low detachment rate or detachment constant. Some antigen binding proteins, for example, have a kd (detachment constant) of 1x10' ² s ^-1 , or 1x10'3 s ^-1 , or 1x10' ⁴ s ^-1 , or 1x10'5 s ^-1 . In some embodiments, the antigen binding protein has a KD (equilibrium binding affinity) of less than 25, 50, 100, 500 pM, 1, 5, 10, 25, or 50 nM.

In another aspect, an antigen-binding protein is provided having a half-life of at least one day in vitro or in vivo (eg, when administered to a human). In one embodiment, the antigen binding protein has a half-life of at least three days. In various other embodiments, the antigen binding protein has a half-life of 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, or 60 days or longer. In another embodiment, the antigen binding protein is derivatized or modified such that it has a longer half-life than a non-derivatized or unmodified antibody. In another embodiment, the antigen binding protein contains point mutations to increase the serum half-life. Additional details regarding such mutant and derivatized forms are provided below. Some of the proposed antigen-binding proteins have a structure commonly associated with naturally occurring antibodies. The structural units of these antibodies usually contain one or more tetramers, each consisting of two identical pairs of polypeptide chains, although some mammalian species also produce antibodies having only one heavy chain. In a typical antibody, each pair or two-element structure contains one full-length light chain (in some embodiments, about 25 kDa) and one full-length heavy chain (in some embodiments, about 50-70 kDa). Each individual immunoglobulin chain is composed of several immunoglobulin domains, each consisting of about 90-110 amino acids and displaying a characteristic folding pattern. These domains are the basic units that make up antibody polypeptides. The amino terminal portion of each chain typically includes a variable domain that is responsible for antigen recognition. The carboxy-terminal region is evolutionarily more conserved than the other end of this chain and is referred to as the constant region or C-region. Human immunoglobulin light chains are generally classified as kappa and lambda light chains, and each contains one variable domain and one constant domain. Typically, heavy chains are classified as mu, delta, gamma, alpha, or epsilon chains, and they define the isotype of an antibody as IgM, IgD, IgG, IgA, and IgE, respectively. IgG has several subtypes, including, but not limited to, IgG1, IgG2, IgG3, and IgG4. IgM subtypes include IgM and IgM2. IgA subtypes include IgA1 and IgA2. In humans, the IgA and IgD isotypes contain four heavy chains and four light chains; IgG and IgE isotypes contain two heavy chains and two light chains; and the IgM isotype contains five heavy chains and five light chains. The heavy chain C region typically contains one or more domains that may be responsible for effector function. The number of heavy chain constant region domains will depend on the isotype. For example, each of the IgG heavy chains contains three C-region domains known as CH1, CH2, and CH3. The proposed antibodies may be of any of these isotypes and subtypes. In some embodiments, the anti-GIPR antibody is of the subtype IgG1, IgG2, or

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IgG4. The terms anti-GIPR antibody and anti-GIPR antibody are used interchangeably throughout the specification and in the figures. Both terms refer to an antibody that binds to GIPR.

In full-length light and heavy chains, the variable and constant regions are connected by a J region of about 12 or more amino acids, while the heavy chain also contains a D region of about ten or more amino acids. See, for example, Fundamental Immunology, ^2nd ed., Ch. 7 (Paul, W., ed.) 1989, New York: Raven Press (incorporated herein by reference in its entirety for all purposes). The variable regions of each light/heavy chain pair typically form an antigen binding site. For the antibodies provided herein, the variable regions of immunoglobulin chains typically exhibit the same general structure, containing relatively conserved framework regions (FRs) connected by three hypervariable regions, more commonly referred to as complementarity determining regions or CDRs. The CDRs from the two chains of each heavy chain/light chain pair mentioned above are typically aligned by framework regions to form a structure that specifically binds a particular epitope on the GIPR. From the N-terminus to the C-terminus, the naturally occurring variable regions of both the light and heavy chains generally correspond to the following order of these elements: FR1, CDR1, FR2, CDR2, FR3, CDR3 and FR4. A numbering system has been developed to assign numbers to the amino acids that occupy positions in each of these domains. This numbering system is defined in Kabat Sequences of Proteins of Immunological Interest (1987 and 1991, NIH, Bethesda, MD) or Chothia & Lesk, 1987, J. Mol. Biol. 196:901-917; Chothia et al., 1989, Nature, 342:878-883.

Sequence information for specific antibodies generated and identified as described in the examples below is summarized in Table 1. 1. Thus, in one embodiment, the antigen-binding protein is an antibody with the sequences of CDR, variable domain, and light and heavy chains, as indicated in one of the lines of the table. 1.

SEQ ID NOs were assigned to the variable light chain, variable heavy chain, light chain, heavy chain, CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 sequences of the antibodies and fragments thereof of the invention and are shown in Table 1. 1. Also, SEQ ID NOs were assigned to the variable light chain, variable heavy chain, light chain, heavy chain, CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 polynucleotide sequences of the antibodies and fragments thereof of the invention and are shown in Table 1. 2. Antigen binding proteins of the invention can be identified by SEQ ID NO, but also by construct name (eg 2C2.005) or identification number (eg iPS: 336175). Antigen-binding proteins listed in table. 1-5 below can be grouped into families based on the design name. For example, the 4B1 family includes designs 4B1, 4B1.010, 4B1.011, 4B1.012, 4B1.013, 4B1.014, 4B1.015, and 4B1.016. The various light chain and heavy chain variable regions provided herein are shown in Table 1. 3. Each of these variable regions can be attached to heavy or light chain constant regions to form a complete antibody heavy and light chain, respectively. In addition, each of the heavy and light chain sequences thus formed can be combined to form the complete antibody structure.

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Amino acids SEQ ID NO

Table 1

Identifier Design VL vh LC HC CDRL1 CDRL2 CDRL3 CDRH1 CDRH2 CDRH3 iPS:336175 2C2.005 1 158 315 472 629 786 943 1100 1257 1414 iPS:335914 4B1 2 159 316 473 630 787 944 1101 1258 1415 iPS:335938 6H1 3 160 317 474 631 788 945 1102 1259 1416 iPS:335941 2F11 4 161 318 475 632 789 946 1103 1260 1417 iPS:335970 5C2 5 162 319 476 633 790 947 1104 1261 1418 iPS:335978 13H12 6 163 320 477 634 791 948 1105 1262 1419 iPS:335986 11C1 7 164 321 478 635 792 949 1106 1263 1420 iPS:335994 12H11 8 165 322 479 636 793 950 1107 1264 1421 iPS:336024 18E3 9 166 323 480 637 794 951 1108 1265 1422 iPS:336041 2G10LC1 10 167 324 481 638 795 952 1109 1266 1423 iPS:336077 4H9.004 eleven 168 325 482 639 796 953 1110 1267 1424 iPS:336088 6A5.004 12 169 326 483 640 797 954 1111 1268 1425 iPS:336099 17H11.004 13 170 327 484 641 798 955 1112 1269 1426 iPS:359621 17H11.004.001 14 171 328 485 642 799 956 1113 1270 1427 iPS:359781 4H9.004.001 15 172 329 486 643 800 957 1114 1271 1428 iPS:360929 4H9.004.002 16 173 330 487 644 801 958 1115 1272 1429 iPS:360936 4H9.004.003 17 174 331 488 645 802 959 1116 1273 1430 iPS:360943 4H9.004.004 18 175 332 489 646 803 960 1117 1274 1431 iPS:360949 4H9.004.005 19 176 333 490 647 804 961 1118 1275 1432 iPS:359761 4H9.004.006 20 177 334 491 648 805 962 1119 1276 1433 iPS:360955 4B1.010 21 178 335 492 649 806 963 1120 1277 1434 iPS:360962 4B1.011 22 179 336 493 650 807 964 1121 1278 1435 iPS:360968 4B1.012 23 180 337 494 651 808 965 1122 1279 1436 iPS:360974 4B1.013 24 181 338 495 652 809 966 1123 1280 1437 iPS:360978 4B1.014 25 182 339 496 653 810 967 1124 1281 1438 iPS:359785 4B1.015 26 183 340 497 654 811 968 1125 1282 1439 iPS:360982 4B1.016 27 184 341 498 655 812 969 1126 1283 1440 iPS:335922 18F2 28 185 342 499 656 813 970 1127 1284 1441 iPS:360986 18F2.002 29 186 343 500 657 814 971 1128 1285 1442 iPS:360995 18F2.003 thirty 187 344 501 658 815 972 1129 1286 1443 iPS:360999 18F2.004 31 188 345 502 659 816 973 1130 1287 1444 iPS:361005 18F2.005 32 189 346 503 660 817 974 1131 1288 1445 iPS:361009 18F2.006 33 190 347 504 661 818 975 1132 1289 1446 iPS:361013 18F2.007 34 191 348 505 662 819 976 1133 1290 1447 iPS:361017 18F2.008 35 192 349 506 663 820 977 1134 1291 1448 iPS:361021 18F2.009 36 193 350 507 664 821 978 1135 1292 1449 iPS:361028 18F2.010 37 194 351 508 665 822 979 1136 1293 1450 iPS:360535 18F2.011 38 195 352 509 666 823 980 1137 1294 1451 iPS:361035 18F2.012 39 196 353 510 667 824 981 1138 1295 1452 iPS:359940 2F11.002 40 197 354 511 668 825 982 1139 1296 1453 iPS:361039 2F11.003 41 198 355 512 669 826 983 1140 1297 1454 iPS:361043 2F11.004 42 199 356 513 670 827 984 1141 1298 1455 iPS:361049 2F11.005 43 200 357 514 671 828 985 1142 1299 1456 iPS:361055 2F11.006 44 201 358 515 672 829 986 1143 1300 1457 iPS:361059 2F11.007 45 202 359 516 673 830 987 1144 1301 1458 iPS:361063 2F11.008 46 203 360 517 674 831 988 1145 1302 1459 iPS:359949 2F11.009 47 204 361 518 675 832 989 1146 1303 1460 iPS:359956 2F11.010 48 205 362 519 676 833 990 1147 1304 1461 iPS:359865 6H1.002 49 206 363 520 677 834 991 1148 1305 1462 iPS:359869 6H1.003 50 207 364 521 678 835 992 1149 1306 1463 iPS:359873 6H1.004 51 208 365 522 679 836 993 1150 1307 1464 iPS:359877 6H1.005 52 209 366 523 680 837 994 1151 1308 1465 iPS:361067 6H1.006 53 210 367 524 681 838 995 1152 1309 1466 iPS:361071 6H1.007 54 211 368 525 682 839 996 1153 1310 1467 iPS:361075 6H1.008 55 212 369 526 683 840 997 1154 1311 1468 iPS:361079 6A5.004.001 56 213 370 527 684 841 998 1155 1312 1469 iPS:361085 6A5.004.002 57 214 371 528 685 842 999 1156 1313 1470 iPS:361091 6A5.004.003 58 215 372 529 686 843 1000 1157 1314 1471 iPS:361095 6A5.004.004 59 216 373 530 687 844 1001 1158 1315 1472 iPS:361101 6A5.004.005 60 217 374 531 688 845 1002 1159 1316 1473 iPS:361105 6A5.004.006 61 218 375 532 689 846 1003 1160 1317 1474 iPS:361109 6A5.004.007 62 219 376 533 690 847 1004 1161 1318 1475 iPS:361113 6A5.004.008 63 220 377 534 691 848 1005 1162 1319 1476 iPS:361120 6A5.004.009 64 221 378 535 692 849 1006 1163 1320 1477 iPS:359896 6A5.004.010 65 222 379 536 693 850 1007 1164 1321 1478 iPS:359890 6A5.004.011 66 223 380 537 694 851 1008 1165 1322 1479

- 26 040374

iPS:359567 2A11.002 67 224 381 538 695 852 1009 1166 1323 1480 iPS:335965 2A11.003 68 225 382 539 696 853 1010 1167 1324 1481 iPS:361158 2A11.004 69 226 383 540 697 854 1011 1168 1325 1482 iPS:361165 2A11.005 70 227 384 541 698 855 1012 1169 1326 1483 iPS:361172 2G10 LC1.003 71 228 385 542 699 856 1013 1170 1327 1484 iPS:361178 2G10 LC1.004 72 229 386 543 700 857 1014 1171 1328 1485 iPS:361185 2G10 LC1.005 73 230 387 544 701 858 1015 1172 1329 1486 iPS:361192 2G10 LC1.006 74 231 388 545 702 859 1016 1173 1330 1487 iPS:359609 2G10 LC1.007 75 232 389 546 703 860 1017 1174 1331 1488 iPS:359615 2G10 LC1.008 76 233 390 547 704 861 1018 1175 1332 1489 iPS:361196 2G10 LC1.009 77 234 391 548 705 862 1019 1176 1333 1490 iPS:361202 2G10 LC1.010 78 235 392 549 706 863 1020 1177 1334 1491 iPS:359644 18E3.002 79 236 393 550 707 864 1021 1178 1335 1492 iPS:361206 18E3.003 80 237 394 551 708 865 1022 1179 1336 1493 iPS:359628 18E3.004 81 238 395 552 709 866 1023 1180 1337 1494 iPS:359637 18E3.005 82 239 396 553 710 867 1024 1181 1338 1495 iPS:361210 18E3.006 83 240 397 554 711 868 1025 1182 1339 1496 iPS:361214 18E3.007 84 241 398 555 712 869 1026 1183 1340 1497 iPS:361218 18E3.008 85 242 399 556 713 870 1027 1184 1341 1498 iPS:361222 5C2.006 86 243 400 557 714 871 1028 1185 1342 1499 iPS:361229 5C2.007 87 244 401 558 715 872 1029 1186 1343 1500 iPS:361236 5C2.008 88 245 402 559 716 873 1030 1187 1344 1501 iPS:359685 5C2.009 89 246 403 560 717 874 1031 1188 1345 1502 iPS:361240 5C2.010 90 247 404 561 718 875 1032 1189 1346 1503 iPS:361247 5C2.011 91 248 405 562 719 876 1033 1190 1347 1504 iPS:361254 5C2.012 92 249 406 563 720 877 1034 1191 1348 1505 iPS:361261 5C2.013 93 250 407 564 721 878 1035 1192 1349 1506 iPS:361268 5C2.014 94 251 408 565 722 879 1036 1193 1350 1507 iPS:359669 5C2.015 95 252 409 566 723 880 1037 1194 1351 1508 iPS:359678 5C2.016 96 253 410 567 724 881 1038 1195 1352 1509 iPS:361275 11C1.002 97 254 411 568 725 882 1039 1196 1353 1510 iPS:361282 11C1.003 98 255 412 569 726 883 1040 1197 1354 1511 iPS:361289 11C1.004 99 256 413 570 727 884 1041 1198 1355 1512 iPS:359712 11C1.005 100 257 414 571 728 885 1042 1199 1356 1513 iPS:361293 11C1.006 101 258 415 572 729 886 1043 1200 1357 1514 iPS:361297 11C1.007 102 259 416 573 730 887 1044 1201 1358 1515 iPS:361301 11C1.008 103 260 417 574 731 888 1045 1202 1359 1516 iPS:359703 11C1.009 104 261 418 575 732 889 1046 1203 1360 1517 iPS:361305 11C1.010 105 262 419 576 733 890 1047 1204 1361 1518 iPS:361312 13H12.002 106 263 420 577 734 891 1048 1205 1362 1519 iPS:359744 13H12.003 107 264 421 578 735 892 1049 1206 1363 1520 iPS:361319 13H12.004 108 265 422 579 736 893 1050 1207 1364 1521 iPS:359737 13H12.005 109 266 423 580 737 894 1051 1208 1365 1522 iPS:361326 13H12.006 110 267 424 581 738 895 1052 1209 1366 1523 iPS:361330 12H11.002 111 268 425 582 739 896 1053 1210 1367 1524 iPS:361337 12H11.003 112 269 426 583 740 897 1054 1211 1368 1525 iPS:361344 12H11.004 113 270 427 584 741 898 1055 1212 1369 1526 iPS:361351 12H11.005 114 271 428 585 742 899 1056 1213 1370 1527 iPS:361358 12H11.006 115 272 429 586 743 900 1057 1214 1371 1528 iPS:361365 12H11.007 116 273 430 587 744 901 1058 1215 1372 1529 iPS:361372 12H11.008 117 274 431 588 745 902 1059 1216 1373 1530 iPS:361379 12H11.009 118 275 432 589 746 903 1060 1217 1374 1531 iPS:361383 12H11.010 119 276 433 590 747 904 1061 1218 1375 1532 iPS:361387 12H11.011 120 277 434 591 748 905 1062 1219 1376 1533 iPS:361391 12H11.012 121 278 435 592 749 906 1063 1220 1377 1534 iPS:361395 12H11.013 122 279 436 593 750 907 1064 1221 1378 1535 iPS:361402 12H11.014 123 280 437 594 751 908 1065 1222 1379 1536 iPS:361406 2C2.005.001 124 281 438 595 752 909 1066 1223 1380 1537 iPS:361412 2C2.005.002 125 282 439 596 753 910 1067 1224 1381 1538 iPS:361418 2C2.005.003 126 283 440 597 754 911 1068 1225 1382 1539 iPS:361424 2C2.005.004 127 284 441 598 755 912 1069 1226 1383 1540 iPS:361430 2C2.005.005 128 285 442 599 756 913 1070 1227 1384 1541 iPS:361436 2C2.005.006 129 286 443 600 757 914 1071 1228 1385 1542 iPS:361442 2C2.005.007 130 287 444 601 758 915 1072 1229 1386 1543 iPS:361448 2C2.005.008 131 288 445 602 759 916 1073 1230 1387 1544 iPS:361454 2C2.005.009 132 289 446 603 760 917 1074 1231 1388 1545 iPS:361460 2C2.005.010 133 290 447 604 761 918 1075 1232 1389 1546 iPS:361466 2C2.005.011 134 291 448 605 762 919 1076 1233 1390 1547 iPS:361472 2C2.005.012 135 292 449 606 763 920 1077 1234 1391 1548 iPS:361478 2C2.005.013 136 293 450 607 764 921 1078 1235 1392 1549

- 27 040374

iPS:361485 2C2.005.014 137 294 451 608 765 922 1079 1236 1393 1550 iPS:361845 18F2.013 138 295 452 609 766 923 1080 1237 1394 1551 iPS:361851 6H1.009 139 296 453 610 767 924 1081 1238 1395 1552 iPS:361855 2C2.005.015 140 297 454 611 768 925 1082 1239 1396 1553 iPS:336067 5G12.006 141 298 455 612 769 926 1083 1240 1397 1554 iPS:336169 17B11.002 142 299 456 613 770 927 1084 1241 1398 1555 iPS:361127 5G12.006.001 143 300 457 614 771 928 1085 1242 1399 1556 iPS:361136 5G12.006.002 144 301 458 615 772 929 1086 1243 1400 1557 iPS:361140 5G12.006.003 145 302 459 616 773 930 1087 1244 1401 1558 iPS:359919 5G12.006.004 146 303 460 617 774 931 1088 1245 1402 1559 iPS:361144 5G12.006.005 147 304 461 618 775 932 1089 1246 1403 1560 iPS:361151 5G12.006.006 148 305 462 619 776 933 1090 1247 1404 1561 iPS:361491 17B11.002.001 149 306 463 620 777 934 1091 1248 1405 1562 iPS:361499 17B11.002.002 150 307 464 621 778 935 1092 1249 1406 1563 iPS:361503 17B11.002.003 151 308 465 622 779 936 1093 1250 1407 1564 iPS:361507 17B11.002.004 152 309 466 623 780 937 1094 1251 1408 1565 iPS:361514 17B11.002.005 153 310 467 624 781 938 1095 1252 1409 1566 iPS:360582 17B11.002.006 154 311 468 625 782 939 1096 1253 1410 1567 iPS:361518 17B11.002.007 155 312 469 626 783 940 1097 1254 1411 1568 iPS:360570 17B11.002.008 156 313 470 627 784 941 1098 1255 1412 1569 iPS:362051 5G12.005.001 157 314 471 628 785 942 1099 1256 1413 1570

table 2

Nucleotide SEQ ID NO

iPS ID:336175 Design 2C2.005 VL 1571 vh 1728 LC 1885 HC 2042 CDRL1 2199 CDRL2 2356 CDRL3 2513 CDRH1 2670 CDRH2 2827 CDRH3 2984 iPS:335914 4B1 1572 1729 1886 2043 2200 2357 2514 2671 2828 2985 iPS: 335938 6H1 1573 1730 1887 2044 2201 2358 2515 2672 2829 2986 iPS: 335941 2F11 1574 1731 1888 2045 2202 2359 2516 2673 2830 2987 iPS: 335970 5C2 1575 1732 1889 2046 2203 2360 2517 2674 2831 2988 iPS: 335978 13H12 1576 1733 1890 2047 2204 2361 2518 2675 2832 2989 iPS: 335986 11C1 1577 1734 1891 2048 2205 2362 2519 2676 2833 2990 iPS: 335994 12H11 1578 1735 1892 2049 2206 2363 2520 2677 2834 2991 iPS:336024 18E3 1579 1736 1893 2050 2207 2364 2521 2678 2835 2992 iPS:336041 2G10LC1 1580 1737 1894 2051 2208 2365 2522 2679 2836 2993 iPS:336077 4H9.004 1581 1738 1895 2052 2209 2366 2523 2680 2837 2994 iPS:336088 6A5.004 1582 1739 1896 2053 2210 2367 2524 2681 2838 2995 iPS:336099 17H11.004 1583 1740 1897 2054 2211 2368 2525 2682 2839 2996 iPS:359621 17H11.004.001 1584 1741 1898 2055 2212 2369 2526 2683 2840 2997 iPS:359781 4H9.004.001 1585 1742 1899 2056 2213 2370 2527 2684 2841 2998 iPS:360929 4H9.004.002 1586 1743 1900 2057 2214 2371 2528 2685 2842 2999 iPS:360936 4H9.004.003 1587 1744 1901 2058 2215 2372 2529 2686 2843 3000 iPS:360943 4H9.004.004 1588 1745 1902 2059 2216 2373 2530 2687 2844 3001 iPS:360949 4H9.004.005 1589 1746 1903 2060 2217 2374 2531 2688 2845 3002 iPS:359761 4H9.004.006 1590 1747 1904 2061 2218 2375 2532 2689 2846 3003 iPS:360955 4B1.010 1591 1748 1905 2062 2219 2376 2533 2690 2847 3004 iPS:360962 4B1.011 1592 1749 1906 2063 2220 2377 2534 2691 2848 3005 iPS:360968 4B1.012 1593 1750 1907 2064 2221 2378 2535 2692 2849 3006 iPS:360974 4B1.013 1594 1751 1908 2065 2222 2379 2536 2693 2850 3007 iPS:360978 4B1.014 1595 1752 1909 2066 2223 2380 2537 2694 2851 3008 iPS:359785 4B1.015 1596 1753 1910 2067 2224 2381 2538 2695 2852 3009 iPS:360982 4B1.016 1597 1754 1911 2068 2225 2382 2539 2696 2853 3010 iPS:335922 18F2 1598 1755 1912 2069 2226 2383 2540 2697 2854 3011 iPS:360986 18F2.002 1599 1756 1913 2070 2227 2384 2541 2698 2855 3012 iPS:360995 18F2.003 1600 1757 1914 2071 2228 2385 2542 2699 2856 3013 iPS:360999 18F2.004 1601 1758 1915 2072 2229 2386 2543 2700 2857 3014 iPS:361005 18F2.005 1602 1759 1916 2073 2230 2387 2544 2701 2858 3015 iPS:361009 18F2.006 1603 1760 1917 2074 2231 2388 2545 2702 2859 3016 iPS:361013 18F2.007 1604 1761 1918 2075 2232 2389 2546 2703 2860 3017 iPS:361017 18F2.008 1605 1762 1919 2076 2233 2390 2547 2704 2861 3018 iPS:361021 18F2.009 1606 1763 1920 2077 2234 2391 2548 2705 2862 3019 iPS:361028 18F2.010 1607 1764 1921 2078 2235 2392 2549 2706 2863 3020 iPS:360535 18F2.011 1608 1765 1922 2079 2236 2393 2550 2707 2864 3021 iPS:361035 18F2.012 1609 1766 1923 2080 2237 2394 2551 2708 2865 3022 iPS:359940 2F11.002 1610 1767 1924 2081 2238 2395 2552 2709 2866 3023 iPS:361039 2F11.003 1611 1768 1925 2082 2239 2396 2553 2710 2867 3024 iPS:361043 2F11.004 1612 1769 1926 2083 2240 2397 2554 2711 2868 3025 iPS:361049 2F11.005 1613 1770 1927 2084 2241 2398 2555 2712 2869 3026

- 28 040374

iPS:361O55 2F11.006 1614 1771 1928 2085 2242 2399 2556 2713 2870 3027 iPS:361O59 2F11.007 1615 1772 1929 2086 2243 2400 2557 2714 2871 3028 iPS:361O63 2F11.008 1616 1773 1930 2087 2244 2401 2558 2715 2872 3029 iPS:359949 2F11.009 1617 1774 1931 2088 2245 2402 2559 2716 2873 3030 iPS:359956 2F11.010 1618 1775 1932 2089 2246 2403 2560 2717 2874 3031 iPS:359865 6H1.002 1619 1776 1933 2090 2247 2404 2561 2718 2875 3032 iPS:359869 6H1.003 1620 1777 1934 2091 2248 2405 2562 2719 2876 3033 iPS:359873 6H1.004 1621 1778 1935 2092 2249 2406 2563 2720 2877 3034 iPS:359877 6H1.005 1622 1779 1936 2093 2250 2407 2564 2721 2878 3035 iPS:361O67 6H1.006 1623 1780 1937 2094 2251 2408 2565 2722 2879 3036 iPS:361O71 6H1.007 1624 1781 1938 2095 2252 2409 2566 2723 2880 3037 iPS:361O75 6H1.008 1625 1782 1939 2096 2253 2410 2567 2724 2881 3038 iPS:361O79 6A5.004.001 1626 1783 1940 2097 2254 2411 2568 2725 2882 3039 iPS:361O85 6A5.004.002 1627 1784 1941 2098 2255 2412 2569 2726 2883 3040 iPS:361O91 6A5.004.003 1628 1785 1942 2099 2256 2413 2570 2727 2884 3041 iPS:361O95 6A5.004.004 1629 1786 1943 2100 2257 2414 2571 2728 2885 3042 iPS:361101 6A5.004.005 1630 1787 1944 2101 2258 2415 2572 2729 2886 3043 iPS:361105 6A5.004.006 1631 1788 1945 2102 2259 2416 2573 2730 2887 3044 iPS:361109 6A5.004.007 1632 1789 1946 2103 2260 2417 2574 2731 2888 3045 iPS:361113 6A5.004.008 1633 1790 1947 2104 2261 2418 2575 2732 2889 3046 iPS:361120 6A5.004.009 1634 1791 1948 2105 2262 2419 2576 2733 2890 3047 iPS:359896 6A5.004.010 1635 1792 1949 2106 2263 2420 2577 2734 2891 3048 iPS:359890 6A5.004.011 1636 1793 1950 2107 2264 2421 2578 2735 2892 3049 iPS:359567 2A11.002 1637 1794 1951 2108 2265 2422 2579 2736 2893 3050 iPS:335965 2A11.003 1638 1795 1952 2109 2266 2423 2580 2737 2894 3051 iPS:361158 2A11.004 1639 1796 1953 2110 2267 2424 2581 2738 2895 3052 iPS:361165 2A11.005 1640 1797 1954 2111 2268 2425 2582 2739 2896 3053 iPS:361172 2G10 LC1.003 1641 1798 1955 2112 2269 2426 2583 2740 2897 3054 iPS:361178 2G10 LC1.004 1642 1799 1956 2113 2270 2427 2584 2741 2898 3055 iPS:361185 2G10 LC1.005 1643 1800 1957 2114 2271 2428 2585 2742 2899 3056 iPS:361192 2G10 LC1.006 1644 1801 1958 2115 2272 2429 2586 2743 2900 3057 iPS:359609 2G10 LC1.007 1645 1802 1959 2116 2273 2430 2587 2744 2901 3058 iPS:359615 2G10 LC1.008 1646 1803 1960 2117 2274 2431 2588 2745 2902 3059 iPS:361196 2G10 LC1.009 1647 1804 1961 2118 2275 2432 2589 2746 2903 3060 iPS:361202 2G10 LC1.010 1648 1805 1962 2119 2276 2433 2590 2747 2904 3061 iPS:359644 18E3.002 1649 1806 1963 2120 2277 2434 2591 2748 2905 3062 iPS:361206 18E3.003 1650 1807 1964 2121 2278 2435 2592 2749 2906 3063 iPS:359628 18E3.004 1651 1808 1965 2122 2279 2436 2593 2750 2907 3064 iPS:359637 18E3.005 1652 1809 1966 2123 2280 2437 2594 2751 2908 3065 iPS:361210 18E3.006 1653 1810 1967 2124 2281 2438 2595 2752 2909 3066 iPS:361214 18E3.007 1654 1811 1968 2125 2282 2439 2596 2753 2910 3067 iPS:361218 18E3.008 1655 1812 1969 2126 2283 2440 2597 2754 2911 3068 iPS:361222 5C2.006 1656 1813 1970 2127 2284 2441 2598 2755 2912 3069 iPS:361229 5C2.007 1657 1814 1971 2128 2285 2442 2599 2756 2913 3070 iPS:361236 5C2.008 1658 1815 1972 2129 2286 2443 2600 2757 2914 3071 iPS:359685 5C2.009 1659 1816 1973 2130 2287 2444 2601 2758 2915 3072 iPS:361240 5C2.010 1660 1817 1974 2131 2288 2445 2602 2759 2916 3073 iPS:361247 5C2.011 1661 1818 1975 2132 2289 2446 2603 2760 2917 3074 iPS:361254 5C2.012 1662 1819 1976 2133 2290 2447 2604 2761 2918 3075 iPS:361261 5C2.013 1663 1820 1977 2134 2291 2448 2605 2762 2919 3076 iPS:361268 5C2.014 1664 1821 1978 2135 2292 2449 2606 2763 2920 3077 iPS:359669 5C2.015 1665 1822 1979 2136 2293 2450 2607 2764 2921 3078 iPS:359678 5C2.016 1666 1823 1980 2137 2294 2451 2608 2765 2922 3079 iPS:361275 11C1.002 1667 1824 1981 2138 2295 2452 2609 2766 2923 3080 iPS:361282 11C1.003 1668 1825 1982 2139 2296 2453 2610 2767 2924 3081 iPS:361289 11C1.004 1669 1826 1983 2140 2297 2454 2611 2768 2925 3082 iPS:359712 11C1.005 1670 1827 1984 2141 2298 2455 2612 2769 2926 3083 iPS:361293 11C1.006 1671 1828 1985 2142 2299 2456 2613 2770 2927 3084 iPS:361297 11C1.007 1672 1829 1986 2143 2300 2457 2614 2771 2928 3085 iPS:361301 11C1.008 1673 1830 1987 2144 2301 2458 2615 2772 2929 3086 iPS:359703 11C1.009 1674 1831 1988 2145 2302 2459 2616 2773 2930 3087 iPS:361305 11C1.010 1675 1832 1989 2146 2303 2460 2617 2774 2931 3088 iPS:361312 13H12.002 1676 1833 1990 2147 2304 2461 2618 2775 2932 3089 iPS:359744 13H12.003 1677 1834 1991 2148 2305 2462 2619 2776 2933 3090 iPS:361319 13H12.004 1678 1835 1992 2149 2306 2463 2620 2777 2934 3091 iPS:359737 13H12.005 1679 1836 1993 2150 2307 2464 2621 2778 2935 3092 iPS:361326 13H12.006 1680 1837 1994 2151 2308 2465 2622 2779 2936 3093 iPS:361330 12H11.002 1681 1838 1995 2152 2309 2466 2623 2780 2937 3094 iPS:361337 12H11.003 1682 1839 1996 2153 2310 2467 2624 2781 2938 3095 iPS:361344 12H11.004 1683 1840 1997 2154 2311 2468 2625 2782 2939 3096

-29040374

iPS:361351 12H11.005 1684 1841 1998 2155 2312 2469 2626 2783 2940 3097 iPS:361358 12H11.006 1685 1842 1999 2156 2313 2470 2627 2784 2941 3098 iPS:361365 12H11.007 1686 1843 2000 2157 2314 2471 2628 2785 2942 3099 iPS:361372 12H11.008 1687 1844 2001 2158 2315 2472 2629 2786 2943 3100 iPS:361379 12H11.009 1688 1845 2002 2159 2316 2473 2630 2787 2944 3101 iPS:361383 12H11.010 1689 1846 2003 2160 2317 2474 2631 2788 2945 3102 iPS:361387 12H11.011 1690 1847 2004 2161 2318 2475 2632 2789 2946 3103 iPS:361391 12H11.012 1691 1848 2005 2162 2319 2476 2633 2790 2947 3104 iPS:361395 12H11.013 1692 1849 2006 2163 2320 2477 2634 2791 2948 3105 iPS:361402 12H11.014 1693 1850 2007 2164 2321 2478 2635 2792 2949 3106 iPS:361406 2C2.005.001 1694 1851 2008 2165 2322 2479 2636 2793 2950 3107 iPS:361412 2C2.005.002 1695 1852 2009 2166 2323 2480 2637 2794 2951 3108 iPS:361418 2C2.005.003 1696 1853 2010 2167 2324 2481 2638 2795 2952 3109 iPS:361424 2C2.005.004 1697 1854 2011 2168 2325 2482 2639 2796 2953 3110 iPS:361430 2C2.005.005 1698 1855 2012 2169 2326 2483 2640 2797 2954 3111 iPS:361436 2C2.005.006 1699 1856 2013 2170 2327 2484 2641 2798 2955 3112 iPS:361442 2C2.005.007 1700 1857 2014 2171 2328 2485 2642 2799 2956 3113 iPS:361448 2C2.005.008 1701 1858 2015 2172 2329 2486 2643 2800 2957 3114 iPS:361454 2C2.005.009 1702 1859 2016 2173 2330 2487 2644 2801 2958 3115 iPS:361460 2C2.005.010 1703 1860 2017 2174 2331 2488 2645 2802 2959 3116 iPS:361466 2C2.005.011 1704 1861 2018 2175 2332 2489 2646 2803 2960 3117 iPS:361472 2C2.005.012 1705 1862 2019 2176 2333 2490 2647 2804 2961 3118 iPS:361478 2C2.005.013 1706 1863 2020 2177 2334 2491 2648 2805 2962 3119 iPS:361485 2C2.005.014 1707 1864 2021 2178 2335 2492 2649 2806 2963 3120 iPS:361845 18F2.013 1708 1865 2022 2179 2336 2493 2650 2807 2964 3121 iPS:361851 6H1.009 1709 1866 2023 2180 2337 2494 2651 2808 2965 3122 iPS:361855 2C2.005.015 1710 1867 2024 2181 2338 2495 2652 2809 2966 3123 iPS:336067 5G12.006 1711 1868 2025 2182 2339 2496 2653 2810 2967 3124 iPS:336169 17B11.002 1712 1869 2026 2183 2340 2497 2654 2811 2968 3125 iPS:361127 5G12.006.001 1713 1870 2027 2184 2341 2498 2655 2812 2969 3126 iPS:361136 5G12.006.002 1714 1871 2028 2185 2342 2499 2656 2813 2970 3127 iPS:361140 5G12.006.003 1715 1872 2029 2186 2343 2500 2657 2814 2971 3128 iPS:359919 5G12.006.004 1716 1873 2030 2187 2344 2501 2658 2815 2972 3129 iPS:361144 5G12.006.005 1717 1874 2031 2188 2345 2502 2659 2816 2973 3130 iPS:361151 5G12.006.006 1718 1875 2032 2189 2346 2503 2660 2817 2974 3131 iPS:361491 17B11.002.001 1719 1876 2033 2190 2347 2504 2661 2818 2975 3132 iPS:361499 17B11.002.002 1720 1877 2034 2191 2348 2505 2662 2819 2976 3133 iPS:361503 17B11.002.003 1721 1878 2035 2192 2349 2506 2663 2820 2977 3134 iPS:361507 17B11.002.004 1722 1879 2036 2193 2350 2507 2664 2821 2978 3135 iPS:361514 17B11.002.005 1723 1880 2037 2194 2351 2508 2665 2822 2979 3136 iPS:360582 17B11.002.006 1724 1881 2038 2195 2352 2509 2666 2823 2980 3137 iPS:361518 17B11.002.007 1725 1882 2039 2196 2353 2510 2667 2824 2981 3138 iPS:360570 17B11.002.008 1726 1883 2040 2197 2354 2511 2668 2825 2982 3139 iPS:362051 5G12.005.001 1727 1884 2041 2198 2355 2512 2669 2826 2983 3140

- 30 040374

Table 3

Exemplary Variable Light and Variable Heavy Regions: Nucleotide (NA) and Amino Acid (AA) Sequences No. iPS

At

VL______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCG TCTGGGACCCCCGGGCAGAGGGTCACCATC TCTTGTTCTGGAAGTAGCTCCAACATCGGA AGTAATACTGTAAACTGGTACCAGCACCTC CCAGGAACGGCCCCCAAACTCCTCATCTAT ACTAATAATCAGCGGCCCTCAGGGGTCCCT GACCGATTCTCTGGCTCCAAGTCTGGCACCT CAGCCTCCCTTGCCATCAGTGGGCTCCAGTC TGAGGATGAGGCTGATTATTTCTGTGCAAC ATTCGATGACAGCCTGAATGGTCCGGTATT CGGCGGAGGGACCAAGCTGACCGTCCTAGG

УН_______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTGAA GAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGC TTCCGGATACACCTTCACCGGCTACTATATGCATTG GGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGA TGGGATGGATCAACCCTAACAGTGGTGGCACAAACT ATGCACAGAAGTTTCAGGGCAGGGTCACCATGACC AGGGACACGTCCATCAGTACAGCCTACATGGAGCTG AGCAGGCTGAGGTCTGACGACACGGCCGTGTATTAC TGTGCGAGAGGGGGGGATTACGTTTGGGGGACTTAT CGGCCTCACTACTACTACGGTATGGACGTCTGGGGC CAAGGGACCACGGTCACCGTCTCCTCA сл сл

SEQIDNO: 1571____________________________

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNT VNWYQHLPGTAPKLLIYTNNQRPSGVPDRFS GSKSGTSASLAISGLQSEDEADYFCATFDDSL NGPVFGGGTKLTVLG________________

SEQ ID NO: 1_____________________________

GACATCCAGATGACCCAGTCTCCATCCTCC CTGTCTGCATCTATAGGAGACAGAGTCACC ATCACTTGCCGGGCAAGTCAGGACATTAGA GATTATTTAGGCTGGTATCAGCAGAAACCA GGGAAAGCCCCTAAGCGCCTGATCTATGGT GCATCCAGTTTGCAAAGTGGGGTCCCTTCA AGGTTCAGCGGCAGTGGATCTGGGACAGAA TTCACTCTCACAATCAGCAGCCTGCAGCCT GAAGATTTCGCAACTTATTACTGTCTACAGC ATAATAATTACCCCTTCACTTTCGGCCCTGG GACCAAAGTGGATATCAAACGA________

SEQIDNO: 1572____________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYL GWYQQKPGKAPKRLIYGASSLQSGVPSRFSG SGSGTEFTLTISSLQPEDFATYYCLQHNNYPFT FGPGTKVDIKR_________ SEQ ID NO: 2_____________________

GACATCCAGATGACCCAGTCTCCATCCTCC CTGTCTGCATCTATAGGAGACAGAGTCACC ATCACTTGCCGGGCAAGTCAGGACATTAGA GATTATTTAGGCTGGTATCAGCAGAAACCA GGGAAAGCCCCTAAGCGCCTGATCTATGGT GCATCCAGTTTGCAAAGTGGGGTCCCTTCA AGGTTCAGCGGCAGTGGATCTGGGACAGAA TTCACTCTCACAATCAGCAGCCTGCAGCCT GAAGATTTCGCAACTTATTACTGTCTACAGC ATAATAATTACCCCTTCACTTTCGGCCCTGG GACCAAAGTGGATATCAAACGA________ SEQIDNO: 1573________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYL GWYQQKPGKAPKRLIYGASSLQSGVPSRFSG SGSGTEFTLTISSLQPEDFATYYCLQHNNYPFT FGPGTKVDIKR_________ SEQ ID NO: 3_____________________________

GACATCCAGATGACCCAGTCTCCATCCTCC CTGTCTGCATCTGTAGGAGACAGAGTCACC ATCACTTGCCAGGCGAGTCAGGACATTAGC AACTATTTAAATTGGTATCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCTACGAT GCATCCAATTTGGAAACAGGGGTCCCATCA AGGTTCAGTGGAAGTGGATCTGGGACAGAT TTTAGTTTCACCATCAGCAGCCTGCAGCCTG AAGATATTGCAACATATTACTGTCAACAGT ATGATATTCTCCTCACTTTCGGCGGAGGGA CCAAGGTGGAGATCAAGCGA

SEQIDNO: 1728_______________________________

QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYYMH WVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTM TRDTSISTAYMELSRLRSDDTAVYYCARGGDYVWGT YRPHYYYGMDVWGQGTTVTVSS_____________ SEQIDNO: 158________________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACTTTCAGTAACTTTGGCATGCACTG GGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGG TGGCAGTTATATGGTATGATGGAAGTAATGAAAACT ATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCA GAGACAATTCCAAGAATACGCTGTATCTGCACATGA ACAGCCTGAGAGTCGCGGACACGGCTGTGTATTATT GTGCGCGAGATGGGACGATCTTTGGAGTGGTCTTGG GGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCT ССТСА_________________________________

SEQIDNO: 1729_______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGMHW VRQAPGKGLEWVAVIWYDGSNENYADSVKGRFTISR DNSKNTLYLHMNSLRVADTAVYYCARDGTIFGVVLG DYWGQGTLVTVSS_______________________ SEQIDNO: 159_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACCTTCAGTTACTTTGGCATGCACTGG GTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGT GGCAGTTATATGGTATGATGGAAGTAATAAATACTA TGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAG AGACAATTCCAAGAACACGCTGTATCTGCAAATGAA CAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTG TGCGCGAGATGGGACGATTTTTGGAGTGCTCTTGGG GGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTC CTCA__________________________________

SEQIDNO: 1730_______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGMHW VRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISR DNSKNTLYLQMNSLRAEDTAVYYCARDGTIFGVLLG DYWGQGTLVTVSS_______________________ SEQIDNO: 160_______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACCTTCAGTAGCTATGGCATGCACTG GGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGG TGGCAGTTATATGGTATGATGGAAGTAATAAATACT ATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCA GCGACAATTCCAAGAACACGCTGTATCTGCAAATGA ACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACT GTGCGAGAGATAGGACGATTTTTGGAGTGGTTCTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCT CA

- 31 040374

SEQ ID NO: 1574__________________________ DIQMTQSPSSLSASVGDRVTITCQASQDISNYL NWYQQKPGKAPKLLIYDASNLETGVPSRFSG SGSGTDFSFTIS SLQPEDIATYYCQQYDILLTF GGGTKVEIKR______________________ SEQ ID NO: 4____________________________ GACATCGTGATGACCCAGTCTCCAGACTCC CTGGCTGTGTCTCTGGGCGAGAGGGCCACC ATCAACTGCAAGTCCAGCCAGAGTGTTTTA TCCAGCTCCAACAATAAGAACTACATAGCT TGGTACCAGCAGCAACCAGGACATCCTCCT AAGCTGCTCATTTACTGGGCATCTACCCGG GAATCCGGGGTCCCTGACCGATTCAGTGGC AGCGGGTCTGGGACAGATTTCACTCTCACC ATCAGCAGCCTGCAGGCTGAAGATGTGGCA GTTTTTTACTGTCAACAATATTATAGTACTC CGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA___________________ SEQ ID NO: 1575__________________________ DIVMTQSPDSLAVSLGERATINCKSSQSVLSSS NNKNYIAWYQQQPGHPPKLLIYWASTRESGV PDRFSGSGSGTDFTLTISSLQAEDVAVFYCQQ YYSTPWTFGQGTKVEIKR_____________ SEQ ID NO: 5_____________________________ GACATCGTGATGACCCAGTCTCCAGACTCC CTGGCTGTGTCTCTGGGCGAGAGGGCCACC ATCAACTGCAAGTCCAGCCAGAGTGTTTTA TCCAGCTCCAACAATAAGAACTACATAGCT TGGTACCAGCAGAAACCAGGACATCCTCCT AAGCTGCTCATTTACTGGGCATCTACCCGG GAATCCGGG GTCCCTGACCGATTCAGTGGC AGCGGGTCTGGGACAGATTTCACTCTCACC ATCAGCAGCCTGCAGGCTGAAGATGTGGCA GTTTTTTACTGTCAACAATATTATAGTACTC CGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA___________________ SEQ ID NO: 1576__________________________ DIVMTQSPDSLAVSLGERATINCKSSQSVLSSS NNKNYIAWYQQKPGHPPKLLIYWASTRESGV PDRFSGSGSGTDFTLTISSLQAEDVAVFYCQQ YYSTPWTFGQGTKVEIKR_____________ SEQ ID NO: 6____________________________ GACATCGTGATGACCCAGTCTCCAGACTCC CTGTCTGTGTCTCTGGGCGAGAGGGCCACC ATCAACTGCAAGTCCAGCCAGAGTGTTTTA TCCAGCTCCAACAATAAGAACTACTTAGCT TGGTACCAACAGAAACCAGGACAGCCTCCT AACCTGCTCATTTACTGGACTTCTACCCGAG ATTCCGGGGTCCCTGACCGATTCAGTGGCA GCGGGTCTGGGACAGATTTCACTCTCACCA TCAACAGCCTGCAGGCTGAAGATGTGGCTG TTTATTACTGTCAGCAATATTATCGTACTCC GTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA____________________ SEQ ID NO: 1577__________________________ DIVMTQSPDSLSVSLGERATINCKSSQSVLSSS NNKNYLAWYQQKPGQPPNLLIYWTSTRDSG VPDRFSGSGSGTDFTLTINSLQAEDVAVYYCQ QYYRTPWTFGQGTKVEIKR____________ SEQ ID NO: 7____________________________ GACATCGTGATGACCCAGTCT CCAGACTCC CTGTCTGTGTCTCTGGGCGAGAGGGCCACC ATCAACTGCAAGTCCAGCCAGAGTGTTTTA TCCAGCTCCAACAATAAGAACTACTTAGCT TGGTACCAGCAGAAACCAGGACAGCCTCCT AACCTGCTCATTTACTGGACTTCTACCCGAG ATTCCGGGGTCCCTGACCGATTCAGTGGCA GCGGGTCTGGGACAGATTTCACTCTCACCA TCAACAGCCTGCAGGCTGAAGATGTGGCTG TTTATTACTGTCAGCAATATTATCGTACTCC GTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA

SEQ ID NO: 1731_________________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHW VRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISS DNSKNTLYLQMNSLRAEDTAVYYCARDRTIFGVVLD YWGQGTLVTVSS________________________ SEQ ID NO: 161__________________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTGAA GAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGC TTCTGGATACACCTTCACCGGCTACTATATCCACTG GGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGA TGGGGTGGATCAACCCTGACAGTGGTGGCACAGACT ATTCACAGAGGTTTCAGGGCAGGTTCACCATGACCA GGGACACGTCCATCAGCACAGCCTACATGGAACTG AACAGGCTGAGATCTGACGACACGGCCGTGTATTAC TGTGCGAGAGAGGCCACGATTTTTGGAATGGTTATT GTACCGTTTGACTACTGGGGCCAGGGAACCCTGGTC ACCGTCTCCTCA

SEQ ID NO: 1732_________________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYIHW

VRQAPGQGLEWMGWINPDSGGTDYSQRFQGRFTMTR DTSISTAYMELNRLRSDDTAVYYCAREATIFGMVIVPF D YWGQGTLVTVSS_______________________

SEQ ID NO: 162__________________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTGAA

GAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGC TTCTGGATACACCTTCACCGGCTACTATATCCACTG GGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGA TGGGGTGGATCAACCCTGACAGTGGTGGCACAGACT ATTCACAGAGGTTTCAGGGCAGGTTCACCATGACCA GGGACACGTCCATCAGCACAGCCTACATGGAACTG AGCAGGCTGAGATCTGACGACACGGCCGTGTATTAC TGTGCGAGAGAGGCCACGATTTTTGGAATGGTTATT GTACCGTTTGACTACTGGGGCCAGGGAACCCTGGTC ACCGTCTCCTCA

SEQ ID NO: 1733_________________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYIHW

VRQAPGQGLEWMGWINPDSGGTDYSQRFQGRFTMTR DTSISTAYMELSRLRSDDTAVYYCAREATIFGMVIVPF D YWGQGTLVTVSS_______________________

SEQ ID NO: 163__________________________________ CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTGAA

GAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGC TTCTGGATACACCTTCACCGGCTACTATATACACTG GGTGCGTCAGGCCCCTGGACAAGGGCTTGTGTGGAT GGGGTGGATCAGCCCTAACAGTGGTGACACAAGCT ATGCACAGAAGTTTCAGGACAGGGTCACCATGACC AGGGACACGTCCATCAGCACAGCCTATATGGAGCTG AGCAGACTGAGATCTGACGACACGGCCGTGTATTTC TGTACGAGAGAGGCCACGATTTTTGGAATGCTTATT GTACCATTTGACTACTGGGGCCAGGGAACCCTGGTC ACCGTCTCCTCA

SEQ ID NO: 1734_________________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYIHW

VRQAPGQGLVWMGWISPNSGDTSYAQKFQDRVTMTR DTSISTAYMELSRLRSDDTAVYFCTREATIFGMLIVPFD YWGQGTLVTVSS________________________ SEQ ID NO: 164__________________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTGAA GAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGC TTCTGGATACACCTTCACCGGCTACTATATACACTG GGTGCGTCAGGCCCCTGGACAAGGGCTTGAGTGGAT GGGGTGGATAAGCCCTAACAATGGTGACACAAACT ATGCACAGAAGTTTCAGGACAGGGTCACCATGACC AGGGACACGTCCATCAGCACAGCCTATATGGAGCTG AGCAGGCTGAGATCTGACGACACGGCCGTGTATTAC TGTACGAGAGAGGCCACGATTTTTGGAATGCTTATT GTACCATTTGACTACTGGGGCCAGGGAACCCTGGTC ACCGTCTCCTCA

- 32 040374

SEQ ID NO: 1578________________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSS NNKNYLAWYQQKPGQPPNLLIYWTSTRDSG VPDRFSGSGSGTDFTLTINSLQAEDVAVYYCQ QYYRTPWTFGQGTKVEIKR____________ SEQ ID NO: 8_____________________________ GAAATTGTGTTGACGCAGTCTCCAGGCACC CTGTCTTTGTCTCCAGGGGAAAGAGCCACC CTCTCCTGCAGGGCCAGTCAGAGTATTAGT TACAGTTACTTAGCCTGGTACCAGCAGAAA CCTGGCCAGGCTCCCCGGCTCCTCATCTATG GTGCATCCAGCAGGGCCACTGGCATCCCAG ACAGGTTCAGTGGCAGTGGGTCTGGGACAG ACTTCACTCTCACCATCAGCAGACAGGAGC CTGATGATTTTGCAGTGTATTACTGTCAGCA GTATGGTAGTTCACCGCTCACTTTCGGCGG AGGGACCAAGGTGGAGATCAAACGA

SEQ ID NO: 1579__________________________ EIVLTQSPGTLSLSPGERATLSCRASQSISYSYL AWYQQKPGQAPRLLIYGASSRATGIPDRFSGS GSGTDFTLTISRQEPDDFAVYYCQQYGSSPLT FGGGTKVEIKR_____________________ SEQ ID NO: 9_____________________________ GAAATAGTGATGACGCAGTCTCCAGCCACC CTGTCTGTGTCTCCAGGGGAAAGAGCCACC CTCTCCTGCAGGGCCAGTCAGAGTGTTAGC AGCAACTTAGCCTGGTACCAGCAGAAACCT GGCCAGGCTCCCAGGCTCCTCATCTATGGT GCAGCCACCAGGGCCACTGGTATCCCAGCC AGGGTCAGTGGCAGTGGGTCTGGGACAGAG TTCACTCTCACCATCAGCAGCCTGCAGTCTG AAGATTTTGCAGTTTATTACTGTCAGCAGTA TAATAACTGGCCTCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAACGA________ SEQ ID NO: 1580__________________________ EIVMTQSPATLSVSPGERATLSCRASQSVSSNL AWYQQKPGQAPRLLIYGAATRATGIPARVSG SGSGTEFTLTISSLQSEDFAVYYCQQYNNWPL TFGGGTKVEIKR____________________ SEQ ID NO: 10____________________________ GACATTCAGATGACCCAGTCTCCATCCTCCC TGTCTGCATCTGTAGGAGACAGAGTCACCA TCACTTGCCGGGCAAGTCAGGGCATTAGAA ATGAGTTAGGCTGGTATCAGCAGAAACCAG GGAAAGCCCCTAAACGCCTGATCTATGGTG CATCCAGTTTGCAAAGTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAGT TCACT CTCACAATCAGCAGCCTGCAGCCTG AAGATTTTGTAACTTATTACTGTCTACAGCA TAATAGTTACCCATTCACTTTCGGCCCTGGG ACCAAAGTGGATGTCAAACGA_________ SEQ ID NO: 1581___________________________ DIQMTQSPSSLSASVGDRVTITCRASQGIRNEL GWYQQKPGKAPKRLIYGASSLQSGVPSRFSG SGSGTEFTLTISSLQPEDFVTYYCLQHNSYPFT FGPGTKVDVKR____________________ SEQ ID NO: 11____________________________ GACATCCAGATGACCCAGTCTCCATCCTCC CTGTCTGCATCTGTGGGGGACAGAGTCACC ATCACTTGCCAGGCGAGTCAGGACATTACC AACTATTTAAATTGGTATCAGCAGAAACCA GGGAAAGCCCCTAAACTCCTGATCTACGAT GCTTCCAATTTGGAGCCAGGGGTCCCATCA AGGTTCAGTGGAAGTGGATCTGGGACAGAT TTTACTTTCACCATCAGCAGCCTGCAGCCTG AAGATATTGCAACATATTACTGTCAACAGT ATGATGATCTATTCACTTTCGGCCCTGGGAC CAAAGTGGATATCAAACGA___________ SEQ ID NO: 1582__________________________ DIQMTQSPSSLSASVGDRVTITCQASQDITNYL

NWYQQKPGKAPKLLIYDASNLEPGVPSRFSG

SEQ ID NO: 1735_________________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYIHW VRQAPGQGLEWMGWISPNNGDTNYAQKFQDRVTMT RDTSISTAYMELSRLRSDDTAVYYCTREATIFGMLIVPF DYWGQGTLVTVSS_______________________ SEQ ID NO: 165__________________________________ CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTGGT GAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGT CTCTGGTGACTCCATCAGCAGTGGTGGTTACTACTG GAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGG AGTGGATTGGGTACATCTATTACAGTGGGAGCACCT ACTACAACCCGTCCCTCAAGAGTCGAGTTACCATAT CAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGC TGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATT ACTGTGCGAGAGATCGTATTACGATTTTTGGAGTGG TTATGGGGGGCGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_______________ SEQ ID NO: 1736_________________________________ QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYYWS WIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDT SKNQFSLKLSSVTAADTAVYYCARDRITIFGVVMGGG MDVWGQGTTVTVS S_____________________ SEQ ID NO: 166__________________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC ATCTGGATTCACCTTCAGTAACTAT GGCATGCACTG GGTCCGCCAGGCTCCAGGCGAGGGGCTGGAGTGGG TGGCAGCTATATGGTTTGATGGAAGTGATAAATACT ATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCA GAGACAACTCCAAGAACACGCTGTATCTGCAAATG AACAGCCTGAGAGCCGAGGACACGGCTGTGTATTA CTGTGCGAGAGATCAGGCGATTTTTGGAGTGGTCCC CGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTC CTCA__________________________________ SEQ ID NO: 1737_________________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHW VRQAPGEGLEWVAAIWFDGSDKYYADSVKGRFTISRD NSKNTLYLQMNSLRAEDTAVYYCARDQAIFGVVPDY WGQGTLVTVSS_________________________ SEQ ID NO: 167__________________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACCTTCAGTTACTTTGGCATGCACTGG GTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGT GGCAGTTATATGGTATGATGGAAGTAATAAATACTA TGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAG AGACAATTCCAAGAACACGCTGTATCTGCAAATGAA CAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTG TGCGCGAGATGGGACGATTTTTGGAGTGCTCTTGGG GGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTC

CTCA__________________________________

SEQ ID NO: 1738_________________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGMHW VRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISR DNSKNTLYLQMNSLRAEDTAVYYCARDGTIFGVLLG DYWGQGTLVTVSS_______________________ SEQ ID NO: 168__________________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCTCCTTCAGTAGCTATGGCATGCACTG GGTCCGCCAGCCTCCAGGCAAGGGGCTGGAGTGGG TGGCAGCTATATGGTATGATGGAAATAATAAATACT ATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCA GAGACAGTTCCAAGAACACGCTGTATCTGCAAATGA ACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACT GTGCGAGAGATCGGACGATTTTTGGAGTGGTCCTTG AGTACCTCGGCCAGGGAACCCTGGTCACCGTCTCCT CA__________________________________ SEQ ID NO: 1739_________________________________ QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGMHW VRQPPGKGLEWVAAIWYDGNNKYYADSVKGRFTISR

- 33 040374

SGSGTDFTFTISSLQPEDIATYYCQQYDDLFTF GPGTKVDIKR_________ SEQ ID NO: 12____________________________

GACATCCAGATGACCCAGTCTCCATCTTCC GTGTCTGCATCTGTAGGAGACAGAGTCACC ATCACTTGTCGGGCGAGTCAGGGTCTTATC ATCTGGTTAGCCTGGTATCAGCAGAAACCG GGGAAAGCCCCTAAACTCCTGATCTATGCT GCATCCAGTTTGCAAAGTGGGGTCCCATCA AGGTTCAGCGGCAGTGGCTCTGGGACAGAT TTCACTCTCACCATCAGCAGCCTACAGCCTG AAGATTTTGCAACTTACTATTGTCAACAGA CTAACAGTTTCCCTCCGACGTTCGGCCAAG GGACCAAGGTGGAAATCAAACGA_______ SEQ ID NO: 1583__________________________ DIQMTQSPSSVSASVGDRVTITCRASQGLIIWL AWYQQKPGKAPKLLIYAASSLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQTNSFPPTF GQGTKVEIKR______________________ SEQ ID NO: 13____________________________ GACATCCAGATGACCCAGTCTCCATCTTCC GTGTCTGCATCTGTAGGAGACAGAGTCACC ATCACTTGTCGGGCGAGTCAGGGTCTTATC ATCTGGTTAGCCTGGTATCAGCAGAAACCG GGGAAAGCCCCTAAACTCCTGATCTATGCT GCATCCAGTTTGCAAAGTGGGGTCCCATCA AGGTTCAGCGGCAGTGGCTCTGGGACAGAT TTCACTCTCACCATCAGCAGCCTACAGCCTG AAGATTTTGCAACTTACTATTGTCAACAGA CTAACAGTTTCCCTCCGACGTTCGGCCAAG GGACCAAGGTGGAAATCAAACGA_______ SEQ ID NO: 1584__________________________ DIQMTQSPSSVSASVGDRVTITCRASQGLIIWL AWYQQKPGKAPKLLIYAASSLQ SGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQTNSFPPTF GQGTKVEIKR_________

SEQ ID NO: 14

DSSKNTLYLQMNSLRAEDTAVYYCARDRTIFGVVLEY LGQGTLVTVSS___________________________ SEQ ID NO: 169__________________________________ CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGT GAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGT CTCTCAGGGCTCCATCAGTAGTTACTACTGGAGCTG GATCCGGCAGCCCGCCGGGAAGGGACTAGAGTGGA TTGGCCGTATCTATACCAGTGGGAGCACCAACTACA ACCCCTCCCTCAAGAGTCGAGTCACCATGTCAATAG ACACGTCCAAGAACCAGTTCTCCCTGAAACTGAACT CTGTGACCGCCGCGGACACGGCCGTGTATTACTGTG CGAGAGATGTAGCAGTGGCTGGCTTTGACTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1740_________________________________

QVQLQESGPGLVKPSETLSLTCTVSQGSISSYYWSWIR QPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMSIDTSKN QFSLKLNSVTAADTAVYYCARDVAVAGFDYWGQGTL VTVSS__________________________________ SEQ ID NO: 170__________________________________ CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGT GAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGT CTCTGGGGGCTCCATCAGTAGTTACTACTGGAGCTG GATCCGGCAGCCCGCCGGGAAGGGACTAGAGTGGA TTGGCCGTATCTATACCAGTGGGAGCACCAACTACA ACCCCTCCCTCAAGAGTCGAGTCACCATGTCAATAG ACACGTCCAAGAACCAGTTCTCCCTGAAACTGAACT CTGTGACCGCCGCGGACACGGCCGTGTATTACTGTG CGAGAGATGTAGCAGTGGCTGGCTTTGACTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1741_________________________________

QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIR QPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMSIDTSKN QFSLKLNSVTAADTAVYYCARDVAVAGFDYWGQGTL VTVSS_________________________________ SEQ ID NO: 171

GACATTCAGATGACCCAGTCTCCATCCTCCC TGTCTGCATCTGTAGGAGACAGAGTCACCA TCACTTGCCGGGCAAGTCAGGGCATTAGAA ATGAGTTAGGCTGGTATCAGCAGAAACCAG GGAAAGCCCCTAAACTCCTGATCTATGGTG CATCCAGTTTGCAAAGTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAGT TCACTCTCACAATCAGCAGCCTGCAGCCTG AAGATTTTGTAACTTATTACTGTCTACAGCA TAATAGTTACCCATTCACTTTCGGCCAAGG GACCAAAGTGGATGTCAAACGA________ SEQ ID NO: 1585__________________________ DIQMTQSPSSLSASVGDRVTITCRASQGIRNEL GWYQQKPGKAPKLLIYGASSLQSGVPSRFSGS GSGTEFTLTIS SLQPEDFVTYYCLQHNSYPFTF GQGTKVDVKR___________________ SEQ ID NO: 15____________________________ GACATTCAGATGACCCAGTCTCCATCCTCCC TGTCTGCATCTGTAGGAGACAGAGTCACCA TCACTTGCCGGGCAAGTCAGGGCATTAGAA ATGAGTTAGGCTGGTATCAGCAGAAACCAG GGAAAGCCCCTAAACTCCTGATCTATGGTG CATCCAGTTTGCAAAGTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAGT TCACTCTCACAATCAGCAGCCTGCAGCCTG AAGATTTTGTAACTTATTACTGTCTACAGCA TAATAGTTACCCATTCACTTTCGGCCAAGG GACCAAAGTGGATGTCAAACGA________ SEQ ID NO: 1586__________________________ DIQMTQSPSSLSASVGDRVTITCRASQGIRNEL GWYQQKPGKAPKLLIYGASSLQ SGVPSRFSGS GSGTEFTLTIS SLQPEDFVTYYCLQHNSYPFTF GQGTKVDVKR______ SEQ ID NO: 16___________________________

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACCTTCAGTTACTTTGGCATGCACTGG GTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGT GGCAGTTATATGGTATGATGCAAGTAATAAATACTA TGCAGACGCCGTGAAGGGCCGCTTCACCATCTCCAG AGACAATTCCAAGAACACGCTGTATCTGCAAATGAA CAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTG TGCGCGAGATGGGACGATTTTTGGAGTGCTCTTGGG GGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTC CTCA__________________________________ SEQ ID NO: 1742_________________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGMHW VRQAPGKGLEWVAVIWYDASNKYYADAVKGRFTISR DNSKNTLYLQMNSLRAEDTAVYYCARDGTIFGVLLG DYWGQGTL VTVSS_______________________

SEQ ID NO: 172__________________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGT

CCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGC GTCTGGATTCACCTTCAGTTACTTTGGCATGCACTGG GTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGT GGCAGTTATATGGTATGATGCAAGTAATAAATACTA TGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAG AGACAATTCCAAGAACACGCTGTATCTGCAAATGAA CAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTG TGCGCGAGATGGGACGATTTTTGGAGTGCTCTTGGG GGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTC CTCA__________________________________ SEQ ID NO: 1743_________________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGMHW VRQAPGKGLEWVAVIWYDASNKYYADSVKGRFTISR DNSKNTLYLQMNSLRAEDTAVYYCARDGTIFGVLLG DYWGQGTL VTVSS_______________________ SEQ ID NO: 173__________________________________

- 34 040374

GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGA

SEQ ID NO: 1587_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKR_____________________________ SEQ ID NO: 17_______________________________ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCCT GGGACCAAAGTGGATGTCAAACGA

SEQ ID NO: 1588_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKVDV KR______________________________ SEQ ID NO: 18_______________________________

GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGA

SEQ ID NO: 1589_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKR_____________________________ SEQ ID NO: 19_______________________________ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGA

SEQ ID NO: 1590_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKR

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1744_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 174______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1745_______ _______________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 175______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1746_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 176______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGC AGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1747_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVS S______________

- 35 040374

SEQ ID NO: 20_SEQ ID NO: 177

iPS:360955 4B1.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1591 SEQ ID NO: 1748 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 21 SEQ ID NO: 178 iPS:360962 4B1.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1592 SEQ ID NO: 1749 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 22 SEQ ID NO: 179 iPS:360968 4B1.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1593 SEQ ID NO: 1750 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 23 SEQ ID NO: 180 iPS:360974 4B1.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCACATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1594 SEQ ID NO: 1751 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADSVKG RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S

- 36 040374

SEQ ID NO: 24_SEQ ID NO: 181

iPS:360978 4B1.014 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCACATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQID NO: 1595 SEQIDNO: 1752 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 25 SEQID NO: 182 iPS:359785 4B1.015 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG AGGACACGGCTGTGTATTATTGTGCGCGAGATA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1596 SEQID NO: 1753 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 26 SEQID NO: 183 iPS:360982 4B1.016 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG AGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1597 SEQIDNO: 1754 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 27 SEQID NO: 184 iPS:335922 18F2 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1598 SEQIDNO: 1755 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S

- 37 040374

SEQ ID NO: 28__SEQ ID NO: 185

iPS:360986 18F2.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1599 SEQ ID NO: 1756 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 29 SEQ ID NO: 186 iPS:360995 18F2.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1600 SEQ ID NO: 1757 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 30 SEQ ID NO: 187 iPS:360999 18F2.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1601 SEQ ID NO: 1758 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 31 SEQ ID NO: 188 iPS:361005 18F2.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1602 SEQ ID NO: 1759 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S

- 38 040374

SEQ ID NO: 32________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1603______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR______________________________ SEQ ID NO: 33________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT

CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1604______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR______________________________ SEQ ID NO: 34________________________________

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1605______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR______________________________ SEQ ID NO: 35________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT

CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1606_____________________________

DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR

SEQ ID NO: 189______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1760_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S______________ SEQ ID NO: 190______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGG AACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1761______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S______________ SEQ ID NO: 191_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1762_____________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S______________ SEQ ID NO: 192______________________________

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1763______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S______________

- 39 040374

SEQ ID NO: 36_SEQ ID NO: 193

iPS:361028 18F2.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1607 SEQ ID NO: 1764 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADSVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 37 SEQ ID NO: 194 iPS:360535 18F2.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1608 SEQ ID NO: 1765 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 38 SEQ ID NO: 195 iPS:361035 18F2.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1609 SEQ ID NO: 1766 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVVLGDYWGQGTLVTVS S SEQ ID NO: 39 SEQ ID NO: 196 iPS:359940 2F11.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1610 SEQ ID NO: 1767 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S

- 40 040374

SEQ ID NO: 40_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1611_______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R_________________________________ SEQ ID NO: 41________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATATTGCAACATATTACTGTC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GGACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1612______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEIKR

SEQ ID NO: 42________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1613______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R_________________________________ SEQ ID NO: 43________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATATTGCAACATATTACTGTC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GGACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1614______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEIKR

SEQ ID NO: 197______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1768______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

SEQ ID NO: 198______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1769_____________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________ SEQ ID NO: 199______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG

GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1770_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

SEQ ID NO: 200______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1771______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

- 41 040374

SEQ ID NO: 44________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1615______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R_________________________________ SEQ ID NO: 45________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1616______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEIKR

SEQ ID NO: 46_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1617______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R_________________________________ SEQ ID NO: 47_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGA

SEQ ID NO: 1618_____________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK R

SEQ ID NO: 201_______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1772_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

SEQ ID NO: 202______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1773______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________ SEQ ID NO: 203_______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1774_____________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

SEQ ID NO: 204______________________________ CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1775______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS S_______________

- 42 040374

SEQ ID NO: 48 SEQ ID NO: 205 iPS:359865 6H1.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1619 SEQIDNO: 1776 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S SEQ ID NO: 49 SEQ ID NO: 206 iPS:359869 6H1.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1620 SEQID NO: 1777 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVS S SEQ ID NO: 50 SEQ ID NO: 207 iPS:359873 6H1.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1621 SEQID NO: 1778 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S SEQID NO: 51 SEQ ID NO: 208 iPS:359877 S001H9 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1622 SEQIDNO: 1779 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVS S

- 43 040374

SEQ ID NO: 52

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1623______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR

SEQ ID NO: 53________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1624______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR

SEQ ID NO: 54

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGA

SEQ ID NO: 1625______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR

SEQ ID NO: 55________________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA

SEQ ID NO: 1626_____________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R

SEQ ID NO: 209

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1780_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 210______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1781_______ _______________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 211

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1782_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVS S______________ SEQ ID NO: 212______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1783______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S_______________

- 44 040374

ΝΑ

SEQ ID NO: 56

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA

ΝΑ

SEQ ID NO: 1627______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK R_________________________________ SEQ ID NO: 57_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA

SL

SEQ ID NO: 1628_____________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R________________________________

SEQ ID NO: 58

ΝΑ

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATTTTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGA

ΝΑ

SEQ ID NO: 1629______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R

SEQ ID NO: 59_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA

SL

SEQIDN0: 1630_________________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK R

SEQ ID NO: 213

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1784_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S_______________

SEQ ID NO: 214______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1785______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSS________________ SEQ ID NO: 215

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQIDN0: 1786___________________________

QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S

SEQ ID NO: 216______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT

GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1787______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSS

- 45 040374

SEQ ID NO: 60 SEQ ID NO: 217 iPS:361105 6A5.004.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATTTTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1631 SEQ ID NO: 1788 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 61 SEQ ID NO: 218 iPS:361109 6A5.004.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATATTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1632 SEQ ID NO: 1789 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK R QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S SEQ ID NO: 62 SEQ ID NO: 219 iPS:361113 6A5.004.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1633 SEQ ID NO: 1790 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDGNNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S SEQ ID NO: 63 SEQ ID NO: 220 iPS:361120 6A5.004.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1634 SEQ ID NO: 1791 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK R QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADSVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S

- 46 040374

SEQ ID NO: 64 SEQ ID NO: 221 iPS:359896 6A5.004.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCAAGG GACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1635 SEQ ID NO: 1792 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS S SEQ ID NO: 65 SEQ ID NO: 222 iPS:359890 6A5.004.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCAAGG GACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1636 SEQ ID NO: 1793 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 66 SEQ ID NO: 223 iPS:359567 2A11.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGAAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1637 SEQ ID NO: 1794 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYEDAVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSS SEQ ID NO: 67 SEQ ID NO: 224 iPS:335965 2A11.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGAAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1638 SEQ ID NO: 1795 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYEDSVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSS

- 47 040374

iPS:361165 iPS:361158 2A11.005 2A11.004 _ . 1 . . . 1 . . ΝΑ AA ΝΑ AA' SEQ ID NO: 68 GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGA SEQ ID NO: 1639 EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR SEQ ID NO: 69 GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGA SEQ ID NO: 1640 EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR SEQ ID NO: 70 SEQ ID NO: 225 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGAAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1796 QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYEDAVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSS SEQ ID NO: 226 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGAAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1797 QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYEDSVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSS SEQ ID NO: 227 iPS:361172 oh oh And o' b eq ΝΑ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1641 SEQ ID NO: 1798 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 71 SEQ ID NO: 228 iPS:361178 2G10LC1.004 ΝΑ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1642 SEQ ID NO: 1799 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS

- 48 040374

SEQ ID NO: 72

SEQ ID NO: 229

NA

NA

ΝΑ in

SL

ΝΑ

GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA

SEQ ID NO: 1643______________________________ EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKR

SEQ ID NO: 73________________________________ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA

SEQ ID NO: 1644______________________________

EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKR_____________________________________ SEQ ID NO: 74

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1800______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDGSDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS

SEQ ID NO: 230_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1801______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS_______________ SEQ ID NO: 231

GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTTCCCTCTCACTTTCGGCGG AGGGACCAAGGTGGAGATCAAACGA

SEQ ID NO: 1645______________________________

EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNFPLTFGGGTKVEI KR_________________________________ SEQ ID NO: 75________________________________ GAAATAGTGATGACGCAGTCTCAGCCACCCTG

TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTATCCTCTCACTTTCGGCGG AGGGACCAAGGTGGAGATCAAACGA

SEQ ID NO: 1646_____________________________

EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNYPLTFGGGTKVEI KR

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1802_____________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS_______________ SEQ ID NO: 232______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA

SEQ ID NO: 1803______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS

- 49 040374

SEQ ID NO: 76 SEQ ID NO: 233 iPS:361196 2G10LC1.009 ΝΑ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1647 SEQ ID NO: 1804 ΑΑ EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE IKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 77 SEQ ID NO: 234 iPS:361202 oh oh And o' 5 η ΝΑ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1648 SEQ ID NO: 1805 ΑΑ EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE IKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSS

SEQ ID NO: 78 SEQ ID NO: 235 iPS:359644 18E3.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1649 SEQ ID NO: 1806 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK R S SEQ ID NO: 79 SEQ ID NO: 236 iPS:361206 18E3.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1650 SEQ ID NO: 1807 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KR S

- 50 040374

SEQ ID NO: 80 SEQ ID NO: 237 iPS:359628 18E3.004 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1651 SEQ ID NO: 1808 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK R S SEQ ID NO: 81 SEQ ID NO: 238 iPS:359637 18E3.005 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1652 SEQ ID NO: 1809 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK R S SEQ ID NO: 82 SEQ ID NO: 239 iPS:361210 O 200 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1653 SEQ ID NO: 1810 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK R S SEQ ID NO: 83 SEQ ID NO: 240 iPS:361214 18E3.007 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1654 SEQ ID NO: 1811 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KR S

- 51 040374

SEQ ID NO: 84 SEQ ID NO: 241 iPS:361218 18E3.008 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1655 SEQ ID NO: 1812 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KR S SEQ ID NO: 85 SEQ ID NO: 242 iPS:361222 5C2.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1656 SEQ ID NO: 1813 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 86 SEQ ID NO: 243 iPS:361229 5C2.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1657 SEQ ID NO: 1814 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 87 SEQ ID NO: 244 iPS:361236 5C2.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1658 SEQ ID NO: 1815 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVS S

- 52 040374

iPS:361240 iPS:359685 5C2.010 5C2.009 NA AA NA AA SEQ ID NO: 88 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA SEQIDNO: 1659 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR SEQ ID NO: 89 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA SEQIDNO: 1660 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR SEQ ID NO: 90 SEQ ID NO: 245 CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQIDNO: 1816 QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVS S SEQ ID NO: 246 CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQIDNO: 1817 QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 247 iPS:361247 5C2.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQIDNO: 1661 SEQIDNO: 1818 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQID NO: 91 SEQ ID NO: 248 iPS:361254 5C2.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQIDNO: 1662 SEQIDNO: 1819 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS

- 53 040374

SEQ ID NO: 92 SEQ ID NO: 249 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1663 SEQ ID NO: 1820 h © eq s© sl C2.013 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVS S neither • M id SEQ ID NO: 93 SEQ ID NO: 250 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA oo SEQ ID NO: 1664 SEQ ID NO: 1821 iPS:359669 iPS:36126 5C2.015 5C2.014 AA NA AA NA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR SEQ ID NO: 94 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA SEQ ID NO: 1665 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR SEQ ID NO: 95 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVS S SEQ ID NO: 251 CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1822 QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNSLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVS S SEQ ID NO: 252 CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA oo SEQ ID NO: 1666 SEQ ID NO: 1823 so os go 5C2.016 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELNSLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS

- 54 040374

SEQ ID NO: 96_SEQ ID NO: 253

iPS:361275 11C1.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1667 SEQ ID NO: 1824 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 97 SEQ ID NO: 254 iPS:361282 11C1.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1668 SEQ ID NO: 1825 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 98 SEQ ID NO: 255 iPS:361289 11C1.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1669 SEQ ID NO: 1826 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 99 SEQ ID NO: 256 iPS:359712 11C1.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1670 SEQ ID NO: 1827 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSS

- 55 040374

SEQ ID NO: 100__SEQ ID NO: 257

iPS:361293 900'1311 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1671 SEQ ID NO: 1828 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 101 SEQ ID NO: 258 iPS:361297 11C1.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1672 SEQ ID NO: 1829 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 102 SEQ ID NO: 259 iPS:361301 800'1311 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1673 SEQ ID NO: 1830 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 103 SEQ ID NO: 260 O OSV? ώ 600'1311 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1674 SEQ ID NO: 1831 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSSLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS

- 56 040374

SEQ ID NO: 104 SEQ ID NO: 261 iPS:361305 11C1.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1675 SEQ ID NO: 1832 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 105 SEQ ID NO: 262 iPS:361312 13H12.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1676 SEQ ID NO: 1833 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 106 SEQ ID NO: 263 iPS:359744 13H12.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1677 SEQ ID NO: 1834 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR FMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 107 SEQ ID NO: 264 iPS:361319 13H12.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1678 SEQ ID NO: 1835 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSS

- 57 040374

SEQ ID NO: 108__SEQ ID NO: 265

0Ί ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA SEQIDN0: 1679 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1836 QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI os oh oh NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR ri AA GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VMTRDTSISTAYMELSSLRSDDTAVYYCAREATI 55 I GTKVEIKR FGMVIVPFDYWGQGTLVTVSS ^h ΝΑ SEQ ID NO: 109 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA SEQ ID NO: 266 CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA s © 8© SEQ ID NO: 1680 SEQ ID NO: 1837 F F DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI JO ri AA NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR I GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VMTRDTSISTAYMELSRLRSDDTAVYYCAREATI ΝΑ GTKVEIKR SEQ ID NO: 110 GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA SEQ ID NO: 1681 FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 267 CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1838 O G) DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI joint venture © NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD JO AA SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA cZ l , i η GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS RF ΝΑ SEQ ID NO: 111 GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA SEQ ID NO: 268 CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA v> SEQ ID NO: 1682 SEQ ID NO: 1839 oh oh DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI JO Yes NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD I SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS

- 58 040374

SEQ ID NO: 112__SEQ ID NO: 269

iPS:361344 12H11.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1683 SEQ ID NO: 1840 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 113 SEQ ID NO: 270 iPS:361351 12H11.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1684 SEQ ID NO: 1841 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 114 SEQ ID NO: 271 iPS:361358 90011HZI NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1685 SEQ ID NO: 1842 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 115 SEQ ID NO: 272 iPS:361365 12H11.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1686 SEQ ID NO: 1843 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSS

- 59 040374

SEQ ID NO: 116__SEQ ID NO: 273

iPS:361372 12H11.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1687 SEQ ID NO: 1844 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 117 SEQ ID NO: 274 iPS:361379 12H11.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1688 SEQ ID NO: 1845 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 118 SEQ ID NO: 275 iPS:361383 12H11.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1689 SEQ ID NO: 1846 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 119 SEQ ID NO: 276 iPS:361387 12H11.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1690 SEQ ID NO: 1847 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS

- 60 040374

SEQ ID NO: 120 SEQ ID NO: 277 iPS:361391 12H11.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1691 SEQ ID NO: 1848 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD RVMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 121 SEQ ID NO: 278 iPS:361395 12H11.013 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1692 SEQ ID NO: 1849 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVMTRDTSISTAYMELSSLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 122 SEQ ID NO: 279 iPS:361402 12H11.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGA CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCA SEQ ID NO: 1693 SEQ ID NO: 1850 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKR QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVMTRDTSISTAYMELSSLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 123 SEQ ID NO: 280 iPS:361406 2C2.005.001 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1694 SEQ ID NO: 1851 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLG QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS S

-61 040374

SEQ ID NO: 124_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1695______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW

YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK LTVLG______________________________ SEQ ID NO: 125_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG

GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1696______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLG______________________________

SEQ ID NO: 126_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1697______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSSGTS ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK LTVLG______________________________

SEQ ID NO: 127_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1698_____________________________

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK LTVLG

SEQ ID NO: 281______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC

AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1852_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG

G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 282______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1853_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 283______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1854_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 284______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1855_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

- 62 040374

SEQ ID NO: 128_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1699______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW

YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK LTVLG______________________________ SEQ ID NO: 129_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG

GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1700______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLNGPVFGGGTK LTVLG______________________________

SEQ ID NO: 130_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1701_______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW

YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLQGPVFGGGTK LTVLG______________________________ SEQ ID NO: 131________________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG

GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1702_____________________________

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLSGPVFGGGTK LTVLG

SEQ ID NO: 285______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC

AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1856_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG

G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 286______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1857_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 287______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1858_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 288______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1859_____________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

- 63 040374

SEQ ID NO: 132_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1703______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW

YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNAPVFGGGTK LTVLG______________________________ SEQ ID NO: 133_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG

GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1704______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSSGTS ASLAISGLQSEDEADYFCATFDSSLNGPVFGGGTK LTVLG______________________________

SEQ ID NO: 134_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1705______________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW

YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK LTVLG______________________________ SEQ ID NO: 135_______________________________ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG

GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT

SEQ ID NO: 1706_____________________________

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK LTVLG

SEQ ID NO: 289______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1860______________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 290______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1861______________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS S

SEQ ID NO: 291_______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA_____________ SEQ ID NO: 1862______________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG GDYVWGTYRPHYYYGMD VWGQGTTVTVS S

SEQ ID NO: 292______________________________ CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGCCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTTCGGGACTTATCGGCCTCACT ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCA______________ SEQ ID NO: 1863______________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVFGTYRPHYYYGMD VWGQGTTVTVS S

- 64 040374

SEQID NO: 136 SEQ ID NO: 293 iPS:361485 2C2.005.014 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTTCGGGACTTATCGGCCTCACT ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCA SEQID NO: 1707 SEQIDNO: 1864 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLG QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VFGTY R PH YYYG M D VWGQGTTVTVS S SEQID NO: 137 SEQ ID NO: 294 iPS:361845 18F2.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQIDNO: 1708 SEQIDNO: 1865 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI KR QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVS S SEQID NO: 138 SEQ ID NO: 295 iPS:361851 600'IH9 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQID NO: 1709 SEQIDNO: 1866 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVS S SEQID NO: 139 SEQ ID NO: 296 iPS:361855 2C2.005.015 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCAACTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQIDNO: 1710 SEQIDNO: 1867 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLSGPVFGGGTK LTVLG QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS S SEQ ID NO: 140 SEQ ID NO: 297

- 65 040374

iPS:336067 5G12.006 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCACACGA CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1711 SEQ ID NO: 1868 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LT1SSLQPEDFATYYCQQSYSTL1SFGQGTKLE1TR QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDGSNKFHADSVKGRF T1SRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA GMPEAFEIWGQGTKVTVS S SEQ ID NO: 141 SEQ ID NO: 298 iPS:336169 17B11.002 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG T CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1712 SEQ ID NO: 1869 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT KLTVLG QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S SEQ ID NO: 142 SEQ ID NO: 299 iPS:361127 5G12.006.001 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1713 SEQ ID NO: 1870 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS S SEQ ID NO: 143 SEQ ID NO: 300 iPS:361136 5G12.006.002 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1714 SEQ ID NO: 1871 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV A (TMPF A FFTWanrtTK VTVS ς

- 66 040374

SEQ ID NO: 144

SEQ ID NO: 301 cl

NA

GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCACACGA о 40* о

about 40s

NA

NA

NA

SEQ ID NO: 1715______________________________

DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITR

SEQ ID NO: 145_______________________________ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA

SEQ ID NO: 1716______________________________

DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF TLTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR

SEQ ID NO: 146

CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1872_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS S

SEQ ID NO: 302______________________________ CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA

SEQ ID NO: 1873_____________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTLVTVS S_______________

SEQ ID NO: 303

GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA

SEQ ID NO: 1717______________________________

DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR

SEQ ID NO: 147_______________________________ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA

SEQ ID NO: 1718______________________________

DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR

CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1874______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADSVKGRF TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA GMPEAFEIWGQGTKVTVS S________________ SEQ ID NO: 304_______________________________ CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1875___ ___________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDGSNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS S

- 67 040374

NA

SEQ ID NO: 148

SEQ ID NO: 305 cl

NA

NA

NA

CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG

SEQ ID NO: 1719______________________________

QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLG

SEQ ID NO: 149_______________________________ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG

CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG

SEQ ID NO: 1720______________________________ QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSSGSKSGT

SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG

TKLTVLG____________________________

SEQ ID NO: 150_______________________________ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG

CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG

SEQ ID NO: 1721______________________________ QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS

WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT KLTVLG____________________________ SEQ ID NO: 151_____________________________ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG

CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG

SEQ ID NO: 1722_____________________________

QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSSGT SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT KLTVLG

CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA___________ SEQ ID NO: 1876______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S

SEQ ID NO: 306_______________________________ CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA___________ SEQ ID NO: 1877______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S

SEQ ID NO: 307_______________________________ CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA___________ SEQ ID NO: 1878______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S

SEQ ID NO: 308_______________________________ CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG

AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA___________ SEQ ID NO: 1879______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S

- 68 040374

SEQ ID NO: 152_______________________________ SEQ ID NO: 309

iPS:360582 iPS:361514 17B11.002.006 17B11.002.005 NA AA NA AA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG T SEQ ID NO: 1723 QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSSGT SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLG SEQ ID NO: 153 CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG T SEQ ID NO: 1724 QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSSGT SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLG SEQ ID NO: 154 CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1880 QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS S SEQ ID NO: 310 CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1881 SEQ ID NO: 311 iPS:361518 17B11.002.007 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG T CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1725 SEQ ID NO: 1882 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLG S SEQ ID NO: 155 SEQ ID NO: 312 O m o so up 17B11.002.008 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG T CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1726 SEQ ID NO: 1883 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSSGT SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT KLTVLG S

- 69 040374

SEQ ID NO: 156 SEQ ID NO: 313 iPS:362051 5G12.005.001 ΝΑ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGCTCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGA CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA SEQ ID NO: 1727 SEQ ID NO: 1884 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF TLTISSLQPEDFATYYCQQSYSTLLSFGQGTKLEIK R QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTLVTVSS SEQ ID NO: 157 SEQ ID NO: 314

Table 4 A

Exemplary nucleotide (NA) and amino acid (AA) _________ sequences CDRL1, CDRL2, CDRL3___________________

No. iPS At Type CDRL1 CDRL2 CDRL3 iPS:336175 2C2.005 NA TCTGGAAGTAGCTCCAACATCGG AAGTAATACTGTAAAC ACTAATAATCAGCGGCCCT CA GCAACATTCGATTGACAGCCT GAATGGTCCGGTA SEQ ID NO: 2199 SEQ ID NO: 2356 SEQ ID NO: 2513 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 629 SEQ ID NO: 786 SEQ ID NO: 943 iPS:335 914 4B1 NA CGGGCAAGTCAGGACATTAGAGA ttatttagggc GGTGCATCCAGTTTGCAAA GT CTACAGCATAATAATTACCCCTTCACT SEQ ID NO: 2200 SEQ ID NO: 2357 SEQ ID NO: 2514 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 630 SEQ ID NO: 787 SEQ ID NO: 944 iPS:335938 6H1 NA CGGGCAAGTCAGGACATTAGAGA TTATTTAGGC GGTGCATCCAGTTTGCAAA GT CTACAGCATAATAATTACCCCTTCACT SEQ ID NO: 2201 SEQ ID NO: 2358 SEQ ID NO: 2515 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 631 SEQ ID NO: 788 SEQ ID NO: 945 iPS:335941 2F11 NA CAGGCGAGTCAGGACATTAGCAACTATTTAAAT GATGCATCCAATTTGGAAA CA CAACAGTATGATATTCTCCTC ACT SEQ ID NO: 2202 SEQ ID NO: 2359 SEQ ID NO: 2516 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 632 SEQ ID NO: 789 SEQ ID NO: 946 iPS:335970 5C2 NA AAGTCCAGCCAGAGTGTTTTATCC AGCTCCAACAATAAGAACTACAT AGCT TGGGCATCTACCCGGGAAT CC CAACAATATTATAGTACTCC GTGGACG SEQ ID NO: 2203 SEQ ID NO: 2360 SEQ ID NO: 2517 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 633 SEQ ID NO: 790 SEQ ID NO: 947 iPS:335978 13H12 NA AAGTCCAGCCAGAGTGTTTTATCC AGCTCCAACAATAAGAACTACAT AGCT TGGGCATCTACCCGGGAAT CC CAACAATATTATAGTACTCC GTGGACG SEQ ID NO: 2204 SEQ ID NO: 2361 SEQ ID NO: 2518 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 634 SEQ ID NO: 791 SEQ ID NO: 948 iPS:335986 HCl NA AAGTCCAGCCAGAGTGTTTTATCC AGCTCCAACAATAAGAACTACTT AGCT TGGACTTCTACCGAGATT CC CAGCAATATTATCGTACTCCG TGGACG SEQ ID NO: 2205 SEQ ID NO: 2362 SEQ ID NO: 2519 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 635 SEQ ID NO: 792 SEQ ID NO: 949 iPS:335994 12H11 NA AAGTCCAGCCAGAGTGTTTTATCC AGCTCCAACAATAAGAACTACTT AGCT TGGACTTCTACCGAGATT CC CAGCAATATTATCGTACTCCG TGGACG SEQ ID NO: 2206 SEQ ID NO: 2363 SEQ ID NO: 2520 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 636 SEQ ID NO: 793 SEQ ID NO: 950

-70040374

AGGGCCAGTCAGAGTATTAGTTA GGTGCATCCAGCAGGGCCA CAGCAGTATGGTAGTTCACC eq g NA CAGTTACTTAGCC CT GCTCACT SEQ ID NO: 2207 SEQ ID NO: 2364 SEQ ID NO: 2521 300 AA RASQSISYSYLA GASSRAT QQYGSSPLT tH SEQ ID NO: 637 SEQ ID NO: 794 SEQ ID NO: 951 AGGGCCAGTCAGAGTGTTAGCAG GGTGCAGCCACCAGGGCC CAGCAGTATAATAACTGGCC O And NA CAACTTAGCC ACT TCTCACT o' SEQ ID NO: 2208 SEQ ID NO: 2365 SEQ ID NO: 2522 do 5 AA RASQSVSSNLA GAATRAT QQYNNWPLT eq SEQ ID NO: 638 SEQ ID NO: 795 SEQ ID NO: 952 CGGGCAAGTCAGGGCATTAGAAA GGTGCATCCAGTTTGCAAA CTACAGCATAATAGTTACCC O NA TGAGTTAGGC GT ATTCACT s SEQ ID NO: 2209 SEQ ID NO: 2366 SEQ ID NO: 2523 (Z A , σν I AA RASQGIRNELG GASSLQS LQHNSYPFT LF SEQ ID NO: 639 SEQ ID NO: 796 SEQ ID NO: 953 00 CAGGCGAGTCAGGACATTACCAA GATGCTTCCAATTTGGAGC CAACAGTATGATGATCTATTC i NA STATTTAAAT CA ACT 1 SEQ ID NO: 2210 SEQ ID NO: 2367 SEQ ID NO: 2524 zz < A Λ QASQDITNYLN DASNLEP QQYDDLFT Cl © AA SEQ ID NO: 640 SEQ ID NO: 797 SEQ ID NO: 954 OS CGGGCGAGTCAGGGTCTTATCATC GGTGCATCCAGTTTGCAAA CAACAGACTAACAGTTTCCC I 11.00- NA TGGTTAGCC GT TCCGACG SEQ ID NO: 2211 SEQ ID NO: 2368 SEQ ID NO: 2525 (Z I Λ Λ RASQGLIIWLA AASSLQS QQTNSFPT Cl tN AA SEQ ID NO: 641 SEQ ID NO: 798 SEQ ID NO: 955

iPS:359621 17H11.004.00 1 N A CGGGCGAGTCAGGGTCTT ATCATCTGGTTAGCC GCTGCATCCAGTTTGCAAAGT CAACAGACTAACAGTTTCCCTC CGACG SEQ ID NO: 2212 SEQ ID NO: 2369 SEQ ID NO: 2526 A A RASQGLIIWLA AASSLQS QQTNSFPT SEQ ID NO: 642 SEQ ID NO: 799 SEQ ID NO: 956 iPS:359781 o o ί I N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2213 SEQ ID NO: 2370 SEQ ID NO: 2527 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 643 SEQ ID NO: 800 SEQ ID NO: 957 iPS:360929 4H9.004.002 N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2214 SEQ ID NO: 2371 SEQ ID NO: 2528 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 644 SEQ ID NO: 801 SEQ ID NO: 958 iPS:360936 2 about ί I N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2215 SEQ ID NO: 2372 SEQ ID NO: 2529 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 645 SEQ ID NO: 802 SEQ ID NO: 959 iPS:360943 4H9.004.004 N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2216 SEQ ID NO: 2373 SEQ ID NO: 2530 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 646 SEQ ID NO: 803 SEQ ID NO: 960 iPS :360949 4Η9.004.005 N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2217 SEQ ID NO: 2374 SEQ ID NO: 2531 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 647 SEQ ID NO: 804 SEQ ID NO: 961

- 71 040374

iPS:359761 4H9.004.006 N A CGGGCAAGTCAGGGCATT AGAAATGAGTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT TCACT SEQ ID NO: 2218 SEQ ID NO: 2375 SEQ ID NO: 2532 A A RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 648 SEQ ID NO: 805 SEQ ID NO: 962 iPS:36O955 4B1.010 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2219 SEQ ID NO: 2376 SEQ ID NO: 2533 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 649 SEQ ID NO: 806 SEQ ID NO: 963 iPS:360962 4B1.011 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2220 SEQ ID NO: 2377 SEQ ID NO: 2534 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 650 SEQ ID NO: 807 SEQ ID NO: 964 iPS:360968 4B1.012 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2221 SEQ ID NO: 2378 SEQ ID NO: 2535 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 651 SEQ ID NO: 808 SEQ ID NO: 965 os o SO 03 4B1.013 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2222 SEQ ID NO: 2379 SEQ ID NO: 2536 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 652 SEQ ID NO: 809 SEQ ID NO: 966 oo OS about SO 03 4B1.014 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2223 SEQ ID NO: 2380 SEQ ID NO: 2537 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 653 SEQ ID NO: 810 SEQ ID NO: 967 iPS:359785 4B1.015 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2224 SEQ ID NO: 2381 SEQID NO: 2538 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 654 SEQ ID NO: 811 SEQ ID NO: 968 iPS:360982 4B1.016 N A CGGGCAAGTCAGGACATT AGAGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2225 SEQ ID NO: 2382 SEQ ID NO: 2539 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 655 SEQ ID NO: 812 SEQ ID NO: 969 iPS:335922 18F2 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2226 SEQ ID NO: 2383 SEQ ID NO: 2540 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 656 SEQ ID NO: 813 SEQ ID NO: 970 iPS:360986 18F2.002 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2227 SEQ ID NO: 2384 SEQID NO: 2541 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 657 SEQ ID NO: 814 SEQID NO: 971 os about so joint venture % 18F2.003 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2228 SEQ ID NO: 2385 SEQ ID NO: 2542 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 658 SEQ ID NO: 815 SEQ ID NO: 972 iPS:360999 18F2.004 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2229 SEQ ID NO: 2386 SEQ ID NO: 2543 RASQDLRNYLG GASSLQS LQHNNYPFT

- 72 040374

A A SEQ ID NO: 659 SEQ ID NO: 816 SEQ ID NO: 973 iPS:361005 18F2.005 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2230 SEQ ID NO: 2387 SEQ ID NO: 2544 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 660 SEQ ID NO: 817 SEQ ID NO: 974 iPS:361009 18F2.006 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2231 SEQ ID NO: 2388 SEQ ID NO: 2545 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 661 SEQ ID NO: 818 SEQ ID NO: 975 iPS:361013 18F2.007 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2232 SEQ ID NO: 2389 SEQ ID NO: 2546 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 662 SEQ ID NO: 819 SEQ ID NO: 976 iPS:361017 18F2.008 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2233 SEQ ID NO: 2390 SEQ ID NO: 2547 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 663 SEQ ID NO: 820 SEQ ID NO: 977 O Λ 18F2.009 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2234 SEQ ID NO: 2391 SEQ ID NO: 2548 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 664 SEQ ID NO: 821 SEQ ID NO: 978 iPS:36 1028 O 2 00 about N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2235 SEQ ID NO: 2392 SEQ ID NO: 2549 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 665 SEQ ID NO: 822 SEQ ID NO: 979 iPS:360535 18F2.011 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2236 SEQ ID NO: 2393 SEQ ID NO: 2550 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 666 SEQ ID NO: 823 SEQ ID NO: 980 iPS:361035 18F2.012 N A CGGGCAAGTCAGGACCTT AGAAATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2237 SEQ ID NO: 2394 SEQ ID NO: 2551 A A RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 667 SEQ ID NO: 824 SEQ ID NO: 981 iPS:359940 2F11.002 N A CAGGCGAGTCAGGACATT AGCAACTATTTAAAT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA CT SEQ ID NO: 2238 SEQ ID NO: 2395 SEQ ID NO: 2552 A A QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 668 SEQ ID NO: 825 SEQ ID NO: 982 iPS:361039 2F11.003 N A CAGGCGAGTCAGGACATT AGCAACTATTTAAAT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA CT SEQ ID NO: 2239 SEQ ID NO: 2396 SEQ ID NO: 2553 A A QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 669 SEQ ID NO: 826 SEQ ID NO: 983 iPS:361043 2F11.004 N A CAGGCGAGTCAGGACATT AGCAACTATTTAAAT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA CT SEQ ID NO: 2240 SEQ ID NO: 2397 SEQ ID NO: 2554 A A QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 670 SEQ ID NO: 827 SEQ ID NO: 984 iPS:36 1049 ABOUT b in η o N A CAGGCGAGTCAGGACATT AGCAACTATTTAAAT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA CT SEQ ID NO: 2241 SEQ ID NO: 2398 SEQ ID NO: 2555

-73040374

A A QASQDISNYLN SEQ ID NO: 671 DASNLET SEQ ID NO: 828 QQYDILLT SEQ ID NO: 985 CAGGCGAGTCAGGACATT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA •P 1P N AGCAACTATTTAAAT CT O © 900 A SEQ ID NO: 2242 SEQ ID NO: 2399 SEQ ID NO: 2556 sl tN A QASQDISNYLN DASNLET QQYDILLT A SEQ ID NO: 672 SEQ ID NO: 829 SEQ ID NO: 986 CAGGCGAGTCAGGACATT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA <P N AGCAACTATTTAAAT CT O VO .007 SEQ ID NO: 2243 SEQ ID NO: 2400 SEQ ID NO: 2557 sl tH A QASQDISNYLN DASNLET QQYDILLT O. A SEQ ID NO: 673 SEQ ID NO: 830 SEQ ID NO: 987 CAGGCGAGTCAGGACATT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA m N AGCAACTATTTAAAT CT g 00 A — s SEQ ID NO: 2244 SEQ ID NO: 2401 SEQ ID NO: 2558 sl A QASQDISNYLN DASNLET QQYDILLT <4 A SEQ ID NO: 674 SEQ ID NO: 831 SEQ ID NO: 988 CAGGCGAGTCAGGACATT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA O' N AGCAACTATTTAAAT CT O'os in i SEQ ID NO: 2245 SEQ ID NO: 2402 SEQ ID NO: 2559 SL tH A QASQDISNYLN DASNLET QQYDILLT % A SEQ ID NO: 675 SEQ ID NO: 832 SEQ ID NO: 989 CAGGCGAGTCAGGACATT GATGCATCCAATTTGGAAACA CAACAGTATGATATTTCTCCTCA in N AGCAACTATTTAAAT CT os o\ "P ABOUT ABOUT SEQ ID NO: 2246 SEQ ID NO: 2403 SEQ ID NO: 2560 SL ^n A QASQDISNYLN DASNLET QQYDILLT % A SEQ ID NO: 676 SEQ ID NO: 833 SEQ ID NO: 990 ABOUT CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT $<n f N AGAGATTATTTAGGC TCACT SL VO I A — OS so eq SEQ ID NO: 2247 SEQ ID NO: 2404 SEQ ID NO: 2561 A RASQDIRDYLG GASSLQS LQHNNYPFT A SEQ ID NO: 677 SEQ ID NO: 834 SEQ ID NO: 991 CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT os © N A AGAGATTATTTAGGC TCACT oo os tn 1 A SEQ ID NO: 2248 SEQ ID NO: 2405 SEQ ID NO: 2562 joint venture nm A RASQDIRDYLG GASSLQS LQHNNYPFT % Ying so A SEQ ID NO: 678 SEQ ID NO: 835 SEQ ID NO: 992 CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT m N l AGAGATTATTTAGGC TCACT oo os tn ί A SEQ ID NO: 2249 SEQ ID NO: 2406 SEQ ID NO: 2563 SL nm A RASQDIRDYLG GASSLQS LQHNNYPFT .¾ D so A SEQ ID NO: 679 SEQ ID NO: 836 SEQ ID NO: 993 CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT N A AGAGATTATTTAGGC TCACT oo tn £ A SEQ ID NO: 2250 SEQ ID NO: 2407 SEQ ID NO: 2564 03 nn A RASQDIRDYLG GASSLQS LQHNNYPFT to so A SEQ ID NO: 680 SEQ ID NO: 837 SEQ ID NO: 994 CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT so N A AGAGATTATTTAGGC TCACT about so so g A SEQ ID NO: 2251 SEQ ID NO: 2408 SEQ ID NO: 2565 SL pl A RASQDIRDYLG GASSLQS LQHNNYPFT a. to so A SEQ ID NO: 681 SEQ ID NO: 838 SEQ ID NO: 995 CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT N A AGAGATTATTTAGGC TCACT about so O SEQ ID NO: 2252 SEQ ID NO: 2409 SEQ ID NO: 2566 SL F mn A RASQDIRDYLG GASSLQS LQHNNYPFT .¾ to so A SEQ ID NO: 682 SEQ ID NO: 839 SEQ ID NO: 996 N CGGGCAAGTCAGGACATT GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT S O ₍ I ®. oo c - c A AGAGATTATTTAGGC TCACT

- 74 040374

SEQ ID NO: 2253 SEQ ID NO: 2410 SEQ ID NO: 2567 A A RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 683 SEQ ID NO: 840 SEQ ID NO: 997 iPS:361079 6A5.004.001 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2254 SEQ ID NO: 2411 SEQ ID NO: 2568 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 684 SEQ ID NO:841 SEQ ID NO: 998 iPS:361085 6A5.004.002 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2255 SEQ ID NO: 2412 SEQ ID NO: 2569 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 685 SEQ ID NO: 842 SEQ ID NO: 999 iPS:361O91 6A5.004.003 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2256 SEQ ID NO: 2413 SEQ ID NO: 2570 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 686 SEQ ID NO: 843 SEQ ID NO: 1000 iPS:361095 6A5.004.004 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2257 SEQ ID NO: 2414 SEQ ID NO: 2571 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 687 SEQ ID NO: 844 SEQ ID NO: 1001 iPS:361101 6A5.004.005 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2258 SEQ ID NO: 2415 SEQ ID NO: 2572 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 688 SEQ ID NO: 845 SEQ ID NO: 1002 SL so © 6A 5.0 04. N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2259 SEQ ID NO: 2416 SEQ ID NO: 2573 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 689 SEQ ID NO: 846 SEQ ID NO: 1003 a £& 6A5.004.007 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2260 SEQ ID NO: 2417 SEQ ID NO: 2574 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 690 SEQ ID NO: 847 SEQ ID NO: 1004 iPS:361113 6A5.004.008 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2261 SEQ ID NO: 2418 SEQ ID NO: 2575 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 691 SEQ ID NO: 848 SEQ ID NO: 1005 iPS:361120 6A5.004.009 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2262 SEQ ID NO: 2419 SEQ ID NO: 2576 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 692 SEQ ID NO: 849 SEQ ID NO: 1006 iPS:359896 6A5.004.010 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2263 SEQ ID NO: 2420 SEQ ID NO: 2577 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 693 SEQ ID NO: 850 SEQ ID NO: 1007 iPS:359890 6A5.004.011 N A CAGGCGAGTCAGGACATT ACCAACTATTTAAAT GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA CT SEQ ID NO: 2264 SEQ ID NO: 2421 SEQ ID NO: 2578 A A QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 694 SEQ ID NO: 851 SEQ ID NO: 1008 .¾ £ 2A 11.002 N A AGGGCCAGTCAGATTTTTTA CCAGCACCTACTTAGCC GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GC

- 75 040374

SEQ ID NO: 2265 SEQ ID NO: 2422 SEQ ID NO: 2579 A A RASQIFTSTYLA GASSRAT QQYGSPR SEQ ID NO: 695 SEQ ID NO: 852 SEQ ID NO: 1009 iPS:335965 2A11.003 N A AGGGCCAGTCAGATTTTTTA CCAGCACCTACTTAGCC GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GC SEQ ID NO: 2266 SEQ ID NO: 2423 SEQ ID NO: 2580 A A RASQIFTSTYLA GASSRAT QQYGSPR SEQ ID NO: 696 SEQ ID NO: 853 SEQ ID NO: 1010 iPS:361158 2A11.004 N A AGGGCCAGTCAGATTTTTTA CCAGCACCTACTTAGCC GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GC SEQ ID NO: 2267 SEQ ID NO: 2424 SEQ ID NO: 2581 A A RASQIFTSTYLA GASSRAT QQYGSPR SEQ ID NO: 697 SEQ ID NO: 854 SEQ ID NO: 1011 iPS:361165 2A11.005 N A AGGGCCAGTCAGATTTTTTA CCAGCACCTACTTAGCC GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GC SEQ ID NO: 2268 SEQ ID NO: 2425 SEQ ID NO: 2582 A A RASQIFTSTYLA GASSRAT QQYGSPR SEQ ID NO: 698 SEQ ID NO: 855 SEQ ID NO: 1012 iPS:361172 2G10LC1.003 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTCTCACT SEQ ID NO: 2269 SEQ ID NO: 2426 SEQ ID NO: 2583 A A RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 699 SEQ ID NO: 856 SEQ ID NO: 1013 iPS:361178 2G10_LC1.00 4 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTCTCACT SEQ ID NO: 2270 SEQ ID NO: 2427 SEQ ID NO: 2584 A A RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 700 SEQ ID NO: 857 SEQ ID NO: 1014 iPS:361185 2G10_LC1.00 5 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTCTCACT SEQ ID NO: 2271 SEQ ID NO: 2428 SEQ ID NO: 2585 A A RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 701 SEQ ID NO: 858 SEQ ID NO: 1015 iPS:361192 2G10_LC1.00 6 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTCTCACT SEQ ID NO: 2272 SEQ ID NO: 2429 SEQ ID NO: 2586 A A RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 702 SEQ ID NO:859 SEQ ID NO: 1016 iPS: 359609 2G10_LC1.00 7 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTTCCCTC TCACT SEQ ID NO: 2273 SEQ ID NO: 2430 SEQ ID NO: 2587 A A RASQSVSSNLA GAATRAT QQYNNFPLT SEQ ID NO: 703 SEQ ID NO: 860 SEQ ID NO: 1017 iPS:359615 2G10LC1.00 8 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTATCCTCTCACT SEQ ID NO: 2274 SEQ ID NO: 2431 SEQ ID NO: 2588 A A RASQSVSSNLA GAATRAT QQYNNYPLT SEQ ID NO: 704 SEQ ID NO: 861 SEQ ID NO: 1018 iPS:361196 2G10 LC1.009 N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC TCACT SEQ ID NO: 2275 SEQ ID NO: 2432 SEQ ID NO: 2589 A A RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 705 SEQ ID NO: 862 SEQ ID NO: 1019 iPS:36120 2 U o ¹ o 0 ®. eq N A AGGGCCAGTCAGAGTGTT AGCAGCAACTTAGCC GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC TCACT SEQ ID NO: 2276 SEQ ID NO: 2433 SEQ ID NO: 2590 RASQSVSSNLA GAATRAT QQYNNWPLT

-76040374

in .002 A A N A SEQ ID NO: 706 AGGGCCAGTCAGAGTATT AGTTACAGTTACTTAGCC SEQ ID NO: 2277 SEQ ID NO:863 GGTGCATCCAGCAGGGCCACT SEQ ID NO: 2434 SEQ ID NO: 1020 CAGCAGTATGGTAGTTCACCGC TCACT SEQ ID NO: 2591 sl AND A RASQSISYSYLA GASSRAT QQYGSSPLT 00 A SEQ ID NO: 707 SEQ ID NO: 864 SEQ ID NO: 1021 AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC so © N AGTTACAGTTACTTAGCC TCACT eq oh oh A SEQ ID NO: 2278 SEQ ID NO: 2435 SEQ ID NO: 2592 SL ω A RASQSISYSYLA GASSRAT QQYGSSPLT a. 00 τΗ A SEQ ID NO: 708 SEQ ID NO: 865 SEQ ID NO: 1022 AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC oo N AGTTACAGTTACTTAGCC TCACT eq A — o\in O SEQ ID NO: 2279 SEQ ID NO: 2436 SEQ ID NO: 2593 SL ω A RASQSISYSYLA GASSRAT QQYGSSPLT 00 A SEQ ID NO: 709 SEQ ID NO:866 SEQ ID NO: 1023 AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC N AGTTACAGTTACTTAGCC TCACT so os in oh oh SEQ ID NO: 2280 SEQ ID NO: 2437 SEQ ID NO: 2594 SL ω A RASQSISYSYLA GASSRAT QQYGSSPLT .¾ 00 A SEQ ID NO: 710 SEQ ID NO: 867 SEQ ID NO: 1024 AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC O N AGTTACAGTTACTTAGCC TCACT eq so .006 SEQ ID NO: 2281 SEQ ID NO: 2438 SEQ ID NO: 2595 SL 2 A RASQSISYSYLA GASSRAT QQYGSSPLT a. 00 A SEQ ID NO: 711 SEQ ID NO: 868 SEQ ID NO: 1025 O AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC N AGTTACAGTTACTTAGCC TCACT £3 s 00 1> A ABOUT SEQ ID NO: 2282 SEQ ID NO: 2439 SEQ ID NO: 2596 A RASQSISYSYLA GASSRAT QQYGSSPLT A SEQ ID NO: 712 SEQ ID NO: 869 SEQ ID NO: 1026 AGGGCCAGTCAGAGTATT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC oo N AGTTACAGTTACTTAGCC TCACT eq .008 A SEQ ID NO: 2283 SEQ ID NO: 2440 SEQ ID NO: 2597 05 2 A RASQSISYSYLA GASSRAT QQYGSSPLT 00 A SEQ ID NO: 713 SEQ ID NO: 870 SEQ ID NO: 1027 AAGTCCAGCCAGAGTGTT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT N TTATCCAGCTCCAACAATA GGACG eq eq A AGAACTACATAGCT so i SEQ ID NO: 2284 SEQ ID NO: 2441 SEQ ID NO: 2598 SL eq* A KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT % and in A SEQ ID NO: 714 SEQ ID NO: 871 SEQ ID NO: 1028 AAGTCCAGCCAGAGTGTT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT N TTATCCAGCTCCAACAATA GGACG OS eq A AGAACTACATAGCT so i SEQ ID NO: 2285 SEQ ID NO: 2442 SEQ ID NO: 2599 SL A KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT (¾ and m A SEQ ID NO: 715 SEQ ID NO: 872 SEQ ID NO: 1029 AAGTCCAGCCAGAGTGTT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT N TTATCCAGCTCCAACAATA GGACG JO A AGAACTACATAGCT :2.008 SEQ ID NO: 2286 SEQ ID NO: 2443 SEQ ID NO: 2600 SL A KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT a. in A SEQ ID NO: 716 SEQ ID NO: 873 SEQ ID NO: 1030 AAGTCCAGCCAGAGTGTT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT N TTATCCAGCTCCAACAATA GGACG m00 A AGAACTACATAGCT os in :2.009 SEQ ID NO: 2287 SEQ ID NO: 2444 SEQ ID NO: 2601 SL A KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT in A SEQ ID NO: 717 SEQ ID NO: 874 SEQ ID NO: 1031 AAGTCCAGCCAGAGTGTT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT N TTATCCAGCTCCAACAATA GGACG O A AGAACTACATAGCT Ό O SEQ ID NO: 2288 SEQ ID NO: 2445 SEQ ID NO: 2602 SL 5C2.C A KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT .¾ A SEQ ID NO: 718 SEQ ID NO: 875 SEQ ID NO: 1032

- 77 040374

iPS:361247 5C2.011 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2289 SEQ ID NO: 2446 SEQ ID NO: 2603 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 719 SEQ ID NO: 876 SEQ ID NO: 1033 iPS:361254 5C2.012 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2290 SEQ ID NO: 2447 SEQ ID NO: 2604 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 720 SEQ ID NO: 877 SEQ ID NO: 1034 iPS:361261 5C2.013 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2291 SEQ ID NO: 2448 SEQ ID NO: 2605 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 721 SEQ ID NO: 878 SEQ ID NO: 1035 iPS:361268 5C2.014 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2292 SEQ ID NO: 2449 SEQ ID NO: 2606 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 722 SEQ ID NO: 879 SEQ ID NO: 1036 iPS:359669 5C2.015 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2293 SEQ ID NO: 2450 SEQ ID NO: 2607 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 723 SEQ ID NO: 880 SEQ ID NO: 1037 iPS:359678 5C2.016 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2294 SEQ ID NO: 2451 SEQ ID NO: 2608 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 724 SEQ ID NO: 881 SEQ ID NO: 1038 iPS:361275 11C1.002 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2295 SEQ ID NO: 2452 SEQ ID NO: 2609 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 725 SEQ ID NO: 882 SEQ ID NO: 1039 iPS:361282 11C1.003 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2296 SEQ ID NO: 2453 SEQ ID NO: 2610 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 726 SEQ ID NO: 883 SEQ ID NO: 1040 iPS:361289 11C1.004 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2297 SEQ ID NO: 2454 SEQ ID NO: 2611 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 727 SEQ ID NO: 884 SEQ ID NO: 1041 iPS:359712 11C1.005 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2298 SEQ ID NO: 2455 SEQ ID NO: 2612 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 728 SEQ ID NO: 885 SEQ ID NO: 1042

-78040374

iPS:361293 900'1311 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2299 SEQ ID NO: 2456 SEQ ID NO: 2613 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 729 SEQ ID NO: 886 SEQ ID NO: 1043 iPS:361297 11C1.007 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2300 SEQ ID NO: 2457 SEQ ID NO: 2614 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 730 SEQ ID NO: 887 SEQ ID NO: 1044 iPS:361301 800'1311 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2301 SEQ ID NO: 2458 SEQ ID NO: 2615 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 731 SEQ ID NO: 888 SEQ ID NO: 1045 iPS:359703 600'1311 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2302 SEQ ID NO: 2459 SEQ ID NO: 2616 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 732 SEQ ID NO: 889 SEQ ID NO: 1046 O SO SL 11C1.010 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2303 SEQ ID NO: 2460 SEQ ID NO: 2617 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 733 SEQ ID NO: 890 SEQ ID NO: 1047 iPS:361312 13H12.002 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2304 SEQ ID NO: 2461 SEQ ID NO: 2618 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 734 SEQ ID NO: 891 SEQ ID NO: 1048 iPS:359744 13H12.003 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2305 SEQ ID NO: 2462 SEQ ID NO: 2619 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 735 SEQ ID NO: 892 SEQ ID NO: 1049 iPS:361319 13H12.004 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2306 SEQ ID NO: 2463 SEQ ID NO: 2620 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 736 SEQ ID NO: 893 SEQ ID NO: 1050 iPS:359737 13H12.005 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2307 SEQ ID NO: 2464 SEQ ID NO: 2621 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 737 SEQ ID NO: 894 SEQ ID NO: 1051 iPS:361326 13H12.006 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CATAGCT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT GGACG SEQ ID NO: 2308 SEQ ID NO: 2465 SEQ ID NO: 2622 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 738 SEQ ID NO: 895 SEQ ID NO: 1052

- 79 040374

iPS:361330 12H11.002 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2309 SEQ ID NO: 2466 SEQ ID NO: 2623 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 739 SEQ ID NO: 896 SEQID NO: 1053 iPS:361337 12H11.003 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2310 SEQ ID NO: 2467 SEQ ID NO: 2624 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 740 SEQ ID NO: 897 SEQID NO: 1054 iPS:361344 12H11.004 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2311 SEQ ID NO: 2468 SEQ ID NO: 2625 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 741 SEQ ID NO: 898 SEQIDNO: 1055 iPS:361351 12H11.005 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2312 SEQ ID NO: 2469 SEQ ID NO: 2626 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 742 SEQ ID NO: 899 SEQIDNO: 1056 iPS:361358 90011HZI NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2313 SEQ ID NO: 2470 SEQ ID NO: 2627 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 743 SEQ ID NO: 900 SEQIDNO: 1057 iPS:361365 12H11.007 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2314 SEQ ID NO: 2471 SEQ ID NO: 2628 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 744 SEQ ID NO: 901 SEQID NO: 1058 iPS:361372 12H11.008 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2315 SEQ ID NO: 2472 SEQ ID NO: 2629 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 745 SEQ ID NO: 902 SEQIDNO: 1059 iPS:361379 12H11.009 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2316 SEQ ID NO: 2473 SEQ ID NO: 2630 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 746 SEQ ID NO: 903 SEQIDNO: 1060 iPS:361383 12H11.010 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2317 SEQ ID NO: 2474 SEQID NO: 2631 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 747 SEQ ID NO: 904 SEQIDNO: 1061 iPS:361387 12H11.011 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2318 SEQ ID NO: 2475 SEQ ID NO: 2632 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 748 SEQ ID NO: 905 SEQIDNO: 1062

- 80 040374

iPS:361391 12H11.012 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2319 SEQ ID NO: 2476 SEQ ID NO: 2633 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 749 SEQ ID NO: 906 SEQ ID NO: 1063 iPS:361395 12H11.013 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2320 SEQ ID NO: 2477 SEQ ID NO: 2634 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 750 SEQ ID NO: 907 SEQ ID NO: 1064 iPS:361402 12H11.014 NA AAGTCCAGCCAGAGTGTTTTAT CCAGCTCCAACAATAAGAACTA CTTAGCT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT GGACG SEQ ID NO: 2321 SEQ ID NO: 2478 SEQ ID NO: 2635 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 751 SEQ ID NO: 908 SEQ ID NO: 1065 iPS:361406 2C2.005.001 NA TCTGGAAGTAGCTCCAACATCG GAAGTCAAACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTGAGTGGTCCGGTA SEQ ID NO: 2322 SEQ ID NO: 2479 SEQ ID NO: 2636 AA SGSSSNIGSQTVN TNNQRPS ATFDESLSGPV SEQ ID NO: 752 SEQ ID NO: 909 SEQ ID NO: 1066 iPS:361412 2C2.005.002 NA TCTGGAAGTAGCTCCAACATCG GAAGTCAAACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG CAAGGTCCGGTA SEQ ID NO: 2323 SEQ ID NO: 2480 SEQ ID NO: 2637 AA SGSSSNIGSQTVN TNNQRPS ATFDESLQGPV SEQ ID NO: 753 SEQ ID NO: 910 SEQ ID NO: 1067 iPS:361418 2C2.005.003 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATTATGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTGAGTGGTCCGGTA SEQ ID NO: 2324 SEQ ID NO: 2481 SEQ ID NO: 2638 AA SGSSSNIGSNYVN TNNQRPS ATFDESLSGPV SEQ ID NO: 754 SEQ ID NO: 911 SEQ ID NO: 1068 iPS:361424 2C2.005.004 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATTATGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG CAAGGTCCGGTA SEQ ID NO: 2325 SEQ ID NO: 2482 SEQ ID NO: 2639 AA SGSSSNIGSNYVN TNNQRPS ATFDESLQGPV SEQ ID NO: 755 SEQ ID NO: 912 SEQ ID NO: 1069 iPS:361430 2C2.005.005 NA TCTGGAAGTAGCTCCAACAT CGGAAGTCAAACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG AATGGTCCGGTA SEQ ID NO: 2326 SEQ ID NO: 2483 SEQ ID NO: 2640 AA SGSSSNIGSQTVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 756 SEQ ID NO: 913 SEQ ID NO: 1070 iPS:361436 2C2.005.006 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATTATGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG AATGGTCCGGTA SEQ ID NO: 2327 SEQ ID NO: 2484 SEQ ID NO: 2641 AA SGSSSNIGSNYVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 757 SEQ ID NO: 914 SEQ ID NO: 1071 iPS:361442 2C2.005.007 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG AATGGTCCGGTA SEQ ID NO: 2328 SEQ ID NO: 2485 SEQ ID NO: 2642 AA SGSSSNIGSNTVN TNNQRPS ATFDESLNGPV SEQ ID NO: 758 SEQ ID NO: 915 SEQ ID NO: 1072 iPS:361448 2C2.005.008 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATTGACAGCCTGC AAGGTCCGGTA SEQ ID NO: 2329 SEQ ID NO: 2486 SEQ ID NO: 2643 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLQGPV SEQ ID NO: 759 SEQ ID NO: 916 SEQ ID NO: 1073

- 81 040374

iPS:361845 iPS:361485 iPS:361478 iPS:361472 iPS:361466 iPS:361460 iPS:361454 18F2.013 2C2.005.014 2C2.005.013 2C2.005.012 2C2.005.011 2C2.005.010 2C2.005.009 NA AA NA AA NA AA NA AA NA AA NA AA NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC SEQ ID NO: 2330 SGSSSNIGSNTVN SEQ ID NO: 760 TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC SEQ ID NO: 2331 SGSSSNIGSNTVN SEQ ID NO: 761 TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC SEQ ID NO: 2332 SGSSSNIGSNTVN SEQ ID NO: 762 TCTGGAAGTAGCTCCAACAT CGGAAGTAATTATGTAAAC SEQ ID NO: 2333 SGSSSNIGSNYVN SEQ ID NO: 763 TCTGGAAGTAGCTCCAACAT CGGAAGTAATTATGTAAAC SEQ ID NO: 2334 SGSSSNIGSNYVN SEQ ID NO: 764 TCTGGAAGTAGCTCCAACAT CGGAAGTCAAACTGTAAAC SEQ ID NO: 2335 SGSSSNIGSQTVN SEQ ID NO: 765 CGGGCAAGTCAGGACCTTAG AAATTATTTAGGC ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2487 TNNQRPS SEQ ID NO: 917 ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2488 TNNQRPS SEQ ID NO: 918 ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2489 TNNQRPS SEQ ID NO: 919 ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2490 TNNQRPS SEQ ID NO: 920 ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2491 TNNQRPS SEQ ID NO: 921 ACTAATAATCAGCGGCCCTCA SEQ ID NO: 2492 TNNQRPS SEQ ID NO: 922 GGTGCATCCAGTTTGCAAAGT GCAACATTCGATGACAGCCTG AGTGGTCCGGTA SEQ ID NO: 2644 ATFDDSLSGPV SEQ ID NO: 1074 GCAACATTCGATGACAGCCTG AATGCTCCGGTA SEQ ID NO: 2645 ATFDDSLNAPV SEQ ID NO: 1075 GCAACATTCGATAGCAGCCTG AATGGTCCGGTA SEQ ID NO: 2646 ATFDSSLNGPV SEQ ID NO: 1076 GCAACATTCGATAGCAGCCTG AATGCTCCGGTA SEQ ID NO: 2647 ATFDSSLNAPV SEQ ID NO: 1077 GCAACATTCGATAGCAGCCTG AATGCTCCGGTA SEQ ID NO: 2648 ATFDSSLNAPV SEQ ID NO: 1078 GCAACATTCGATGAAAGCCTG AGTGGTCCGGTA SEQ ID NO: 2649 ATFDESLSGPV SEQ ID NO: 1079 CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2336 SEQ ID NO: 2493 SEQ ID NO: 2650 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 766 SEQ ID NO: 923 SEQ ID NO: 1080 iPS:361851 600'IH9 NA CGGGCAAGTCAGGACATTAG AGATTATTTAGGC GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCCT TCACT SEQ ID NO: 2337 SEQ ID NO: 2494 SEQ ID NO: 2651 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 767 SEQ ID NO: 924 SEQ ID NO: 1081 iPS:361855 2C2.005.015 NA TCTGGAAGTAGCTCCAACAT CGGAAGTAATACTGTAAAC ACTAATAATCAGCGGCCCTCA GCAACATTCGATAGCAGCCTG AGTGGTCCGGTA SEQ ID NO: 2338 SEQ ID NO: 2495 SEQ ID NO: 2652 AA SGSSSNIGSNTVN TNNQRPS ATFDSSLSGPV SEQ ID NO: 768 SEQ ID NO: 925 SEQ ID NO: 1082 iPS:336067 5G12.006 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2339 SEQ ID NO: 2496 SEQ ID NO: 2653 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 769 SEQ ID NO: 926 SEQ ID NO: 1083 iPS:336169 17B11.002 NA TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC GACAATAATAAGCGACCCCTCA GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2340 SEQ ID NO: 2497 SEQ ID NO: 2654 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 770 SEQ ID NO: 927 SEQ ID NO: 1084 iPS:361127 5G12.006.0 01 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2341 SEQ ID NO: 2498 SEQ ID NO: 2655 AA RASQTISRFLN VASSLQS QQSYSTLIS

- 82 040374

SEQ ID NO: 771 SEQ ID NO: 928 SEQ ID NO: 1085 iPS:361136 5G12.006.002 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2342 SEQ ID NO: 2499 SEQ ID NO: 2656 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 772 SEQ ID NO: 929 SEQ ID NO: 1086 iPS:361140 5G12.006.003 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2343 SEQ ID NO: 2500 SEQ ID NO: 2657 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 773 SEQ ID NO: 930 SEQ ID NO: 1087 iPS:359919 5G12.006.004 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2344 SEQ ID NO: 2501 SEQ ID NO: 2658 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 774 SEQ ID NO: 931 SEQ ID NO: 1088 iPS:361144 5G12.006.005 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2345 SEQ ID NO: 2502 SEQ ID NO: 2659 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 775 SEQ ID NO: 932 SEQ ID NO: 1089 iPS:361151 5G12.006.006 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG ATCAGT SEQ ID NO: 2346 SEQ ID NO: 2503 SEQ ID NO: 2660 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 776 SEQ ID NO: 933 SEQ ID NO: 1090 iPS:36149 1 17B11.002 .001 NA TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC GACAATAATAAGCGACCCCTCA GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2347 SEQ ID NO: 2504 SEQ ID NO: 2661 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV iPS:360570 iPS:36151 _ipS:360582 iPS:361514 iPS:361507 iPS:361503 iPS:361499 O 17B11.002.00 17B11.002 17B11.002.00 17B11.002.00 17B11.002.00 17B11.002.00 17B11.002.00 8.007 6 5 4 3 2 NA AA NA AA NA AA NA AA NA AA NA AA NA AA SEQ ID NO: 777 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2348 SGSSSNIGNNYVS SEQ ID NO: 778 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2349 SGSSSNIGNNYVS SEQ ID NO: 779 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2350 SGSSSNIGNNYVS SEQ ID NO: 780 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2351 SGSSSNIGNNYVS SEQ ID NO: 781 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2352 SGSSSNIGNNYVS SEQ ID NO: 782 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2353 SGSSSNIGNNYVS SEQ ID NO: 783 TCTGGAAGCAGCTCCAACAT TGGAAATAATTATGTATCC SEQ ID NO: 2354 SGSSSNIGNNYVS SEQ ID NO: 784 SEQ ID NO: 934 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2505 DNNKRPS SEQ ID NO: 935 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2506 DNNKRPS SEQ ID NO: 936 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2507 DNNKRPS SEQ ID NO: 937 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2508 DNNKRPS SEQ ID NO: 938 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2509 DNNKRPS SEQ ID NO: 939 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2510 DNNKRPS SEQ ID NO: 940 GACAATAATAAGCGACCCCTCA SEQ ID NO: 2511 DNNKRPS SEQ ID NO: 941 SEQ ID NO: 1091 GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2662 SEQ ID NO: 1092 GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2663 SEQ ID NO: 1093 GGAACATTCGAAAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2664 GTFESSLSAVV SEQ ID NO: 1094 GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2665 SEQ ID NO: 1095 GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2666 SEQ ID NO: 1096 GGAACATGGGATAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2667 SEQ ID NO: 1097 GGAACATTCGAAAGCAGCCTG AGTGCTGTGGTA SEQ ID NO: 2668 GTFESSLSAVV SEQ ID NO: 1098 iPS:362051 5G12.005.001 NA CGGGCAAGTCAGACCATTAG CAGGTTTTTAAAT GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTGC TCAGT SEQ ID NO: 2355 SEQ ID NO: 2512 SEQ ID NO: 2669 AA RASQTISRFLN VASSLQS QQSYSTLLS SEQ ID NO: 785 SEQ ID NO: 942 SEQ ID NO: 1099

- 83 040374

Exemplary Nucleotide (NA) and Amino Acid (AA) Sequences of CDRH1, CDRH2 and CDRH3

Table 4B

No. iPS At Type CDRH1 CDRH2 CDRH3 GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT from ΝΑ TTCAGGGC ACGGTATGGACGTC 2S2.005 SEQ ID NO: 2670 SEQ ID NO: 2827 SEQ ID NO: 2984 SL AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1100 SEQ ID NO: 1257 SEQ ID NO: 1414 AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC ΝΑ GAAGGGC ohm tn SEQ ID NO: 2671 SEQ ID NO: 2828 SEQ ID NO: 2985 SL 4B1 AA NFGMH VIWYDGSNENYADSVKG DGTIFGVVLGDY Rts SEQ ID NO: 1101 SEQ ID NO: 1258 SEQ ID NO: 1415 FACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GO MA GAAGGGC P SEQ ID NO: 2672 SEQ ID NO: 2829 SEQ ID NO: 2986 iPS:3 ______________________________1 YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY AND AA SEQ ID NO: 1102 SEQ ID NO: 1259 SEQ ID NO: 1416 AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GATAGGACGATTTTTGGAGTGG ATAAATACTATGCAGACTCCGT TTCTTGACTAC MA GAAGGGC OM $ SEQ ID NO: 2673 SEQ ID NO: 2830 SEQ ID NO: 2987 iPS:3 SYGMH VIWYDGSNKYYADSVKG DRTIFGVVLDY bs eq AA SEQ ID NO: 1103 SEQ ID NO: 1260 SEQ ID NO: 1417 GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC O MA TCAGGGC tn SEQ ID NO: 2674 SEQ ID NO: 2831 SEQ ID NO: 2988 SL eq GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY % tn SEQ ID NO: 1104 SEQ ID NO: 1261 SEQ ID NO: 1418 ( GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC GO 1 MA TCAGGGC OM tn um_ SEQ ID NO: 2675 SEQ ID NO: 2832 SEQ ID NO: 2989 joint venture sch ( A A GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY mj AA, SEQ ID NO: 1105 SEQ ID NO: 1262 SEQ ID NO: 1419 ( GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGG ACACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC OO 1 MA TTCAGGAC os from SEQ ID NO: 2676 SEQ ID NO: 2833 SEQ ID NO: 2990 SL And ( A A_ GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY .¾ ι-Η AA, SEQ ID NO: 1106 SEQ ID NO: 1263 SEQ ID NO: 1420 GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGG ACACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC NA TTCAGGAC tn SEQ ID NO: 2677 SEQ ID NO: 2834 SEQ ID NO: 2991 iPS:3 12H1 AA GYYIH SEQ ID NO: 1107 WISPNNGDTNYAQKFQD SEQ ID NO: 1264 EATIFGMLIVPFDY SEQ ID NO: 1421 AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG eq NA GAGT ACGTC § SEQ ID NO: 2678 SEQ ID NO: 2835 SEQ ID NO: 2992 iPS:3 18EZ AA SGGYYWS SEQ ID NO: 1108 YIYYSGSTYYNPSLKS SEQ ID NO: 1265 DRITIFGVVMGGGMDV SEQ ID NO: 1422 AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG ATAAATACTATGCAGACTCCGT TCCCCGACTAC g And NA GAAGGGC Y about ¹ SEQ ID NO: 2679 SEQ ID NO: 2836 SEQ ID NO: 2993 SL G A A NYGMH AIWFDGSDKYYADSVKG DQAIFGVVPDY % eq AA SEQ ID NO: 1109 SEQ ID NO: 1266 SEQ ID NO: 1423 TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC NA GAAGGGC O 8 3 SEQ ID NO: 2680 SEQ ID NO: 2837 SEQ ID NO: 2994 O\ YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY joint venture (¾ AND AA SEQ ID NO: 1110 SEQ ID NO: 1267 SEQ ID NO: 1424 AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG ATAAATACTATGCAGACTCCGT TCCTTGAGTAC OO 00 NA GAAGGGC about m© 3 SEQ ID NO: 2681 SEQ ID NO: 2838 SEQ ID NO: 2995 joint venture 6A5.C AA SYGMH AIWYDGNNKYYADSVKG DRTIFGVVLEY .¾ SEQ ID NO: 1111 SEQ ID NO: 1268 SEQ ID NO: 1425

- 84 040374

iPS:336099 17H11.004 ΝΑ AGTTACTACTGGAGC CGTATCTATACCAGTGGGAGCA CCAACTACAACCCCTCCCTCAA GAGT GATGTAGCAGTGGCTGGCTTTG ACTAC SEQ ID NO: 2682 SEQ ID NO: 2839 SEQ ID NO: 2996 AA SYYWS RIYTSGSTNYNPSLKS DVAVAGFDY SEQ ID NO: 1112 SEQ ID NO: 1269 SEQ ID NO: 1426 iPS:359621 oh oh 3 about I ΝΑ AGTTACTACTGGAGC CGTATCTATACCAGTGGGAGCA CCAACTACAACCCCTCCCTCAA GAGT GATGTAGCAGTGGCTGGCTTTG ACTAC SEQ ID NO: 2683 SEQ ID NO: 2840 SEQ ID NO: 2997 AA SYYWS RIYTSGSTNYNPSLKS DVAVAGFDY SEQ ID NO: 1113 SEQ ID NO: 1270 SEQ ID NO: 1427 iPS:359781 4H9.004.001 ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2684 SEQ ID NO: 2841 SEQ ID NO: 2998 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1114 SEQ ID NO: 1271 SEQ ID NO: 1428 iPS:360929 4Н9.004.002 ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACTCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2685 SEQ ID NO: 2842 SEQ ID NO: 2999 AA YFGMH VIWYDASNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1115 SEQ ID NO: 1272 SEQ ID NO: 1429 iPS:360936 4H9.004.003 ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2686 SEQ ID NO: 2843 SEQ ID NO: 3000 AA YFGMH VIWYDGSNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1116 SEQ ID NO: 1273 SEQ ID NO: 1430 iPS:360943 4H9.004.004 ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2687 SEQ ID NO: 2844 SEQ ID NO: 3001 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1117 SEQ ID NO: 1274 SEQ ID NO: 1431 iPS:360949 4H9.004.005 ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2688 SEQ ID NO: 2845 SEQ ID NO: 3002 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1118 SEQ ID NO: 1275 SEQ ID NO: 1432 iPS:359761 £o 3 about AND ΝΑ TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATAGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2689 SEQ ID NO: 2846 SEQ ID NO: 3003 AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY SEQ ID NO: 1119 SEQ ID NO: 1276 SEQ ID NO: 1433 iPS:36O955 4В1.010 ΝΑ AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2690 SEQ ID NO: 2847 SEQ ID NO: 3004 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1120 SEQ ID NO: 1277 SEQ ID NO: 1434 iPS:360962 4В1.011 ΝΑ AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2691 SEQ ID NO: 2848 SEQ ID NO: 3005 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1121 SEQ ID NO: 1278 SEQ ID NO: 1435

- 85 040374

iPS:36O968 4B1.012 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2692 SEQ ID NO: 2849 SEQ ID NO: 3006 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1122 SEQ ID NO: 1279 SEQ ID NO: 1436 iPS:360974 4B1.O13 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACTCCGT GAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2693 SEQ ID NO: 2850 SEQ ID NO: 3007 AA NFGMH VIWYDASNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1123 SEQ ID NO: 1280 SEQ ID NO: 1437 iPS:360978 4B1.014 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2694 SEQ ID NO: 2851 SEQ ID NO: 3008 AA NFGMH VIWYDGSNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1124 SEQ ID NO: 1281 SEQ ID NO: 1438 iPS:359785 4B1.O15 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATAGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2695 SEQ ID NO: 2852 SEQ ID NO: 3009 AA NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY SEQ ID NO: 1125 SEQ ID NO: 1282 SEQ ID NO: 1439 iPS:360982 4B1.016 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2696 SEQ ID NO: 2853 SEQ ID NO: 3010 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1126 SEQ ID NO: 1283 SEQ ID NO: 1440 iPS:335922 18F2 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATGAAAACTATGCAGACTCCGT GAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2697 SEQ ID NO: 2854 SEQ ID NO: 3011 AA NFGMH VIWYDGSNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1127 SEQ ID NO: 1284 SEQ ID NO: 1441 iPS:360986 18F2.002 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2698 SEQ ID NO: 2855 SEQ ID NO: 3012 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1128 SEQ ID NO: 1285 SEQ ID NO: 1442 iPS:360995 18F2.003 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2699 SEQ ID NO: 2856 SEQ ID NO: 3013 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1129 SEQ ID NO: 1286 SEQ ID NO: 1443 iPS:360999 18F2.004 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2700 SEQ ID NO: 2857 SEQ ID NO: 3014 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1130 SEQ ID NO: 1287 SEQ ID NO: 1444 iPS:361005 18F2.005 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 2701 SEQ ID NO: 2858 SEQ ID NO: 3015 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1131 SEQ ID NO: 1288 SEQ ID NO: 1445

- 86 040374

1VO .006 NA AACTTTGGCATGCAC SEQ ID NO: 2702 GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC SEQ ID NO: 2859 GATGGGACGATCTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 3016 iPS:3 18F2 AA NFGMH SEQ ID NO: 1132 VIWYDASNENYADAVKG SEQ ID NO: 1289 DGTIFGVVLGDY SEQ ID NO: 1446 AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC NA TGAAGGGC VO s SEQ ID NO: 2703 SEQ ID NO: 2860 SEQ ID NO: 3017 iPS:3 18F2 AA NFGMH SEQ ID NO: 1133 VIWYDASNENYADAVKG SEQ ID NO: 1290 DGTIFGVVLGDY SEQ ID NO: 1447 AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC sz NA TGAAGGGC o \© § O SEQ ID NO: 2704 SEQ ID NO: 2861 SEQ ID NO: 3018 SL RC 18F2. AA NFGMH SEQ ID NO: 1134 VIWYDASNENYADAVKG SEQ ID NO: 1291 DGTIFGVVLGDY SEQ ID NO: 1448 AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC CM NA TGAAGGGC o h © oh oh SEQ ID NO: 2705 SEQ ID NO: 2862 SEQ ID NO: 3019 iPS:3 18F2. AA NFGMH SEQ ID NO: 1135 VIWYDGSNENYADAVKG SEQ ID NO: 1292 DGTIFGVVLGDY SEQ ID NO: 1449 AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC 00 ABOUT O NA GAAGGGC VO O SEQ ID NO: 2706 SEQ ID NO: 2863 SEQ ID NO: 3020 iPS:3 18F2 AA NFGMH SEQ ID NO: 1136 VIWYDASNENYADSVKG SEQ ID NO: 1293 DGTIFGVVLGDY SEQ ID NO: 1450 AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATCTTTGGAGTGG SL jn 2 NA ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC .¾® ABOUT TGAAGGGC SEQ ID NO: 2707 SEQ ID NO: 2864 SEQ ID NO: 3021 NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY AA SEQ ID NO: 1137 SEQ ID NO: 1294 SEQ ID NO: 1451 AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC in NA TGAAGGGC h© ABOUT SEQ ID NO: 2708 SEQ ID NO: 2865 SEQ ID NO: 3022 iPS:3 18F2. AA NFGMH SEQ ID NO: 1138 VIWYDASNENYADAVKG SEQ ID NO: 1295 DGTIFGVVLGDY SEQ ID NO: 1452 AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG ATAAATACTATGCAGACGCCGT TTCTTGACTAC O NA GAAGGGC in O SEQ ID NO: 2709 SEQ ID NO: 2866 SEQ ID NO: 3023 ώ 2F11. AA SYGMH SEQ ID NO: 1139 VIWYDASNKYYADAVKG SEQ ID NO: 1296 DRTIFGVVLDY SEQ ID NO: 1453 AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG ATAAATACTATGCAGACGCCGT TTCTTGACTAC σ\ NA GAAGGGC h© S SEQ ID NO: 2710 SEQ ID NO: 2867 SEQ ID NO: 3024 iPS:3 2F11. AA SYGMH SEQ ID NO: 1140 VIWYDASNKYYADAVKG SEQ ID NO: 1297 DRTIFGVVLDY SEQ ID NO: 1454 AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG ATAAATACTATGCAGACGCCGT TTCTTGACTAC i VO NA GAAGGGC oh oh SEQ ID NO: 2711 SEQ ID NO: 2868 SEQ ID NO: 3025 SL AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY a. SEQ ID NO: 1141 SEQ ID NO: 1298 SEQ ID NO: 1455

- 87 040374

77 iPS:359873 iPS:359869 iPS:359865 iPS:359956 iPS:359949 iPS:361063 iPS:361059 iPS:361O55 iPS:361O49 6H1.004 6H1.003 6H1.002 2F11.010 2F11.009 2F11.008 2F11.007 2F11.006 2F11.005 NA AA NA AA NA AA NA AA NA AA NA AA NA AA NA AA NA AA NA AGCTATGGCATGCAC SEQ ID NO: 2712 SYGMH SEQ ID NO: 1142 AGCTATGGCATGCAC SEQ ID NO: 2713 SYGMH SEQ ID NO: 1143 AGCTATGGCATGCAC SEQ ID NO: 2714 SYGMH SEQ ID NO: 1144 AGCTATGGCATGCAC SEQ ID NO: 2715 SYGMH SEQ ID NO: 1145 AGCTATGGCATGCAC SEQ ID NO: 2716 SYGMH SEQ ID NO: 1146 AGCTATGGCATGCAC SEQ ID NO: 2717 SYGMH SEQ ID NO: 1147 TACTTTGGCATGCAC SEQ ID NO: 2718 YFGMH SEQ ID NO: 1148 TACTTTGGCATGCAC SEQ ID NO: 2719 YFGMH SEQ ID NO: 1149 TACTTTGGCATGCAC SEQ ID NO: 2720 YFGMH SEQ ID NO: 1150 TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2869 VIWYDASNKYYADAVKG SEQ ID NO: 1299 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2870 VIWYDASNKYYADAVKG SEQ ID NO: 1300 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2871 VIWYDASNKYYADAVKG SEQ ID NO: 1301 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2872 VIWYDASNKYYADAVKG SEQ ID NO: 1302 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACTCCGT GAAGGGC SEQ ID NO: 2873 VIWYDASNKYYADSVKG SEQ ID NO: 1303 GTTATATGGTATGATGGAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2874 VIWYDGSNKYYADAVKG SEQ ID NO: 1304 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2875 VIWYDASNKYYADAVKG SEQ ID NO: 1305 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2876 VIWYDASNKYYADAVKG SEQ ID NO: 1306 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2877 VIWYDASNKYYADAVKG SEQ ID NO: 1307 GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3026 DRTIFGVVLDY SEQ ID NO: 1456 GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3027 DRTIFGVVLDY SEQ ID NO: 1457 GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3028 DRTIFGVVLDY SEQ ID NO: 1458 GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3029 DRTIFGVVLDY SEQ ID NO: 1459 GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3030 DRTIFGVVLDY SEQ ID NO: 1460 GATAGGACGATTTTTGGAGTGG TTCTTGACTAC SEQ ID NO: 3031 DRTIFGVVLDY SEQ ID NO: 1461 GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 3032 DGTIFGVLLGDY SEQ ID NO: 1462 GATAGGACGATTTTTGGAGTGG TCTTGGGGGACTAC SEQ ID NO: 3033 DRTIFGVLLGDY SEQ ID NO: 1463 GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 3034 DGTIFGVLLGDY SEQ ID NO: 1464 GATAGGACGATTTTTGGAGTGG TCTTGGGGGACTAC 90 in S001H9 SEQ ID NO: 2721 SEQ ID NO: 2878 SEQ ID NO: 3035 SL AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY % SEQ ID NO: 1151 SEQ ID NO: 1308 SEQ ID NO: 1465

- 88 040374

iPS:361O67 6H1.006 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATAAATACTATGCAGACTCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2722 SEQ ID NO: 2879 SEQ ID NO: 3036 AA YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY SEQIDNO: 1152 SEQIDNO: 1309 SEQ ID NO: 1466 iPS:361O71 6H1.007 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATAAATACTATGCAGACTCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2723 SEQ ID NO: 2880 SEQ ID NO: 3037 AA YFGMH VIWYDASNKYYADSVKG DGTIFGVLLGDY SEQIDNO: 1153 SEQIDNO: 1310 SEQ ID NO: 1467 iPS:361075 6H1.008 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATGGGACGATTTTTGGAGTGC TCTTGGGGGACTAC SEQ ID NO: 2724 SEQID NO: 2881 SEQIDNO: 3038 AA YFGMH VIWYDGSNKYYADAVKG DGTIFGVLLGDY SEQID NO: 1154 SEQIDNO: 1311 SEQ ID NO: 1468 iPS:361079 6A5.004.001 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2725 SEQ ID NO: 2882 SEQ ID NO: 3039 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1155 SEQIDNO: 1312 SEQ ID NO: 1469 iPS:361085 6A5.004.002 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2726 SEQ ID NO: 2883 SEQ ID NO: 3040 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1156 SEQIDNO: 1313 SEQ ID NO: 1470 iPS:361O91 6A5.004.003 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2727 SEQ ID NO: 2884 SEQIDNO: 3041 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1157 SEQIDNO: 1314 SEQIDNO: 1471 iPS:361095 6A5.004.004 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2728 SEQ ID NO: 2885 SEQ ID NO: 3042 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1158 SEQIDNO: 1315 SEQ ID NO: 1472 iPS:361101 6A5.004.005 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2729 SEQ ID NO: 2886 SEQ ID NO: 3043 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQID NO: 1159 SEQIDNO: 1316 SEQ ID NO: 1473 iPS:361105 6A5.004.006 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQ ID NO: 2730 SEQ ID NO: 2887 SEQ ID NO: 3044 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1160 SEQIDNO: 1317 SEQ ID NO: 1474 iPS:361109 6A5.004.007 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA ATAAATACTATGCAGACGCCGT GAAGGGC GATCGGACGATTTTTGGAGTGG TCCTTGAGTAC SEQID NO: 2731 SEQ ID NO: 2888 SEQ ID NO: 3045 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQIDNO: 1161 SEQIDNO: 1318 SEQ ID NO: 1475

- 89 040374

AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG ATAAATACTATGCAGACGCCGT TCCTTGAGTAC S ΝΑ GAAGGGC mN s© g SEQ ID NO: 2732 SEQ ID NO: 2889 SEQ ID NO: 3046 in SYGMH AIWYDGNNKYYADAVKG DRTIFGVVLEY ζΛ Λ Λ % << h© ΑΑ SEQ ID NO: 1162 SEQ ID NO: 1319 SEQ ID NO: 1476 AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG ATAAATACTATGCAGACTCCGT TCCTTGAGTAC about eq oh oh ΝΑ GAAGGGC mN s© 3 SEQ ID NO: 2733 SEQ ID NO: 2890 SEQ ID NO: 3047 GP in SYGMH AIWYDANNKYYADSVKG DRTIFGVVLEY ζΛ Λ Λ D ΑΑ SEQ ID NO: 1163 SEQ ID NO: 1320 SEQ ID NO: 1477 AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG O ATAAATACTATGCAGACGCCGT TCCTTGAGTAC h © OS O ΝΑ GAAGGGC in 3 f SEQ ID NO: 2734 SEQ ID NO: 2891 SEQ ID NO: 3048 in SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY A A · — h© SEQ ID NO: 1164 SEQ ID NO: 1321 SEQ ID NO: 1478 AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG ATAAATACTATGCAGACGCCGT TCCTTGAGTAC about σν O ΝΑ GAAGGGC oo σ,m 3 SEQ ID NO: 2735 SEQ ID NO: 2892 SEQ ID NO: 3049 in SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY CH Λ Λ O. ΑΑ SEQ ID NO: 1165 SEQ ID NO: 1322 SEQ ID NO: 1479 AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GGGATTACGATTTTTGGTCATG ATAAATACTATGAAGACGCCGT GGTTTGAATAT ΝΑ GAAGGGC "η OS in § SEQ ID NO: 2736 SEQ ID NO: 2893 SEQ ID NO: 3050 mN SYGMH VIWYDASNKYYEDAVKG GITIFGHGFEY ζΛ ΑΛ He eq ΑΑ SEQ ID NO: 1166 SEQ ID NO: 1323 SEQ ID NO: 1480 AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GGGATTACGATTTTTGGTCATG ATAAATACTATGAAGACTCCGT GGTTTGAATAT w h © ΝΑ GAAGGGC OS in oh oh SEQ ID NO: 2737 SEQ ID NO: 2894 SEQ ID NO: 3051 cn SYGMH VIWYDGSNKYYEDSVKG GITIFGHGFEY go eq AA SEQ ID NO: 1167 SEQ ID NO: 1324 SEQ ID NO: 1481 AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GGGATTACGATTTTTGGTCATG ATAAATACTATGAAGACGCCGT GGTTTGAATAT 00 m ΝΑ GAAGGGC oh oh SEQ ID NO: 2738 SEQ ID NO: 2895 SEQ ID NO: 3052 joint venture SYGMH VIWYDGSNKYYEDAVKG GITIFGHGFEY joint venture eq AA SEQ ID NO: 1168 SEQ ID NO: 1325 SEQ ID NO: 1482 AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GGGATTACGATTTTTGGTCATG ATAAATACTATGAAGACTCCGT GGTTTGAATAT m h© "η ΝΑ GAAGGGC h© oh oh SEQ ID NO: 2739 SEQ ID NO: 2896 SEQ ID NO: 3053 SYGMH VIWYDASNKYYEDSVKG GITIFGHGFEY AA eq SEQ ID NO: 1169 SEQ ID NO: 1326 SEQ ID NO: 1483 (*> AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG oh oh ATAAATACTATGCAGACGCCGT TCCCCGACTAC eq And ΝΑ GAAGGGC h© SEQ ID NO: 2740 SEQ ID NO: 2897 SEQ ID NO: 3054 Oh g and A Λ NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY hh AA SEQ ID NO: 1170 SEQ ID NO: 1327 SEQ ID NO: 1484 tg AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG Oh oh ATAAATACTATGCAGACTCCGT TCCCCGACTAC 00 O ΝΑ GAAGGGC mH h© SEQ ID NO: 2741 SEQ ID NO: 2898 SEQ ID NO: 3055 ch about ¹ g Λ Λ NYGMH AIWFDASDKYYADSVKG DQAIFGVVPDY .¾ 4J ΑΑ SEQ ID NO: 1171 SEQ ID NO: 1328 SEQ ID NO: 1485

- 90 040374

in 00 LC1.005 NA AACTATGGCATGCAC SEQ ID NO: 2742 GCTATATGGTTTGATGGAAGTG ATAAATACTATGCAGACGCCGT GAAGGGC SEQ ID NO: 2899 GATCAGGCGATTTTTGGAGTGG TCCCCGACTAC SEQ ID NO: 3056 sl ABOUT NYGMH AIWFDGSDKYYADAVKG DQAIFGVVPDY eq AA SEQ ID NO: 1172 SEQ ID NO: 1329 SEQ ID NO: 1486 AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG O ATAAATACTATGCAGACGCCGT TCCCCGACTAC eq ©4 And NA GAAGGGC *Ό SEQ ID NO: 2743 SEQ ID NO: 2900 SEQ ID NO: 3057 sl ABOUT NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY O. eq AA SEQ ID NO: 1173 SEQ ID NO: 1330 SEQ ID NO: 1487 O AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG S ATAAATACTATGCAGACGCCGT TCCCCGACTAC s And NA GAAGGGC in SEQ ID NO: 2744 SEQ ID NO: 2901 SEQ ID NO: 3058 at 5 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY eq SEQ ID NO: 1174 SEQ ID NO: 1331 SEQ ID NO: 1488 AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG g ATAAATACTATGCAGACGCCGT TCCCCGACTAC in And NA GAAGGGC in SEQ ID NO: 2745 SEQ ID NO: 2902 SEQ ID NO: 3059 sl O NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY O. and eq AA SEQ ID NO: 1175 SEQ ID NO: 1332 SEQ ID NO: 1489 AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG oh oh ATAAATACTATGCAGACGCCGT TCCCCGACTAC h© 04 And NA GAAGGGC h© SEQ ID NO: 2746 SEQ ID NO: 2903 SEQ ID NO: 3060 sl ABOUT NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY % and eq AA SEQ ID NO: 1176 SEQ ID NO: 1333 SEQ ID NO: 1490 O AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG O ATAAATACTATGCAGACGCCGT TCCCCGACTAC eq O O NA GAAGGGC eq h© SEQ ID NO: 2747 SEQ ID NO: 2904 SEQ ID NO: 3061 sl about ¹ gn A A NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY b eq AA SEQ ID NO: 1177 SEQ ID NO: 1334 SEQ ID NO: 1491 AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG NA GAGT ACGTC 04 in § SEQ ID NO: 2748 SEQ ID NO: 2905 SEQ ID NO: 3062 sl 2 A A SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV % AA SEQ ID NO: 1178 SEQ ID NO: 1335 SEQ ID NO: 1492 AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG h © O NA GAGT ACGTC oh oh SEQ ID NO: 2749 SEQ ID NO: 2906 SEQ ID NO: 3063 2 SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV • ⁱⁿ SEQ ID NO: 1179 SEQ ID NO: 1336 SEQ ID NO: 1493 AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG 00eq NA GAGT ACGTC cho 04 η oh oh SEQ ID NO: 2750 SEQ ID NO: 2907 SEQ ID NO: 3064 SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV ζΛ A A .¾ 00 AA SEQ ID NO: 1180 SEQ ID NO: 1337 SEQ ID NO: 1494 AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG gp NA GAGT ACGTC 04 in O SEQ ID NO: 2751 SEQ ID NO: 2908 SEQ ID NO: 3065 sl 2 A A SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV .¾ AA SEQ ID NO: 1181 SEQ ID NO: 1338 SEQ ID NO: 1495

- 91 040374

iPS:361210 18E3.006 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA CCTACTACAACCCGTCCCTCAA GAGT GATCGTATTACGATTTTTGGAG TGGTTATGGGGGGCGGTATGG ACGTC SEQ ID NO: 2752 SEQ ID NO: 2909 SEQ ID NO: 3066 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1182 SEQ ID NO: 1339 SEQ ID NO: 1496 iPS:361214 18E3.007 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA CCTACTACAACCCGTCCCTCAA GAGT GATCGTATTACGATTTTTGGAG TGGTTATGGGGGGCGGTATGG ACGTC SEQ ID NO: 2753 SEQ ID NO: 2910 SEQ ID NO: 3067 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1183 SEQ ID NO: 1340 SEQ ID NO: 1497 iPS:361218 18E3.008 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA CCTACTACAACCCGTCCCTCAA GAGT GATCGTATTACGATTTTTGGAG TGGTTATGGGGGGCGGTATGG ACGTC SEQ ID NO: 2754 SEQ ID NO: 2911 SEQ ID NO: 3068 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1184 SEQ ID NO: 1341 SEQ ID NO: 1498 iPS:361222 5C2.006 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2755 SEQ ID NO: 2912 SEQ ID NO: 3069 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1185 SEQ ID NO: 1342 SEQ ID NO: 1499 iPS:361229 5C2.007 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2756 SEQ ID NO: 2913 SEQ ID NO: 3070 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1186 SEQ ID NO: 1343 SEQ ID NO: 1500 iPS:361236 5C2.008 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2757 SEQ ID NO: 2914 SEQ ID NO: 3071 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1187 SEQ ID NO: 1344 SEQ ID NO: 1501 iPS:359685 5C2.009 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2758 SEQ ID NO: 2915 SEQ ID NO: 3072 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1188 SEQ ID NO: 1345 SEQ ID NO: 1502 iPS:361240 5C2.010 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2759 SEQ ID NO: 2916 SEQ ID NO: 3073 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1189 SEQ ID NO: 1346 SEQ ID NO: 1503 iPS:361247 5C2.011 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2760 SEQ ID NO: 2917 SEQ ID NO: 3074 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1190 SEQ ID NO: 1347 SEQ ID NO: 1504 iPS:361254 5C2.012 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2761 SEQ ID NO: 2918 SEQ ID NO: 3075 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1191 SEQ ID NO: 1348 SEQ ID NO: 1505

- 92 040374

iPS:361261 5C2.013 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2762 SEQ ID NO: 2919 SEQ ID NO: 3076 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1192 SEQ ID NO: 1349 SEQ ID NO: 1506 iPS:361268 5C2.014 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2763 SEQ ID NO: 2920 SEQ ID NO: 3077 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1193 SEQ ID NO: 1350 SEQ ID NO: 1507 iPS:359669 5C2.015 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2764 SEQ ID NO: 2921 SEQ ID NO: 3078 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1194 SEQ ID NO: 1351 SEQ ID NO: 1508 iPS:359678 5C2.016 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GCACAGACTATTCACAGAGGTT TCAGGGC GAGGCCACGATTTTTGGAATGG TTATTGTACCGTTTGACTAC SEQ ID NO: 2765 SEQ ID NO: 2922 SEQ ID NO: 3079 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1195 SEQ ID NO: 1352 SEQ ID NO: 1509 iPS:361275 11C1.002 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG AAACAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2766 SEQ ID NO: 2923 SEQ ID NO: 3080 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1196 SEQ ID NO: 1353 SEQ ID NO: 1510 iPS:361282 11C1.003 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG ACCAAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2767 SEQ ID NO: 2924 SEQ ID NO: 3081 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1197 SEQ ID NO: 1354 SEQ ID NO: 1511 iPS:361289 11C1.004 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG AAACAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2768 SEQ ID NO: 2925 SEQ ID NO: 3082 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1198 SEQ ID NO: 1355 SEQ ID NO: 1512 iPS:359712 11C1.005 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG AAACAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2769 SEQ ID NO: 2926 SEQ ID NO: 3083 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1199 SEQ ID NO: 1356 SEQ ID NO: 1513 iPS:361293 11C1.006 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG ACCAAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2770 SEQ ID NO: 2927 SEQ ID NO: 3084 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1200 SEQ ID NO: 1357 SEQ ID NO: 1514 iPS:361297 11C1.007 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG AAACAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGG TTATTGTACCATTTGACTAC SEQ ID NO: 2771 SEQ ID NO: 2928 SEQ ID NO: 3085 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1201 SEQ ID NO: 1358 SEQ ID NO: 1515

-93040374

Φ h© .008 NA GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG ACCAAAGCTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGC TTATTGTACCATTTGACTAC SEQ ID NO: 2772 SEQ ID NO: 2929 SEQ ID NO: 3086 l And AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY % SEQ ID NO: 1202 SEQ ID NO: 1359 SEQ ID NO: 1516 GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC 2 NA TTCAGGAC S SEQ ID NO: 2773 SEQ ID NO: 2930 SEQ ID NO: 3087 Xia And AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY % SEQ ID NO: 1203 SEQ ID NO: 1360 SEQ ID NO: 1517 GGCTACTATATACAC TGGATCAGCCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC 2 NA TTCAGGAC ABOUT SEQ ID NO: 2774 SEQ ID NO: 2931 SEQ ID NO: 3088 SA And GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY % AA SEQ ID NO: 1204 SEQ ID NO: 1361 SEQ ID NO: 1518 GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC eq eq NA TCAGGGC h© About rq* SEQ ID NO: 2775 SEQ ID NO: 2932 SEQ ID NO: 3089 Xia I AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY b SEQ ID NO: 1205 SEQ ID NO: 1362 SEQ ID NO: 1519 GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC 2 NA TCAGGGC o \ 1L f rq* SEQ ID NO: 2776 SEQ ID NO: 2933 SEQ ID NO: 3090 Xia And AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY .¾ SEQ ID NO: 1206 SEQ ID NO: 1363 SEQ ID NO: 1520 GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC σν O NA TCAGGGC h© about rq* SEQ ID NO: 2777 SEQ ID NO: 2934 SEQ ID NO: 3091 Xia I GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY .¾ AA SEQ ID NO: 1207 SEQ ID NO: 1364 SEQ ID NO: 1521 GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC O NA TCAGGGC o \ 1L f rq* SEQ ID NO: 2778 SEQ ID NO: 2935 SEQ ID NO: 3092 Xia I GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY .¾ AA SEQ ID NO: 1208 SEQ ID NO: 1365 SEQ ID NO: 1522 GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC h © eq O NA TCAGGGC h© f rq* SEQ ID NO: 2779 SEQ ID NO: 2936 SEQ ID NO: 3093 f I GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY .¾ AA SEQ ID NO: 1209 SEQ ID NO: 1366 SEQ ID NO: 1523 GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC O rq F NA TTTCAGGAC h© f _f SEQ ID NO: 2780 SEQ ID NO: 2937 SEQ ID NO: 3094 iPS:3 12H1 AA GYYIH SEQ ID NO: 1210 WISPNQGETNYAQKFQD SEQ ID NO: 1367 EATIFGMLIVPFDY SEQ ID NO: 1524 GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC GACACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC 2 NA TTTCAGGAC © O SEQ ID NO: 2781 SEQ ID NO: 2938 SEQ ID NO: 3095 Xia I AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY % SEQ ID NO: 1211 SEQ ID NO: 1368 SEQ ID NO: 1525

- 94 040374

iPS:361344 12H11.004 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAAACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2782 SEQ ID NO: 2939 SEQ ID NO: 3096 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1212 SEQ ID NO: 1369 SEQ ID NO: 1526 iPS:361351 12H11.005 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG AAACAAACTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2783 SEQ ID NO: 2940 SEQ ID NO: 3097 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1213 SEQ ID NO: 1370 SEQ ID NO: 1527 iPS:361358 900TIHZI NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG ACACAAACTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGC TTATTGTACCATTTGACTAC SEQ ID NO: 2784 SEQ ID NO: 2941 SEQ ID NO: 3098 AA GYYIH WISPNNGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1214 SEQ ID NO: 1371 SEQ ID NO: 1528 iPS:361365 12H11.007 NA GGCTACTATATACAC TGGATAAGCCCCTAACCAAGGT GACACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2785 SEQ ID NO: 2942 SEQ ID NO: 3099 AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1215 SEQ ID NO: 1372 SEQ ID NO: 1529 iPS:361372 12H11.008 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG AAACAAACTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2786 SEQ ID NO: 2943 SEQ ID NO: 3100 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1216 SEQ ID NO: 1373 SEQ ID NO: 1530 iPS:361379 12H11.009 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAAACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2787 SEQ ID NO: 2944 SEQ ID NO: 3101 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1217 SEQ ID NO: 1374 SEQ ID NO: 1531 iPS:361383 12H11.010 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG ACACAAACTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGC TTATTGTACCATTTGACTAC SEQ ID NO: 2788 SEQ ID NO: 2945 SEQ ID NO: 3102 AA GYYIH WISPNNGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1218 SEQ ID NO: 1375 SEQ ID NO: 1532 iPS:361387 12H11.O11 NA GGCTACTATATACAC TGGATAAGCCCCTAACCAAGGT GACACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2789 SEQ ID NO: 2946 SEQ ID NO: 3103 AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1219 SEQ ID NO: 1376 SEQ ID NO: 1533 iPS:361391 12H11.012 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG AAACAAACTATGCACAGAAGT TTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2790 SEQ ID NO: 2947 SEQ ID NO: 3104 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1220 SEQ ID NO: 1377 SEQ ID NO: 1534 iPS:361395 12H11.013 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAAACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2791 SEQ ID NO: 2948 SEQ ID NO: 3105 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1221 SEQ ID NO: 1378 SEQ ID NO: 1535

- 95 040374

iPS:361402 12H11.014 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAAACAAACTATGCACAGAAG TTTCAGGAC GAGGCCACGATTTTTGGAATGCTTATTGTACCATTTGACTAC SEQ ID NO: 2792 SEQ ID NO: 2949 SEQIDNO: 3106 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1222 SEQIDNO: 1379 SEQIDNO: 1536 iPS:361406 2C2.005.001 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACT ACGGTATGGACGTC SEQ ID NO: 2793 SEQ ID NO: 2950 SEQIDNO: 3107 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1223 SEQID NO: 1380 SEQID NO: 1537 iPS:361412 2C2.005.002 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACT ACGGTATGGACGTC SEQ ID NO: 2794 SEQIDNO: 2951 SEQIDNO: 3108 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1224 SEQIDNO: 1381 SEQID NO: 1538 iPS:361418 2C2.005.003 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACT ACGGTATGGACGTC SEQ ID NO: 2795 SEQ ID NO: 2952 SEQIDNO: 3109 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1225 SEQIDNO: 1382 SEQIDNO: 1539 iPS:361424 2C2.005.004 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 2796 SEQ ID NO: 2953 SEQIDNO: 3110 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1226 SEQIDNO: 1383 SEQID NO: 1540 iPS:361430 2C2.005.005 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 2797 SEQ ID NO: 2954 SEQIDNO: 3111 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1227 SEQID NO: 1384 SEQIDNO: 1541 iPS:361436 2C2.005.006 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 2798 SEQ ID NO: 2955 SEQIDNO: 3112 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1228 SEQID NO: 1385 SEQID NO: 1542 iPS:361442 2C2.005.007 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 2799 SEQ ID NO: 2956 SEQIDNO: 3113 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1229 SEQIDNO: 1386 SEQID NO: 1543 iPS:361448 2C2.005.008 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 2800 SEQ ID NO: 2957 SEQIDNO: 3114 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1230 SEQID NO: 1387 SEQIDNO: 1544 iPS:361454 2C2.005.009 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQID NO: 2801 SEQIDNO: 2958 SEQIDNO: 3115 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQIDNO: 1231 SEQIDNO: 1388 SEQIDNO: 1545

- 96 040374

45 iPS:361485 iPS:361478 iPS:361472 iPS:361466 iPS:361460 S 2C2.005.014 2C2.005.013 2C2.005.012 2C2.005.011 2C2.005.010 NA AA NA AA NA AA NA AA NA AA NA GGCTACTATATGCAT SEQ ID NO: 2802 GYYMH SEQ ID NO: 1232 GGCTACTATATGCAT SEQ ID NO: 2803 GYYMH SEQ ID NO: 1233 GGCTACTATATGCAT SEQ ID NO: 2804 GYYMH SEQ ID NO: 1234 GGCTACTATATGCAT SEQ ID NO: 2805 GYYMH SEQ ID NO: 1235 GGCTACTATATGCAT SEQ ID NO: 2806 GYYMH SEQ ID NO: 1236 AACTTTGGCATGCAC TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC SEQ ID NO: 2959 WINPNSGGTNYAQKFQG SEQ ID NO: 1389 TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC SEQ ID NO: 2960 WINPNSGGTNYAQKFQG SEQ ID NO: 1390 TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC SEQ ID NO: 2961 WINPNSGGTNYAQKFQG SEQ ID NO: 1391 TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC SEQ ID NO: 2962 WINPNSGGTNYAQKFQG SEQ ID NO: 1392 TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC SEQ ID NO: 2963 WINPNSGGTNYAQKFQG SEQ ID NO: 1393 GTTATATGGTATGATGCAAGTA ATGAAAACTATGCAGACGCCG TGAAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 3116 GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1546 GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 3117 GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1547 GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACTACT ACGGTATGGACGTC SEQ ID NO: 3118 GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1548 GGGGGGGATTACGTTTTCGGGA CTTACGGCCTCACTACTACTA CGGTATGGACGTC SEQ ID NO: 3119 GGDYVFGTYRPHYYYGMDV SEQ ID NO: 1549 GGGGGGGATTACGTTTTCGGGA CTTACGGCCTCACTACTACTA CGGTATGGACGTC SEQ ID NO: 3120 GGDYVFGTYRPHYYYGMDV SEQ ID NO: 1550 GATAGGACGATCTTTGGAGTGG TCTTGGGGGACTAC 90 4© O SEQ ID NO: 2807 SEQ ID NO: 2964 SEQ ID NO: 3121 SL ri AA NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY 90 SEQ ID NO: 1237 SEQ ID NO: 1394 SEQ ID NO: 1551 in NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA ATAAATACTATGCAGACGCCGT GAAGGGC GATAGGACGATTTTTGGAGTGG TCTTGGGGGACTAC 90 4© 04 O SEQ ID NO: 2808 SEQ ID NO: 2965 SEQ ID NO: 3122 SL 6H1.( AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY % SEQ ID NO: 1238 SEQ ID NO: 1395 SEQ ID NO: 1552 in m in about NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GCACAAACTATGCACAGAAGT TTCAGGGC GGGGGGGATTACGTTTGGGGG ACTTATCGGCCTCACTACTACT ACGGTATGGACGTC 90 4© £ SEQ ID NO: 2809 SEQ ID NO: 2966 SEQ ID NO: 3123 SL 2C2.C AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV .¾ SEQ ID NO: 1239 SEQ ID NO: 1396 SEQ ID NO: 1553 4© NA AGCTATGGCATACAC GTTATATGGTATGATGGAAGTA ATAAGTTCCATGCAGACTCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC about 40 q SEQ ID NO: 2810 SEQ ID NO: 2967 SEQ ID NO: 3124 SL 5G12 AA SYGIH VIWYDGSNKFHADSVKG GKVAGMPEAFEI .¾ SEQ ID NO: 1240 SEQ ID NO: 1397 SEQ ID NO: 1554 04 40 1.002 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA ACACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC 4© SEQ ID NO: 2811 SEQ ID NO: 2968 SEQ ID NO: 3125 SL s AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV .¾ SEQ ID NO: 1241 SEQ ID NO: 1398 SEQ ID NO: 1555

- 97 040374

iPS:361127 5G12.006.001 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2812 SEQ ID NO: 2969 SEQ ID NO: 3126 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1242 SEQ ID NO: 1399 SEQ ID NO: 1556 iPS:361136 5G12.006.002 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2813 SEQ ID NO: 2970 SEQ ID NO: 3127 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1243 SEQ ID NO: 1400 SEQ ID NO: 1557 iPS:36114O 5G12.006.003 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2814 SEQ ID NO: 2971 SEQ ID NO: 3128 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1244 SEQ ID NO: 1401 SEQ ID NO: 1558 iPS:359919 5G12.006.004 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2815 SEQ ID NO: 2972 SEQ ID NO: 3129 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1245 SEQ ID NO: 1402 SEQ ID NO: 1559 iPS:361144 5G12.006.005 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACTCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2816 SEQ ID NO: 2973 SEQ ID NO: 3130 AA SYGIH VIWYDASNKFHADSVKG GKVAGMPEAFEI SEQ ID NO: 1246 SEQ ID NO: 1403 SEQ ID NO: 1560 iPS:361151 5G12.006.006 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGGAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2817 SEQ ID NO: 2974 SEQ ID NO: 3131 AA SYGIH VIWYDGSNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1247 SEQ ID NO: 1404 SEQ ID NO: 1561 iPS:361491 17B11.002.001 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2818 SEQ ID NO: 2975 SEQ ID NO: 3132 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1248 SEQ ID NO: 1405 SEQ ID NO: 1562 iPS:361499 17B11.002.002 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA ACACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2819 SEQ ID NO: 2976 SEQ ID NO: 3133 AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1249 SEQ ID NO: 1406 SEQ ID NO: 1563 O 40 SL % 17B11.002.003 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2820 SEQ ID NO: 2977 SEQ ID NO: 3134 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1250 SEQ ID NO: 1407 SEQ ID NO: 1564 iPS:361507 3 about oh oh Y ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2821 SEQ ID NO: 2978 SEQ ID NO: 3135 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1251 SEQ ID NO: 1408 SEQ ID NO: 1565

- 98 040374

iPS:361514 17B11.002.005 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2822 SEQ ID NO: 2979 SEQ ID NO: 3136 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1252 SEQ ID NO: 1409 SEQ ID NO: 1566 iPS:360582 17B11.002.006 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA ACACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTGGGGG AGTTATCGTCCCCTACTACTACT ACTACGGTATGGACGTC SEQ ID NO: 2823 SEQ ID NO: 2980 SEQ ID NO: 3137 AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1253 SEQ ID NO: 1410 SEQ ID NO: 1567 iPS:361518 17B11.002.007 ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTTCGGGA GTTATCGTCCCCTACTACTA CTACGGTATGGACGTC SEQ ID NO: 2824 SEQ ID NO: 2981 SEQ ID NO: 3138 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVFGSYRPYYYYYGMDV SEQ ID NO: 1254 SEQ ID NO: 1411 SEQ ID NO: 1568 iPS:360570 § O oh oh Y ΝΑ AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GCACAGGCTATGCACAGAAGT TCCAGGGC GGGGGTGATTACGTTTTCGGGA GTTATCGTCCCCTACTACTA CTACGGTATGGACGTC SEQ ID NO: 2825 SEQ ID NO: 2982 SEQ ID NO: 3139 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVFGSYRPYYYYYGMDV SEQ ID NO: 1255 SEQ ID NO: 1412 SEQ ID NO: 1569 iPS:362051 5G12.005.001 ΝΑ AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA ATAAGTTCCATGCAGACGCCGT GAAGGGC GGAAAAGTGGCTGGTATGCCCT GAAGCTTTTGAAATC SEQ ID NO: 2826 SEQ ID NO: 2983 SEQ ID NO: 3140 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1256 SEQ ID NO: 1413 SEQ ID NO: 1570

Table 5

Illustrative Nucleotide (NA) and Amino Acid (AA) Light and Heavy Chain Sequences

No. iPS At Type LC HC iPS:336175 2C2.005 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTG GCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA

- 99 040374

GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGAACGTCTTCATGCTCCGTGATGCAT GAGGCTCCGTGACAACCACTACCCAGAATCGC SEQ ID NO: 1885 SEQ ID NO: 2042 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSC QVTAPTEGSTVEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS S A ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 315 SEQ ID NO:472 4B1 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCACATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCGACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAGCATGGGGGG ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1886 SEQ ID NO: 2043 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYGTVSLSSVVTVPSSSL

- 100 040374

LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 316 SEQ ID NO: 473 iPS :335938 6H1 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1887 SEQ ID NO: 2044 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLSST LTLSKADYTKHNKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 317 SEQ ID NO: 474 iPS:335941 2F11 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGACAAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGCAGACTCCGTGAAGGGC

- 101 040374

CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT

SEQIDNO: 1888_________________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDIAIYYCQQYDILLTFGGGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQTKDSKDSIYSLSST LTLSKADYEKHKS

ΝΑ sl

SEQ ID NO: 318_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCC GGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2045______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK_______________________________ SEQ ID NO: 475_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGA CACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG

- 102 040374 in sl

ΝΑ

SEQ ID NO: 1889______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK

SEQ ID NO: 319_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2046______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPP CPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 476_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTG TGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA

- 103 040374

SEQ ID NO: 1890______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK

SEQ ID NO: 320

GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1891______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS

GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2047______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN

VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 477

CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2048______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS

- 104 040374 sl.¾

KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNRGEC GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 321 SEQ ID NO: 478 12H11 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1892 SEQ ID NO: 2049 ΑΑ DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK

- 105 040374

SEQ ID NO: 322

SEQ ID NO: 479

GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGAACGG TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA GCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG AGAAACACAAAGTCTACGCCTGCGAAGTCACCC ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT TCAACAGGGGAGAGTGT

SEQ ID NO: 1893______________________________ EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSLS STLTLSKADYEKHKVYACEVTHQGLS SPVTKSFN RGEC

SEQ ID NO: 323

GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG

CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAA TGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA_____________________ SEQ ID NO: 2050______________________________ QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 480

CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA AGTGATAAATACTATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG

- 106 040374

CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1894 SEQ ID NO: 2051 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSQTYTK SSTLTLSKADYEKTHKSSVYACEVE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDGSDKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVLSTFCSQVMAL SEQ ID NO: 324 SEQ ID NO: 481 4H9.004 ΝΑ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCCT GGGACCAAAGTGGATGTCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT

- 107 040374

CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1895 SEQ ID NO: 2052 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVIYYCLQHNSYPFTFGPGTKVDV KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQTKDSKDSIYSLS STLTLVSYGLECTHSCACEPV QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 325 SEQ ID NO: 482 iPS:336O88 6A5.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTGACCATCAGCCC CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTTCTCCTTCAGTAGCTATGGCA TGCACTGGTCCGCCAGCCTCCAGGCAAGGGGC CAGCCTGAAGATATTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGAACGGTGGCTGCAC CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT AACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTG GACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1896 SEQ ID NO: 2053

- 108 040374

AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDIAIYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQTKDSKDSIYPVSLSFY GLVTLSKADYPVEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDGNNKYYADSVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 326 SEQ ID NO:483 iPS:336O99 17H11.004 NA GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC TGGGACAGATTTCACTCTCACCATCAGCAGCCT ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGAACGGTGGC TGCACCATCTGTCTTCATCTTCCCGCCATCTGAT GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTG TGCCTGCTGAATAACTTCTATCCCAGAGAGGCC AAAGTACAGTGGAAGGTGGATAACGCCCTCCAA TCGGGTAACTCCCAGGAGAGTGTCACAGAGCAG GACAGCAAGGACAGCACCTACAGCCTCAGCAGC ACCCTGACGCTGAGCAAAGCAGACTACGAGAA ACACAAAGTCTACGCCTGCGAAGTCACCCATCA GGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAA CAGGGGAGAGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC ACTGTCTCTCAGGGCTCCATCAGTAGTTACTACT GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA CTAGAGTGGATTGGCCGTATCTATACCAGTGGG AGCACCAACTACAACCCCTCCCTCAAGAGTCGA GTCACCATGTCAATAGACACGTCCAAGAACCAG TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG GACACGGCCGTGTATTACTGTGCGAGAGATGTA GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA ACCCTGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1897 SEQ ID NO: 2054 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD QVQLQESGPGLVKPSETLSLTCTVSQGSISSYYWS WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF DYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGT AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV LQSSGLYSLSSVVTVPSSSLGTQIYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPCEEQYGSIYRCVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKS RWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

- 109 040374

SEQ ID NO: 327__SEQ ID NO: 484

iPS:359621 17H11.004.001 ΝΑ GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC TGGGACAGATTTCACTCTCACCATCAGCAGCCT ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGAACGGTGGC TGCACCATCTGTCTTCATCTTCCCGCCATCTGAT GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTG TGCCTGCTGAATAACTTCTATCCCAGAGAGGCC AAAGTACAGTGGAAGGTGGATAACGCCCTCCAA TCGGGTAACTCCCAGGAGAGTGTCACAGAGCAG GACAGCAAGGACAGCACCTACAGCCTCAGCAGC ACCCTGACGCTGAGCAAAGCAGACTACGAGAA ACACAAAGTCTACGCCTGCGAAGTCACCCATCA GGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAA CAGGGGAGAGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGGGGCTCCATCAGTAGTTACTACT GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA CTAGAGTGGATTGGCCGTATCTATACCAGTGGG AGCACCAACTACAACCCCTCCCTCAAGAGTCGA GTCACCATGTCAATAGACACGTCCAAGAACCAG TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG GACACGGCCGTGTATTACTGTGCGAGAGATGTA GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA ACCCTGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTC CAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1898 SEQ ID NO: 2055 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWS WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF DYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGT AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV LQSSGLYSLSSVVTVPSSSLGTQIYICNVNHKPSNT KVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPCEEQYGSIYRCVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKS RWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 328 SEQ ID NO: 485 iPS:359781 oh oh 3 o σν I ΝΑ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC

- 110 040374

GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1899 SEQ ID NO: 2056 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKRTVAAPSVFIFPPSDEQLKSGTASVVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKDSSSTYS LSSTLTLECSKADVSFEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV

SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 329 SEQ ID NO: 486 iPS:360929 4H9.004.002 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC

- 111 040374

SEQ ID NO: 1900_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKRTVAAPSVFIFPPSDEQLKSGTASVVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKDSSSTYS LSSTLTLECSKADVSFEKHKVY

ΝΑ

SEQ ID NO: 330_______________________________ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT

SEQ ID NO: 1901_____________________________

DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD

CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2057______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 487_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGC CTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAG AAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2058______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG

- 112 040374 sl.¾

VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGEC TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 331 SEQ ID NO: 488 4Н9.004.004 ΝΑ GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCCT GGGACCAAAGTGGATGTCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1902 SEQ ID NO: 2059 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKVDV KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 113 040374

SEQ ID NO: 332 SEQ ID NO: 489 iPS:360949 4H9.004.005 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1903 SEQ ID NO: 2060 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKRTVAAPSVFIFPPSDEQLKSGTASVVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKRGSSTYS LSSTLTLECSKADVSFEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 333 SEQ ID NO: 490 iPS:359761 4H9.004.006 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAGTTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGGACCAAAGTGGATGTCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 114 040374 sl

ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1904 SEQ ID NO: 2061 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD VKRTVAAPSVFIFPPSDEQLKSGTASVVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKDSSSTYS LSSTLTLECSKADVSFEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 334 SEQ ID NO:491 4B1.010 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 115 040374

SEQ ID NO: 1905______________________________ DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS TLTLSKADYEKHKVYACEVTHQGLS SPVTKSFNR

GEC

SEQ ID NO: 335_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT

SEQ ID NO: 1906______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2062______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 492_______________________________ CAGGTGC AGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAG GTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2063______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG

- 116 040374

GEC RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 336 SEQ ID NO: 493 iPS:360968 4B1.012 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1907 SEQ ID NO: 2064 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFAIYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSIYSLSSF LTLSKADVECTHQKVY S QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 117 040374

SEQ ID NO: 337__SEQ ID NO: 494

iPS: 360974 4B1.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCACATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1908 SEQ ID NO: 2065 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYGLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADSVKG RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 338 SEQ ID NO: 495 iPS: 360978 4B1.014 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCACATGAACAGCCTGAGAGTCG CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 118 040374

CGGGTAACTCCCAGGAGAGTGTCACAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1909 SEQ ID NO: 2066 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYGLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 339 SEQ ID NO: 496 iPS:359785 4B1.015 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG AGGACACGGCTGTGTATTATTGTGCGCGAGATA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 119 040374

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1910 SEQ ID NO: 2067 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFAIYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQTKDSKDSIYPVSLSS TLVTLSKADYGLACEEKHKSS QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 340 SEQ ID NO: 497 iPS:360982 4B1.016 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG AGGACACGGCTGTGTATTATTGTGCGCGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1911 SEQ ID NO: 2068 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG

- 120 040374

GEC RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO:341 SEQ ID NO: 498 iPS:335922 18F2 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1912 SEQ ID NO: 2069 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADYEKHNKSFTH SPVTH QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 121 040374

SEQ ID NO: 342__SEQ ID NO: 499

iPS: 360986 18F2.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1913 SEQ ID NO: 2070 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSLS STLTLSKADYSFEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 343 SEQ ID NO: 500 iPS :360995 18F2.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 122 040374

CGGGTAACTCCCAGGAGAGTGTCACAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1914 SEQ ID NO: 2071 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADEVEKGLQKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED

PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 344 SEQ ID NO: 501 iPS :360999 18F2.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 123 040374

iPS:361005 18F2.005 AA NA SEQIDNO: 1915 DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFAIYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSLS STLTLSKADYSFEKHKVY SEQ ID NO: 345 GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2072 QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 502 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1916 SEQ ID NO: 2073 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG

- 124 040374

FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 346 SEQ ID NO: 503 iPS:361009 18F2.006 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1917 SEQ ID NO: 2074 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADYEKHNKSFTH SPVTH QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 125 040374

iPS:361O13 18F2.007 NA SEQ ID NO: 347 GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT SEQ ID NO: 504 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCACATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1918 SEQ ID NO: 2075 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADYEKHNKSFTH SPVTH QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 348 SEQ ID NO: 505 iPS:361O17 18F2.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 126 040374 sl.¾

CGGGTAACTCCCAGGAGAGTGTCACAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1919 SEQ ID NO: 2076 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADYEKHNKSFTH SPVTH QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 349 SEQ ID NO: 506 18F2.009 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 127 040374

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1920 SEQ ID NO: 2077 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADEVEKGLQKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 350 SEQ ID NO: 507 iPS:361028 18F2.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGCAACTGGACAGAATTCACTCTCAATCAGCCTAG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGC AAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1921 SEQ ID NO: 2078 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADSVKG

- 128 040374

FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLS SPVTKSFN RGEC RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 351 SEQ ID NO: 508 iPS:360535 18F2.011 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1922 SEQ ID NO: 2079 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYSFEKHKVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 129 040374

SEQ ID NO: 352 SEQ ID NO: 509 iPS:361035 18F2.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATG GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1923 SEQ ID NO: 2080 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLS STLTLSKADEVEKGLQKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 353 SEQ ID NO: 510 iPS:359940 2F11.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC

- 130 040374

GGTAACTCCCAGGAGAGTGTCACAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQID NO: 1924 SEQ ID NO: 2081 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 354 SEQ ID NO: 511 2F11.003 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 131 040374

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1925 SEQ ID NO: 2082 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFAIYYCQQYDILLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQTKDSKDSIYPVSLSS TLVTLSKADYGLACEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 355 SEQ ID NO: 512 iPS:361O43 2F11.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGACAAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCGATTACCATGGCAGCC CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GGACCAAGGTGGAGATCAAGCGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAA GCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1926 SEQ ID NO: 2083 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG

- 132 040374

FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG EC RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 356 SEQ ID NO: 513 iPS:361O49 2F11.005 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1927 SEQ ID NO: 2084 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK

-133040374

SEQ ID NO: 357 SEQ ID NO: 514 iPS:361055 2F11.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATATTGCAACATATTACTGTC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GGACCAAGGTGGAGATCAAGCGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTG CAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1928 SEQ ID NO: 2085 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDIAIYYCQQYDILLTFGGGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSKNSSVACEPVACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 358 SEQ ID NO: 515 iPS:361059 2F11.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGCGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC

- 134 040374

GGTAACTCCCAGGAGAGTGTCACAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1929 SEQ ID NO: 2086 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 359 SEQ ID NO: 516 iPS:361063 2F11.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 135 040374

SEQ ID NO: 1930______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSF LTLSKADYGLEKHKVY

ΝΑ

SEQ ID NO: 360_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT

SEQ ID NO: 1931_____________________________

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW

YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2087______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK_______________________________ SEQ ID NO: 517_______________________________ CAGGTGC AACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTC TCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2088______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG

- 136 040374

GEC RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 361 SEQ ID NO: 518 iPS:359956 2F11.010 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTACGATGCATCCAATTTGGAAA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT CTGGGACAGATTTTAGTCTCACCATCAGCAGCC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GACCAAGGTGGAGATCAAGCGAACGGTGGCTG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG GGGAGAGTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGGGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1932 SEQ ID NO: 2089 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLDYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK

- 137 040374

SEQ ID NO: 362__SEQ ID NO: 519

iPS:359865 6H1.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1933 SEQ ID NO: 2090 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLSST LTLSKADYTKHNKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 363 SEQ ID NO: 520 iPS:359869 6H1.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 138 040374

CGGGTAACTCCCAGGAGAGTGTCACAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1934 SEQ ID NO: 2091 iPS:359873 6H1.004 AA NA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYTKHKVYACE SEQ ID NO: 364 GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 521 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 139 040374

ΝΑ sl

s.

I

SEQIDNO: 1935___________________________ DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFAIYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSIYSLSS TLTLSKADYEKHKVYACEVTHQGLS SPVTKSFNR

GEC

SEQ ID NO: 365_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT

SEQIDNO: 1936_________________________________

DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2092______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 522_______________________________ CAGGTGC AGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAG GTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2093______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG

- 140 040374

GEC RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 366 SEQ ID NO: 523 iPS:361O67 6H1.006 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1937 SEQ ID NO: 2094 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSRGTYSLSST LTLSKADYTKHKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

- 141 040374

SEQ ID NO: 367__SEQ ID NO: 524

iPS:361071 6H1.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACTCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAA GTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1938 SEQ ID NO: 2095 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYTKHKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 368 SEQ ID NO: 525 iPS:361075 6H1.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCCT GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC

- 142 040374

CGGGTAACTCCCAGGAGAGTGTCACAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1939 SEQ ID NO: 2096 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFAIYYCLQHNNYPFTFGPGTKVDIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSIYSLSSF LTLSKADVECTHQKVY S QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 369 SEQ ID NO: 526 6A5.004.001 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA

- 143 040374

AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1940 SEQ ID NO: 2097 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYPVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 370 SEQ ID NO: 527 iPS:361085 6A5.004.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTG CAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1941 SEQ ID NO: 2098 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG

- 144 040374

GEC RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 371 SEQ ID NO: 528 iPS:361O91 6A5.004.003 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1942 SEQ ID NO: 2099 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYPVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK

- 145 040374

iPS:361095 6A5.004.004 NA SEQ ID NO: 372 GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATTTTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGAACGGTGGCTGCAC CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT AACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT SEQ ID NO: 529 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTG CAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1943 SEQ ID NO: 2100 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSSSTYSFACEPVTK QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 373 SEQ ID NO: 530 iPS:361101 6A5.004.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATATTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT

- 146 040374

ΝΑ

AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT

SEQ ID NO: 1944_____________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS

SEQ ID NO: 374_______________________________

GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATTTTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGAACGGTGGCTGCAC CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT AACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT

CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCC CTGTCTCCGGGTAAA

SEQ ID NO: 2101______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK________________________________ SEQ ID NO: 531_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCT CCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT

- 147 040374

SEQ ID NO: 1945______________________________

DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLVACESFY GLVTLSKADYEKHKS

SEQ ID NO: 375_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG CAGCCTGAAGATATTGCAACATATTACTGTCAA CAGTATGATGATCTATTCACTTTCGGCCCTGGGA CCAAAGTGGATATCAAACGAACGGTGGCTGCAC CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT AACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT

GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

SEQ ID NO: 2102______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK________________________________ SEQ ID NO: 532_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGG TCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

- 148 040374

SEQID NO: 1946 SEQ ID NO: 2103 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTSTLVTLSKADYEKHKS GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 376 SEQ ID NO: 533 iPS:361113 6A5.004.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQID NO: 1947 SEQ ID NO: 2104 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYPVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDGNNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK

- 149 040374

SEQ ID NO: 377 SEQ ID NO: 534 ABOUT 03 6A5.004.009 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCCTGGG ACCAAAGTGGATATCAAACGAACGGTGGCTGCA CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG CAAGGACAGCACCTACAGCCTCAGCAGCACCCT GACGCTGAGCAAAGCAGACTACGAGAAACACA AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACTCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTG CAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1948 SEQ ID NO: 2105 AA DIQMTQSPSSLSASVGDRVTITCQASQDrrNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYGLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADSVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 378 SEQ ID NO: 535 iPS:359896 6А5.004.010 ΝΑ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCAAGG GACCAAAGTGGATATCAAACGAACGGTGGCTGC ACCATCTGTCTTCATCTTCCCGCCATCTGATGAG CAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCC TGCTGAATAACTTCTATCCCAGAGAGGCCAAAG TACAGTGGAAGGTGGATAACGCCCTCCAATCGG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG

- 150 040374

GTAACTCCCAGGAGAGTGTCACAGCAGGACA GCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACGCTGAGCAAAGCAGACTACGAGAAACAC AAAGTCTACGCCTGCGAAGTCACCCATCAGGGC CTGAGCTCGCCCGTCACAAAGAGCTTCAACAGG GGAGAGTGT AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1949 SEQ ID NO: 2106 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTVNGLAECHQS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE

VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 379 SEQ ID NO: 536 iPS :359890 6A5.004.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTGGGGGACAGAGTCACCATCACTT GCCAGGCGAGTCAGGACATTACCAACTATTTAA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AACTCCTGATCTACGATGCTTCCAATTTGGAGCC AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACAGTATGATGATCTATTCACTTTCGGCCAAGG GACCAAAGTGGATATCAAACGAACGGTGGCTGC ACCATCTGTCTTCATCTTCCCGCCATCTGATGAG CAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCC TGCTGAATAACTTCTATCCCAGAGAGGCCAAAG TACAGTGGAAGGTGGATAACGCCCTCCAATCGG GTAACTCCCAGGAGAGTGTCACAGAGCAGGACA GCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACGCTGAGCAAAGCAGACTACGAGAAACAC AAAGTCTACGCCTGCGAAGTCACCCATCAGGGC CTGAGCTCGCCCGTCACAAAGAGCTTCAACAGG GGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA ATAATAAATACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAGTTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA

- 151 040374

SEQ ID NO: 1950______________________________ DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLS SPVTKSFN RGEC

SEQ ID NO: 380_______________________________ GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT

SEQ ID NO: 1951______________________________

EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW

YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF

AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

SEQ ID NO: 2107______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK________________________________ SEQ ID NO: 537_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGAAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCT CCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

SEQ ID NO: 2108______________________________

QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYEDAVKG

- 152 040374

TLTISRLEPEDFAVYYCQQYGS SPRFGQGTRLEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG EC RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 381 SEQ ID NO: 538 iPS :335965 2A11.003 ΝΑ GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGAAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1952 SEQ ID NO: 2109 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGS SPRFGQGTRLEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYECLSTKST LTLSKADYEKTHKGLVYACEVS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYEDSVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK

- 153 040374

SEQ ID NO: 382 SEQ ID NO: 539 QO in i-H 3 ΝΑ GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAATACTATGAAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTG CAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC Cho O ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG SL AACCAGGTCAGCCCTGACCTGCCTGGTCAAAGGC Xi TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG "η AA ΝΑ SEQ ID NO: 1953 EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGS SPRFGQGTRLEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYECLSTKST LTLSKADYEKTHKGLVYACEVS SEQ ID NO: 383 GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GATTGGAGCCTGAAGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC AAGGGACACGACTGGAGATTAAACGAACGGTG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2110 QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDGSNKYYEDAVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 540 CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAATACTATGAAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG 1.005 GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT gp ATGAGCAGTTGAAATCTGGAACTGCTCTCTGTTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC 03 TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG eq CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG

- 154 040374

AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA GACCTACATCTGCAACGTGAATCACAAGCCCAG CAACACCAAGGTGGACAAGAAAGTTGAGCCCA AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDN0: 1954 SEQ ID NO: 2111 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPEDFAVYYCQQYGS SPRFGQGTRLEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYECLSTKST LTLSKADYEKTHKGLVYACEVS QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM HWVRQAPGKGLEWVAVIWYDASNKYYEDSVKG RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 384 SEQ ID NO: 541 2 o and o ¹ 5 eq NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 155 040374

SEQ ID NO: 1955______________________________ EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQSSKDSSIYYACEK

RGEC

SEQ ID NO: 385_______________________________ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT

SEQ ID NO: 1956_____________________________

EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW

YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2112______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK_______________________________ SEQ ID NO: 542_______________________________ CAGGTGC AGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTC TCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2113______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADSVKG

- 156 040374

FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 386 SEQ ID NO: 543 iPS:361185 2G10LC1.005 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1957 SEQ ID NO: 2114 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSQTYTK SSTLTLSKADYEKHKSSVYACEVE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDGSDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK

- 157 040374

SEQ ID NO: 387__SEQ ID NO: 544

iPS:361192 2G10LC1.006 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTG CAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1958 SEQ ID NO: 2115 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSIYSL SSTLTLSKADYEKHKSSVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 388 SEQ ID NO: 545 iPS:359609 2G10LC1.007 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTTCCCTCTCACTTTCGGCGG AGGGACCAAGGTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC

- 158 040374

ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1959 SEQ ID NO: 2116 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNFPLTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSQTYSTK STLTLSKADYEKHKGVYACEVS QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 389 SEQ ID NO: 546 iPS:359615 2G10LC1.008 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTATCCTCTCACTTTCGGCGG AGGGACCAAGGTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG

- 159 040374

CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1960 SEQ ID NO: 2117 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNYPLTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSTKLS STLTLSKADYEKTHKGLVYACEV QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 390 SEQ ID NO: 547 iPS:361196 2G10LC1.009 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTG CAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQIDNO: 1961 SEQ ID NO: 2118 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG

- 160 040374

FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN RGEC RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 391 SEQ ID NO: 548 ΝΑ GAAATAGTGATGACGCAGTCTCCAGCCACCCTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGGACCAAGGTGGAGATCAAACGAACGGTG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCATCTGGATTCACCTTCAGTAACTATGGC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA AGTGATAAATACTATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGAT CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 1962 SEQ ID NO: 2119 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP REAKVQWKVDNALQSGNSQESVTEQDSKDSQTYTK SSTLTLSKADYEKHKSSVY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK

- 161 040374

SEQ ID NO: 392__SEQ ID NO: 549

iPS:359644 n o o 2GO NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGAACGGT GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG CAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAA TGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 1963 SEQ ID NO: 2120 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSECTYSLSS TLTLSKADYEKTHKGLPV SACE QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 393 SEQ ID NO: 550 iPS:361206 18E3.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGAACGG TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT

- 162 040374

GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA GCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG AGAAACACAAAGTCTACGCCTGCGAAGTCACCC ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT TCAACAGGGGAGAGTGT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 1964 SEQ ID NO: 2121 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSLS QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY WSWIRQPPGKGLEWIGYIYYSGSIYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVVPHTIVVTIQNSSLFPSS STLTLSKADYEKHKVYACEVTHQGLS SPVTKSFN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 394 SEQ ID NO: 551 18E3.004 ΝΑ GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGAACGGT GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG CAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA

- 163 040374

SEQ ID NO: 1965______________________________ EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW

GEC

AA

ΝΑ

SEQ ID NO: 395_______________________________ GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGAACGGT GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG CAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT

AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA_____________________ SEQ ID NO: 2122______________________________ QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFS CSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 552_______________________________ CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTG GAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT

- 164 040374

GCACAACCACTACACGCAGAAGAGCCTCTCCCT GCTCCCGGGTAAA SEQ ID NO: 1966 SEQ ID NO: 2123 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSECTYSLSS TLTLSKADYEKTHKGLPV SACE QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 396 SEQ ID NO: 553 iPS:361210 18E3.006 NA AA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGAACGGT GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG CAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC AACAGGGGAGAGTGT SEQ ID NO: 1967 EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSECTYSLSS TLTLSKADYEKTHKGLPV SACE CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAA TGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2124 QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVS SASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF

- 165 040374

YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 397 SEQ ID NO: 554 iPS:361214 18E3.007 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGAACGG TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA GCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG AGAAACACAAAGTCTACGCCTGCGAAGTCACCC ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT TCAACAGGGGAGAGTGT CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAA TGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 1968 SEQ ID NO: 2125 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSIYSLS STLTLSKADVEKHKVY QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 398 SEQ ID NO: 555 iPS:361218 18E3.008 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GGTCTGGGACAGACTTCACTCTCACCATCAGCA GACAGGAGCCTGATGATTTTGCAGTGTATTACT GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGAACGG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA AGGGCCTGGAGTGGATTGGGTACATCTATTACA GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GTCGAGTTACCATATCAGTAGACACGTCTAAGA ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC

- 166 040374

TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA GCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG AGAAACACAAAGTCTACGCCTGCGAAGTCACCC ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT TCAACAGGGGAGAGTGT

SEQ ID NO: 1969______________________________ EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLS SPVTKSFN RGEC

SEQ ID NO: 399______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGCTTGGGCACCCAGACCTACATCTGCAACGT GAATCACAAGCCCAGCAACACCAAGGTGGACA AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTC CGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA_____________________ SEQ ID NO: 2126______________________________ QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 556_______________________________ CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGG AATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC

- 167 040374

ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQID NO: 1970 SEQ ID NO: 2127 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

SEQ ID NO: 400 SEQ ID NO: 557

361229 .007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT SL A eq o CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA pH • Ι/Ί GTGGGAGAGCAATGGGCAGCCGGAGAACAACT

- 168 040374

SEQ ID NO: 1971______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTHKHECKS

ΝΑ οο η

SEQ ID NO: 401_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1972______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK

ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2128______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 558_______________________________ CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AG GGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATG GGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA______________________________ SEQ ID NO: 2129______________________________ QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL

- 169 040374

LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKLSPGQQKHE SEQ ID NO: 402 SEQ ID NO: 559 iPS:359685 5C2.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1973 SEQ ID NO: 2130 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 403 SEQ ID NO: 560 iPS:361240 5C2.010 NA GACATCGTGATGACCCAGTCTCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCTCAGTGAAGGTCTCCTGC AAGGCTTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC

- 170 040374

GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1974______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK DSVTYSLSSTLTHKADY VECACE

ΝΑ

SEQ ID NO: 404______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAA TGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2131______________________________ QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 561_______________________________ CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTAT TCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT

- 171 040374

TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1975 SEQ ID NO: 2132 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 405 SEQ ID NO: 562 5C2.012 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT

- 172 040374

SEQ ID NO: 1976______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP VTKSFNRGEC сл η

ΝΑ

SEQ ID NO: 406_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1977______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL

GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2133______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 563_______________________________ CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATC CACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCC CCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA______________________________ SEQ ID NO: 2134______________________________ QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA

- 173 040374

ΝΑ

NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP VTKSFNRGEC

SEQ ID NO: 407______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1978______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK

PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK______________________________ SEQ ID NO: 564_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2135______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGT LVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK

- 174 040374

SEQ ID NO: 408__SEQ ID NO: 565

iPS :359669 5C2.015 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1979 SEQ ID NO: 2136 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG RVTMTRDTSISTAYMELNSLRSDDTAVYYCAREA TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 409 SEQ ID NO: 566 iPS:359678 5C2.016 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAACAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG

- 175 040374

TTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQIDNO: 1980 SEQ ID NO: 2137 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS G QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELNSLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYQSLTSSVVTVPSSSLG DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 410 SEQ ID NO: 567 11C1.002 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT

- 176 040374

GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1981 SEQ ID NO: 2138 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 411 SEQ ID NO: 568 NA GACATCGTGATGACCCAGTCTCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTA TCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA

- 177 040374

CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1982 SEQ ID NO: 2139 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 412 SEQ ID NO: 569 iPS:361289 11C1.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1983 SEQ ID NO: 2140 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF

- 178 040374

YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 413 SEQ ID NO: 570 iPS:359712 11C1.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1984 SEQ ID NO: 2141 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 414 SEQ ID NO: 571 iPS:361293 900'1311 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG

- 179 040374

ΝΑ

AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1985______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY

SEQ ID NO: 415______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG

TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATG CATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA______________________________ SEQ ID NO: 2142______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 572_______________________________ CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTACGAGAGAG GCCACGATTTTTGGA ATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC

- 180 040374

ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1986 SEQ ID NO: 2143 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 416 SEQ ID NO: 573 8001EP ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT GGTGACACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT

- 181 040374

iPS:359703 6001EP AA NA SEQ ID NO: 1987 DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY SEQ ID NO: 417 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2144 QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 574 CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1988 SEQ ID NO: 2145 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVTGTEQDS KDSTYSLSSTKGLSFSKADY QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSSLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL

- 182 040374

iPS:361305 11C1.010 NA SEQ ID NO: 418 GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAACAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDVMGSFFLY SKLTVQSRWQGNVCSK SEQ ID NO: 575 CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GACGACACGGCCGTGTATTTCTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1989 SEQ ID NO: 2146 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 419 SEQ ID NO: 576 iPS:361312 13H12.002 NA GACATCGTGATGACCCAGTCTCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC

- 183 040374

GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 1990______________________________

DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK

SEQ ID NO: 420_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT

AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAA TGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2147______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 577_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTAT TCACAGAGGTTTCAGGGC AGGTTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT

- 184 040374

AA SEQ ID NO: 1991 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2148 QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 421 SEQ ID NO: 578 iPS:361319 13H12.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACATCCTCCTAAGCTGCTCATTTACT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG TGGCAGTTTTTTACTGTCAACAATATTATAGTAC TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA AATCAAACGAACGGTGGCTGCACCATCTGTCTT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG TGGATAACGCCCTCCAATCGGGTAACTCCCAGG AGAGTGTCACAGAGCAGGACAGCAAGGACAGC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC AAAGCAGACTACGAGAAACACAAAGTCTACGC CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT

- 185 040374

iPS:359737 13H12.005 AA NA SEQ ID NO: 1992 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK SEQ ID NO: 422 GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT GACCAAGAACCAGGTCAGCCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTATCCGCACAACCCG SEQ ID NO: 2149 QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 579 CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1993 SEQ ID NO: 2150 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELS SLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS

- 186 040374

NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP VTKSFNRGEC SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 423 SEQ ID NO: 580 iPS:361326 13H12.006 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACATAGCTTGGTACCAGCAG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGTGGCACAGACTATTCACAGAGGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQID NO: 1994 SEQ ID NO: 2151 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL NNFYPREAKVQWKVDNALQSGQNSQESVTEQDSK DSVTYSLSSTLTLSKADY VACEK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 424 SEQ ID NO: 581

- 187 040374

12H11.002 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1995 SEQ ID NO: 2152 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 425 SEQ ID NO: 582 12H11.003 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA

- 188 040374

GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1996 SEQ ID NO: 2153 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKLSPGQQKHE SEQ ID NO: 426 SEQ ID NO: 583 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC

- 189 040374

SEQ ID NO: 1997______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY

ΝΑ

SEQ ID NO: 427_______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG

TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA______________________________ SEQ ID NO: 2154______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK____________ _________________ SEQ ID NO: 584_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGC AGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA

- 190 040374

1P sl RC

SEQ ID NO: 1998 SEQ ID NO: 2155 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 428 SEQ ID NO: 585 90011HZI ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 1999 SEQ ID NO: 2156 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL

- 191 040374

SEQ ID NO: 429______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG

TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 2000______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVRGTEQDS KDSTYSLSSTKGLSFSKADY

SEQ ID NO: 430______________________________

GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT

YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK_____________________________ SEQ ID NO: 586_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGA CGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA______________________________ SEQ ID NO: 2157______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK_____________________________ SEQ ID NO: 587_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTACGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT

- 192 040374

TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAG AGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2001 SEQ ID NO: 2158 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNRGEC PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 431 SEQ ID NO: 588 ΝΑ GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC

- 193 040374 y© sl .¾

CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG ТААА

SEQ ID NO: 2002 SEQ ID NO: 2159 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 432 SEQ ID NO: 589 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT

- 194 040374

SEQ ID NO: 2003______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY

ΝΑ οο sl

SEQ ID NO: 433______________________________ GACATCGTGATGACCCAGTCTCCAGACTCCCTG

TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT

SEQ ID NO: 2004______________________________

DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY

ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2160______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK_____________________________ SEQ ID NO: 590_______________________________ CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGACACAAACTATGCACAGAAGTTTCAGGAC AGG GTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGG GCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA_____________________________ SEQ ID NO: 2161______________________________ QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL

- 195 040374

LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVVMLDSDGSFFCS YSKQLTVDKLSWQHEGNVK SEQ ID NO: 434 SEQ ID NO: 591 iPS:361391 12H11.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2005 SEQ ID NO: 2162 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVLTNKSFSKADY QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 435 SEQ ID NO: 592 iPS:361395 12H11.013 NA GACATCGTGATGACCCAGTCTCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC

- 196 040374

CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAA TGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2006 SEQ ID NO: 2163 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRDSGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVTGTEQDS KDSTYSLSSTKGLTFSKADY QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 436 SEQ ID NO: 593 iPS:361402 12H11.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AACAATAAGAACTACTTAGCTTGGTACCAGCAG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG AAATCAAACGAACGGTGGCTGCACCATCTGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAG CACCTACAGCCTCAGCAGCACCCTGACGCTGAG CAAAGCAGACTACGAGAAACACAAAGTCTACG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCGGCTACTAT ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA GGTGAAACAAACTATGCACAGAAGTTTCAGGAC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGAG GCCACGATTTTTGGAATGCTTATTGTACCATTTG ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG GGCACCCAGACCTACATCTGCAACGTGAATCAC AAGCCCAGCAACACCAAGGTGGACAAGAAAGT

- 197 040374

AA SEQ ID NO: 2007 DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC LLNNFYPREAKVQWKVDNALQSGNSQESVTGTEQDS KDSTYSLSSTKGLSFSKADY TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2164 QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYIC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSIYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO:437 SEQ ID NO: 594 iPS:361406 2C2.005.001 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTG GCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC

- 198 040374

iPS:361412 2C2.005.002 AA NA SEQ ID NO: 2008 QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV SEQ ID NO:438 CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2165 QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 595 CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTG GCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2009 SEQ ID NO: 2166 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK LTVLGQPKAAP SVTLFPPS SEELQANKATLVCLISD SAST

- 199 040374

FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV APTECS KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 439 SEQ ID NO: 596 iPS:361418 2C2.005.003 ΝΑ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2010 SEQ ID NO: 2167 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS S A ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 440 SEQ ID NO: 597

- 200 040374

CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG iPS:361424 2C2.005.004 NA GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTC CAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2011 SEQ ID NO: 2168 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHECSTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS S A ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:441 SEQ ID NO: 598 iPS:361430 2C2.005.005 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT

- 201 040374

CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2012 SEQ ID NO: 2169 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS SAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTVMKSNGQPENNYKTTVMKSVDLSDHQLSHEQL SEQ ID NO:442 SEQ ID NO: 599 iPS:361436 2C2.005.006 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG

- 202 040374 sl

CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2013 SEQ ID NO: 2170 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VWGTY R PH Y Y YG M D VWGQGTTVTVS SAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 443 SEQ ID NO: 600 2C2.005.007 ΝΑ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGT GGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA

- 203 040374 oo

joint venture

SEQ ID NO: 2014 SEQ ID NO: 2171 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLNGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSC QVTAPHEGSTVEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:444 SEQ ID NO: 601 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGCAAGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2015 SEQ ID NO: 2172 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLQGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV

- 204 040374

LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 445 SEQ ID NO: 602 iPS:361454 2C2.005.009 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTG GCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2016 SEQ ID NO: 2173 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLSGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSC QVTAPHEGSTVEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:446 SEQ ID NO: 603 iPS:361460 2C2.005.010 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGACAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG

- 205 040374 sl.¾

GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAA CCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2017 SEQ ID NO: 2174 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDDSLNAPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV APTECS KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:447 SEQ ID NO: 604 2C2.005.011 ΝΑ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC

- 206 040374

GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2018 SEQ ID NO: 2175 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLNGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSC QVTAPTEGSTVEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:448 SEQ ID NO: 605 iPS:3 6147 dl η o NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACC GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA

- 207 040374

CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2019 SEQ ID NO: 2176 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:449 SEQ ID NO: 606 iPS:361478 2C2.005.013 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATTATG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAATGCTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGCCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTTCGGGACTTATCGGCCTCACT ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCAGCCTCCACCAAGG GCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAA GAGCACCTCTGGGGGCACAGCGGCCCTGGGCTG CCTGGTCAAGGACTACTTCCCCGAACCGGTGAC GGTGTCGTGGAACTCAGGCGCCCTGACCAGCGG CGTGCACACCTTCCCGGCTGTCCTACAGTCCTCA GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA GGACTCTACTCCCTCAGCAGCGTGGTGACCGTG CCCTCCAGCAGCTTGGGCACCCAGACCTACATC TGCAACGTGAATCACAAGCCCAGCAACACCAAG GTGGACAAGAAAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCT GAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCC CCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACG TGAGCCACGAAGACCCTGAGGTCAAGTTCAACT GGTACGTGGACGGCGTGGAGGTGCATAATGCCA AGACAAAGCCGTGTGAGGAGCAGTACGGCAGC ACGTACCGTTGTGTCAGCGTCCTCACCGTCCTGC ACCAGGACTGGCTGAATGGCAAGGAGTACAAGT GCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTACACCCTGCCCCCAT CCCGGGAGGAGATGACCAAGAACCAGGTCAGC CTGACCTGCCTGGTCAAAGGCTTCTATCCCAGC GACATCGCCGTGGAGTGGGAGAGCAATGGGCA GCCGGAGAACAACTACAAGACCACGCCTCCCGT GCTGGACTCCGACGGCTCCTTCTTCCTCTATAGC AAGCTCACCGTGGACAAGAGCAGGTGGCAGCA GGGGAACGTCTTCTCATGCTCCGTGATGCATGA GGCTCTGCACAACCACTACACGCAGAAGAGCCT CTCCCTGTCTCCGGGTAAA SEQ ID NO: 2020 SEQ ID NO: 2177 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVFGTYRPHYYYGMD VWGQGTTVTVS SASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCEE QYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKA

- 208 040374

LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK SEQ ID NO: 450 SEQ ID NO: 607 iPS:361485 2C2.005.014 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG TAAACTGGTACCAGCACCTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTTCGGGACTTATCGGCCTCACT ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCAGCCTCCACCAAGG GCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAA GAGCACCTCTGGGGGCACAGCGGCCCTGGGCTG CCTGGTCAAGGACTACTTCCCCGAACCGGTGAC GGTGTCGTGGAACTCAGGCGCCCTGACCAGCGG CGTGCACACCTTCCCGGCTGTCCTACAGTCCTCA GGACTCTACTCCCTCAGCAGCGTGGTGACCGTG CCCTCCAGCAGCTTGGGCACCCAGACCTACATC TGCAACGTGAATCACAAGCCCAGCAACACCAAG GTGGACAAGAAAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCT GAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCC CCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACG TGAGCCACGAAGACCCTGAGGTCAAGTTCAACT GGTACGTGGACGGCGTGGAGGTGCATAATGCCA AGACAAAGCCGTGTGAGGAGCAGTACGGCAGC ACGTACCGTTGTGTCAGCGTCCTCACCGTCCTGC ACCAGGACTG GCTGAATGGCAAGGAGTACAAGT GCAAGGTCTCCAACAAAGCCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTACACCCTGCCCCCAT CCCGGGAGGAGATGACCAAGAACCAGGTCAGC CTGACCTGCCTGGTCAAAGGCTTCTATCCCAGC GACATCGCCGTGGAGTGGGAGAGCAATGGGCA GCCGGAGAACAACTACAAGACCACGCCTCCCGT GCTGGACTCCGACGGCTCCTTCTTCCTCTATAGC AAGCTCACCGTGGACAAGAGCAGGTGGCAGCA GGGGAACGTCTTCTCATGCTCCGTGATGCATGA GGCTCTGCACAACCACTACACGCAGAAGAGCCT CTCCCTGTCTCCGGGTAAA SEQ ID NO: 2021 SEQ ID NO: 2178 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK LTVLGPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY AASSYLSLTPEQWKSHRSYSCQVTHEGSEKTV QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G D Y VFGTY R PH Y Y YG M D VWGQGTTVTVS SASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCEE QYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKA LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK SEQ ID NO:451 SEQ ID NO: 608 iPS:361845 18F2.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATGAAAACTATGCAGACGCCGTGAAGGGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGAGAGATA

- 209 040374

ΝΑ sl

s.

I

GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT

SEQ ID NO: 2022______________________________

DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYSFEKHKVY

SEQ ID NO: 452_______________________________ GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CTGCATCTATAGGAGACAGAGTCACCATCACTT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT CTGGGACAGAATTCACTCTCACAATCAGCAGCC TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT ACAGCATAATAATTACCCCTTCACTTTCGGCCAA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA GGGGAGAGTGT

GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAG GGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2179______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM HWVRQAPGKGLEWVAVIWYDASNENYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK______________________________ SEQ ID NO: 609_______________________________ CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTAATAAATACTATGCAGACGCCGTGAAGGGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGACGATTTTTGGAGTGCT CTTGGGGGACTACT GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCC AGCAACACCAAGGTGGACAAGAAAGTTGAGCC CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG

- 210 040374

CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2023 SEQ ID NO: 2180 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYGLVACESFY GLVTLSKADYEKHKS QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 453 SEQ ID NO: 610 2C2.005.015 ΝΑ CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT CTGGAAGTAGCTCCAACATCGGAAGTAATACTG TAAACTGGTACCAGCAACTCCCAGGAACGGCCC CCAAACTCCTCATCTATACTAATAATCAGCGGC CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG CAACATTCGATAGCAGCCTGAGTGGTCCGGTAT TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCCTACAGAATGTTCA CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCCGGATACACCTTCACCGGCTACTAT ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATCAACCCTAACAGT GGTGGCACAAACTATGCACAGAAGTTTCAGGGC AGGGTCACCATGACCAGGGACACGTCCATCAGT ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGGGATTACGTTTGGGGGACTTATCGGCCTCAC TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CTGCAACGTGAATCACAAGCCCAGCAACACCAA GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTG GCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG

- 211 040374

SEQ ID NO: 2024_____________________________ QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW YQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS ASLAISGLQSEDEADYFCATFDSSLSGPVFGGGTK LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD FYPGAVTVKADSSPVKAGVETTTPSKQSNNTVKAGVETTTPSKQSNNTVKAGVETTTPSKQSNNTVKAGVETTTPSKQSNNTVKAGVETTTPSKQSNNTVKAGVETTTPSKQSNNTVKSKY AASHREKSYLTSC

SEQ ID NO: 454_______________________________ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCACACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT

SEQ ID NO: 2025______________________________ DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG

EU

CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA_____________ SEQ ID NO: 2181______________________________ QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG G DY VWGTY R PH YYYG M D VWGQGTTVTVS SA ST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK___________________ SEQ ID NO: 611_______________________________ CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAGTTCCATGCAGACTCCGTGAAGGG C CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGG CAGCCGGAGAACAACTACA AGACACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA

SEQ ID NO: 2182______________________________ QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDGSNKFHADSVKGRF TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA GMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP

- 212 040374

SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVCSQHEALSLHKK SEQ ID NO: 455 SEQ ID NO: 612 iPS:336169 17B11.002 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2026 SEQ ID NO: 2183 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK YAASSYLSCSLTPEQWKSHRSYSCQVTHE QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMD VWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:456 SEQ ID NO: 613 iPS:361127 5G12.006.001 NA GACATCCAGCTGACCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGTCCCATCAAGATTCAGTGGCAGTGGTTC CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTACACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA

- 213 040374 sl

TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCA A SEQ ID NO: 2027 SEQ ID NO: 2184 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO:457 SEQ ID NO: 614 5G12.006.002 ΝΑ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG

- 214 040374

CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2028 SEQ ID NO: 2185 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACE QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 458 SEQ ID NO: 615 iPS:361140 5G12.006.003 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCACACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAA GTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT

- 215 040374

GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2029 SEQ ID NO: 2186 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDRGSIYSLSST LTLSKADVEKHKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQIYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSIYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO:459 SEQ ID NO: 616 iPS:359919 5G12.006.004 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGA GGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2030 SEQ ID NO: 2187 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF TLTISSLQPEDFAIYYCQQSYSTLISFGQGTKLEIKR QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV

- 216 040374

ΝΑ

ΑΑ

TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG EC

SEQ ID NO: 460______________________________ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT

SEQ ID NO: 2031______________________________ DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLS SPVTKSFNRG

EU

SEQ ID NO:461

AGMPEAFEIWGQGTLVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK_______________________________ SEQ ID NO: 617_______________________________ CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAG GACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A________________________________ SEQ ID NO: 2188______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADSVKGRF TISRDNSKNTLYLQMNS LRAEDSAMYFCARGKVA GMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK________________________________ SEQ ID NO: 618

- 217 040374

4© NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAA GTGCAAGGTCTCCAACAAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC iPS:361151 5G12.006.00 — AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2032 SEQ ID NO: 2189 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACE QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDGSNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTKVTVS SASTKGPSVFPLAPS S KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 462 SEQ ID NO: 619 iPS:361491 17B11.002.001 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG

- 218 040374 sl

AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2033 SEQ ID NO: 2190 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KYAASSYLSLTPEQWKSHRSYAPSCQVTHE QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTVMKSNGQPENNYKTTVMKSVDLSDHQLSHEQL SEQ ID NO: 463 SEQ ID NO: 620 17В11.002.002 ΝΑ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC

- 219 040374 sl

NA

SEQ ID NO: 2034_____________________________

QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KYAASSYLSLTPEQWKSHRSYSCQVTHE

SEQ ID NO: 464_______________________________ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA

AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA____________ SEQ ID NO: 2191______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMD VWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK____ _______________ SEQ ID NO: 621_______________________________ CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTG TGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA

- 220 040374

SEQ ID NO: 2035 SEQ ID NO: 2192 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK YAASSYLSCSLTPEQWKSHRSYSCQVTHE QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 465 SEQ ID NO: 622 iPS:361507 17B11.002.004 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2036 SEQ ID NO: 2193 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK YAASSYLSLTPEQWKSHRSYSCQVTHECS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV

- 221 040374

ΝΑ

SEQ ID NO: 466

CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA

SEQ ID NO: 2037_____________________________

QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KYAASSYLSLTPEQWKSTVSYQVTHESC in TVHECS

ΝΑ

SEQ ID NO: 467_______________________________ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG

CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC

LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK___________________ SEQ ID NO: 623 CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTG CATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA____________ SEQ ID NO: 2194______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS SAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTV DKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK___________________ SEQ ID NO: 624_______________________________ CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTAACACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG

- 222 040374 sl

CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCAC AACCACTACACCGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2038 SEQ ID NO: 2195 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQAPGQGLEWMGWMNPNSGNTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVWGSYRPYYYYYGMDVWGQGTTVTVS SAS SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK TVAPTECS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO:468 SEQ ID NO: 625 ΝΑ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGGCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG

- 223 040374

ID

joint venture

ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2039 SEQ ID NO: 2196 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KYAASSYLSLTPEQWKSHRSYSCQVTHE QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG GDYVFGSYRPYYYYYGMD VWGQGTTVTVS SAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 469 SEQ ID NO: 626 ΝΑ CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT CTGGAAGCAGCTCCAACATTGGAAATAATTATG TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC CCAAACTCCTCATTTATGACAATAATAAGCGAC CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GTCTGGCACGTCAGCCACCCTGGCCATCACCGG ACTCCAGACTGGGGACGAGGCCGATTATTACTG CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CACACCCTCCAAACAAAGCAACAACAAGTACGC GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT CACGCATGAAGGGAGCACCGTGGAGAAGACAG TGGCCCCTACAGAATGTTCA CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC AAGGCTTCTGGATACACCTTCACCAGTTATGAT ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CTTGAGTGGATGGGATGGATGAACCCTAACAGT GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC AGAGTCACCATGACCAGGGACACCTCCATAAGC ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT GACGACACGGCCGTGTATTACTGTGCGAGAGGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT ACTACTACTACGGTATGGACGTCTGGGGCCAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGA CTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG

- 224 040374 in

ΝΑ sl

AA

SEQ ID NO: 2040______________________________ QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSSKSGT SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS DFYPGAVTVKADSSPVKSNKAGVETTTPSKQPESYLS

SEQ ID NO: 470_______________________________ GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CTGCATCTGTAGGAGACAGAGTCACTATCACTT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC TGGGACAGATTTCACTCTCACCATCAGCAGTCT GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACAGAGTTACAGTACCCTGCTCAGTTTTGGCCA GGGGACCAAGCTGGAGATCAAACGAACGGTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCACCCTGACGCTGAGCAAAGCAGACTACGAGA AACACAAAGTCTACGCCTGCGAAGTCACCCATC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGT

SEQ ID NO: 2041_____________________________

DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF TLTISSLQPEDFATYYCQQSYSTLLSFGQGTKLEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYPVACESFY GLVSKADYEKHKS

SEQ ID NO:471

GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA____________ SEQ ID NO: 2197______________________________ QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG GDYVFGSYRPYYYYYGMD VWGQGTTVTVS SAST KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK___________________ SEQ ID NO: 627_______________________________ CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC CGATT CACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA CCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAG CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGG AGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A________________________________ SEQ ID NO: 2198______________________________ QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV AGMPEAFEIWGQGTLVTVSSASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK_______________________________ SEQ ID NO: 628

In one embodiment, the antibody or fragment thereof contains a light chain variable region containing a sequence selected from the group consisting of SEQ ID NOs: 1-157. In one embodiment, the antibody or fragment thereof contains a heavy chain variable region containing a sequence selected from the group consisting of SEQ ID NOs: 158-314. In one

- 225 040374 embodiment, the antibody or fragment thereof contains a light chain variable region containing a sequence selected from the group consisting of SEQ ID NO: 1-157, and a heavy chain variable region containing a sequence selected from the group consisting of

SEQ ID NO: 158-314. In one embodiment, the antibody or fragment thereof comprises a combination of a light chain variable region and a heavy chain variable region selected from the group consisting of a light chain variable region comprising SEQ ID NO: 158;

a light chain variable region comprising SEQ ID NO: 159;

a light chain variable region comprising SEQ ID NO: 160;

a light chain variable region comprising SEQ ID NO: 161;

a light chain variable region comprising SEQ ID NO: 162;

a light chain variable region comprising SEQ ID NO: 163;

a light chain variable region comprising SEQ ID NO: 164;

a light chain variable region comprising SEQ ID NO: 165;

a light chain variable region comprising SEQ ID NO: 166;

a light chain variable region comprising SEQ ID NO: 167;

a light chain variable region comprising SEQ ID NO: 168;

a light chain variable region comprising SEQ ID NO: 169;

a light chain variable region comprising SEQ ID NO: 170;

a light chain variable region comprising SEQ ID NO: 171;

a light chain variable region comprising SEQ ID NO: 172;

a light chain variable region comprising SEQ ID NO: 173;

a light chain variable region comprising SEQ ID NO: 174;

a light chain variable region comprising SEQ ID NO: 175;

a light chain variable region comprising SEQ ID NO: 176;

a light chain variable region comprising SEQ ID NO: 177;

a light chain variable region comprising SEQ ID NO: 178;

a light chain variable region comprising SEQ ID NO: 179;

a light chain variable region comprising SEQ ID NO: 180;

a light chain variable region comprising SEQ ID NO: 181;

a light chain variable region comprising SEQ ID NO: 182;

a light chain variable region comprising SEQ ID NO: 183;

a light chain variable region comprising SEQ ID NO: 184;

a light chain variable region comprising SEQ ID NO: 185;

circuit containing SEQ ID NO: 1, circuit containing SEQ ID NO: 2, circuit containing SEQ ID NO: 3, circuit containing SEQ ID NO: 4, circuit containing SEQ ID NO: 5, circuit containing SEQ ID NO: 6, chain containing SEQ ID NO: 7, chain containing SEQ ID NO: 8, chain containing SEQ ID NO: 9, chain containing SEQ ID NO: 10, chain containing SEQ ID NO: 11, chain containing SEQ ID NO: 12, a circuit containing SEQ ID NO: 13, a circuit containing SEQ ID NO: 14, a circuit containing SEQ ID NO: 15, a circuit containing SEQ ID NO: 16, a circuit containing SEQ ID NO : 17, chain containing SEQ ID NO: 18, chain containing SEQ ID NO: 19, chain containing SEQ ID NO: 20, chain containing SEQ ID NO: 21, chain containing SEQ ID NO: 22, chain, containing SEQ ID NO: 23, a circuit containing SEQ ID NO: 24, a circuit containing SEQ ID NO: 25, a circuit containing SEQ ID NO: 26, a circuit containing SEQ ID NO: 27, a circuit containing SEQ ID NO: 28, and the variable region of the severe and variable region of the severe and variable region of the severe and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy and variable region heavy

- 226 040374 light chain variable region containing SEQ ID NO: 29, and heavy chain variable region containing SEQ ID NO: 186;

a light chain variable region comprising SEQ ID NO: 30 and a heavy chain variable region comprising SEQ ID NO: 187;

a light chain variable region comprising SEQ ID NO: 31 and a heavy chain variable region comprising SEQ ID NO: 188;

a light chain variable region comprising SEQ ID NO: 32 and a heavy chain variable region comprising SEQ ID NO: 189;

a light chain variable region comprising SEQ ID NO: 33 and a heavy chain variable region comprising SEQ ID NO: 190;

a light chain variable region comprising SEQ ID NO: 34 and a heavy chain variable region comprising SEQ ID NO: 191;

a light chain variable region comprising SEQ ID NO: 35 and a heavy chain variable region comprising SEQ ID NO: 192;

a light chain variable region comprising SEQ ID NO: 36 and a heavy chain variable region comprising SEQ ID NO: 193;

a light chain variable region comprising SEQ ID NO: 37 and a heavy chain variable region comprising SEQ ID NO: 194;

a light chain variable region comprising SEQ ID NO: 38 and a heavy chain variable region comprising SEQ ID NO: 195;

a light chain variable region comprising SEQ ID NO: 39 and a heavy chain variable region comprising SEQ ID NO: 196;

a light chain variable region comprising SEQ ID NO: 40 and a heavy chain variable region comprising SEQ ID NO: 197;

a light chain variable region comprising SEQ ID NO: 41 and a heavy chain variable region comprising SEQ ID NO: 198;

a light chain variable region comprising SEQ ID NO: 42 and a heavy chain variable region comprising SEQ ID NO: 199;

a light chain variable region comprising SEQ ID NO: 43 and a heavy chain variable region comprising SEQ ID NO: 200;

a light chain variable region comprising SEQ ID NO: 44 and a heavy chain variable region comprising SEQ ID NO: 201;

a light chain variable region comprising SEQ ID NO: 45 and a heavy chain variable region comprising SEQ ID NO: 202;

a light chain variable region comprising SEQ ID NO: 46 and a heavy chain variable region comprising SEQ ID NO: 203;

a light chain variable region comprising SEQ ID NO: 47 and a heavy chain variable region comprising SEQ ID NO: 204;

a light chain variable region comprising SEQ ID NO: 48 and a heavy chain variable region comprising SEQ ID NO: 205;

a light chain variable region comprising SEQ ID NO: 49 and a heavy chain variable region comprising SEQ ID NO: 206;

a light chain variable region comprising SEQ ID NO: 50 and a heavy chain variable region comprising SEQ ID NO: 207;

a light chain variable region comprising SEQ ID NO: 51 and a heavy chain variable region comprising SEQ ID NO: 208;

a light chain variable region comprising SEQ ID NO: 52 and a heavy chain variable region comprising SEQ ID NO: 209;

a light chain variable region comprising SEQ ID NO: 53 and a heavy chain variable region comprising SEQ ID NO: 210;

a light chain variable region comprising SEQ ID NO: 54 and a heavy chain variable region comprising SEQ ID NO: 211;

a light chain variable region comprising SEQ ID NO: 55 and a heavy chain variable region comprising SEQ ID NO: 212;

a light chain variable region comprising SEQ ID NO: 56 and a heavy chain variable region comprising SEQ ID NO: 213;

a light chain variable region comprising SEQ ID NO: 57 and a heavy chain variable region comprising SEQ ID NO: 214;

a light chain variable region comprising SEQ ID NO: 58 and a heavy chain variable region comprising SEQ ID NO: 215;

a light chain variable region comprising SEQ ID NO: 59 and a heavy chain variable region comprising SEQ ID NO: 216;

- 227 040374 light chain variable region containing SEQ ID NO: 60, and heavy chain variable region containing SEQ ID NO: 217;

a light chain variable region comprising SEQ ID NO: 61 and a heavy chain variable region comprising SEQ ID NO: 218;

a light chain variable region comprising SEQ ID NO: 62 and a heavy chain variable region comprising SEQ ID NO: 219;

a light chain variable region comprising SEQ ID NO: 63 and a heavy chain variable region comprising SEQ ID NO: 220;

a light chain variable region containing chains comprising SEQ ID NO: 221;

a light chain variable region containing chains comprising SEQ ID NO: 222;

a light chain variable region containing chains comprising SEQ ID NO: 223;

a light chain variable region containing chains comprising SEQ ID NO: 224;

a light chain variable region containing chains comprising SEQ ID NO: 225;

a light chain variable region containing chains containing SEQ ID NO: 226;

a light chain variable region containing chains comprising SEQ ID NO: 227;

a light chain variable region containing chains comprising SEQ ID NO: 228;

a light chain variable region containing chains comprising SEQ ID NO: 229;

a light chain variable region containing chains comprising SEQ ID NO: 230;

a light chain variable region containing chains comprising SEQ ID NO: 231;

a light chain variable region containing chains comprising SEQ ID NO: 232;

a light chain variable region containing chains comprising SEQ ID NO: 233;

a light chain variable region containing chains comprising SEQ ID NO: 234;

a light chain variable region containing chains comprising SEQ ID NO: 235;

a light chain variable region containing chains comprising SEQ ID NO: 236;

a light chain variable region containing chains comprising SEQ ID NO: 237;

a light chain variable region containing chains comprising SEQ ID NO: 238;

a light chain variable region containing chains comprising SEQ ID NO: 239;

a light chain variable region containing chains comprising SEQ ID NO: 240;

a light chain variable region containing chains comprising SEQ ID NO: 241;

a light chain variable region containing chains comprising SEQ ID NO: 242;

a light chain variable region containing chains comprising SEQ ID NO: 243;

a light chain variable region containing chains comprising SEQ ID NO: 244;

a light chain variable region containing chains comprising SEQ ID NO: 245;

a light chain variable region containing chains comprising SEQ ID NO: 246;

a light chain variable region containing chains comprising SEQ ID NO: 247;

SEQ ID NO: 64, and variable region severe

SEQ ID NO: 65, and variable region severe

SEQ ID NO: 66, and variable region severe

SEQ ID NO: 67, and variable region severe

SEQ ID NO: 68, and variable region severe

SEQ ID NO: 69, and variable region severe

SEQ ID NO: 70, and variable region severe

SEQ ID NO: 71, and variable region severe

SEQ ID NO: 72, and variable region severe

SEQ ID NO: 73, and variable region severe

SEQ ID NO: 74, and variable region severe

SEQ ID NO: 75, and variable region severe

SEQ ID NO: 76, and variable region severe

SEQ ID NO: 77, and variable region severe

SEQ ID NO: 78, and variable region severe

SEQ ID NO: 79, and variable region severe

SEQ ID NO: 80, and variable region severe

SEQ ID NO: 81, and variable region severe

SEQ ID NO: 82, and variable region severe

SEQ ID NO: 83, and variable region severe

SEQ ID NO: 84, and variable region severe

SEQ ID NO: 85, and variable region severe

SEQ ID NO: 86, and variable region severe

SEQ ID NO: 87, and variable region severe

SEQ ID NO: 88, and variable region severe

SEQ ID NO: 89, and variable region severe

SEQ ID NO: 90, and variable region severe

- 228 040374 light chain variable region containing SEQ ID NO: 91, and heavy chain variable region containing SEQ ID NO: 248;

a light chain variable region comprising SEQ ID NO: 92 and a heavy chain variable region comprising SEQ ID NO: 249;

a light chain variable region comprising SEQ ID NO: 93 and a heavy chain variable region comprising SEQ ID NO: 250;

a light chain variable region comprising SEQ ID NO: 94 and a heavy chain variable region comprising SEQ ID NO: 251;

a light chain variable region comprising SEQ ID NO: 95 and a heavy chain variable region comprising SEQ ID NO: 252;

a light chain variable region comprising SEQ ID NO: 96 and a heavy chain variable region comprising SEQ ID NO: 253;

a light chain variable region comprising SEQ ID NO: 97 and a heavy chain variable region comprising SEQ ID NO: 254;

a light chain variable region comprising SEQ ID NO: 98 and a heavy chain variable region comprising SEQ ID NO: 255;

a light chain variable region comprising SEQ ID NO: 99 and a heavy chain variable region comprising SEQ ID NO: 256;

a light chain variable region containing chains comprising SEQ ID NO: 257;

a light chain variable region containing chains comprising SEQ ID NO: 258;

a light chain variable region containing chains comprising SEQ ID NO: 259;

a light chain variable region containing chains comprising SEQ ID NO: 260;

a light chain variable region containing chains comprising SEQ ID NO: 261;

a light chain variable region containing chains comprising SEQ ID NO: 262;

a light chain variable region containing chains comprising SEQ ID NO: 263;

a light chain variable region containing chains comprising SEQ ID NO: 264;

a light chain variable region containing chains comprising SEQ ID NO: 265;

a light chain variable region containing chains comprising SEQ ID NO: 266;

a light chain variable region containing chains comprising SEQ ID NO: 267;

a light chain variable region containing chains comprising SEQ ID NO: 268;

a light chain variable region containing chains comprising SEQ ID NO: 269;

a light chain variable region containing chains comprising SEQ ID NO: 270;

a light chain variable region containing chains comprising SEQ ID NO: 271;

a light chain variable region containing chains comprising SEQ ID NO: 272;

a light chain variable region containing chains comprising SEQ ID NO: 273;

a light chain variable region containing chains comprising SEQ ID NO: 274;

a light chain variable region containing chains comprising SEQ ID NO: 275;

a light chain variable region containing chains comprising SEQ ID NO: 276;

a light chain variable region containing chains comprising SEQ ID NO: 277;

a light chain variable region containing chains comprising SEQ ID NO: 278;

SEQ ID NO: 100, and variable region severe

SEQ ID NO: 101, and variable region severe

SEQ ID NO: 102, and variable region severe

SEQ ID NO: 103, and variable region severe

SEQ ID NO: 104, and variable region severe

SEQ ID NO: 105, and variable region severe

SEQ ID NO: 106, and variable region severe

SEQ ID NO: 107, and variable region severe

SEQ ID NO: 108, and variable region severe

SEQ ID NO: 109, and variable region severe

SEQ ID NO: 110, and variable region severe

SEQ ID NO: 111, and variable region severe

SEQ ID NO: 112, and variable region severe

SEQ ID NO: 113, and variable region severe

SEQ ID NO: 114, and variable region severe

SEQ ID NO: 115, and variable region severe

SEQ ID NO: 116, and variable region severe

SEQ ID NO: 117, and variable region severe

SEQ ID NO: 118, and variable region severe

SEQ ID NO: 119, and variable region severe

SEQ ID NO: 120, and variable region severe

SEQ ID NO: 121, and variable region severe

- 229 040374 variable region of the light chain containing chains containing SEQ ID NO: 279;

a light chain variable region containing chains comprising SEQ ID NO: 280;

a light chain variable region containing chains comprising SEQ ID NO: 281;

a light chain variable region containing chains comprising SEQ ID NO: 282;

a light chain variable region containing chains comprising SEQ ID NO: 283;

a light chain variable region containing chains comprising SEQ ID NO: 284;

a light chain variable region containing chains comprising SEQ ID NO: 285;

a light chain variable region containing chains comprising SEQ ID NO: 286;

a light chain variable region containing chains comprising SEQ ID NO: 287;

a light chain variable region containing chains comprising SEQ ID NO: 288;

a light chain variable region containing chains comprising SEQ ID NO: 289;

a light chain variable region containing chains comprising SEQ ID NO: 290;

a light chain variable region containing chains comprising SEQ ID NO: 291;

a light chain variable region containing chains comprising SEQ ID NO: 292;

a light chain variable region containing chains comprising SEQ ID NO: 293;

a light chain variable region containing chains comprising SEQ ID NO: 294;

a light chain variable region containing chains comprising SEQ ID NO: 295;

a light chain variable region containing chains comprising SEQ ID NO: 296;

a light chain variable region containing chains comprising SEQ ID NO: 297;

a light chain variable region containing chains comprising SEQ ID NO: 298;

a light chain variable region containing chains comprising SEQ ID NO: 299;

a light chain variable region containing chains containing SEQ ID NO: 300;

a light chain variable region containing chains comprising SEQ ID NO: 301;

a light chain variable region containing chains comprising SEQ ID NO: 302;

a light chain variable region containing chains comprising SEQ ID NO: 303;

a light chain variable region containing chains comprising SEQ ID NO: 304;

a light chain variable region containing chains comprising SEQ ID NO: 305;

a light chain variable region containing chains comprising SEQ ID NO: 306;

a light chain variable region containing chains comprising SEQ ID NO: 307;

a light chain variable region containing chains comprising SEQ ID NO: 308;

a light chain variable region containing chains comprising SEQ ID NO: 309;

SEQ ID NO: 122, and variable region severe

SEQ ID NO: 123, and variable region severe

SEQ ID NO: 124, and variable region severe

SEQ ID NO: 125, and variable region severe

SEQ ID NO: 126, and variable region severe

SEQ ID NO: 127, and variable region severe

SEQ ID NO: 128, and variable region severe

SEQ ID NO: 129, and variable region severe

SEQ ID NO: 130, and variable region severe

SEQ ID NO: 131, and variable region severe

SEQ ID NO: 132, and variable region severe

SEQ ID NO: 133, and variable region severe

SEQ ID NO: 134, and variable region severe

SEQ ID NO: 135, and variable region severe

SEQ ID NO: 136, and variable region severe

SEQ ID NO: 137, and variable region severe

SEQ ID NO: 138, and variable region severe

SEQ ID NO: 139, and variable region severe

SEQ ID NO: 140, and variable region severe

SEQ ID NO: 141, and variable region severe

SEQ ID NO: 142, and variable region severe

SEQ ID NO: 143, and variable region severe

SEQ ID NO: 144, and variable region severe

SEQ ID NO: 145, and variable region severe

SEQ ID NO: 146, and variable region severe

SEQ ID NO: 147, and variable region severe

SEQ ID NO: 148, and variable region severe

SEQ ID NO: 149, and variable region severe

SEQ ID NO: 150, and variable region severe

SEQ ID NO: 151, and variable region severe

SEQ ID NO: 152, and variable region severe

- 230 040374 light chain variable region containing SEQ ID NO: 153, and heavy chain variable region containing SEQ ID NO: 310;

a light chain variable region comprising SEQ ID NO: 154 and a heavy chain variable region comprising SEQ ID NO: 311;

a light chain variable region comprising SEQ ID NO: 155 and a heavy chain variable region comprising SEQ ID NO: 312;

a light chain variable region comprising SEQ ID NO: 156 and a heavy chain variable region comprising SEQ ID NO: 313;

and a light chain variable region comprising SEQ ID NO: 157 and a heavy chain variable region comprising SEQ ID NO: 314.

In one embodiment, the antibody or fragment thereof comprises a light chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1571-1727. In one embodiment, the antibody or fragment thereof comprises a heavy chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1728-1884. In one embodiment, the antibody or fragment thereof comprises a light chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1571-1727 and a heavy chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1728-1884.

In one embodiment, the antibody or fragment thereof comprises a combination of a light chain variable region and a heavy chain variable region selected from the group consisting of a light chain variable region, which is encoded by a polynucleotide sequence comprising SEQ ID NO: 1571, and a heavy chain variable region, which encoded by a polynucleotide sequence containing SEQ ID NO: 1728;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1572, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1729;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1573, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1730;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1574, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1731;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1575, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1732;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1576, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1733;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1577, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1734;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1578, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1735;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1579, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1736;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1580, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1737;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1581, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1738;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1582, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1739;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1583, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1740;

a light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1584, and a heavy chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1741;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1585, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1742;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1586, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1743;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1587, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1744;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1588, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1745;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1589, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1746;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1590, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1747;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1591, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1748;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1592, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1749;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1593, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1750;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1594, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1751;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1595, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1752;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1596, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1753;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1597, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1754;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1598, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1755;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1599, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1756;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1600, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1757;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1601, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1758;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1602, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1759;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1603, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1760;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1604, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1761;

the variable region of the light chain, which is encoded by the polynucleotide sequence,

- 232 040374 containing SEQ ID NO: 1605, and the variable region of the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1762;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1606, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1763;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1607, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1764;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1608, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1765;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1609, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1766;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1610, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1767;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1611, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1768;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1612, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1769;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1613, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1770;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1614, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1771;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1615, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1772;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1616, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1773;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1617, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1774;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1618, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1775;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1619, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1776;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1620, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1777;

a light chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1621, and a heavy chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1778;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1622, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1779;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1623, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1780;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1624, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1781;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1625, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1782;

- 233 040374 variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1626, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1783;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1627, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1784;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1628, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1785;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1629, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1786;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1630, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1787;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1631, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1788;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1632, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1789;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1633, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1790;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1634, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1791;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1635, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1792;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1636, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1793;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1637, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1794;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1638, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1795;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1639, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1796;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1640, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1797;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1641, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1798;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1642, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1799;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1643, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1800;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1644, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1801;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1645, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1802;

a light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1646, and a heavy chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1803;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1647, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1804;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1648, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1805;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1649, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1806;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1650, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1807;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1651, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1808;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1652, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1809;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1653, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1810;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1654, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1811;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1655, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1812;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1656, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1813;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1657, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1814;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1658, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1815;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1659, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1816;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1660, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1817;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1661, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1818;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1662, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1819;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1663, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1820;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1664, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1821;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1665, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1822;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1666, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1823;

the variable region of the light chain, which is encoded by the polynucleotide sequence,

- 235 040374 containing SEQ ID NO: 1667, and the variable region of the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1824;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1668, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1825;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1669, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1826;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1670, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1827;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1671, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1828;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1672, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1829;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1673, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1830;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1674, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1831;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1675, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1832;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1676, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1833;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1677, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1834;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1678, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1835;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1679, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1836;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1680, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1837;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1681, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1838;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1682, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1839;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1683, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1840;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1684, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1841;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1685, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1842;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1686, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1843;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1687, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1844;

- 236 040374 variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1688, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1845;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1689, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1846;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1690, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1847;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1691, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1848;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1692, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1849;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1693, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1850;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1694, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1851;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1695, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1852;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1696, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1853;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1697, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1854;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1698, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1855;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1699, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1856;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1700, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1857;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1701, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1858;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1702, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1859;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1703, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1860;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1704, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1861;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1705, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1862;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1706, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1863;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1707, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1864;

a light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1708, and a heavy chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1865;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1709, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1866;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1710, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1867;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1711, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1868;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1712, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1869;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1713, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1870;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1714, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1871;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1715, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1872;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1716, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1873;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1717, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1874;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1718, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1875;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1719, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1876;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1720, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1877;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1721, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1878;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1722, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1879;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1723, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1880;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1724, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1881;

the variable region of the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1725, and the variable region of the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1882;

the light chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1726, and the heavy chain variable region, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1883; and a light chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1727, and a heavy chain variable region, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1884.

Some antigen-binding proteins contain a variable light domain and a variable heavy domain, as indicated in one of the rows for one of the antibodies listed in table. 3. In some cases, the antigen-binding protein contains two identical variable light domains and two identical variable heavy domains from one of the antibodies listed in table. 3. Some

- 238 040374 antigen-binding proteins, which are proposed according to the invention, contain a variable light domain and a variable heavy domain, as listed in one of the lines for one of the antibodies listed in table. 3, except that one or both domains differ from the sequence listed in the table by only 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 amino acid residues , each such sequence difference being independently either a single amino acid deletion, insertion, or substitution, wherein the deletions, insertions, and/or substitutions result in no more than 1, 2, 3, 4, 5, 6, 7, 8, 9 , 10, 11, 12, 13, 14 or 15 amino acid changes relative to the sequences of the variable domain shown in table. 3. In one embodiment, the antigen-binding protein contains the sequence of the variable region of the table. 3, but with the N-terminal methionine removed. Other antigen-binding proteins also contain a variable light domain and a variable heavy domain, as listed in one of the rows for one of the antibodies listed in table. 3, except that one or both of the domains differ from the sequence shown in the table in that the heavy chain variable domain and/or the light chain variable domain contains or consists of an amino acid sequence that has at least 70, 75, 80 , 85, 90, 95, 96, 97, 98, or 99% sequence identity with the amino acid sequences of the heavy chain variable domain or the light chain variable domain, as indicated in Table 1. 3.

In another aspect, the antigen-binding protein consists of only the variable light or variable heavy domain from the antibody listed in Table 1. 3. In another aspect, the antigen-binding protein contains two or more of the same variable heavy domains or two or more of the same variable light domains of those listed in Table. 3. Such domain antibodies can be fused or connected via a linker, as described in more detail below. Domain antibodies can also be fused or linked to one or more molecules to extend the half-life (eg, PEG or albumin).

Other antigen-binding proteins that are proposed according to the invention are variants of antibodies formed by a combination of heavy and light chains shown in table. 3 and contain light and/or heavy chains, each of which has at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identity with the amino acid sequences of these chains. In some cases, such antibodies include at least one heavy chain and one light chain, while in other cases, variant forms contain two identical light chains and two identical heavy chains.

Various combinations of heavy chain variable regions can be combined with any of the various combinations of light chain variable regions. In a further embodiment, the isolated antigen-binding protein provided herein is a human antibody comprising the sequence as shown in Table 1. 3 and is of the IgG1-, IgG2-, IgG3-, or IgG4-type.

The antigen binding proteins disclosed herein are polypeptides into which one or more CDRs are grafted, inserted and/or attached. The antigen binding protein may have 1, 2, 3, 4, 5 or 6 CDRs. Thus, an antigen binding protein may have, for example, one heavy chain CDR1 (CDRH1) and/or one heavy chain CDR2 (CDRH2) and/or one heavy chain CDR3 (CDRH3) and/or one light chain CDR1 (CDRL1) , and/or one light chain CDR2 (CDRL2), and/or one light chain CDR3 (CDRL3). Some antigen binding proteins include both CDRH3 and CDRL3. Specific CDR light and heavy chains are listed in table. 4A and 4B, respectively.

Complementarity determining regions (CDRs) and framework regions (FRs) of a given antibody can be identified using the system described by Kabat et al. in Sequences of Proteins of Immunological Interest, ^5th Ed., US Dept. of Health and Human Services, PHS, NIH, NIH Publication no. 913242, 1991. Certain antibodies, which are disclosed in this document, contain one or more amino acid sequences that are identical or have a significant sequence identity with the amino acid sequences of one or more of the CDRs presented in table. 4A and 4B. The CDR data use the system described by Kabat et al., as above.

The structure and properties of the CDR within a naturally occurring antibody have been described above. Briefly, in a conventional antibody, the CDRs are inserted into the framework of the heavy and light chain variable regions, where they form the regions responsible for antigen binding and recognition. The variable region contains at least three heavy or light chain CDRs, see above (Kabat et al., 1991, Sequences of Proteins of Immunological Interest, Public Health Service N.I.H., Bethesda, MD; see also Chothia and Lesk, 1987, J Mol Biol. et al., 1991, supra; see also Chothia and Lesk, 1987, supra). However, the CDRs provided herein can not only be used to define the antigen-binding domain of a conventional antibody structure, but can be incorporated into a variety of other polypeptide structures as described herein.

In one embodiment, the antibody or fragment thereof contains CDRL1, CDRL2, CDRL3,

- 239 040374

CDRH1, CDRH2 and CDRH3. In one embodiment, the antibody or fragment thereof contains a CDRL1 containing a sequence selected from the group consisting of SEQ ID NO: 629-785. In one embodiment, the antibody or fragment thereof contains a CDRL2 containing a sequence selected from the group consisting of SEQ ID NO: 786-942. In one embodiment, the antibody or fragment thereof contains a CDRL3 containing a sequence selected from the group consisting of SEQ ID NO: 943-1099. In one embodiment, the antibody or fragment thereof contains a CDRH1 containing a sequence selected from the group consisting of SEQ ID NO: 11001256. In one embodiment, the antibody or fragment thereof contains a CDRH2 containing a sequence selected from the group consisting of SEQ ID NO: 1257-1413. In one embodiment, the antibody or fragment thereof contains a CDRH3 containing a sequence selected from the group consisting of SEQ ID NO: 1414-1570.

In one embodiment, the antibody or fragment thereof comprises CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, each CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, respectively, containing a sequence selected from the group consisting of

SEQ ID NO: 629, SEQ ID NO: 786, SEQ ID NO: 943, SEQ ID NO: 1100, SEQ ID NO: 1257 and SEQ ID NO: 1414;

SEQ ID NO: 630, SEQ ID NO: 787, SEQ ID NO: 944, SEQ ID NO: 1101, SEQ ID NO: 1258 and SEQ ID NO: 1415;

SEQ ID NO: 631, SEQ ID NO: 788, SEQ ID NO: 945, SEQ ID NO: 1102, SEQ ID NO: 1259 and SEQ ID NO: 1416;

SEQ ID NO: 632, SEQ ID NO: 789, SEQ ID NO: 946, SEQ ID NO: 1103, SEQ ID NO: 1260 and SEQ ID NO: 1417;

SEQ ID NO: 633, SEQ ID NO: 790, SEQ ID NO: 947, SEQ ID NO: 1104, SEQ ID NO: 1261 and SEQ ID NO: 1418;

SEQ ID NO: 634, SEQ ID NO: 791, SEQ ID NO: 948, SEQ ID NO: 1105, SEQ ID NO: 1262 and SEQ ID NO: 1419;

SEQ ID NO: 635, SEQ ID NO: 792, SEQ ID NO: 949, SEQ ID NO: 1106, SEQ ID NO: 1263 and SEQ ID NO: 1420;

SEQ ID NO: 636, SEQ ID NO: 793, SEQ ID NO: 950, SEQ ID NO: 1107, SEQ ID NO: 1264 and SEQ ID NO: 1421;

SEQ ID NO: 637, SEQ ID NO: 794, SEQ ID NO: 951, SEQ ID NO: 1108, SEQ ID NO: 1265 and SEQ ID NO: 1422;

SEQ ID NO: 638, SEQ ID NO: 795, SEQ ID NO: 952, SEQ ID NO: 1109, SEQ ID NO: 1266 and SEQ ID NO: 1423;

SEQ ID NO: 639, SEQ ID NO: 796, SEQ ID NO: 953, SEQ ID NO: 1110, SEQ ID NO: 1267 and SEQ ID NO: 1424;

SEQ ID NO: 640, SEQ ID NO: 797, SEQ ID NO: 954, SEQ ID NO: 1111, SEQ ID NO: 1268 and SEQ ID NO: 1425;

SEQ ID NO: 641, SEQ ID NO: 798, SEQ ID NO: 955, SEQ ID NO: 1112, SEQ ID NO: 1269 and SEQ ID NO: 1426;

SEQ ID NO: 642, SEQ ID NO: 799, SEQ ID NO: 956, SEQ ID NO: 1113, SEQ ID NO: 1270 and SEQ ID NO: 1427;

SEQ ID NO: 643, SEQ ID NO: 800, SEQ ID NO: 957, SEQ ID NO: 1114, SEQ ID NO: 1271 and SEQ ID NO: 1428;

SEQ ID NO: 644, SEQ ID NO: 801, SEQ ID NO: 958, SEQ ID NO: 1115, SEQ ID NO: 1272 and SEQ ID NO: 1429;

SEQ ID NO: 645, SEQ ID NO: 802, SEQ ID NO: 959, SEQ ID NO: 1116, SEQ ID NO: 1273 and SEQ ID NO: 1430;

SEQ ID NO: 646, SEQ ID NO: 803, SEQ ID NO: 960, SEQ ID NO: 1117, SEQ ID NO: 1274 and SEQ ID NO: 1431;

SEQ ID NO: 647, SEQ ID NO: 804, SEQ ID NO: 961, SEQ ID NO: 1118, SEQ ID NO: 1275 and SEQ ID NO: 1432;

SEQ ID NO: 648, SEQ ID NO: 805, SEQ ID NO: 962, SEQ ID NO: 1119, SEQ ID NO: 1276 and SEQ ID NO: 1433;

SEQ ID NO: 649, SEQ ID NO: 806, SEQ ID NO: 963, SEQ ID NO: 1120, SEQ ID NO: 1277 and SEQ ID NO: 1434;

SEQ ID NO: 650, SEQ ID NO: 807, SEQ ID NO: 964, SEQ ID NO: 1121, SEQ ID NO: 1278 and SEQ ID NO: 1435;

SEQ ID NO: 651, SEQ ID NO: 808, SEQ ID NO: 965, SEQ ID NO: 1122, SEQ ID NO: 1279 and SEQ ID NO: 1436;

SEQ ID NO: 652, SEQ ID NO: 809, SEQ ID NO: 966, SEQ ID NO: 1123, SEQ ID NO: 1280 and SEQ ID NO: 1437;

- 240 040374

SEQ ID NO: 653, SEQ ID NO: 810, SEQ ID NO: 967, SEQ ID NO: 1124, SEQ ID NO: 1281 and SEQ ID

NO: 1438;

SEQ ID NO: 654, SEQ ID NO: 811, SEQ ID NO: 968, SEQ ID NO: 1125, SEQ ID NO: 1282 and SEQ ID NO: 1439;

SEQ ID NO: 655, SEQ ID NO: 812, SEQ ID NO: 969, SEQ ID NO: 1126, SEQ ID NO: 1283 and SEQ ID NO: 1440;

SEQ ID NO: 656, SEQ ID NO: 813, SEQ ID NO: 970, SEQ ID NO: 1127, SEQ ID NO: 1284 and SEQ ID NO: 1441;

SEQ ID NO: 657, SEQ ID NO: 814, SEQ ID NO: 971, SEQ ID NO: 1128, SEQ ID NO: 1285 and SEQ ID NO: 1442;

SEQ ID NO: 658, SEQ ID NO: 815, SEQ ID NO: 972, SEQ ID NO: 1129, SEQ ID NO: 1286 and SEQ ID NO: 1443;

SEQ ID NO: 659, SEQ ID NO: 816, SEQ ID NO: 973, SEQ ID NO: 1130, SEQ ID NO: 1287 and SEQ ID NO: 1444;

SEQ ID NO: 660, SEQ ID NO: 817, SEQ ID NO: 974, SEQ ID NO: 1131, SEQ ID NO: 1288 and SEQ ID NO: 1445;

SEQ ID NO: 661, SEQ ID NO: 818, SEQ ID NO: 975, SEQ ID NO: 1132, SEQ ID NO: 1289 and SEQ ID NO: 1446;

SEQ ID NO: 662, SEQ ID NO: 819, SEQ ID NO: 976, SEQ ID NO: 1133, SEQ ID NO: 1290 and SEQ ID NO: 1447;

SEQ ID NO: 663, SEQ ID NO: 820, SEQ ID NO: 977, SEQ ID NO: 1134, SEQ ID NO: 1291 and SEQ ID NO: 1448;

SEQ ID NO: 664, SEQ ID NO: 821, SEQ ID NO: 978, SEQ ID NO: 1135, SEQ ID NO: 1292 and SEQ ID NO: 1449;

SEQ ID NO: 665, SEQ ID NO: 822, SEQ ID NO: 979, SEQ ID NO: 1136, SEQ ID NO: 1293 and SEQ ID NO: 1450;

SEQ ID NO: 666, SEQ ID NO: 823, SEQ ID NO: 980, SEQ ID NO: 1137, SEQ ID NO: 1294 and SEQ ID NO: 1451;

SEQ ID NO: 667, SEQ ID NO: 824, SEQ ID NO: 981, SEQ ID NO: 1138, SEQ ID NO: 1295 and SEQ ID NO: 1452;

SEQ ID NO: 668, SEQ ID NO: 825, SEQ ID NO: 982, SEQ ID NO: 1139, SEQ ID NO: 1296 and SEQ ID NO: 1453;

SEQ ID NO: 669, SEQ ID NO: 826, SEQ ID NO: 983, SEQ ID NO: 1140, SEQ ID NO: 1297 and SEQ ID NO: 1454;

SEQ ID NO: 670, SEQ ID NO: 827, SEQ ID NO: 984, SEQ ID NO: 1141, SEQ ID NO: 1298 and SEQ ID NO: 1455;

SEQ ID NO: 671, SEQ ID NO: 828, SEQ ID NO: 985, SEQ ID NO: 1142, SEQ ID NO: 1299 and SEQ ID NO: 1456;

SEQ ID NO: 672, SEQ ID NO: 829, SEQ ID NO: 986, SEQ ID NO: 1143, SEQ ID NO: 1300 and SEQ ID NO: 1457;

SEQ ID NO: 673, SEQ ID NO: 830, SEQ ID NO: 987, SEQ ID NO: 1144, SEQ ID NO: 1301 and SEQ ID NO: 1458;

SEQ ID NO: 674, SEQ ID NO: 831, SEQ ID NO: 988, SEQ ID NO: 1145, SEQ ID NO: 1302 and SEQ ID NO: 1459;

SEQ ID NO: 675, SEQ ID NO: 832, SEQ ID NO: 989, SEQ ID NO: 1146, SEQ ID NO: 1303 and SEQ ID NO: 1460;

SEQ ID NO: 676, SEQ ID NO: 833, SEQ ID NO: 990, SEQ ID NO: 1147, SEQ ID NO: 1304 and SEQ ID NO: 1461;

SEQ ID NO: 677, SEQ ID NO: 834, SEQ ID NO: 991, SEQ ID NO: 1148, SEQ ID NO: 1305 and SEQ ID NO: 1462;

SEQ ID NO: 678, SEQ ID NO: 835, SEQ ID NO: 992, SEQ ID NO: 1149, SEQ ID NO: 1306 and SEQ ID NO: 1463;

SEQ ID NO: 679, SEQ ID NO: 836, SEQ ID NO: 993, SEQ ID NO: 1150, SEQ ID NO: 1307 and SEQ ID NO: 1464;

SEQ ID NO: 680, SEQ ID NO: 837, SEQ ID NO: 994, SEQ ID NO: 1151, SEQ ID NO: 1308 and SEQ ID NO: 1465;

SEQ ID NO: 681, SEQ ID NO: 838, SEQ ID NO: 995, SEQ ID NO: 1152, SEQ ID NO: 1309 and SEQ ID NO: 1466;

SEQ ID NO: 682, SEQ ID NO: 839, SEQ ID NO: 996, SEQ ID NO: 1153, SEQ ID NO: 1310 and SEQ ID NO: 1467;

SEQ ID NO: 683, SEQ ID NO: 840, SEQ ID NO: 997, SEQ ID NO: 1154, SEQ ID NO: 1311 and SEQ ID NO: 1468;

- 241 040374

SEQ ID NO: 684, SEQ ID NO: 841, SEQ ID NO: SEQ ID NO: 1469;

SEQ ID NO: 685, SEQ ID NO: 842, SEQ ID NO: SEQ ID NO: 1470;

SEQ ID NO: 686, SEQ ID NO: 843, SEQ ID NO: SEQ ID NO: 1471;

SEQ ID NO: 687, SEQ ID NO: 844, SEQ ID NO: SEQ ID NO: 1472;

SEQ ID NO: 688, SEQ ID NO: 845, SEQ ID NO: SEQ ID NO: 1473;

SEQ ID NO: 689, SEQ ID NO: 846, SEQ ID NO: SEQ ID NO: 1474;

SEQ ID NO: 690, SEQ ID NO: 847, SEQ ID NO: SEQ ID NO: 1475;

SEQ ID NO: 691, SEQ ID NO: 848, SEQ ID NO: SEQ ID NO: 1476;

SEQ ID NO: 692, SEQ ID NO: 849, SEQ ID NO: SEQ ID NO: 1477;

SEQ ID NO: 693, SEQ ID NO: 850, SEQ ID NO: SEQ ID NO: 1478;

SEQ ID NO: 694, SEQ ID NO: 851, SEQ ID NO: SEQ ID NO: 1479;

SEQ ID NO: 695, SEQ ID NO: 852, SEQ ID NO: SEQ ID NO: 1480;

SEQ ID NO: 696, SEQ ID NO: 853, SEQ ID NO: SEQ ID NO: 1481;

SEQ ID NO: 697, SEQ ID NO: 854, SEQ ID NO: SEQ ID NO: 1482;

SEQ ID NO: 698, SEQ ID NO: 855, SEQ ID NO: SEQ ID NO: 1483;

SEQ ID NO: 699, SEQ ID NO: 856, SEQ ID NO: SEQ ID NO: 1484;

SEQ ID NO: 700, SEQ ID NO: 857, SEQ ID NO: SEQ ID NO: 1485;

SEQ ID NO: 701, SEQ ID NO: 858, SEQ ID NO: SEQ ID NO: 1486;

SEQ ID NO: 702, SEQ ID NO: 859, SEQ ID NO: SEQ ID NO: 1487;

SEQ ID NO: 703, SEQ ID NO: 860, SEQ ID NO: SEQ ID NO: 1488;

SEQ ID NO: 704, SEQ ID NO: 861, SEQ ID NO: SEQ ID NO: 1489;

SEQ ID NO: 705, SEQ ID NO: 862, SEQ ID NO: SEQ ID NO: 1490;

SEQ ID NO: 706, SEQ ID NO: 863, SEQ ID NO: SEQ ID NO: 1491;

SEQ ID NO: 707, SEQ ID NO: 864, SEQ ID NO: SEQ ID NO: 1492;

SEQ ID NO: 708, SEQ ID NO: 865, SEQ ID NO: SEQ ID NO: 1493;

SEQ ID NO: 709, SEQ ID NO: 866, SEQ ID NO: SEQ ID NO: 1494;

SEQ ID NO: 710, SEQ ID NO: 867, SEQ ID NO: SEQ ID NO: 1495;

SEQ ID NO: 711, SEQ ID NO: 868, SEQ ID NO: SEQ ID NO: 1496;

SEQ ID NO: 712, SEQ ID NO: 869, SEQ ID NO: SEQ ID NO: 1497;

SEQ ID NO: 713, SEQ ID NO: 870, SEQ ID NO: SEQ ID NO: 1498;

SEQ ID NO: 714, SEQ ID NO: 871, SEQ ID NO: SEQ ID NO: 1499;

998, SEQ ID NO: 1155, SEQ ID NO: 1312 and

999, SEQ ID NO: 1156, SEQ ID NO: 1313 and

1000, SEQ ID NO: 1157, SEQ ID NO: 1314 and

1001, SEQ ID NO: 1158, SEQ ID NO: 1315 and

1002, SEQ ID NO: 1159, SEQ ID NO: 1316 and

1003, SEQ ID NO: 1160, SEQ ID NO: 1317 and

1004, SEQ ID NO: 1161, SEQ ID NO: 1318 and

1005, SEQ ID NO: 1162, SEQ ID NO: 1319 and

1006, SEQ ID NO: 1163, SEQ ID NO: 1320 and

1007, SEQ ID NO: 1164, SEQ ID NO: 1321 and

1008, SEQ ID NO: 1165, SEQ ID NO: 1322 and

1009, SEQ ID NO: 1166, SEQ ID NO: 1323 and

1010, SEQ ID NO: 1167, SEQ ID NO: 1324 and

1011, SEQ ID NO: 1168, SEQ ID NO: 1325 and

1012, SEQ ID NO: 1169, SEQ ID NO: 1326 and

1013, SEQ ID NO: 1170, SEQ ID NO: 1327 and

1014, SEQ ID NO: 1171, SEQ ID NO: 1328 and

1015, SEQ ID NO: 1172, SEQ ID NO: 1329 and

1016, SEQ ID NO: 1173, SEQ ID NO: 1330 and

1017, SEQ ID NO: 1174, SEQ ID NO: 1331 and

1018, SEQ ID NO: 1175, SEQ ID NO: 1332 and

1019, SEQ ID NO: 1176, SEQ ID NO: 1333 and

1020, SEQ ID NO: 1177, SEQ ID NO: 1334 and

1021, SEQ ID NO: 1178, SEQ ID NO: 1335 and

1022, SEQ ID NO: 1179, SEQ ID NO: 1336 and

1023, SEQ ID NO: 1180, SEQ ID NO: 1337 and

1024, SEQ ID NO: 1181, SEQ ID NO: 1338 and

1025, SEQ ID NO: 1182, SEQ ID NO: 1339 and

1026, SEQ ID NO: 1183, SEQ ID NO: 1340 and

1027, SEQ ID NO: 1184, SEQ ID NO: 1341 and

1028, SEQ ID NO: 1185, SEQ ID NO: 1342 and

- 242 040374

SEQ ID NO: 715, SEQ ID NO: SEQ ID NO: 1500;

SEQ ID NO: 716, SEQ ID NO: SEQ ID NO: 1501;

SEQ ID NO: 717, SEQ ID NO: SEQ ID NO: 1502;

SEQ ID NO: 718, SEQ ID NO: SEQ ID NO: 1503;

SEQ ID NO: 719, SEQ ID NO: SEQ ID NO: 1504;

SEQ ID NO: 720, SEQ ID NO: SEQ ID NO: 1505;

SEQ ID NO: 721, SEQ ID NO: SEQ ID NO: 1506;

SEQ ID NO: 722, SEQ ID NO: SEQ ID NO: 1507;

SEQ ID NO: 723, SEQ ID NO: SEQ ID NO: 1508;

SEQ ID NO: 724, SEQ ID NO: SEQ ID NO: 1509;

SEQ ID NO: 725, SEQ ID NO: SEQ ID NO: 1510;

SEQ ID NO: 726, SEQ ID NO: SEQ ID NO: 1511;

SEQ ID NO: 727, SEQ ID NO: SEQ ID NO: 1512;

SEQ ID NO: 728, SEQ ID NO: SEQ ID NO: 1513;

SEQ ID NO: 729, SEQ ID NO: SEQ ID NO: 1514;

SEQ ID NO: 730, SEQ ID NO: SEQ ID NO: 1515;

SEQ ID NO: 731, SEQ ID NO: SEQ ID NO: 1516;

SEQ ID NO: 732, SEQ ID NO: SEQ ID NO: 1517;

SEQ ID NO: 733, SEQ ID NO: SEQ ID NO: 1518;

SEQ ID NO: 734, SEQ ID NO: SEQ ID NO: 1519;

SEQ ID NO: 735, SEQ ID NO: SEQ ID NO: 1520;

SEQ ID NO: 736, SEQ ID NO: SEQ ID NO: 1521;

SEQ ID NO: 737, SEQ ID NO: SEQ ID NO: 1522;

SEQ ID NO: 738, SEQ ID NO: SEQ ID NO: 1523;

SEQ ID NO: 739, SEQ ID NO: SEQ ID NO: 1524;

SEQ ID NO: 740, SEQ ID NO: SEQ ID NO: 1525;

SEQ ID NO: 741, SEQ ID NO: SEQ ID NO: 1526;

SEQ ID NO: 742, SEQ ID NO: SEQ ID NO: 1527;

SEQ ID NO: 743, SEQ ID NO: SEQ ID NO: 1528;

SEQ ID NO: 744, SEQ ID NO: SEQ ID NO: 1529;

SEQ ID NO: 745, SEQ ID NO: SEQ ID NO: 1530;

872, SEQ ID NO: 1029, SEQ

873, SEQ ID NO: 1030, SEQ

874, SEQ ID NO: 1031, SEQ

875, SEQ ID NO: 1032, SEQ

876, SEQ ID NO: 1033, SEQ

877, SEQ ID NO: 1034, SEQ

878, SEQ ID NO: 1035, SEQ

879, SEQ ID NO: 1036, SEQ

880, SEQ ID NO: 1037, SEQ

881, SEQ ID NO: 1038, SEQ

882, SEQ ID NO: 1039, SEQ

883, SEQ ID NO: 1040, SEQ

884, SEQ ID NO: 1041, SEQ

885, SEQ ID NO: 1042, SEQ

886, SEQ ID NO: 1043, SEQ

887, SEQ ID NO: 1044, SEQ

888, SEQ ID NO: 1045, SEQ

889, SEQ ID NO: 1046, SEQ

890, SEQ ID NO: 1047, SEQ

891, SEQ ID NO: 1048, SEQ

892, SEQ ID NO: 1049, SEQ

893, SEQ ID NO: 1050, SEQ

894, SEQ ID NO: 1051, SEQ

895, SEQ ID NO: 1052, SEQ

896, SEQ ID NO: 1053, SEQ

897, SEQ ID NO: 1054, SEQ

898, SEQ ID NO: 1055, SEQ

899, SEQ ID NO: 1056, SEQ

900, SEQ ID NO: 1057, SEQ

901, SEQ ID NO: 1058, SEQ

902, SEQ ID NO: 1059, SEQ

ID NO: 1186, SEQ ID NO: 1343 and

ID NO: 1187, SEQ ID NO: 1344 and

ID NO: 1188, SEQ ID NO: 1345 and

ID NO: 1189, SEQ ID NO: 1346 and

ID NO: 1190, SEQ ID NO: 1347 and

ID NO: 1191, SEQ ID NO: 1348 and

ID NO: 1192, SEQ ID NO: 1349 and

ID NO: 1193, SEQ ID NO: 1350 and

ID NO: 1194, SEQ ID NO: 1351 and

ID NO: 1195, SEQ ID NO: 1352 and

ID NO: 1196, SEQ ID NO: 1353 and

ID NO: 1197, SEQ ID NO: 1354 and

ID NO: 1198, SEQ ID NO: 1355 and

ID NO: 1199, SEQ ID NO: 1356 and

ID NO: 1200, SEQ ID NO: 1357 and

ID NO: 1201, SEQ ID NO: 1358 and

ID NO: 1202, SEQ ID NO: 1359 and

ID NO: 1203, SEQ ID NO: 1360 and

ID NO: 1204, SEQ ID NO: 1361 and

ID NO: 1205, SEQ ID NO: 1362 and

ID NO: 1206, SEQ ID NO: 1363 and

ID NO: 1207, SEQ ID NO: 1364 and

ID NO: 1208, SEQ ID NO: 1365 and

ID NO: 1209, SEQ ID NO: 1366 and

ID NO: 1210, SEQ ID NO: 1367 and

ID NO: 1211, SEQ ID NO: 1368 and

ID NO: 1212, SEQ ID NO: 1369 and

ID NO: 1213, SEQ ID NO: 1370 and

ID NO: 1214, SEQ ID NO: 1371 and

ID NO: 1215, SEQ ID NO: 1372 and

ID NO: 1216, SEQ ID NO: 1373 and

- 243 040374

SEQ ID NO: 746, SEQ ID NO: SEQ ID NO: 1531;

SEQ ID NO: 747, SEQ ID NO: SEQ ID NO: 1532;

SEQ ID NO: 748, SEQ ID NO: SEQ ID NO: 1533;

SEQ ID NO: 749, SEQ ID NO: SEQ ID NO: 1534;

SEQ ID NO: 750, SEQ ID NO: SEQ ID NO: 1535;

SEQ ID NO: 751, SEQ ID NO: SEQ ID NO: 1536;

SEQ ID NO: 752, SEQ ID NO: SEQ ID NO: 1537;

SEQ ID NO: 753, SEQ ID NO: SEQ ID NO: 1538;

SEQ ID NO: 754, SEQ ID NO: SEQ ID NO: 1539;

SEQ ID NO: 755, SEQ ID NO: SEQ ID NO: 1540;

SEQ ID NO: 756, SEQ ID NO: SEQ ID NO: 1541;

SEQ ID NO: 757, SEQ ID NO: SEQ ID NO: 1542;

SEQ ID NO: 758, SEQ ID NO: SEQ ID NO: 1543;

SEQ ID NO: 759, SEQ ID NO: SEQ ID NO: 1544;

SEQ ID NO: 760, SEQ ID NO: SEQ ID NO: 1545;

SEQ ID NO: 761, SEQ ID NO: SEQ ID NO: 1546;

SEQ ID NO: 762, SEQ ID NO: SEQ ID NO: 1547;

SEQ ID NO: 763, SEQ ID NO: SEQ ID NO: 1548;

SEQ ID NO: 764, SEQ ID NO: SEQ ID NO: 1549;

SEQ ID NO: 765, SEQ ID NO: SEQ ID NO: 1550;

SEQ ID NO: 766, SEQ ID NO: SEQ ID NO: 1551;

SEQ ID NO: 767, SEQ ID NO: SEQ ID NO: 1552;

SEQ ID NO: 768, SEQ ID NO: SEQ ID NO: 1553;

SEQ ID NO: 769, SEQ ID NO: SEQ ID NO: 1554;

SEQ ID NO: 770, SEQ ID NO: SEQ ID NO: 1555;

SEQ ID NO: 771, SEQ ID NO: SEQ ID NO: 1556;

SEQ ID NO: 772, SEQ ID NO: SEQ ID NO: 1557;

SEQ ID NO: 773, SEQ ID NO: SEQ ID NO: 1558;

SEQ ID NO: 774, SEQ ID NO: SEQ ID NO: 1559;

SEQ ID NO: 775, SEQ ID NO: SEQ ID NO: 1560;

SEQ ID NO: 776, SEQ ID NO: SEQ ID NO: 1561;

903, SEQ ID NO: 1060, SEQ

904, SEQ ID NO: 1061, SEQ

905, SEQ ID NO: 1062, SEQ

906, SEQ ID NO: 1063, SEQ

907, SEQ ID NO: 1064, SEQ

908, SEQ ID NO: 1065, SEQ

909, SEQ ID NO: 1066, SEQ

910, SEQ ID NO: 1067, SEQ

911, SEQ ID NO: 1068, SEQ

912, SEQ ID NO: 1069, SEQ

913, SEQ ID NO: 1070, SEQ

914, SEQ ID NO: 1071, SEQ

915, SEQ ID NO: 1072, SEQ

916, SEQ ID NO: 1073, SEQ

917, SEQ ID NO: 1074, SEQ

918, SEQ ID NO: 1075, SEQ

919, SEQ ID NO: 1076, SEQ

920, SEQ ID NO: 1077, SEQ

921, SEQ ID NO: 1078, SEQ

922, SEQ ID NO: 1079, SEQ

923, SEQ ID NO: 1080, SEQ

924, SEQ ID NO: 1081, SEQ

925, SEQ ID NO: 1082, SEQ

926, SEQ ID NO: 1083, SEQ

927, SEQ ID NO: 1084, SEQ

928, SEQ ID NO: 1085, SEQ

929, SEQ ID NO: 1086, SEQ

930, SEQ ID NO: 1087, SEQ

931, SEQ ID NO: 1088, SEQ

932, SEQ ID NO: 1089, SEQ

933, SEQ ID NO: 1090, SEQ

ID NO: 1217, SEQ ID NO: 1374 and

ID NO: 1218, SEQ ID NO: 1375 and

ID NO: 1219, SEQ ID NO: 1376 and

ID NO: 1220, SEQ ID NO: 1377 and

ID NO: 1221, SEQ ID NO: 1378 and

ID NO: 1222, SEQ ID NO: 1379 and

ID NO: 1223, SEQ ID NO: 1380 and

ID NO: 1224, SEQ ID NO: 1381 and

ID NO: 1225, SEQ ID NO: 1382 and

ID NO: 1226, SEQ ID NO: 1383 and

ID NO: 1227, SEQ ID NO: 1384 and

ID NO: 1228, SEQ ID NO: 1385 and

ID NO: 1229, SEQ ID NO: 1386 and

ID NO: 1230, SEQ ID NO: 1387 and

ID NO: 1231, SEQ ID NO: 1388 and

ID NO: 1232, SEQ ID NO: 1389 and

ID NO: 1233, SEQ ID NO: 1390 and

ID NO: 1234, SEQ ID NO: 1391 and

ID NO: 1235, SEQ ID NO: 1392 and

ID NO: 1236, SEQ ID NO: 1393 and

ID NO: 1237, SEQ ID NO: 1394 and

ID NO: 1238, SEQ ID NO: 1395 and

ID NO: 1239, SEQ ID NO: 1396 and

ID NO: 1240, SEQ ID NO: 1397 and

ID NO: 1241, SEQ ID NO: 1398 and

ID NO: 1242, SEQ ID NO: 1399 and

ID NO: 1243, SEQ ID NO: 1400 and

ID NO: 1244, SEQ ID NO: 1401 and

ID NO: 1245, SEQ ID NO: 1402 and

ID NO: 1246, SEQ ID NO: 1403 and

ID NO: 1247, SEQ ID NO: 1404 and

- 244 040374

SEQ ID NO SEQ ID NO: 1562;

SEQ ID NO: SEQ ID NO: 1563;

SEQ ID NO: SEQ ID NO: 1564;

SEQ ID NO: SEQ ID NO: 1565;

SEQ ID NO: SEQ ID NO: 1566;

SEQ ID NO: SEQ ID NO: 1567;

SEQ ID NO: SEQ ID NO: 1568;

SEQ ID NO: SEQ ID NO: 1569;

SEQ ID NO: SEQ ID NO: 1570.

777, SEQ ID NO: 934,

778, SEQ ID NO: 935,

779, SEQ ID NO: 936,

780, SEQ ID NO: 937,

781, SEQ ID NO: 938,

782, SEQ ID NO: 939,

783, SEQ ID NO: 940,

784, SEQ ID NO: 941,

785, SEQ ID NO: 942,

SEQ ID NO: 1091

SEQ ID NO: 1092

SEQ ID NO: 1093

SEQ ID NO: 1094

SEQ ID NO: 1095

SEQ ID NO: 1096

SEQ ID NO: 1097

SEQ ID NO: 1098

SEQ ID NO: 1099

SEQ ID NO: 1248

SEQ ID NO: 1249

SEQ ID NO: 1250

SEQ ID NO: 1251

SEQ ID NO: 1252

SEQ ID NO: 1253

SEQ ID NO: 1254

SEQ ID NO: 1255

SEQ ID NO: 1256

SEQ ID NO: 1405 and

SEQ ID NO: 1406 and

SEQ ID NO: 1407 and

SEQ ID NO: 1408 and

SEQ ID NO: 1409 and

SEQ ID NO: 1410 and

SEQ ID NO: 1411 and

SEQ ID NO: 1412 and

SEQ ID NO: 1413 and

In one embodiment, the antibody or fragment thereof contains CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 encoded by the polynucleotide. In one embodiment, the antibody or fragment thereof contains a CDRL1 encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 2199-2355. In one embodiment, the antibody or fragment thereof contains a CDRL2 encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 2356-2512. In one embodiment, the antibody or fragment thereof contains a CDRL3 encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 2513-2669. In one embodiment, the antibody or fragment thereof contains a CDRH1 encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 2700-2826. In one embodiment, the antibody or fragment thereof contains a CDRH2 encoded by a polynucleotide sequence selected from the group consisting of

SEQ ID NO: 2827-2983. In one embodiment, the antibody or fragment thereof contains a CDRH3 encoded by a polynucleotide sequence selected from the group consisting of

SEQ ID NO: 2984-3140.

In one embodiment, the antibody or fragment thereof comprises CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, each CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, respectively, being encoded by a sequence selected from the group consisting of

SEQ ID NO: 2199, SEQ ID NO: 2356, SEQ ID NO: 2513, SEQ ID NO: 2670, SEQ ID NO: 2827 and SEQ ID NO: 2984;

SEQ ID NO: 2200, SEQ ID NO: 2357, SEQ ID NO: 2514, SEQ ID NO: 2671, SEQ ID NO: 2828 and SEQ ID NO: 2985;

SEQ ID NO: 2201, SEQ ID NO: 2358, SEQ ID NO: 2515, SEQ ID NO: 2672, SEQ ID NO: 2829 and SEQ ID NO: 2986;

SEQ ID NO: 2202, SEQ ID NO: 2359, SEQ ID NO: 2516, SEQ ID NO: 2673, SEQ ID NO: 2830 and SEQ ID NO: 2987;

SEQ ID NO: 2203, SEQ ID NO: 2360, SEQ ID NO: 2517, SEQ ID NO: 2674, SEQ ID NO: 2831 and SEQ ID NO: 2988;

SEQ ID NO: 2204, SEQ ID NO: 2361, SEQ ID NO: 2518, SEQ ID NO: 2675, SEQ ID NO: 2832 and SEQ ID NO: 2989;

SEQ ID NO: 2205, SEQ ID NO: 2362, SEQ ID NO: 2519, SEQ ID NO: 2676, SEQ ID NO: 2833 and SEQ ID NO: 2990;

SEQ ID NO: 2206, SEQ ID NO: 2363, SEQ ID NO: 2520, SEQ ID NO: 2677, SEQ ID NO: 2834 and SEQ ID NO: 2991;

SEQ ID NO: 2207, SEQ ID NO: 2364, SEQ ID NO: 2521, SEQ ID NO: 2678, SEQ ID NO: 2835 and SEQ ID NO: 2992;

SEQ ID NO: 2208, SEQ ID NO: 2365, SEQ ID NO: 2522, SEQ ID NO: 2679, SEQ ID NO: 2836 and SEQ ID NO: 2993;

SEQ ID NO: 2209, SEQ ID NO: 2366, SEQ ID NO: 2523, SEQ ID NO: 2680, SEQ ID NO: 2837 and SEQ ID NO: 2994;

SEQ ID NO: 2210, SEQ ID NO: 2367, SEQ ID NO: 2524, SEQ ID NO: 2681, SEQ ID NO: 2838 and SEQ ID NO: 2995;

SEQ ID NO: 2211, SEQ ID NO: 2368, SEQ ID NO: 2525, SEQ ID NO: 2682, SEQ ID NO: 2839 and SEQ ID NO: 2996;

SEQ ID NO: 2212, SEQ ID NO: 2369, SEQ ID NO: 2526, SEQ ID NO: 2683, SEQ ID NO: 2840 and

- 245 040374

SEQ ID NO: 2997;

SEQ ID NO: 2213, SEQ ID NO: SEQ ID NO: 2998;

SEQ ID NO: 2214, SEQ ID NO: SEQ ID NO: 2999;

SEQ ID NO: 2215, SEQ ID NO: SEQ ID NO: 3000;

SEQ ID NO: 2216, SEQ ID NO: SEQ ID NO: 3001;

SEQ ID NO: 2217, SEQ ID NO: SEQ ID NO: 3002;

SEQ ID NO: 2218, SEQ ID NO: SEQ ID NO: 3003;

SEQ ID NO: 2219, SEQ ID NO: SEQ ID NO: 3004;

SEQ ID NO: 2220, SEQ ID NO: SEQ ID NO: 3005;

SEQ ID NO: 2221, SEQ ID NO: SEQ ID NO: 3006;

SEQ ID NO: 2222, SEQ ID NO: SEQ ID NO: 3007;

SEQ ID NO: 2223, SEQ ID NO: SEQ ID NO: 3008;

SEQ ID NO: 2224, SEQ ID NO: SEQ ID NO: 3009;

SEQ ID NO: 2225, SEQ ID NO: SEQ ID NO: 3010;

SEQ ID NO: 2226, SEQ ID NO: SEQ ID NO: 3011;

SEQ ID NO: 2227, SEQ ID NO: SEQ ID NO: 3012;

SEQ ID NO: 2228, SEQ ID NO: SEQ ID NO: 3013;

SEQ ID NO: 2229, SEQ ID NO: SEQ ID NO: 3014;

SEQ ID NO: 2230, SEQ ID NO: SEQ ID NO: 3015;

SEQ ID NO: 2231, SEQ ID NO: SEQ ID NO: 3016;

SEQ ID NO: 2232, SEQ ID NO: SEQ ID NO: 3017;

SEQ ID NO: 2233, SEQ ID NO: SEQ ID NO: 3018;

SEQ ID NO: 2234, SEQ ID NO: SEQ ID NO: 3019;

SEQ ID NO: 2235, SEQ ID NO: SEQ ID NO: 3020;

SEQ ID NO: 2236, SEQ ID NO: SEQ ID NO: 3021;

SEQ ID NO: 2237, SEQ ID NO: SEQ ID NO: 3022;

SEQ ID NO: 2238, SEQ ID NO: SEQ ID NO: 3023;

SEQ ID NO: 2239, SEQ ID NO: SEQ ID NO: 3024;

SEQ ID NO: 2240, SEQ ID NO: SEQ ID NO: 3025;

SEQ ID NO: 2241, SEQ ID NO: SEQ ID NO: 3026;

SEQ ID NO: 2242, SEQ ID NO: SEQ ID NO: 3027;

SEQ ID NO: 2243, SEQ ID NO:

2370, SEQ ID NO: 2527, SEQ

2371, SEQ ID NO: 2528, SEQ

2372, SEQ ID NO: 2529, SEQ

2373, SEQ ID NO: 2530, SEQ

2374, SEQ ID NO: 2531, SEQ

2375, SEQ ID NO: 2532, SEQ

2376, SEQ ID NO: 2533, SEQ

2377, SEQ ID NO: 2534, SEQ

2378, SEQ ID NO: 2535, SEQ

2379, SEQ ID NO: 2536, SEQ

2380, SEQ ID NO: 2537, SEQ

2381, SEQ ID NO: 2538, SEQ

2382, SEQ ID NO: 2539, SEQ

2383, SEQ ID NO: 2540, SEQ

2384, SEQ ID NO: 2541, SEQ

2385, SEQ ID NO: 2542, SEQ

2386, SEQ ID NO: 2543, SEQ

2387, SEQ ID NO: 2544, SEQ

2388, SEQ ID NO: 2545, SEQ

2389, SEQ ID NO: 2546, SEQ

2390, SEQ ID NO: 2547, SEQ

2391, SEQ ID NO: 2548, SEQ

2392, SEQ ID NO: 2549, SEQ

2393, SEQ ID NO: 2550, SEQ

2394, SEQ ID NO: 2551, SEQ

2395, SEQ ID NO: 2552, SEQ

2396, SEQ ID NO: 2553, SEQ

2397, SEQ ID NO: 2554, SEQ

2398, SEQ ID NO: 2555, SEQ

2399, SEQ ID NO: 2556, SEQ

2400, SEQ ID NO: 2557, SEQ

ID NO: 2684, SEQ ID NO: 2841 and

ID NO: 2685, SEQ ID NO: 2842 and

ID NO: 2686, SEQ ID NO: 2843 and

ID NO: 2687, SEQ ID NO: 2844 and

ID NO: 2688, SEQ ID NO: 2845 and

ID NO: 2689, SEQ ID NO: 2846 and

ID NO: 2690, SEQ ID NO: 2847 and

ID NO: 2691, SEQ ID NO: 2848 and

ID NO: 2692, SEQ ID NO: 2849 and

ID NO: 2693, SEQ ID NO: 2850 and

ID NO: 2694, SEQ ID NO: 2851 and

ID NO: 2695, SEQ ID NO: 2852 and

ID NO: 2696, SEQ ID NO: 2853 and

ID NO: 2697, SEQ ID NO: 2854 and

ID NO: 2698, SEQ ID NO: 2855 and

ID NO: 2699, SEQ ID NO: 2856 and

ID NO: 2700, SEQ ID NO: 2857 and

ID NO: 2701, SEQ ID NO: 2858 and

ID NO: 2702, SEQ ID NO: 2859 and

ID NO: 2703, SEQ ID NO: 2860 and

ID NO: 2704, SEQ ID NO: 2861 and

ID NO: 2705, SEQ ID NO: 2862 and

ID NO: 2706, SEQ ID NO: 2863 and

ID NO: 2707, SEQ ID NO: 2864 and

ID NO: 2708, SEQ ID NO: 2865 and

ID NO: 2709, SEQ ID NO: 2866 and

ID NO: 2710, SEQ ID NO: 2867 and

ID NO: 2711, SEQ ID NO: 2868 and

ID NO: 2712, SEQ ID NO: 2869 and

ID NO: 2713, SEQ ID NO: 2870 and

ID NO: 2714, SEQ ID NO: 2871 and

- 246 040374

SEQ ID NO: 3028;

SEQ ID NO: 2244, SEQ ID NO: SEQ ID NO: 3029;

SEQ ID NO: 2245, SEQ ID NO: SEQ ID NO: 3030;

SEQ ID NO: 2246, SEQ ID NO: SEQ ID NO: 3031;

SEQ ID NO: 2247, SEQ ID NO: SEQ ID NO: 3032;

SEQ ID NO: 2248, SEQ ID NO: SEQ ID NO: 3033;

SEQ ID NO: 2249, SEQ ID NO: SEQ ID NO: 3034;

SEQ ID NO: 2250, SEQ ID NO: SEQ ID NO: 3035;

SEQ ID NO: 2251, SEQ ID NO: SEQ ID NO: 3036;

SEQ ID NO: 2252, SEQ ID NO: SEQ ID NO: 3037;

SEQ ID NO: 2253, SEQ ID NO: SEQ ID NO: 3038;

SEQ ID NO: 2254, SEQ ID NO: SEQ ID NO: 3039;

SEQ ID NO: 2255, SEQ ID NO: SEQ ID NO: 3040;

SEQ ID NO: 2256, SEQ ID NO: SEQ ID NO: 3041;

SEQ ID NO: 2257, SEQ ID NO: SEQ ID NO: 3042;

SEQ ID NO: 2258, SEQ ID NO: SEQ ID NO: 3043;

SEQ ID NO: 2259, SEQ ID NO: SEQ ID NO: 3044;

SEQ ID NO: 2260, SEQ ID NO: SEQ ID NO: 3045;

SEQ ID NO: 2261, SEQ ID NO: SEQ ID NO: 3046;

SEQ ID NO: 2262, SEQ ID NO: SEQ ID NO: 3047;

SEQ ID NO: 2263, SEQ ID NO: SEQ ID NO: 3048;

SEQ ID NO: 2264, SEQ ID NO: SEQ ID NO: 3049;

SEQ ID NO: 2265, SEQ ID NO: SEQ ID NO: 3050;

SEQ ID NO: 2266, SEQ ID NO: SEQ ID NO: 3051;

SEQ ID NO: 2267, SEQ ID NO: SEQ ID NO: 3052;

SEQ ID NO: 2268, SEQ ID NO: SEQ ID NO: 3053;

SEQ ID NO: 2269, SEQ ID NO: SEQ ID NO: 3054;

SEQ ID NO: 2270, SEQ ID NO: SEQ ID NO: 3055;

SEQ ID NO: 2271, SEQ ID NO: SEQ ID NO: 3056;

SEQ ID NO: 2272, SEQ ID NO: SEQ ID NO: 3057;

SEQ ID NO: 2273, SEQ ID NO: SEQ ID NO: 3058;

SEQ ID NO: 2274, SEQ ID NO:

2401, SEQ ID NO: 2558, SEQ

2402, SEQ ID NO: 2559, SEQ

2403, SEQ ID NO: 2560, SEQ

2404, SEQ ID NO: 2561, SEQ

2405, SEQ ID NO: 2562, SEQ

2406, SEQ ID NO: 2563, SEQ

2407, SEQ ID NO: 2564, SEQ

2408, SEQ ID NO: 2565, SEQ

2409, SEQ ID NO: 2566, SEQ

2410, SEQ ID NO: 2567, SEQ

2411, SEQ ID NO: 2568, SEQ

2412, SEQ ID NO: 2569, SEQ

2413, SEQ ID NO: 2570, SEQ

2414, SEQ ID NO: 2571, SEQ

2415, SEQ ID NO: 2572, SEQ

2416, SEQ ID NO: 2573, SEQ

2417, SEQ ID NO: 2574, SEQ

2418, SEQ ID NO: 2575, SEQ

2419, SEQ ID NO: 2576, SEQ

2420, SEQ ID NO: 2577, SEQ

2421, SEQ ID NO: 2578, SEQ

2422, SEQ ID NO: 2579, SEQ

2423, SEQ ID NO: 2580, SEQ

2424, SEQ ID NO: 2581, SEQ

2425, SEQ ID NO: 2582, SEQ

2426, SEQ ID NO: 2583, SEQ

2427, SEQ ID NO: 2584, SEQ

2428, SEQ ID NO: 2585, SEQ

2429, SEQ ID NO: 2586, SEQ

2430, SEQ ID NO: 2587, SEQ

2431, SEQ ID NO: 2588, SEQ

ID NO: 2715, SEQ ID NO: 2872 and

ID NO: 2716, SEQ ID NO: 2873 and

ID NO: 2717, SEQ ID NO: 2874 and

ID NO: 2718, SEQ ID NO: 2875 and

ID NO: 2719, SEQ ID NO: 2876 and

ID NO: 2720, SEQ ID NO: 2877 and

ID NO: 2721, SEQ ID NO: 2878 and

ID NO: 2722, SEQ ID NO: 2879 and

ID NO: 2723, SEQ ID NO: 2880 and

ID NO: 2724, SEQ ID NO: 2881 and

ID NO: 2725, SEQ ID NO: 2882 and

ID NO: 2726, SEQ ID NO: 2883 and

ID NO: 2727, SEQ ID NO: 2884 and

ID NO: 2728, SEQ ID NO: 2885 and

ID NO: 2729, SEQ ID NO: 2886 and

ID NO: 2730, SEQ ID NO: 2887 and

ID NO: 2731, SEQ ID NO: 2888 and

ID NO: 2732, SEQ ID NO: 2889 and

ID NO: 2733, SEQ ID NO: 2890 and

ID NO: 2734, SEQ ID NO: 2891 and

ID NO: 2735, SEQ ID NO: 2892 and

ID NO: 2736, SEQ ID NO: 2893 and

ID NO: 2737, SEQ ID NO: 2894 and

ID NO: 2738, SEQ ID NO: 2895 and

ID NO: 2739, SEQ ID NO: 2896 and

ID NO: 2740, SEQ ID NO: 2897 and

ID NO: 2741, SEQ ID NO: 2898 and

ID NO: 2742, SEQ ID NO: 2899 and

ID NO: 2743, SEQ ID NO: 2900 and

ID NO: 2744, SEQ ID NO: 2901 and

ID NO: 2745, SEQ ID NO: 2902 and

- 247 040374

SEQ ID NO: 3059;

SEQ ID NO: 2275, SEQ ID NO: SEQ ID NO: 3060;

SEQ ID NO: 2276, SEQ ID NO: SEQ ID NO: 3061;

SEQ ID NO: 2277, SEQ ID NO: SEQ ID NO: 3062;

SEQ ID NO: 2278, SEQ ID NO: SEQ ID NO: 3063;

SEQ ID NO: 2279, SEQ ID NO: SEQ ID NO: 3064;

SEQ ID NO: 2280, SEQ ID NO: SEQ ID NO: 3065;

SEQ ID NO: 2281, SEQ ID NO: SEQ ID NO: 3066;

SEQ ID NO: 2282, SEQ ID NO: SEQ ID NO: 3067;

SEQ ID NO: 2283, SEQ ID NO: SEQ ID NO: 3068;

SEQ ID NO: 2284, SEQ ID NO: SEQ ID NO: 3069;

SEQ ID NO: 2285, SEQ ID NO: SEQ ID NO: 3070;

SEQ ID NO: 2286, SEQ ID NO: SEQ ID NO: 3071;

SEQ ID NO: 2287, SEQ ID NO: SEQ ID NO: 3072;

SEQ ID NO: 2288, SEQ ID NO: SEQ ID NO: 3073;

SEQ ID NO: 2289, SEQ ID NO: SEQ ID NO: 3074;

SEQ ID NO: 2290, SEQ ID NO: SEQ ID NO: 3075;

SEQ ID NO: 2291, SEQ ID NO: SEQ ID NO: 3076;

SEQ ID NO: 2292, SEQ ID NO: SEQ ID NO: 3077;

SEQ ID NO: 2293, SEQ ID NO: SEQ ID NO: 3078;

SEQ ID NO: 2294, SEQ ID NO: SEQ ID NO: 3079;

SEQ ID NO: 2295, SEQ ID NO: SEQ ID NO: 3080;

SEQ ID NO: 2296, SEQ ID NO: SEQ ID NO: 3081;

SEQ ID NO: 2297, SEQ ID NO: SEQ ID NO: 3082;

SEQ ID NO: 2298, SEQ ID NO: SEQ ID NO: 3083;

SEQ ID NO: 2299, SEQ ID NO: SEQ ID NO: 3084;

SEQ ID NO: 2300, SEQ ID NO: SEQ ID NO: 3085;

SEQ ID NO: 2301, SEQ ID NO: SEQ ID NO: 3086;

SEQ ID NO: 2302, SEQ ID NO: SEQ ID NO: 3087;

SEQ ID NO: 2303, SEQ ID NO: SEQ ID NO: 3088;

SEQ ID NO: 2304, SEQ ID NO: SEQ ID NO: 3089;

SEQ ID NO: 2305, SEQ ID NO:

2432, SEQ ID NO: 2589, SEQ

2433, SEQ ID NO: 2590, SEQ

2434, SEQ ID NO: 2591, SEQ

2435, SEQ ID NO: 2592, SEQ

2436, SEQ ID NO: 2593, SEQ

2437, SEQ ID NO: 2594, SEQ

2438, SEQ ID NO: 2595, SEQ

2439, SEQ ID NO: 2596, SEQ

2440, SEQ ID NO: 2597, SEQ

2441, SEQ ID NO: 2598, SEQ

2442, SEQ ID NO: 2599, SEQ

2443, SEQ ID NO: 2600, SEQ

2444, SEQ ID NO: 2601, SEQ

2445, SEQ ID NO: 2602, SEQ

2446, SEQ ID NO: 2603, SEQ

2447, SEQ ID NO: 2604, SEQ

2448, SEQ ID NO: 2605, SEQ

2449, SEQ ID NO: 2606, SEQ

2450, SEQ ID NO: 2607, SEQ

2451, SEQ ID NO: 2608, SEQ

2452, SEQ ID NO: 2609, SEQ

2453, SEQ ID NO: 2610, SEQ

2454, SEQ ID NO: 2611, SEQ

2455, SEQ ID NO: 2612, SEQ

2456, SEQ ID NO: 2613, SEQ

2457 SEQ ID NO: 2614 SEQ

2458, SEQ ID NO: 2615, SEQ

2459, SEQ ID NO: 2616, SEQ

2460, SEQ ID NO: 2617, SEQ

2461, SEQ ID NO: 2618, SEQ

2462, SEQ ID NO: 2619, SEQ

ID NO: 2746, SEQ ID NO: 2903 and

ID NO: 2747, SEQ ID NO: 2904 and

ID NO: 2748, SEQ ID NO: 2905 and

ID NO: 2749, SEQ ID NO: 2906 and

ID NO: 2750, SEQ ID NO: 2907 and

ID NO: 2751, SEQ ID NO: 2908 and

ID NO: 2752, SEQ ID NO: 2909 and

ID NO: 2753, SEQ ID NO: 2910 and

ID NO: 2754, SEQ ID NO: 2911 and

ID NO: 2755, SEQ ID NO: 2912 and

ID NO: 2756, SEQ ID NO: 2913 and

ID NO: 2757, SEQ ID NO: 2914 and

ID NO: 2758, SEQ ID NO: 2915 and

ID NO: 2759, SEQ ID NO: 2916 and

ID NO: 2760, SEQ ID NO: 2917 and

ID NO: 2761, SEQ ID NO: 2918 and

ID NO: 2762, SEQ ID NO: 2919 and

ID NO: 2763, SEQ ID NO: 2920 and

ID NO: 2764, SEQ ID NO: 2921 and

ID NO: 2765, SEQ ID NO: 2922 and

ID NO: 2766, SEQ ID NO: 2923 and

ID NO: 2767, SEQ ID NO: 2924 and

ID NO: 2768, SEQ ID NO: 2925 and

ID NO: 2769, SEQ ID NO: 2926 and

ID NO: 2770, SEQ ID NO: 2927 and

ID NO: 2771, SEQ ID NO: 2928 and

ID NO: 2772, SEQ ID NO: 2929 and

ID NO: 2773, SEQ ID NO: 2930 and

ID NO: 2774, SEQ ID NO: 2931 and

ID NO: 2775, SEQ ID NO: 2932 and

ID NO: 2776, SEQ ID NO: 2933 and

- 248 040374

SEQ ID NO: 3090;

SEQ ID NO: 2306, SEQ ID NO: SEQ ID NO: 3091;

SEQ ID NO: 2307, SEQ ID NO: SEQ ID NO: 3092;

SEQ ID NO: 2308, SEQ ID NO: SEQ ID NO: 3093;

SEQ ID NO: 2309, SEQ ID NO: SEQ ID NO: 3094;

SEQ ID NO: 2310, SEQ ID NO: SEQ ID NO: 3095;

SEQ ID NO: 2311, SEQ ID NO: SEQ ID NO: 3096;

SEQ ID NO: 2312, SEQ ID NO: SEQ ID NO: 3097;

SEQ ID NO: 2313, SEQ ID NO: SEQ ID NO: 3098;

SEQ ID NO: 2314, SEQ ID NO: SEQ ID NO: 3099;

SEQ ID NO: 2315, SEQ ID NO: SEQ ID NO: 3100;

SEQ ID NO: 2316, SEQ ID NO: SEQ ID NO: 3101;

SEQ ID NO: 2317, SEQ ID NO: SEQ ID NO: 3102;

SEQ ID NO: 2318, SEQ ID NO: SEQ ID NO: 3103;

SEQ ID NO: 2319, SEQ ID NO: SEQ ID NO: 3104;

SEQ ID NO: 2320, SEQ ID NO: SEQ ID NO: 3105;

SEQ ID NO: 2321, SEQ ID NO: SEQ ID NO: 3106;

SEQ ID NO: 2322, SEQ ID NO: SEQ ID NO: 3107;

SEQ ID NO: 2323, SEQ ID NO: SEQ ID NO: 3108;

SEQ ID NO: 2324, SEQ ID NO: SEQ ID NO: 3109;

SEQ ID NO: 2325, SEQ ID NO: SEQ ID NO: 3110;

SEQ ID NO: 2326, SEQ ID NO: SEQ ID NO: 3111;

SEQ ID NO: 2327, SEQ ID NO: SEQ ID NO: 3112;

SEQ ID NO: 2328, SEQ ID NO: SEQ ID NO: 3113;

SEQ ID NO: 2329, SEQ ID NO: SEQ ID NO: 3114;

SEQ ID NO: 2330, SEQ ID NO: SEQ ID NO: 3115;

SEQ ID NO: 2331, SEQ ID NO: SEQ ID NO: 3116;

SEQ ID NO: 2332, SEQ ID NO: SEQ ID NO: 3117;

SEQ ID NO: 2333, SEQ ID NO: SEQ ID NO: 3118;

SEQ ID NO: 2334, SEQ ID NO: SEQ ID NO: 3119;

SEQ ID NO: 2335, SEQ ID NO: SEQ ID NO: 3120;

SEQ ID NO: 2336, SEQ ID NO:

2463, SEQ ID NO: 2620, SEQ

2464, SEQ ID NO: 2621, SEQ

2465, SEQ ID NO: 2622, SEQ

2466, SEQ ID NO: 2623, SEQ

2467, SEQ ID NO: 2624, SEQ

2468, SEQ ID NO: 2625, SEQ

2469, SEQ ID NO: 2626, SEQ

2470, SEQ ID NO: 2627, SEQ

2471, SEQ ID NO: 2628, SEQ

2472, SEQ ID NO: 2629, SEQ

2473, SEQ ID NO: 2630, SEQ

2474, SEQ ID NO: 2631, SEQ

2475, SEQ ID NO: 2632, SEQ

2476, SEQ ID NO: 2633, SEQ

2477 SEQ ID NO: 2634 SEQ

2478, SEQ ID NO: 2635, SEQ

2479, SEQ ID NO: 2636, SEQ

2480, SEQ ID NO: 2637, SEQ

2481, SEQ ID NO: 2638, SEQ

2482, SEQ ID NO: 2639, SEQ

2483, SEQ ID NO: 2640, SEQ

2484, SEQ ID NO: 2641, SEQ

2485, SEQ ID NO: 2642, SEQ

2486, SEQ ID NO: 2643, SEQ

2487 SEQ ID NO: 2644 SEQ

2488, SEQ ID NO: 2645, SEQ

2489, SEQ ID NO: 2646, SEQ

2490, SEQ ID NO: 2647, SEQ

2491, SEQ ID NO: 2648, SEQ

2492, SEQ ID NO: 2649, SEQ

2493, SEQ ID NO: 2650, SEQ

ID NO: 2777, SEQ ID NO: 2934 and

ID NO: 2778, SEQ ID NO: 2935 and

ID NO: 2779, SEQ ID NO: 2936 and

ID NO: 2780, SEQ ID NO: 2937 and

ID NO: 2781, SEQ ID NO: 2938 and

ID NO: 2782, SEQ ID NO: 2939 and

ID NO: 2783, SEQ ID NO: 2940 and

ID NO: 2784, SEQ ID NO: 2941 and

ID NO: 2785, SEQ ID NO: 2942 and

ID NO: 2786, SEQ ID NO: 2943 and

ID NO: 2787, SEQ ID NO: 2944 and

ID NO: 2788, SEQ ID NO: 2945 and

ID NO: 2789, SEQ ID NO: 2946 and

ID NO: 2790, SEQ ID NO: 2947 and

ID NO: 2791, SEQ ID NO: 2948 and

ID NO: 2792, SEQ ID NO: 2949 and

ID NO: 2793, SEQ ID NO: 2950 and

ID NO: 2794, SEQ ID NO: 2951 and

ID NO: 2795, SEQ ID NO: 2952 and

ID NO: 2796, SEQ ID NO: 2953 and

ID NO: 2797, SEQ ID NO: 2954 and

ID NO: 2798, SEQ ID NO: 2955 and

ID NO: 2799, SEQ ID NO: 2956 and

ID NO: 2800, SEQ ID NO: 2957 and

ID NO: 2801, SEQ ID NO: 2958 and

ID NO: 2802, SEQ ID NO: 2959 and

ID NO: 2803, SEQ ID NO: 2960 and

ID NO: 2804, SEQ ID NO: 2961 and

ID NO: 2805, SEQ ID NO: 2962 and

ID NO: 2806, SEQ ID NO: 2963 and

ID NO: 2807, SEQ ID NO: 2964 and

- 249 040374

SEQ ID NO: 3121;

SEQ ID NO: 2337, SEQ ID NO: SEQ ID NO: 3122;

SEQ ID NO: 2338, SEQ ID NO: SEQ ID NO: 3123;

SEQ ID NO: 2339, SEQ ID NO: SEQ ID NO: 3124;

SEQ ID NO: 2340, SEQ ID NO: SEQ ID NO: 3125;

SEQ ID NO: 2341, SEQ ID NO: SEQ ID NO: 3126;

SEQ ID NO: 2342, SEQ ID NO: SEQ ID NO: 3127;

SEQ ID NO: 2343, SEQ ID NO: SEQ ID NO: 3128;

SEQ ID NO: 2344, SEQ ID NO: SEQ ID NO: 3129;

SEQ ID NO: 2345, SEQ ID NO: SEQ ID NO: 3130;

SEQ ID NO: 2346, SEQ ID NO: SEQ ID NO: 3131;

SEQ ID NO: 2347, SEQ ID NO: SEQ ID NO: 3132;

SEQ ID NO: 2348, SEQ ID NO: SEQ ID NO: 3133;

SEQ ID NO: 2349, SEQ ID NO: SEQ ID NO: 3134;

SEQ ID NO: 2350, SEQ ID NO: SEQ ID NO: 3135;

SEQ ID NO: 2351, SEQ ID NO: SEQ ID NO: 3136;

SEQ ID NO: 2352, SEQ ID NO: SEQ ID NO: 3137;

SEQ ID NO: 2353, SEQ ID NO: SEQ ID NO: 3138;

SEQ ID NO: 2354, SEQ ID NO: SEQ ID NO: 3139;

2494, SEQ ID NO: 2651, SEQ ID NO: 2808, SEQ ID NO: 2965 and

2495, SEQ ID NO: 2652, SEQ ID NO: 2809, SEQ ID NO: 2966 and

2496, SEQ ID NO: 2653, SEQ ID NO: 2810, SEQ ID NO: 2967 and

2497, SEQ ID NO: 2654, SEQ ID NO: 2811, SEQ ID NO: 2968 and

2498, SEQ ID NO: 2655, SEQ ID NO: 2812, SEQ ID NO: 2969 and

2499, SEQ ID NO: 2656, SEQ ID NO: 2813, SEQ ID NO: 2970 and

2500, SEQ ID NO: 2657, SEQ ID NO: 2814, SEQ ID NO: 2971 and

2501, SEQ ID NO: 2658, SEQ ID NO: 2815, SEQ ID NO: 2972 and

2502, SEQ ID NO: 2659, SEQ ID NO: 2816, SEQ ID NO: 2973 and

2503, SEQ ID NO: 2660, SEQ ID NO: 2817, SEQ ID NO: 2974 and

2504, SEQ ID NO: 2661, SEQ ID NO: 2818, SEQ ID NO: 2975 and

2505, SEQ ID NO: 2662, SEQ ID NO: 2819, SEQ ID NO: 2976 and

2506, SEQ ID NO: 2663, SEQ ID NO: 2820, SEQ ID NO: 2977 and

2507, SEQ ID NO: 2664, SEQ ID NO: 2821, SEQ ID NO: 2978 and

2508, SEQ ID NO: 2665, SEQ ID NO: 2822, SEQ ID NO: 2979 and

2509, SEQ ID NO: 2666, SEQ ID NO: 2823, SEQ ID NO: 2980 and

2510, SEQ ID NO: 2667, SEQ ID NO: 2824, SEQ ID NO: 2981 and

2511, SEQ ID NO: 2668, SEQ ID NO: 2825, SEQ ID NO: 2982 and SEQ ID NO: 2355, SEQ ID NO: 2512, SEQ ID NO: 2669, SEQ ID NO: 2826, SEQ ID NO: 2983 and

SEQ ID NO: 3140.

In another aspect, the antigen-binding protein includes 1, 2, 3, 4, 5, or 6 variant CDR forms listed in Table. 4A and 4B, each of which has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity with the CDR sequence shown in Table 4A. 4A and 4B. Some antigen-binding proteins include 1, 2, 3, 4, 5, or 6 CDRs listed in Table. 4A and 4B, each or all of which differ by no more than 1, 2, 3, 4, or 5 amino acids from the listed CDRs in this table. In various other embodiments, the antigen binding protein is derived from such antibodies. For example, in one aspect, the antigen-binding protein contains 1, 2, 3, 4, 5, or all 6 CDRs listed in one of the rows for any particular antibody shown in Table. 4A and 4B. In another aspect, the antigen-binding protein includes 1, 2, 3, 4, 5, or 6 variant forms of the CDRs listed in one of the rows for the antibody in Table. 4A and 4B, each of the CDRs has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity with the CDR sequence shown in Table 4A. 4A and 4B. Some antigen-binding proteins include 1, 2, 3, 4, 5 or 6 CDRs listed in one of the rows of Table. 4A and 4B, each differing by no more than 1, 2, 3, 4, or 5 amino acids from those listed in these CDR tables. In another aspect, the antigen-binding protein contains all 6 CDRs listed in the row of the table. 4A and 4B, and the total number of amino acid substitutions in the CDRs is no more than 1, 2, 3, 4, or 5 amino acids in total.

In one embodiment, the antibody or fragment thereof contains a light chain containing a sequence selected from the group consisting of SEQ ID NO: 472-628. In one embodiment, the antibody or fragment thereof contains a heavy chain containing a sequence selected from the group consisting of SEQ ID NO: 472-628. In one embodiment, the antibody or fragment thereof comprises a light chain containing a sequence selected from the group consisting of SEQ ID NOs: 472-628 and a heavy chain containing a sequence selected from the group consisting of SEQ ID NOs: 250 040374 472-628.

light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain , containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing SEQ ID NO light chain, with containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing light chain SEQ ID NO, containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ ID NO of a light chain containing SEQ light chain ID NO containing SEQ light chain NO containing SEQ ID light chain NO containing SEQ ID light chain NO containing light chain SEQ ID NO light chain containing SEQ ID light chain NO containing SEQ ID light chain NO containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO light chain containing SEQ ID NO

In one embodiment, the antibody or fragment thereof comprises a combination of a light chain and a heavy chain selected from the group consisting of

315, and a heavy chain containing SEQ ID NO: 472;

316, and a heavy chain containing SEQ ID NO: 473;

317 and a heavy chain containing SEQ ID NO: 474;

318, and a heavy chain containing SEQ ID NO: 475;

319, and a heavy chain containing SEQ ID NO: 476;

320, and a heavy chain containing SEQ ID NO: 477;

321, and a heavy chain containing SEQ ID NO: 478;

322, and a heavy chain containing SEQ ID NO: 479;

323, and a heavy chain containing SEQ ID NO: 480;

324, and a heavy chain containing SEQ ID NO: 481;

325, and a heavy chain containing SEQ ID NO: 482;

326, and a heavy chain containing SEQ ID NO: 483;

327, and a heavy chain containing SEQ ID NO: 484;

328, and a heavy chain containing SEQ ID NO: 485;

329, and a heavy chain containing SEQ ID NO: 486;

330, and a heavy chain containing SEQ ID NO: 487;

331, and a heavy chain containing SEQ ID NO: 488;

332, and a heavy chain containing SEQ ID NO: 489;

333, and a heavy chain containing SEQ ID NO: 490;

334, and a heavy chain containing SEQ ID NO: 491;

335, and a heavy chain containing SEQ ID NO: 492;

336, and a heavy chain containing SEQ ID NO: 493;

337 and a heavy chain containing SEQ ID NO: 494;

338, and a heavy chain containing SEQ ID NO: 495;

339, and a heavy chain containing SEQ ID NO: 496;

340, and a heavy chain containing SEQ ID NO: 497;

341, and a heavy chain containing SEQ ID NO: 498;

342, and a heavy chain containing SEQ ID NO: 499;

343, and a heavy chain containing SEQ ID NO: 500;

344, and a heavy chain containing SEQ ID NO: 501;

345, and a heavy chain containing SEQ ID NO: 502;

346, and a heavy chain containing SEQ ID NO: 503;

347, and a heavy chain containing SEQ ID NO: 504;

348, and a heavy chain containing SEQ ID NO: 505;

349, and a heavy chain containing SEQ ID NO: 506;

350, and a heavy chain containing SEQ ID NO: 507;

351, and a heavy chain containing SEQ ID NO: 508;

352, and a heavy chain containing SEQ ID NO: 509;

353, and a heavy chain containing SEQ ID NO: 510;

354, and a heavy chain containing SEQ ID NO: 511;

355, and a heavy chain containing SEQ ID NO: 512;

356, and a heavy chain containing SEQ ID NO: 513;

357, and a heavy chain containing SEQ ID NO: 514;

358, and a heavy chain containing SEQ ID NO: 515;

359, and a heavy chain containing SEQ ID NO: 516;

360, and a heavy chain containing SEQ ID NO: 517;

361, and a heavy chain containing SEQ ID NO: 518;

362, and a heavy chain containing SEQ ID NO: 519;

363, and a heavy chain containing SEQ ID NO: 520;

364, and a heavy chain containing SEQ ID NO: 521;

365, and a heavy chain containing SEQ ID NO: 522;

366, and a heavy chain containing SEQ ID NO: 523;

367, and a heavy chain containing SEQ ID NO: 524;

368, and a heavy chain containing SEQ ID NO: 525;

369, and a heavy chain containing SEQ ID NO: 526;

370, and a heavy chain containing SEQ ID NO: 527;

371, and a heavy chain containing SEQ ID NO: 528;

372, and a heavy chain containing SEQ ID NO: 529;

373, and a heavy chain containing SEQ ID NO: 530;

- 251 040374 a light chain containing SEQ ID NO: 374 and a light chain containing SEQ ID NO: 375 and a light chain containing SEQ ID NO: 376 and a light chain containing SEQ ID NO: 377 and a light chain, containing SEQ ID NO: 378 and a light chain containing SEQ ID NO: 379 and a light chain containing SEQ ID NO: 380 and a light chain containing SEQ ID NO: 381 and a light chain containing SEQ ID NO: 382 , and a light chain containing SEQ ID NO: 383, and a light chain containing SEQ ID NO: 384, and a light chain containing SEQ ID NO: 385, and a light chain containing SEQ ID NO: 386, and a light chain containing SEQ ID NO: 387 and a light chain containing SEQ ID NO: 388 and a light chain containing SEQ ID NO: 389 and a light chain containing SEQ ID NO: 390 and a light chain containing SEQ ID NO: 391, and a light chain containing SEQ ID NO: 392 and a light chain containing SEQ ID NO: 393 and a light chain containing SEQ ID NO: 394 and a light chain containing SEQ ID NO: 395 and a light chain containing SEQ ID NO: 396, and a light chain containing her SEQ ID NO: 397, and a light chain containing SEQ ID NO: 398, and a light chain containing SEQ ID NO: 399, and a light chain containing SEQ ID NO: 400, and a light chain containing SEQ ID NO: 401 , and a light chain containing SEQ ID NO: 402, and a light chain containing SEQ ID NO: 403, and a light chain containing SEQ ID NO: 404, and a light chain containing SEQ ID NO: 405, and a light chain containing SEQ ID NO: 406 and a light chain containing SEQ ID NO: 407 and a light chain containing SEQ ID NO: 408 and a light chain containing SEQ ID NO: 409 and a light chain containing SEQ ID NO: 410, and a light chain containing SEQ ID NO: 411 and a light chain containing SEQ ID NO: 412 and a light chain containing SEQ ID NO: 413 and a light chain containing SEQ ID NO: 414 and a light chain containing SEQ ID NO: 415 and a light chain containing SEQ ID NO: 416 and a light chain containing SEQ ID NO: 417 and a light chain containing SEQ ID NO: 418 and a light chain containing SEQ ID NO: 419, and a light chain comprising SEQ ID NO: 420 and a light chain containing SEQ ID NO: 421 and a light chain containing SEQ ID NO: 422 and a light chain containing SEQ ID NO: 423 and a light chain containing SEQ ID NO: 424 and a light chain containing SEQ ID NO: 425 , and a light chain containing SEQ ID NO: 426, and a light chain containing SEQ ID NO: 427, and a light chain containing SEQ ID NO: 428, and a light chain containing SEQ ID NO: 429, and a light chain containing SEQ ID NO: 430 and a light chain containing SEQ ID NO: 431 and a light chain containing SEQ ID NO: 432 and a light chain containing SEQ ID NO: 433 and a light chain containing SEQ ID NO: 434, and a light chain containing SEQ ID NO: 435 and a heavy chain containing SEQ ID NO: 531;

a heavy chain containing SEQ ID NO: 532;

a heavy chain containing SEQ ID NO: 533;

a heavy chain containing SEQ ID NO: 534;

a heavy chain containing SEQ ID NO: 535;

a heavy chain containing SEQ ID NO: 536;

a heavy chain containing SEQ ID NO: 537;

a heavy chain containing SEQ ID NO: 538;

a heavy chain containing SEQ ID NO: 539;

a heavy chain containing SEQ ID NO: 540;

a heavy chain containing SEQ ID NO: 541;

a heavy chain containing SEQ ID NO: 542;

a heavy chain containing SEQ ID NO: 543;

a heavy chain containing SEQ ID NO: 544;

a heavy chain containing SEQ ID NO: 545;

a heavy chain containing SEQ ID NO: 546;

a heavy chain containing SEQ ID NO: 547;

a heavy chain containing SEQ ID NO: 548;

a heavy chain containing SEQ ID NO: 549;

a heavy chain containing SEQ ID NO: 550;

a heavy chain containing SEQ ID NO: 551;

a heavy chain containing SEQ ID NO: 552;

a heavy chain containing SEQ ID NO: 553;

a heavy chain containing SEQ ID NO: 554;

a heavy chain containing SEQ ID NO: 555;

a heavy chain containing SEQ ID NO: 556;

a heavy chain containing SEQ ID NO: 557;

a heavy chain containing SEQ ID NO: 558;

a heavy chain containing SEQ ID NO: 559;

a heavy chain containing SEQ ID NO: 560;

a heavy chain containing SEQ ID NO: 561;

a heavy chain containing SEQ ID NO: 562;

a heavy chain containing SEQ ID NO: 563;

a heavy chain containing SEQ ID NO: 564;

a heavy chain containing SEQ ID NO: 565;

a heavy chain containing SEQ ID NO: 566;

a heavy chain containing SEQ ID NO: 567;

a heavy chain containing SEQ ID NO: 568;

a heavy chain containing SEQ ID NO: 569;

a heavy chain containing SEQ ID NO: 570;

a heavy chain containing SEQ ID NO: 571;

a heavy chain containing SEQ ID NO: 572;

a heavy chain containing SEQ ID NO: 573;

a heavy chain containing SEQ ID NO: 574;

a heavy chain containing SEQ ID NO: 575;

a heavy chain containing SEQ ID NO: 576;

a heavy chain containing SEQ ID NO: 577;

a heavy chain containing SEQ ID NO: 578;

a heavy chain containing SEQ ID NO: 579;

a heavy chain containing SEQ ID NO: 580;

a heavy chain containing SEQ ID NO: 581;

a heavy chain containing SEQ ID NO: 582;

a heavy chain containing SEQ ID NO: 583;

a heavy chain containing SEQ ID NO: 584;

a heavy chain containing SEQ ID NO: 585;

a heavy chain containing SEQ ID NO: 586;

a heavy chain containing SEQ ID NO: 587;

a heavy chain containing SEQ ID NO: 588;

a heavy chain containing SEQ ID NO: 589;

a heavy chain containing SEQ ID NO: 590;

a heavy chain containing SEQ ID NO: 591;

a heavy chain containing SEQ ID NO: 592;

- 252 040374 a light chain containing SEQ ID NO: 436 and a heavy chain containing SEQ ID NO: 593;

a light chain containing SEQ ID NO: 437 and a heavy chain containing SEQ ID NO: 594;

a light chain containing SEQ ID NO: 438 and a heavy chain containing SEQ ID NO: 595;

a light chain containing SEQ ID NO: 439 and a heavy chain containing SEQ ID NO: 596;

a light chain containing SEQ ID NO: 440 and a heavy chain containing SEQ ID NO: 597;

a light chain containing SEQ ID NO: 441 and a heavy chain containing SEQ ID NO: 598;

a light chain containing SEQ ID NO: 442 and a heavy chain containing SEQ ID NO: 599;

a light chain containing SEQ ID NO: 443 and a heavy chain containing SEQ ID NO: 600;

a light chain containing SEQ ID NO: 444 and a heavy chain containing SEQ ID NO: 601;

a light chain containing SEQ ID NO: 445 and a heavy chain containing SEQ ID NO: 602;

a light chain containing SEQ ID NO: 446 and a heavy chain containing SEQ ID NO: 603;

a light chain containing SEQ ID NO: 447 and a heavy chain containing SEQ ID NO: 604;

a light chain containing SEQ ID NO: 448 and a heavy chain containing SEQ ID NO: 605;

a light chain containing SEQ ID NO: 449 and a heavy chain containing SEQ ID NO: 606;

a light chain containing SEQ ID NO: 450 and a heavy chain containing SEQ ID NO: 607;

a light chain containing SEQ ID NO: 451 and a heavy chain containing SEQ ID NO: 608;

a light chain containing SEQ ID NO: 452 and a heavy chain containing SEQ ID NO: 609;

a light chain containing SEQ ID NO: 453 and a heavy chain containing SEQ ID NO: 610;

a light chain containing SEQ ID NO: 454 and a heavy chain containing SEQ ID NO: 611;

a light chain containing SEQ ID NO: 455 and a heavy chain containing SEQ ID NO: 612;

a light chain containing SEQ ID NO: 456 and a heavy chain containing SEQ ID NO: 613;

a light chain containing SEQ ID NO: 457 and a heavy chain containing SEQ ID NO: 614;

a light chain containing SEQ ID NO: 458 and a heavy chain containing SEQ ID NO: 615;

a light chain containing SEQ ID NO: 459 and a heavy chain containing SEQ ID NO: 616;

a light chain containing SEQ ID NO: 460 and a heavy chain containing SEQ ID NO: 617;

a light chain containing SEQ ID NO: 461 and a heavy chain containing SEQ ID NO: 618;

a light chain containing SEQ ID NO: 462 and a heavy chain containing SEQ ID NO: 619;

a light chain containing SEQ ID NO: 463 and a heavy chain containing SEQ ID NO: 620;

a light chain containing SEQ ID NO: 464 and a heavy chain containing SEQ ID NO: 621;

a light chain containing SEQ ID NO: 465 and a heavy chain containing SEQ ID NO: 622;

a light chain containing SEQ ID NO: 466 and a heavy chain containing SEQ ID NO: 623;

a light chain containing SEQ ID NO: 467 and a heavy chain containing SEQ ID NO: 624;

a light chain containing SEQ ID NO: 468 and a heavy chain containing SEQ ID NO: 625;

a light chain containing SEQ ID NO: 469 and a heavy chain containing SEQ ID NO: 626;

a light chain containing SEQ ID NO: 470 and a heavy chain containing SEQ ID NO: 627;

a light chain containing SEQ ID NO: 471 and a heavy chain containing SEQ ID NO: 628.

In one embodiment, the antibody or fragment thereof contains a light chain that is encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 18852014. In one embodiment, the antibody or fragment thereof contains a heavy chain that is encoded by a polynucleotide sequence selected from the group, consisting of SEQ ID NO: 2042-2198. In one embodiment, the antibody or fragment thereof contains a light chain that is encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1885-2014 and a heavy chain containing a sequence selected from the group consisting of SEQ ID NO: 2042- 2198.

In one embodiment, the antibody or fragment thereof comprises a combination of a light chain variable region and a heavy chain variable region selected from the group consisting of a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1885, and a heavy chain, which is encoded by a polynucleotide sequence, containing SEQ ID NO: 2042;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1886, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2043;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1887, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2044;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1888, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2045;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1889, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2046;

light chain, which is encoded by a polynucleotide sequence containing

- 253 040374

SEQ ID NO: 1890, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2047;

light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 1891, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2048;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1892, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2049;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1893, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2050;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1894, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2051;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1895, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2052;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1896, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2053;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1897, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2054;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1898, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2055;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1899, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2056;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1900, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2057;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1901, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2058;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1902, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2059;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1903, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2060;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1904, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2061;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1905, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2062;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1906, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2063;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1907, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2064;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1908, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2065;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1909, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2066;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1910, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2067;

- 254 040374 light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 1911, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2068;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1912, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2069;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1913, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2070;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1914, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2071;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1915, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2072;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1916, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2073;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1917, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2074;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1918, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2075;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1919, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2076;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1920, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2077;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1921, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2078;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1922, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2079;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1923, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2080;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1924, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2081;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1925, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2082;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1926, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2083;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1927, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2084;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1928, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2085;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1929, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2086;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1930, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2087;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1931, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2088;

light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 1932, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2089;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1933, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2090;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1934, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2091;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1935, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2092;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1936, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2093;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1937, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2094;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1938, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2095;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1939, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2096;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1940, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2097;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1941, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2098;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1942, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2099;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1943, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2100;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1944, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2101;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1945, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2102;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1946, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2103;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1947, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2104;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1948, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2105;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1949, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2106;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1950, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2107;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1951, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2108;

light chain, which is encoded by a polynucleotide sequence containing

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SEQ ID NO: 1952, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2109;

light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 1953, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2110;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1954, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2111;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1955, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2112;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1956, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2113;

a light chain encoded by a polynucleotide sequence containing SEQ ID NO: 1957 and a heavy chain encoded by a polynucleotide sequence containing SEQ ID NO: 2114;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1958, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2115;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1959, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2116;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1960, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2117;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1961, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2118;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1962, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2119;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1963, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2120;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1964, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2121;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1965, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2122;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1966, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2123;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1967, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2124;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1968, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2125;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1969, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2126;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1970, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2127;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1971, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2128;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1972, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2129;

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SEQ ID NO: 1973, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2130;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1974, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2131;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1975, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2132;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1976, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2133;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1977, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2134;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1978, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2135;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1979, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2136;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1980, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2137;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1981, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2138;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1982, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2139;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1983, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2140;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1984, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2141;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1985, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2142;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1986, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2143;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1987, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2144;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1988, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2145;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1989, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2146;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1990, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2147;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1991, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2148;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1992, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2149;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 1993, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2150;

light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 1994, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2151;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1995, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2152;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1996, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2153;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1997, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2154;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1998, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2155;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 1999, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2156;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2000, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2157;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2001, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2158;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2002, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2159;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2003, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2160;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2004, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2161;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2005, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2162;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2006, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2163;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2007, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2164;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2008, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2165;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2009, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2166;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2010, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2167;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2011, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2168;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2012, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2169;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2013, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2170;

light chain, which is encoded by a polynucleotide sequence containing

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SEQ ID NO: 2014, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2171;

light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 2015, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2172;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2016, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2173;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2017, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2174;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2018, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2175;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2019, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2176;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2020, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2177;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2021, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2178;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2022, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2179;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2023, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2180;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2024, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2181;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2025, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2182;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2026, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2183;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2027, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2184;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2028, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2185;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2029, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2186;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2030, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2187;

a light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2031, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2188;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2032, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2189;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2033, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2190;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2034, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2191;

- 260 040374 light chain, which is encoded by a polynucleotide sequence containing

SEQ ID NO: 2035, and the heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2192;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2036, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2193;

a light chain encoded by a polynucleotide sequence containing SEQ ID NO: 2037 and a heavy chain encoded by a polynucleotide sequence containing SEQ ID NO: 2194;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2038, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2195;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2039, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2196;

a light chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2040, and a heavy chain, which is encoded by a polynucleotide sequence containing SEQ ID NO: 2197;

the light chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2041, and the heavy chain, which is encoded by the polynucleotide sequence containing SEQ ID NO: 2198.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 123-134 of SEQ ID NO: 3141. In one embodiment, the antibody or fragment thereof binds to GIPR in within the intermittent epitope of residues 29-30 and 123-134 of SEQ ID NO: 3141. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less along at least one GIPR residue (SEQ ID NO: 3141) selected from the group consisting of G29, Q30, T31, A32, G33, E34, L35, Y36, Q37, R38, W39, E40, R43, F65, D66, M67, Y68, V69, W71, P85, Y87, L88, P89, W90, R101, L111, W112, R113, H115, T116, C118, E119, N120, E122, K123, N124, E125, A126, L128, D129, Q130, R131, L132, I133 and L134. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of G29, Q30, K123, N124, E125, A126, L128, D129, Q130, R131, L132, I133 and L134. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of K123, N124, E125, A126, L128, D129, Q130, R131, L132, I133 and L134. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 , 10, 11, 12 or 13 GIPR residues (SEQ ID NO: 3141) selected from the group consisting of G29, Q30, K123, N124, E125, A126, L128, D129, Q130, R131, L132, I133 and L134. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 , 10 or 11 GIPR residues (SEQ ID NO: 3141) selected from the group consisting of K123, N124, E125, A126, L128, D129, Q130, R131, L132, I133 and L134.

In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of Q30, T31, A32, G33, E34, L35, Y36, Q37, W39, D66, M67, Y68, Y87, L88, P89, W90, R101, R113, H115, E119, K123, E125, L128, D129, L132 and I133. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of Q30, T31, K123, E125, L128, D129, L132 and I133. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of K123, E125, L128, D129, L132 and I133. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, or 8 GIPR residues. (SEQ ID NO: 3141) selected from the group consisting of Q30, T31, K123, E125, L128, D129, L132 and I133. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located 5 angstroms or less from at least 2, 3, 4, 5, or 6 GIPR residues (SEQ ID NO : 3141) selected from the group consisting of K123, E125,

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L128, D129, L132 and I133.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 102-107 of SEQ ID NO: 3141. In one embodiment, the antibody or fragment thereof binds to GIPR within the intermittent epitope of residues 60-63 and 102-107 of SEQ ID NO: 3141. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less at least one GIPR residue (SEQ ID NO: 3141) selected from the group consisting of Q30, T31, A32, G33, E34, L35, Y36, W39, E40, R43, Q47, A60, C61, N62, G63 , S64, F65, D66, M67, Y68, V69, W71, N77, P85, Y87, L88, P89, W90, V99, L100, R101, Q102, C103, G104, S105, D106, G107, Q108, W109, G110 , L111, W112, R113, D114, H115, T116, Q117, C118, E119, N120 and P121. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of Q30, A60, C61, N62, G63, N77, L100, Q102, C103, G104, S105, D106, G107, W109 and G110. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of A60, C61, N62, G63, Q102, C103, G104, S105, D106 and G107. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 , 10, 11, 12, 13, 14 or 15 GIPR residues (SEQ ID nO: 3141) selected from the group consisting of Q30, A60, C61, N62, G63, N77, L100, Q102, C103, G104, S105, D106, G107, W109 and G110. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 GIPR residues (SEQ ID NO: 3141) selected from the group consisting of A60, C61, N62, G63, Q102, C103, G104, S105, D106 and G107.

In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of T31, A32, L35, Y36, W39, N62, S64, F65, D66, M67, Y68, W71, Y87, L88, P89, W90, R101, G104, S105, D106, Q108, W109, G110, L111, W112, R113, D114, H115, T116 and E119. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of T31, N62, S64, W71, R101, G104, S105, D106, Q108, W109, G110, L111, W112, D114 and T116. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of R101, G104, S105, D106, Q108, W109, G110, L111, W112, D114 and T116. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 , 10, 11, 12, 13, 14 or 15 GIPR residues (SEQ ID NO: 3141) selected from the group consisting of T31, N62, S64, W71, R101, G104, S105, D106, Q108, W109, G110, L111, W112, D114 and T116. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9 , 10 or 11 GIPR residues (SEQ ID NO: 3141) selected from the group consisting of R101, G104, S105, D106, Q108, W109, G110, L111, W112, D114 and T116.

In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of A32, G33, E34, L35, Y36, Q37, R38, W39, E40, R43, F65, D66, M67, Y68, P85, Y87, L88, P89, W90, L111, W112, R113, D114, H115, C118, E119, N120 and P121. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of A32, G33, E34, L35, Y36, Q37, W39, E40, R43, D66, M67, Y87, L88, P89, W90, L111, W112, H115, E119 and N120. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of E34, L111, W112 and N120.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 102-107 of SEQ ID NO: 3141. In one embodiment, the antibody or fragment thereof binds to GIPR in within the intermittent epitope of residues 60-63 and 102-107 of SEQ ID NO: 3141. In some

- 262 040374 In other embodiments, when the antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from group consisting of Q30, T31, A32, G33, E34, L35, Y36, Q37, R38, W39, E40, R43, F65, D66, M67, Y68, V69, W71, P85, Y87, L88, P89, W90, V99, R101, L111, R113, D114, H115, T116, C118, E119 and N120. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 8 angstroms or less from Q30 GIPR (SEQ ID NO: 3141).

In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of Q30, T31, A32, G33, L35, Y36, Q37, W39, E40, R43, D66, M67, Y68, Y87, L88, P89, W90, R113, H115 and E119. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located at a distance of 5 angstroms or less from at least one GIPR residue (SEQ ID NO: 3141) selected from the group, consisting of Q30 and T31. In some embodiments, when an antibody or fragment thereof is associated with GIPR, the antibody or fragment thereof, when associated with GIPR, is located 5 angstroms or less from Q30 and T31 of the GIPR (SEQ ID NO: 3141).

In some aspects, the invention includes an antibody that binds to GIPR, wherein the antibody binds to GIPR and reduces the likelihood that GIPR binds to GIP.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 28-108 of SEQ ID NO: 231 of the heavy chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of T28, F29, S30, N31, Y32 , G33, A50, I51, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, A61, D62, V64, K65, G66, R67, F68, T69, I70, S71, R72, D73, N74 , S75, Q82, N84, S85, R98, D99, Q100, A101, I102, F103, G104, V105, V106, and D108, of the corresponding heavy chain of SEQ ID NO: 231. GIPR, GIPR is placed 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, or 44 residues heavy chain of an antibody or fragment thereof selected from the group consisting of T28, F29, S30, N31, Y32, G33, A50, I51, W52, F53, D54, A55, S56, D57, K58 , Y59, Y60, A61, D62, V64, K65, G66, R67, F68, T69, I70, S71, R72, D73, N74, S75, Q82, N84, S85, R98, D99, Q100, A101, I102, F103 , G104, V105, V106, and D108 corresponding to the heavy chain of SEQ ID NO: 231. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody, or a fragment thereof selected from the group consisting of S30, N31, Y32, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, K65, G66, R67, T69, I70, S71, N84, Q100, A101 , I102, F103, and V105 corresponding to the heavy chain of SEQ ID NO: 231. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24 heavy chain residues of an antibody or fragment thereof, selected from the group consisting of from S30, N31, Y32, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, K65, G66, R67, T69, I70, S71, N84, Q100, A101, I102, F103 and V105 corresponding to the heavy chain of SEQ ID NO: 231.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 29-96 of SEQ ID NO: 74 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of V29, S30, S31, N32, L33 , L46, Y49, G50, T53, Q90, Y91, N92, N93, W94, P95, and L96 corresponding to the light chain of SEQ ID NO: 74. 8 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 light chain residues of an antibody or fragment thereof selected from the group consisting of from V29, S30, S31, N32, L33, L46, Y49, G50, T53, Q90, Y91, N92, N93, W94, P95 and L96 corresponding to the light chain of SEQ ID NO: 74.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of S30, N32, Y49, Y91, N92 , N93, W94, and L96 corresponding to the light chain of SEQ ID NO: 74. In some embodiments, when an antibody or fragment thereof is bound to GIPR, the GIPR is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7 or 8 light chain residues of an antibody or fragment thereof selected from the group consisting of S30, N32, Y49, Y91, N92, N93, W94 and L96 corresponding to the light chain of SEQ ID NO: 74.

- 263 040374

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 28-108 of SEQ ID NO: 231 of the heavy chain of the antibody or fragment thereof, and within the region corresponding to residues 29-96 of SEQ ID NO: 74 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of T28, F29, S30, N31, Y32 , G33, A50, I51, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, A61, D62, V64, K65, G66, R67, F68, T69, I70, S71, R72, D73, N74 , S75, Q82, N84, S85, R98, D99, Q100, A101, I102, F103, G104, V105, V106 and D108 corresponding to the heavy chain of SEQ ID NO: 231; and 8 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of V29, S30, S31, N32, L33, L46, Y49, G50, T53, Q90, Y91, N92, N93, W94, P95, and L96 corresponding to the light chain of SEQ ID NO: 74. In some embodiments, when the antibody or fragment thereof is bound to GIPR, the GIPR is located 8 angstroms or less from at least 2, 3, 4, 5, 6 , 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 , 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, or 44 heavy chain residues of an antibody or fragment thereof selected from the group consisting of T28, F29, S30, N31, Y32, G33, A50, I51, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, A61, D62, V64, K65, G66, R67, F68, T69, I70, S71, R72, D73, N74, S75, Q82, N84, S85, R98, D99, Q100, A101, I102, F103, G104, V105, V106 and D108, corresponding to the heavy chain of SEQ ID NO: 231; and 8 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 light chain residues of an antibody or fragment thereof selected from the group, consisting of V29, S30, S31, N32, L33, L46, Y49, G50, T53, Q90, Y91, N92, N93, W94, P95 and L96 corresponding to the light chain of SEQ ID NO: 74.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of S30, N31, Y32, W52, F53 , D54, A55, S56, D57, K58, Y59, Y60, K65, G66, R67, T69, I70, S71, N84, Q100, A101, I102, F103 and V105, corresponding to the heavy chain of SEQ ID NO: 231; and 5 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of S30, N32, Y49, Y91, N92, N93, W94, and L96 corresponding to the light chain of SEQ ID NO: 74. B in some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 , 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24 heavy chain residues of an antibody or fragment thereof selected from the group consisting of S30, N31, Y32, W52, F53, D54, A55, S56, D57, K58, Y59, Y60, K65, G66, R67, T69, I70, S71, N84, Q100, A101, I102, F103 and V105, corresponding to the heavy chain of SEQ ID NO: 231; and 5 angstroms or less from at least 2, 3, 4, 5, 6, 7 or 8 light chain residues of an antibody or fragment thereof selected from the group consisting of S30, N32, Y49, Y91, N92, N93, W94 and L96 corresponding to the light chain of SEQ ID NO: 74.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 1-118 of SEQ ID NO: 294 of the heavy chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of Q1, M2, S25, G26, Y27 , T28, F29, T30, G31, Y32, N54, R98, G99, G100, D101, Y102, V103, F104, G105, T106, Y107, R108, P109, H110, Y111, Y112, Y113, G114, M115, D116 , V117 and W118 corresponding to the heavy chain of SEQ ID NO: 294. In some embodiments, when the antibody or fragment thereof is associated with GIPR, the GIPR is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 or 32 heavy chain residues of an antibody or fragment thereof selected from the group consisting of Q1, M2, S25, G26, Y27, T28, F29, T30, G31, Y32, N54, R98, G99, G100, D101, Y102, V103, F104 , G105, T106, Y107, R108, P109, H110, Y111, Y112, Y113, G114, M115, D116, V117 and W118 corresponding to the heavy chain of SEQ ID NO: 294.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of M2, G26, Y27, T28, Y32 , R98, G100, D101, Y102, F104, G105, Y107, H110, Y111, Y112, Y113, and D116, corresponding to the heavy chain of SEQ ID NO: 294. at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17 residues of the heavy chain of the antibody or its fragment, selected from the group consisting of M2, G26, Y27, T28, Y32, R98, G100, D101, Y102, F104, G105, Y107, H110, Y111, Y112, Y113 and D116 corresponding to the heavy chain of SEQ ID NO: 294. In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within a region corresponding to residues 32-63 of SEQ ID NO: 137 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof

- 264 040374 is associated with GIPR, GIPR is located at a distance of 8 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of Q32, T33, N35, Y37, K46, L47, L48, 149, Y50, T51, N53, Q54, R55, P56, S57, G58, V59, P60, D61, R62, and F63 corresponding to the light chain of SEQ ID NO: 137. In some embodiments, when an antibody or fragment thereof is associated with GIPR, GIPR placed 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21 an antibody light chain residue or fragment thereof selected from the group consisting of Q32, T33, N35, Y37, K46, L47, L48, I49, Y50, T51, N53, Q54, R55, P56, S57, G58, V59, P60, D61, R62 and F63 corresponding to the light chain of SEQ ID NO: 137.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of L47, Y50, Q54, R55, P56 , S57, G58, V59, or D61 corresponding to the light chain of SEQ ID NO: 137. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, or 9 light chain residues of an antibody or fragment thereof selected from the group consisting of L47, Y50, Q54, R55, P56, S57, G58, V59, or D61 corresponding to the light chain of SEQ ID NO: 137.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 1-118 of SEQ ID NO: 294 of the heavy chain of the antibody or fragment thereof, and within the region corresponding to residues 32-63 of SEQ ID NO: 137 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of Q1, M2, S25, G26, Y27 , T28, F29, T30, G31, Y32, N54, R98, G99, G100, D101, Y102, V103, F104, G105, T106, Y107, R108, P109, H110, Y111, Y112, Y113, G114, M115, D116 , V117 and W118 corresponding to the heavy chain of SEQ ID NO: 294; and 8 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of Q32, T33, N35, Y37, K46, L47, L48, I49, Y50, T51, N53, Q54, R55, P56, S57, G58, V59, P60, D61, R62, and F63 corresponding to the light chain of SEQ ID NO:137. from 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 , 27, 28, 29, 30, 31, or 32 residues of the heavy chain of an antibody or fragment thereof selected from the group consisting of Q1, M2, S25, G26, Y27, T28, F29, T30, G31, Y32, N54, R98, G99, G100, D101, Y102, V103, F104, G105, T106, Y107, R108, P109, H110, Y111, Y112, Y113, G114, M115, D116, V117 and W118, corresponding to the heavy chain of SEQ ID NO: 294; and 8 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21 light residues an antibody chain or fragment thereof selected from the group consisting of Q32, T33, N35, Y37, K46, L47, L48, I49, Y50, T51, N53, Q54, R55, P56, S57, G58, V59, P60, D61, R62 and F63 corresponding to the light chain of SEQ ID NO: 137. In some embodiments, when the antibody or fragment thereof is associated with GIPR, the GIPR is located at a distance of 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of M2, G26, Y27, T28, Y32, R98, G100, D101, Y102, F104, G105, Y107, H110, Y111, Y112, Y113 and D116 corresponding to the heavy chain of SEQ ID NO: 294; and 5 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of L47, Y50, Q54, R55, P56, S57, G58, V59, or D61 corresponding to the light chain of SeQ ID NO: 137 In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 , 14, 15, 16 or 17 heavy chain residues of an antibody or fragment thereof selected from the group consisting of M2, G26, Y27, T28, Y32, R98, G100, D101, Y102, F104, G105, Y107, H110, Y111, Y112, Y113 and D116 corresponding to the heavy chain of SEQ ID NO: 294; and 5 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, or 9 light chain residues of an antibody or fragment thereof selected from the group consisting of L47, Y50, Q54, R55, P56, S57, G58, V59 or D61 corresponding to the light chain of SEQ ID NO: 137.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 26-110 of SEQ ID NO: 208 of the heavy chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of G26, F27, T28, F29, S30 . NO: 208. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, or 27 heavy chain residues of an antibody or fragment thereof selected from the group consisting of G26, F27, T28 , F29, S30, Y31, F32, W52, Y53, D54, S56, N57, Y59, N74, N77, R98, D99, G100, T101, I102, F103, G104, V105, L106, L107, D109 and Y110, match

- 265 040374 ca heavy chain SEQ ID NO: 208.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of T28, Y31, F32, W52, Y53 , R98, G100, T101, I102, F103, G104, V105, and L106 corresponding to the heavy chain of SEQ ID NO: 208. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 5 angstroms or less of at least at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 heavy chain residues of an antibody or fragment thereof selected from the group consisting of T28, Y31, F32, W52, Y53, R98, G100 , T101, I102, F103, G104, V105 and L106 corresponding to the heavy chain of SEQ ID NO: 208.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 29-96 of SEQ ID NO: 51 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of I29, R30, D31, Y32, L33 , L46, I48, Y49, G50, A51, S52, S53, L54, Q55, S56, Q90, H91, N92, N93, Y94, and F96 corresponding to the light chain of SEQ ID NO: 51. In some embodiments, when the antibody or its fragment is associated with GIPR, GIPR is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21 light chain residues of an antibody or fragment thereof selected from the group consisting of I29, R30, D31, Y32, L33, L46,148, Y49, G50, A51, S52, S53, L54, Q55, S56 , Q90, H91, N92, N93, Y94 and F96 corresponding to the light chain of SEQ ID NO: 51.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of Y32, Y49, G50, S53, Q55 , H91, N92, N93, and Y94 corresponding to the light chain of SEQ ID NO: 51. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8 or 9 light chain residues of an antibody or fragment thereof selected from the group consisting of Y32, Y49, G50, S53, Q55, H91, N92, N93 and Y94 corresponding to the light chain of SEQ ID NO: 51.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 26-110 of SEQ ID NO: 208 of the heavy chain of the antibody or fragment thereof, and within the region corresponding to residues 29-96 of SEQ ID NO: 51 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of G26, F27, T28, F29, S30 . NO: 208; and 8 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of I29, R30, D31, Y32, L33, L46, I48, Y49, G50, A51, S52, S53, L54, Q55, S56, q90, H91, N92, N93, Y94, and F96, corresponding to the light chain of SEQ ID NO: 51. from 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 or 27 heavy chain residues of an antibody or fragment thereof selected from the group consisting of G26, F27, T28, F29, S30, Y31, F32, W52, Y53, D54, S56, N57, Y59, N74, N77, R98, D99, G100, T101, I102, F103, G104, V105, L106, L107, D109 and Y110 corresponding to the heavy chain of SEQ ID NO: 208; and 8 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21 light residues antibody chain or fragment selected from the group consisting of I29, R30, D31, Y32, L33, L46, I48, Y49, G50, A51, S52, S53, L54, Q55, S56, Q90, H91, N92, N93, Y94 and F96 corresponding to the light chain of SEQ ID NO: 51. In some embodiments, when the antibody or fragment thereof is associated with GIPR, the GIPR is located at a distance of 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of T28, Y31, F32, W52, Y53, R98, G100, T101, I102, F103, G104, V105 and L106 corresponding to the heavy chain of SEQ ID NO: 208; and 5 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of Y32, Y49, G50, S53, Q55, H91, N92, N93, and Y94 corresponding to the light chain of SEQ ID NO: 51 In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 residues of the heavy an antibody or fragment chain selected from the group consisting of T28, Y31, F32, W52, Y53, R98, G100, T101, I102, F103, G104, V105 and L106 corresponding to the heavy chain of SEQ ID NO: 208; and 5 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, or 9 light chain residues of an antibody or fragment thereof selected from the group consisting of Y32, Y49, G50, S53, Q55, H91, N92, N93 and Y94 corresponding to the light chain of SEQ ID NO: 51.

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In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 30-106 of SEQ ID NO: 171 of the heavy chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y33, Y52 , R97, D98, V99, A100, V101, A102, G103, F104, D105, and Y106 corresponding to the heavy chain of SEQ ID NO: 171. In some embodiments, when an antibody or fragment thereof is bound to GIPR, the GIPR is located at a distance of 8 angstroms or less than at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 heavy chain residues of the antibody or fragment thereof selected from the group consisting of S30, S31 , Y32, Y33, Y52, R97, D98, V99, A100, V101, A102, G103, F104, D105 and Y106 corresponding to the heavy chain of SEQ ID NO: 171.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y52, R97 , D98, V99, A100, V101, A102, and D105 corresponding to the heavy chain of SEQ ID NO: 171. In some embodiments, when an antibody or fragment thereof is bound to GIPR, the GIPR is located at a distance of 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 heavy chain residues of an antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y52, R97, D98, V99, A100, V101, A102 and D105 corresponding to the heavy chain of SEQ ID NO: 171. In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 27-94 of SEQ ID NO: 14 light chain of an antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 8 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of Q27, G28, L29, I30, I31 , W32, A34, L46, L47, I48, Y49, A50, A51, S52, S53, L54, Q55, S56, G57, S65, G66, S67, G68, F71, Q90, T91, N92, S93, F94 corresponding light chain SEQ ID NO: 14. In some embodiments, when the antibody or fragment thereof is associated with GIPR, the GIPR is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, or 29 light chain residues of an antibody or fragment thereof selected from the group consisting of Q27, G28, L29, I30, I31, W32, A34, L46, L47, I48, Y49, A50, A51, S52, S53, L54, Q55, S56, G57, S65, G66, S67, G68, F71 , Q90, T91, N92, S93 and F94 corresponding to the light chain of SEQ ID NO: 14.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one light chain residue of the antibody or fragment thereof selected from the group consisting of I30, I31, W32, L46, Y49 , S52, S53, L54, Q55, S56, S67, T91, and N92 corresponding to the light chain of SEQ ID NO: 14. at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13 light chain residues of an antibody or fragment thereof selected from the group consisting of I30, I31, W32, L46, Y49, S52 , S53, L54, Q55, S56, S67, T91 and N92 corresponding to the light chain of SEQ ID NO: 14.

In some aspects, the invention includes an antibody or fragment thereof that binds to GIPR, wherein the antibody or fragment thereof binds to GIPR within the region corresponding to residues 30-106 of SEQ ID NO: 171 of the heavy chain of the antibody or fragment thereof, and within the region corresponding to residues 27-94 of SEQ ID NO: 14 of the light chain of the antibody or fragment thereof. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located at a distance of 8 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y33, Y52 , R97, D98, V99, A100, V101, A102, G103, F104, D105 and Y106 corresponding to the heavy chain of SEQ ID NO: 171; and 8 angstroms or less from at least one light chain residue of an antibody or fragment thereof selected from the group consisting of Q27, G28, L29, I30, I31, W32, A34, L46, L47, I48, Y49, A50, A51, S52, S53, L54, Q55, S56, G57, S65, G66, S67, G68, F71, Q90, T91, N92, S93, and F94 of the corresponding light chain of SEQ ID NO: 14. In some embodiments, when the antibody or its fragment is associated with GIPR, GIPR is located at a distance of 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 residues of the heavy chain of the antibody or its a fragment selected from the group consisting of S30, S31, Y32, Y33, Y52, R97, D98, V99, A100, V101, A102, G103, F104, D105 and Y106 corresponding to the heavy chain of SEQ ID NO: 171; and 8 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 , 23, 24, 25, 26, 27, 28 or 29 light chain residues of an antibody or fragment thereof selected from the group consisting of Q27, G28, L29, I30, I31, W32, A34, L46, L47, I48, Y49, A50, A51, S52, S53, L54, Q55, S56, G57, S65, G66, S67, G68, F71, Q90, T91, N92, S93 and F94, corresponding to the light chain of SEQ ID NO: 14.

In some embodiments, when an antibody or fragment thereof is bound to a GIPR, the GIPR is located 5 angstroms or less from at least one heavy chain residue of the antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y52, R97 , D98, V99, A100, V101, A102 and D105 corresponding to the heavy chain of SEQ ID NO: 171; and 5 angstroms or less

- 267 040374 at least one light chain residue of an antibody or fragment thereof selected from the group consisting of I30, I31, W32, L46, Y49, S52, S53, L54, Q55, S56, S67, T91 and N92 corresponding to the light chain SEQ ID NO: 14. In some embodiments, when an antibody or fragment thereof is associated with a GIPR, the GIPR is located 5 angstroms or less from at least 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11 heavy chain residues of an antibody or fragment thereof selected from the group consisting of S30, S31, Y32, Y52, R97, D98, V99, A100, V101, A102 and D105 corresponding to the heavy chain of SEQ ID NO: 171; and 5 angstroms or less of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13 light chain residues of an antibody or fragment thereof selected from the group consisting of I30, I31, W32, L46, Y49, S52, S53, L54, Q55, S56, S67, T91 and N92 corresponding to the light chain of SEQ ID NO: 14.

In another aspect, the antigen binding protein comprises a full length light chain and a full length heavy chain as listed in one of the rows for one of the antibodies listed in Table 1. 5. Some antigen-binding proteins, which are proposed according to the invention, contain a full-length light chain and a full-length heavy chain, as listed in one of the rows for one of the antibodies listed in table. 5, except that one or both chains differ from the sequence shown in the table only by 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 amino acid residues , each such sequence difference being independently either a deletion, insertion, or substitution of a single amino acid, wherein the deletions, insertions, and/or substitutions result in no more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 amino acid changes relative to the full-length sequences shown in table. 5. In one embodiment, the antigen-binding protein contains a full-length light chain and/or a full-length heavy chain from table. 5 with the N-terminal methionine removed. In one embodiment, the antigen-binding protein contains a full-length light chain and/or a full-length heavy chain from table. 5 with the C-terminal lysine removed. Other antigen-binding proteins also contain a full-length light chain and a full-length heavy chain, as listed in one of the rows for one of the antibodies listed in Table. 5, except that one or both chains differ from the sequence shown in the table in that the light chain and/or heavy chain contains or consists of an amino acid sequence that has at least 70, 75, 80, 85, 90 , 95, 96, 97, 98 or 99% sequence identity with the amino acid sequences of the light chain or heavy chain, as indicated in table. 5.

In another embodiment, the antigen-binding protein consists simply of a light or heavy chain polypeptide as shown in Table 1. 5.

In another aspect, antigen-binding proteins containing CDRs, variable domains and/or full-length sequences listed in table. 3, 4A, 4B, and 5 are a monoclonal antibody, a chimeric antibody, a humanized antibody, a human antibody, a multispecific antibody, or an antibody fragment of the foregoing. In another embodiment, an antibody fragment of the isolated antigen-binding proteins provided herein is a Fab fragment, Fab' fragment, F(ab')2 fragment, Fv fragment, diabody, or scFv based antibody with the sequences listed in Table 1. 5.

In yet another aspect, the isolated antigen-binding protein provided in Table. 5 can be linked to a marker group and can compete for GIPR binding with an antigen-binding protein of one of the isolated antigen-binding proteins provided herein.

In another embodiment, antigen-binding proteins are provided that compete with one of the exemplary antibodies or functional fragments described above for specific binding to human GIPR (eg, SEQ ID NO: 3141). Such antigen-binding proteins may bind to the same epitope as one of the antigen-binding proteins described herein, or to an overlapping epitope. It is expected that antigen-binding proteins and fragments that compete with exemplary antigen-binding proteins will show similar functional properties. Illustrative antigen-binding proteins and fragments include those described above, including those with heavy and light chains, variable region domains, and CDRs included in Table. 3, 4A, 4B, and 5. Thus, as a specific example, proposed antigen-binding proteins include those that compete with an antibody having all six CDRs listed for any antibody shown in Table. 4A and 4B; and VH and VL listed for any antibody presented in the table.; or two light chains and two heavy chains, as indicated for any antibody presented in table. 5.

Proposed antigen-binding proteins include monoclonal antibodies that bind to GIPR. Monoclonal antibodies can be obtained using any method known in the art, for example, by immortalizing spleen cells harvested from a transgenic animal after completion of the immunization plan. Spleen cells can be immortalized using any method known in the art, such as by fusing them with myeloma cells to form hybridomas. Myeloma cells for use in hybridoma-producing hybridization methods are preferably cells that do not produce antibodies, have high hybridization efficiency, and are deficient in enzymes,

- 268 040374 which render them unable to grow in certain selective media which support the growth of only the desired hybrid cells (hybridomas). Examples of suitable cell lines for use in mouse hybridization include Sp-20, P3-X63/Ag8, P3-X63-Ag8.653, NS1/1.Ag4 1, Sp210-Ag14, FO, NSO/U, MPC-11, MPC11 -X45-GTG 1.7 and S194/5XXO Bul; examples of cell lines used in rat hybridization include R210.RCY3, Y3-Ag 1.2.3, IR983F and 4B210. Other cell lines used for cell hybridization are U-266, GM1500-GRG2, LICR-LON-HMy2 and UC729-6. In some cases, a hybridoma cell line is obtained by immunizing an animal (eg, a transgenic animal having human immunoglobulin sequences) with a GIPR immunogen; collecting spleen cells from an immunized animal; hybridizing the harvested spleen cells with a myeloma cell line, thereby obtaining hybridoma cells; obtaining hybridoma cell lines from hybridoma cells; and determining a hybridoma cell line that produces an antibody that binds a GIPR polypeptide. Such hybridoma cell lines and the anti-GIPR monoclonal antibodies produced by them are aspects of the present invention.

Monoclonal antibodies secreted by a hybridoma cell line can be purified using any method known in the art. Hybridomas or mAbs (monoclonal antibodies) can be further screened to identify mAbs with certain properties, such as the ability to increase GIPR activity.

Also proposed chimeric and humanized antibodies based on the above sequences. Monoclonal antibodies for use as therapeutic agents can be modified in various ways prior to use. One example is a chimeric antibody, which is an antibody composed of protein segments from different antibodies that are covalently linked to form functional immunoglobulin light or heavy chains, or immunologically functional portions thereof. In general, as a rule, part of the heavy chain and/or light chain is identical or homologous to the corresponding sequence in antibodies derived from a particular species or belonging to a particular class or subclass of antibodies, while the rest of the chain(s) is identical or homologous to the corresponding sequence in antibodies derived from a different species or belonging to a different class or subclass of an antibody. For methods relating to chimeric antibodies, see, for example, US patent No. 4816567 and Morrison et al., 1985, Proc. Natl. Acad. sci. USA, 81:6851-6855, which are incorporated herein by reference. CDR transplantation is described, for example, in US Pat. Nos. 6,180,370; 5,693,762; 5,693,761;

Typically, the goal of obtaining a chimeric antibody is to create a chimeric construct in which the number of amino acids from the intended patient species is maximized. One example is a CDR-grafted antibody, in which the antibody contains one or more complementarity determining regions (CDRs) from a particular species or belonging to a particular class or subclass of antibodies, while the remainder of the antibody chain(s) is identical or homologous to the corresponding sequences in antibodies derived from a different species or belonging to a different class or subclass of antibodies. For use in humans, the variable region or selected CDRs from a rodent antibody are often transplanted into a human antibody, replacing the naturally occurring variable regions or CDRs of the human antibody. One useful type of chimeric antibody is a humanized antibody. Typically, a humanized antibody is derived from a monoclonal antibody originally derived from a non-human animal. Certain amino acid residues in a given monoclonal antibody, typically from regions of the antibody that do not recognize the antigen, are modified to be homologous to corresponding residues in the human antibody of the appropriate isotype. Humanization can be performed, for example, using various methods by replacing at least a portion of the variable region of a rodent antibody with the corresponding regions of a human antibody (see, for example, US patents No. 5585089 and 5693762; Jones et al., 1986, Nature, 321: 522-525; Riechmann et al., 1988, Nature, 332:323-27; Verhoeyen et al., 1988, Science, 239:1534-1536).

In one aspect, the CDRs of the light and heavy chain variable regions of the antibodies provided herein are transplanted into framework regions (FRs) from antibodies of the same or different phylogenetic species. For example, CDRs of heavy and light chain variable regions VH1, V _H 2, V _H 3, V _H 4, V _H 5, V _H 6, V H 7, V _H 8, V _H 9, _{V H} 10, V _H 11 , V _H 12 and/or V _L 1 and V _L 2 can be transplanted into human consensus FRs. To generate human consensus FRs, FRs from multiple human heavy chain or light chain amino acid sequences can be aligned to identify a consensus amino acid sequence. In other embodiments, a heavy chain or light chain FR disclosed herein is replaced with a FR from a different heavy chain or light chain. In one aspect, the rare amino acids in the heavy and light chain FRs of the anti-GIPR antibodies are not replaced, while the rest of the FR amino acids are replaced. A rare amino acid is a specific amino acid that is in a position where that specific amino acid is not normally found in FR. Alternatively, transplanted variable regions from

- 269 040374 one heavy or light chain can be used with a constant region that is different from the constant region of a specific heavy or light chain, as described in this document. In other embodiments, the grafted variable regions are part of a single chain Fv antibody. In some embodiments, constant regions from a non-human species can be used along with human variable region(s) to generate hybrid antibodies.

Fully human anti-GIPR antibodies are also provided. Methods are available to produce fully human antibodies specific for a given antigen, without exposure to the antigen in humans (fully human antibodies). One specific method proposed for the production of fully human antibodies is the humanization of the murine humoral immune system. Introduction of human immunoglobulin (Ig) loci into the genome of mice in which endogenous Ig genes have been inactivated is one way to generate fully human monoclonal antibodies (mAbs) in a mouse animal that can be immunized with any desired antigen. The use of fully human antibodies can minimize the immunogenic and allergic reactions that can sometimes be induced by administering murine or mouse-derived mAbs as therapeutic agents to humans.

Fully human antibodies can be obtained by immunizing transgenic animals (usually mice) that are capable of producing the human antibody repertoire in the absence of endogenous immunoglobulin production. Antigens used for this purpose typically contain six or more contiguous amino acids and are optionally conjugated to a carrier such as a hapten. See, for example, Jakobovits et al., 1993, Proc. Natl. Acad. sci. USA 90:2551-2555; Jakobovits et al., 1993, Nature, 362:255-258; and Bruggermann et al., 1993, Year in Immunol. 7:33. In one example of such a method, transgenic animals are produced by neutralizing endogenous mouse immunoglobulin loci encoding mouse immunoglobulin heavy and light chains and inserting into the mouse genome large fragments of human genomic DNA containing loci that encode human heavy and light chain proteins. The partially modified animals that have an incomplete set of human immunoglobulin loci are then cross-bred to produce an animal with all the desired immune system modifications. Upon administration of an immunogen, these transgenic animals produce antibodies that are immunospecific for that immunogen but have human rather than murine amino acid sequences, including variable regions. For more information on such methods see, for example, WO 96/33735 and WO 94/02602. Additional methods regarding the use of transgenic mice to obtain human antibodies are described in US patents No. 5545807; 6713610; 6673986; 6162963; 5545807; 6300129; 6255458; 5877397; 5874299 and 5545806; in PCT publications WO 91/10741, WO 90/04036 and EP 546073B1 and EP 546073A1. The transgenic mice described above, referred to herein as HuMab mice, contain a human immunoglobulin gene mini-locus that encodes unrearranged human immunoglobulin heavy ([mu] and [gamma]) and light [kappa] chain sequences, along with targeting mutations that inactivate endogenous [mu] and [kappa] chain loci (Lonberg et al., 1994, Nature, 368:856-859). Accordingly, these mice exhibit reduced expression of mouse IgM or [kappa] and, in response to immunization, the introduced human heavy and light chain transgenes undergo class switching and somatic mutation to produce high-affinity human IgG [kappa] monoclonal antibodies (Lonberg et al., supra. ; Lonberg and Huszar, 1995, Intern. Rev. Immunol. 13:65-93; Harding and Lonberg, 1995, Ann. N. Y Acad. Sci. 764:536-546). The production of HuMab mice is described in detail in Taylor et al., 1992, Nucleic Acids Research, 20:6287-6295; Chen et al., 1993, International Immunology, 5:647-656; Tuaillon et al., 1994, J. Immunol. 152:2912-2920; Lonberg et al., 1994, Nature, 368:856-859; Lonberg, 1994, Handbook of Exp. Pharmacology, 113:49-101; Taylor et al., 1994, International Immunology, 6:579-591; Lonberg and Huszar, 1995, Intern. Rev. Immunol. 13:65-93; Harding and Lonberg, 1995, Ann. N.Y Acad. sci. 764:536-546; Fishwild et al., 1996, Nature Biotechnology, 14:845-851; the foregoing references are incorporated herein by reference in their entirety for all purposes. See also US Pat. Nos. 5,545,806; 5569825; 5625126; 5633425; 5789650; 5877397; 5661016; 5814318; 5874299 and 5770429; and also 5545807; international publications No. WO 93/1227; W092/22646; and WO 92/03918, the disclosures of which are incorporated herein by reference in their entirety for all purposes. Technologies used to generate human antibodies in these transgenic mice are also described in WO 98/24893 and Mendez et al., 1997, Nature Genetics, 15:146-156, which are incorporated herein by reference. For example, transgenic mouse strains HCo7 and HCo12 can be used to create human monoclonal antibodies to GIPR. Additional details regarding the production of human antibodies using transgenic mice are provided below.

Using hybridoma technology, human antigen-specific mAbs with the desired specificity can be generated and selected from transgenic mice, such as those described above. Such antibodies can be cloned and expressed using an appropriate vector and host cell, or these antibodies can be collected from cultured hybridoma cells.

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Fully human antibodies can also be generated from phage display libraries (as disclosed in Hoogenboom et al., 1991, J. Mol. Biol. 227:381 and Marks et al., 1991, J. Mol. Biol. 222:581). Phage display techniques mimic immune selection by displaying antibody repertoires on the surface of a filamentous bacteriophage and then selecting the phage by binding them to a chosen antigen. One such method is described in PCT Publication No. WO 99/10494 (incorporated herein by reference).

The GIPR binding protein may also be a variant, mimetic, derivative or oligomer based on the structure of antigen-binding proteins to GIPR having CDRs, variable regions and/or full length chains as described above.

In one embodiment, by way of example, the antigen-binding protein is a variant form of the antigen-binding proteins disclosed above.

For example, some of the antigen binding proteins have one or more conservative amino acid substitutions in one or more of the heavy or light chains, variable regions, or CDRs.

Naturally occurring amino acids can be classified into classes based on common side chain properties:

1) hydrophobic: norleucine, Met, Ala, Val, Leu, Ile;

2) neutral hydrophilic: Cys, Ser, Thr, Asn, Gln;

3) acidic: Asp, Glu;

4) basic: His, Lys, Arg;

5) residues that affect chain orientation: Gly, Pro; And

6) aromatic: Trp, Tyr, Phe.

Conservative amino acid substitutions may include replacing a member of one of these classes with another member of the same class. Conservative amino acid substitutions may include non-naturally occurring amino acid residues that are typically introduced through chemical peptide synthesis rather than through synthesis in biological systems. They include peptidomimetics and other reversed or inverted forms of amino acid components.

Non-conservative substitutions may involve replacing a member of one of the above classes with a member from another class. Such substituted residues may be introduced into regions of the antibody that are homologous to human antibodies, or into non-homologous regions of the molecule.

When making such changes, in accordance with some embodiments, the hydrophobicity index of the amino acids can be taken into account. The hydrophobicity profile of a protein is calculated by assigning each amino acid a numerical value (hydrophobicity index) and then re-averaging these values over the entire peptide chain. Each amino acid is assigned a hydrophobicity index based on its hydrophobicity and charge characteristics. They make up isoleucine (+4.5); valine (+4.2); leucine (+3.8); phenylalanine (+2.8); cysteine/cystine (+2.5); methionine (+1.9); alanine (+1.8); glycine (-0.4); threonine (-0.7); serine (-0.8); tryptophan (-0.9); tyrosine (-1.3); proline (-1.6); histidine (-3.2); glutamate (-3.5); glutamine (-3.5); aspartate (-3.5); asparagine (-3.5); lysine (-3.9) and arginine (-4.5).

The importance of the hydrophobicity profile in providing the biological function of the interaction on the protein in this area is obvious (see, for example, Kyte et al., 1982, J. Mol. Biol. 157:105-131). It is known that some amino acids can be replaced by other amino acids having a similar index or index of hydrophobicity while maintaining a similar biological activity. When making changes based on the hydrophobicity index, in some embodiments, the implementation includes the replacement of amino acids, hydrophobicity indices of which are in the range of ±2. In some aspects, those within ±1 are included, and in other aspects, those within ±0.5 are included.

It is also known in the art that substitution of such amino acids can be effected efficiently on the basis of hydrophilicity, in particular if a biologically functional protein or peptide thus constructed is intended to be used in immunological embodiments, as is the case here. In some embodiments, the highest local average hydrophilicity of a protein, which is due to the hydrophilicity of its adjacent amino acids, correlates with its immunogenicity and antigen-binding properties or immunogenicity, i. with the biological properties of this protein. These amino acid residues have been assigned the following hydrophilicity values: arginine (+3.0); lysine (+3.0); aspartate (+3.0±1); glutamate (+3.0±1); serine (+0.3); asparagine (+0.2); glutamine (+0.2); glycine (0); threonine (-0.4); proline (-0.5±1); alanine (-0.5); histidine (-0.5); cysteine (-1.0); methionine (-1.3); valine (-1.5); leucine (-1.8); isoleucine (-1.8); tyrosine (-2.3); phenylalanine (-2.5) and tryptophan (-3.4). When making changes based on such hydrophilicity values, certain embodiments include substitutions for amino acids whose hydrophilicity values are within ±2, other embodiments include those that are within ±1, and still other embodiments include those which are in the range of ±0.5. In some cases, epitopes from primary amino acid sequences can also be identified based on hydrophilicity. These regions are also referred to as epitope core regions. Illustrative conservative amino acid substitutions are shown in table. 6.

Table 6

Conservative amino acid substitutions

Initial balances Illustrative substitutions Ala Ser Arg Lys Asn Gin,His asp Glu Cys Ser gin Asn Glu asp gly Pro His Asn, Gin He Leu, Vai Leu He, Vai Lys Arg, Gin, Glu Met Leu, He Phe Met, Leu, Tyr Ser Thr Thr Ser trp Tyr Tyr Trp, Phe Vai He, Leu

One of ordinary skill in the art will readily be able to determine suitable variants of the polypeptides described herein using well known methods. A person skilled in the art can determine suitable regions of the molecule that can be altered without disturbing its activity by targeting regions that are not considered important for the activity of the molecule. One of skill in the art will also be able to identify residues and portions of molecules that are conserved among similar polypeptides. In additional embodiments, conservative amino acid substitutions can be made without disrupting biological activity or adversely affecting polypeptide structure, even regions that may be important to biological activity or structure.

In addition, one of skill in the art can review structure-function studies to identify residues in such polypeptides that are important for activity or structure. Given this comparison, one can predict the importance of amino acid residues in a protein that correspond to amino acid residues important for activity or structure in similar proteins. One skilled in the art can make a selection of chemically similar amino acid substitutions for such predicted important amino acid residues.

One of skill in the art can also perform 3D structure and amino acid sequence analysis relative to that structure in such polypeptides. Given such information, one skilled in the art can predict the alignment of amino acid residues of an antibody, given its three-dimensional structure. One skilled in the art may decide not to make radical changes to amino acid residues that are thought to be on the surface of the protein, since such residues may be involved in important interactions with other molecules. In addition, one skilled in the art can create test variants containing one amino acid substitution at each desired amino acid residue. These variants can then be screened with GIPR activity assays and thus provide information as to which amino acids can and should not be changed. In other words, based on the information gathered from such routine experiments, one skilled in the art can readily determine amino acid positions at which additional substitutions should be avoided, either alone or in combination with other mutations.

A number of scientific publications have been devoted to the prediction of the secondary structure. See Moult, 1996, Curr. Op. in Biotech. 7:422-427; Chou et al., 1974, Biochem. 13:222-245; Chou et al., 1974, Biochemistry, 113:211-222; Chou et al., 1978, Adv. Enzymol. Relat. Areas Mol. Biol. 47:45-148; Chou et al., 1979, Ann. Rev. Biochem.

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47:251-276 and Chou et al., 1979, Biophys. J. 26:367-384. In addition, computer programs are now available to help predict secondary structure. One way to predict secondary structure is based on homologous modeling. For example, two polypeptides or proteins that share greater than 30% sequence identity or greater than 40% similarity may have similar structural topologies. The recent growth of the Protein Structure Database (PDB) has provided enhanced capabilities for secondary structure prediction, including the prediction of the possible number of fold variants in a polypeptide or protein structure. See, Holm et al., 1999, Nucl. acid. Res. 27:244-247. It is suggested (Brenner et al., 1997, Curr. Op. Struct. Biol. 7:369-376) that there are a limited number of fold variants in a given polypeptide or protein, and that once a critical number of structures has been established, structural predictions will become significant. more accurate.

Additional methods for predicting secondary structure include pulling (Jones, 1997, Curr. Opin. Struct. Biol. 7:377-387; Sippl et al., 1996, Structure, 4:15-19), profiling (Bowie et al., 1991, Science, 253:164-170; Gribskov et al., 1990, Meth. Enzym. 183:146-159; Gribskov et al., 1987, Proc. Nat. Acad. Sci. 84:4355-4358) and evolutionary linkage (see Holm, 1999, supra; and Brenner, 1997, supra). In some embodiments, amino acid substitutions are made that (1) desensitize proteolysis, (2) desensitize oxidation, (3) alter binding affinity for protein complex formation, (4) alter binding affinities for ligands or antigens, and/or (4) impart other physicochemical or functional properties to or modify such polypeptides. For example, one or more amino acid substitutions (in some embodiments, conservative amino acid substitutions) can be made in a naturally occurring sequence. Substitutions can be made in that part of the antibody that lies outside the domain(s) that forms the intermolecular contacts. In such embodiments, conservative amino acid substitutions may be used that do not substantially change the structural characteristics of the original sequence (e.g., one or more amino acid substitutions that do not disrupt the secondary structure characteristic of the original or native antigen-binding protein). Examples of secondary and tertiary polypeptide structures accepted in the art are described in Proteins, Structures and Molecular Principles (Creighton, Ed.), 1984, W.H. New York: Freeman and Company; Introduction to Protein Structure (Branden and Tooze, eds.), 1991, New York: Garland Publishing; and Thornton et al., 1991, Nature, 354:105, which are incorporated herein by reference.

Additional preferred antibody variants include cysteine variants wherein one or more cysteine residues in the original or native amino acid sequence are removed or replaced with another amino acid (eg, serine). Cysteine variants are particularly useful if antibodies are to be refolded into a biologically active conformation. Cysteine variants may contain fewer cysteine residues than the native antibody, and generally contain an even number to minimize mismatched cysteine interactions.

The disclosed heavy and light chains, variable region domains, and CDRs can be used to generate polypeptides that contain an antigen-binding region that can specifically bind to GIPR. For example, one or more CDRs can be inserted into a molecule (eg, polypeptide) covalently or non-covalently to form an immunoadhesin. The immunoadhesin may contain one or more CDRs as part of a longer polypeptide chain, may covalently link the CDRs to another polypeptide chain, or may join the CDRs non-covalently. The CDR allows the immunoadhesin to specifically bind to a particular antigen of interest (eg, a GIPR polypeptide or epitope thereof).

Mimetics (eg, peptide mimetics or peptidomimetics) based on the variable region domains and CDRs are also provided, as described herein. These analogs may be peptides, non-peptides, or combinations of peptide and non-peptide regions. Fauchere, 1986, Adv. DrugRes. 15:29; Veber and Freidinger, 1985, TINS p. 392 and Evans et al., 1987, J. Med. Chem. 30:1229, which are incorporated herein by reference for any purpose. Peptide mimetics that are similar in structure to therapeutically useful peptides can be used to obtain a similar therapeutic or prophylactic effect. Such compounds are often developed using computerized molecular modeling. Generally speaking, peptidomimetics are proteins that are structurally similar to an antibody that exhibits the desired biological activity, such as the ability to specifically bind GIPR mentioned herein, but in which one or more peptide bonds are optionally replaced by a bond selected from - CH2NH-, -CH ₂ S-, -CH2-CH2-, -CH-CH-(cis and trans), -COCH2-, -CH(OH)CH ₂ - and -CH2SO-, using methods well known in this field of technology. Systematic replacement of one or more amino acids of the consensus sequence with a D-amino acid of the same type (eg, D-lysine instead of L-lysine) can be used in some embodiments to create more stable proteins. In addition, peptides with limited conformational freedom containing a consensus sequence or a substantially identical variant of the consensus sequence can be prepared by methods known in the art (Rizo and Gierasch, 1992, Ann. Rev. Biochem. 61 :387, incorporated herein by reference), for example, by adding internal cysteine residues capable of forming intramolecular disulfide bridges, resulting in cyclization of the peptide.

Derivatives of the antigen-binding proteins described herein are also provided. Derivatives of antigen binding proteins may contain any molecule or substance that imparts a desired property to an antibody or fragment, such as an increased half-life under the conditions of a particular application. An antigen-binding protein derivative may contain, for example, a detectable (or labeling) moiety (e.g., a radioactive, colorimetric, antigenic, or enzymatic molecule, a detectable bead (such as a magnetic or electrically dense (e.g., gold) bead), or a molecule that binds to another molecule ( e.g., biotin or streptavidin)), a therapeutic or diagnostic moiety (e.g., a radioactive, cytotoxic, or pharmaceutically active moiety), or a molecule that improves the suitability of a given antibody for a particular application (e.g., administration to a subject such as a human, or for other in vivo applications or in vitro). Examples of molecules that can be used to derivatize the antigen binding protein include albumin (eg, human serum albumin) and polyethylene glycol (PEG). Albumin-bound or pegylated derivatives of antigen-binding proteins can be obtained using methods well known in the art. Some antigen binding proteins include the pegylated single chain polypeptide described herein. In one embodiment, the antigen binding protein is conjugated or otherwise linked to a transthyretin (TTR) or a TTR variant. The TTR or variant TTR may be chemically modified, for example, with a chemical selected from the group consisting of dextran, poly(n-vinylpyrrolidone), polyethylene glycols, propylene glycol homopolymers, polypropylene oxide/ethylene oxide copolymers, polyoxyethylated polyols, and polyvinyl alcohols.

Other derivatives include covalent or aggregated conjugates of antigen-binding proteins to GIPR with other proteins or polypeptides, for example, resulting from the expression of recombinant fusion proteins containing heterologous polypeptides fused to the N-terminus or C-terminus of the antigen-binding protein to GIPR. For example, the conjugated peptide may be a heterologous signal (or leader) polypeptide, such as a yeast alpha factor leader peptide, or a peptide such as an epitope tag. Fusion proteins containing antigen-binding protein to GIPR may contain peptides added to facilitate purification or identification of antigen-binding protein to GIPR (eg, poly-His). The GIPR antigen binding protein can also be coupled to the FLAG peptide described in Hoop et al., 1988, Bio/Technology, 6:1204; and US Pat. No. 5,011,912. The FLAG peptide is highly antigenic and provides reversible epitope binding to a specific monoclonal antibody (mAb), enabling rapid analysis and facilitating purification of the expressed recombinant protein. Reagents used to generate fusion proteins in which the FLAG peptide is fused to the desired polypeptide are commercially available (Sigma, St. Louis, MO).

In some embodiments, the implementation of the antigen binding protein contains one or more labels. The term labeling group or label means any detectable label. Examples of suitable labeling groups include, but are not limited to, radioisotopes or radionuclides (e.g. ³ H, ¹⁴ C, ¹⁵ N, ³⁵ S, ⁹⁰ Y, ⁹⁹ Tc, ⁿ¹ In, ¹²⁵ I, ¹³¹ I), fluorescent groups (e.g., FITC, rhodamine, lanthanide complex phosphors), enzyme groups (e.g., horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase), chemiluminescent groups, biotinyl groups, or specified polypeptide epitopes recognized by the secondary reporter (e.g., paired sequences leucine zippers, binding sites for secondary antibodies, metal binding domains, epitope tags). In some embodiments, the implementation of the labeling group is attached to the antigen binding protein using spacer legs of various lengths to reduce possible steric mismatch. Various methods of labeling proteins are known in the art and can be used if deemed appropriate.

The term effector group means any group attached to an antigen-binding protein that acts as a cytotoxic agent. Examples of suitable effector groups are radioisotopes or radionuclides (eg ³ H, ¹⁴ C, ¹⁵ N, ³⁵ S, ⁹⁰ Y, ⁹⁹ Tc, ⁿ¹ In, ¹²⁵ I, ¹³¹ I). Other suitable groups include toxins, therapeutic groups or chemotherapeutic groups. Examples of suitable groups include calicheamicin, auristatins, geldanamycin and maytansine. In some embodiments, the effector group is attached to the antigen binding protein with spacer legs of various lengths to reduce potential steric mismatch.

In general, as a rule, labels are assigned to different classes depending on the analysis in which they are detected: a) isotopic labels, which may be radioactive or heavy isotopes; b) magnetic marks (for example, magnetic particles); c) redox-active fragments; d) optical dyes; enzyme groups (eg, horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase); e) biotinylated groups; and e) predetermined polypeptide epitopes recognized by the secondary reporter (eg, paired leucine zipper sequences, binding sites for secondary antibodies, metal binding domains, epitope tags, etc.). In some embodiments, the implementation of the labeling group is attached to the antigen binding protein using spacer legs of various lengths to reduce possible steric mismatch. Various methods for labeling proteins are known in the art.

Specific labels include optical dyes, including but not limited to chromophores, luminophores and fluorophores, the latter being specific in many cases. Fluorophores can be either small molecule fluorescent agents or protein fluorescent agents. A fluorescent label is understood to mean any molecule that can be detected due to its inherent fluorescent properties. Suitable fluorescent labels include, but are not limited to, fluorescein, rhodamine, tetramethylrhodamine, eosin, erythrosin, coumarin, methylcoumarins, pyrene, Malacite green, stilbene, Lucifer Yellow, Cascade BlueJ, Texas Red, IAEDANS, EDANS, BODIPYFL, LC Red 640, Cy 5, Cy 5.5, LC Red 705, Oregon green, Alexa-Fluor dyes (Alexa Fluor 350, Alexa Fluor 430, Alexa Fluor 488, Alexa Fluor 546, Alexa Fluor 568, Alexa Fluor 594, Alexa Fluor 633 , Alexa Fluor 660, Alexa Fluor 680), Cascade Blue, Cascade Yellow, and R-Phycoerythrin (PE) (Molecular Probes, Eugene, OR), FITC, Rhodamine, and Texas Red (Pierce, Rockford, IL), Cy5, Cy5.5 , Cy7 (Amersham Life Science, Pittsburgh, PA).

Suitable optical dyes, including fluorophores, are described in the Molecular Probes Handbook by Richard P. Haugland, specifically incorporated herein by reference.

Suitable protein fluorescent labels also include, but are not limited to, green fluorescent protein (GFP), including GFP of the species Renilla, Ptilosarcus or Aequorea (Chalfie et al., 1994, Science, 263:802-805), EGFP (Clontech Labs., Inc., Genbank Accession Number U55762), blue fluorescent protein (BFP, Quantum Biotechnologies, Inc., Quebec, Canada; Stauber, 1998, Biotechniques, 24:462-471; Heim et al., 1996, Curr Biol. 6:178-182), enhanced yellow fluorescent protein (EYFP, Clontech Labs., Inc.), luciferase (Ichiki et al., 1993, J. Immunol. 150:5408-5417), β-galactosidase (Nolan et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:2603-2607) and Renilla (WO 92/15673, WO 95/07463, WO 98/14605, WO 98/26277, WO 99/49019, patents US No. 5292658, 418155, 5683888, 5741668, 5777079, 5804387, 5874304, 5876995, 5925558).

Also provided are nucleic acids that encode the antigen-binding proteins described herein, or portions thereof, including nucleic acids encoding one or both of an antibody chain or fragment, derivative, mutein, or variant thereof, polynucleotides encoding heavy chain variable regions, or CDRs alone. , polynucleotides suitable for use as hybridization probes, PCR primers, or sequencing primers for identifying, assaying, mutating, or amplifying a polynucleotide encoding a polypeptide, antisense nucleic acids for inhibiting the expression of a polynucleotide, and complementary sequences of all of the above. Nucleic acids can be of any length. For example, their length can be 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 75, 100, 125, 150, 175, 200, 250, 300, 350, 400, 450, 500, 750, 1000, 1500, 3000, 5000 or more nucleotides, and/or they may contain one or more additional sequences, such as regulatory sequences, and/or be part of a longer nucleic acid, such as a vector. Nucleic acids may be single-stranded or double-stranded and may contain RNA and/or DNA nucleotides, as well as artificial variants thereof (eg, peptide nucleic acids). Any variable region provided herein can be fused to these constant regions to form complete heavy and light chain sequences. However, it should be understood that these constant region sequences are provided only as specific examples. In some embodiments, variable region sequences are fused to other constant region sequences known in the art.

Nucleic acids encoding specific antigen-binding proteins or portions thereof (eg, full-length antibody, heavy or light chain, variable domain, or CDRH1, CDRH2, CDRH3, CDRL1, CDRL2, or CDRL3) can be isolated from B lymphocytes from mice that have been immunized with GIPR or its immunogenic fragment. The nucleic acid can be isolated using conventional procedures such as the polymerase chain reaction (PCR). Phage display is another example of a known method by which antibody derivatives and other antigen-binding proteins can be obtained. In one approach, polypeptides that are components of an antigen-binding protein of interest are expressed in any suitable recombinant expression system and allow folding of the expression.

- 275 040374 bath polypeptides for the formation of antigen-binding proteins.

In one aspect, nucleic acids are further provided that hybridize to other nucleic acids under specific hybridization conditions. Nucleic acid hybridization methods are well known in the art. See, for example, Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. As defined herein, under moderately stringent hybridization conditions, use a prewash solution containing 5x sodium chloride/sodium citrate (SSC), 0.5% SDS, 1.0 mM EDTA (pH 8.0), buffer for hybridization from about 50% formamide, 6x SSC, and a hybridization temperature of 55°C (or other similar hybridization solutions such as those containing about 50% formamide at a hybridization temperature of 42°C) and washing conditions at 60°C, in 0.5x SSC, 0.1% SDS. Under stringent hybridization conditions, hybridization is carried out in 6x SSC at 45°C, followed by one or more washes in 0.1x SSC, 0.2% SDS at 68°C. In addition, one skilled in the art can control the hybridization and/or wash conditions to increase or decrease the stringency of hybridization such that nucleic acids containing nucleotide sequences that are at least 65, 70, 75, 80, 85, 90 , 95, 98 or 99% identical to each other, as a rule, hybridized with each other.

The main parameters influencing the selection of hybridization conditions and guidance for developing suitable conditions are given, for example, in Sambrook, Fritsch, and Maniatis (2001, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., supra; and Current Protocols in Molecular Biology, 1995, Ausubel et al., eds., John Wiley & Sons, Inc., sections 2.10 and 6.3-6.4) and can be easily determined by those of ordinary skill in the art, based, for example, on the length and/or nucleotide composition of the nucleic acid.

Through mutations, changes can be made to a nucleic acid, thereby resulting in changes in the amino acid sequence of the polypeptide (eg, antibody or antibody derivative) that it encodes. Mutations can be introduced using any method known in the art. In one embodiment, one or more specific amino acid residues are altered using, for example, a site-directed mutagenesis protocol. In another embodiment, one or more randomly selected residues are altered using, for example, a random mutagenesis protocol. Regardless of the method of implementation, the mutant polypeptide can be expressed and screened for the desired property.

Mutations can be introduced into a nucleic acid without significantly altering the biological activity of the polypeptide it encodes. For example, nucleotide substitutions can be made resulting in amino acid substitutions at non-essential amino acid residues. Alternatively, one or more mutations can be introduced into a nucleic acid that selectively alters the biological activity of the polypeptide it encodes. For example, a mutation can quantitatively or qualitatively change the biological activity. Examples of quantitative changes include an increase, decrease or disappearance of activity. Examples of qualitative changes include a change in the antigenic specificity of an antibody. In one embodiment, a nucleic acid encoding any antigen-binding protein described herein can be mutated to change the amino acid sequence using molecular biology techniques generally recognized in the art. Another aspect relates to nucleic acid molecules that are suitable for use as primers or hybridization probes for the detection of nucleotide sequences. The nucleic acid molecule may contain only a portion of the nucleotide sequence encoding a full-length polypeptide, such as a fragment that can be used as a probe or primer, or a fragment encoding the active site of the polypeptide. Probes based on the nucleic acid sequence can be used to detect a nucleic acid or similar nucleic acids, such as transcripts encoding a polypeptide. The probe may contain a labeling group, such as a radioisotope, a fluorescent compound, an enzyme, or an enzyme cofactor. Such probes can be used to identify a cell that expresses a given polypeptide.

Another aspect relates to vectors containing a nucleic acid encoding a polypeptide or a portion thereof (eg, a fragment containing one or more CDRs or one or more variable region domains). Examples of vectors include, but are not limited to, plasmids, viral vectors, non-episomal mammalian vectors, and expression vectors, such as recombinant expression vectors. Recombinant expression vectors may contain the nucleic acid in a form suitable for expression of the nucleic acid in a host cell. Recombinant expression vectors contain one or more regulatory sequences selected based on host cells to be used for expression that is operably linked to the nucleotide sequence to be expressed. Regulatory sequences include sequences that

- 276 040374 control the constitutive expression of a nucleotide sequence in many types of host cells (e.g. SV40 early gene enhancer, Rous sarcoma virus promoter and cytomegalovirus promoter), sequences that control the expression of a nucleotide sequence only in some host cells (e.g. tissue-specific regulatory sequences , see Voss et al., 1986, Trends Biochem. Sci. 11:287, Maniatis et al., 1987, Science, 236:1237, incorporated herein by reference in its entirety), as well as the sequences that control the inducible expression of a nucleotide sequence in response to a particular treatment or condition (e.g., the metallothionein promoter in mammalian cells and the tet- and/or streptomycin-sensitive promoter in both prokaryotic and eukaryotic systems (see ibid.). Those skilled in the art should be taken into account that the construction of expression The specific vector may depend on such factors as the choice of the host cell to be transformed, the level of expression of the desired protein, etc. Expression vectors can be introduced into host cells to thereby produce proteins or peptides, including nucleic acid-encoded fusion proteins or peptides, as described herein.

Another aspect relates to host cells into which a recombinant expression vector has been introduced. The host cell can be any prokaryotic cell (eg E. coli) or eukaryotic cell (eg yeast, insect or mammalian cells (eg CHO cells)). Vector DNA can be introduced into prokaryotic or eukaryotic cells using conventional transformation or transfection techniques. It is known that for stable transfection of mammalian cells, depending on the used expression vector and transfection method, only a small part of cells can integrate foreign DNA into their genome. To identify and select for these integrants, a gene that encodes a selectable marker (eg, antibiotic resistance) is typically introduced into host cells along with the gene of interest. Preferred selection markers include drug resistance markers such as G418, hygromycin and methotrexate. Cells stably transfected with the introduced nucleic acid, among other methods, can be identified by drug susceptibility selection (eg, cells into which a selectable marker gene is introduced will survive while other cells will die).

Also provided herein are expression systems and constructs in the form of plasmids, expression vectors, transcription or expression cassettes that contain at least one polynucleotide as described above, as well as host cells containing such expression systems and constructs.

The antigen binding proteins provided herein may be prepared by any of a variety of conventional methods. For example, GIPR antigen-binding proteins can be generated by recombinant expression systems using any method known in the art. See, for example, Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyzes, Kennet et al. (eds.) Plenum Press, New York (1980); and Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1988).

Antigen binding proteins may be expressed in hybridoma cell lines (eg, certain antibodies may be expressed in hybridomas) or in cell lines other than hybridomas. Expression constructs encoding these antibodies can be used to transform a mammalian, insect or microbial host cell. Transformation can be performed using any known method of introducing polynucleotides into a host cell, including, for example, packaging the polynucleotide into a virus or bacteriophage, and transducing the host cell with this construct, in accordance with transfection techniques known in the art, examples of which are given in US patent No. 4399216; 4912040; 4740461; No. 4,959,455. The optimal transformation technique used will depend on the type of host cell to be transformed. Methods for introducing heterologous polynucleotides into mammalian cells are well known in the art and include, but are not limited to, dextran-mediated transfection, calcium phosphate precipitation, polybren-mediated transfection, protoplast fusion, electroporation, encapsulation of polynucleotide(s) into liposomes, mixing of nucleic acid with positively charged lipids, as well as direct microinjection of DNA into nuclei.

Recombinant expression constructs typically contain a nucleic acid molecule encoding a polypeptide containing one or more of the following: one or more of the CDRs provided herein; light chain constant region; light chain variable region; a heavy chain constant region (eg, C _H 1, CH2 and/or CH3) and/or another GIPR antigen-binding protein backbone. These nucleotide sequences are inserted into the appropriate expression vector using standard ligation techniques. In one embodiment, a heavy or light chain constant region is added to the C-terminus of an anti-GIPR-specific heavy or light chain variable region and ligated into an expression vector. The vector is usually chosen in such a way that it is functional in

- 277 040374 to the specific host cell used (ie the vector is compatible with the host cell apparatus, allowing amplification and/or gene expression to be carried out). In some embodiments, vectors are used that are involved in the structural analysis of the complementation of protein fragments using protein reporters such as dihydrofolate reductase (see, for example, US patent No. 6270964, which is incorporated herein by reference). Suitable expression vectors can be purchased from, for example, Invitrogen Life Technologies or BD Biosciences (formerly Clontech). Other suitable vectors for cloning and expression of antibodies and fragments include those described in Bianchi and McGrew, 2003, Biotech. Biotechnol. Bioeng. 84:439-44, which is incorporated herein by reference. Additional suitable expression vectors are discussed, for example, in Methods Enzymol., vol. 185 (D.V. Goeddel, ed.), 1990, New York: Academic Press. Typically, expression vectors used in any of the host cells contain sequences for maintaining plasmids as well as for cloning and expression of exogenous nucleotide sequences. Such sequences, collectively referred to as flanking sequences, typically include one or more of the following nucleotide sequences: a promoter, one or more enhancer sequences, an origin of replication, a transcription termination sequence, a complete intron sequence containing a donor and an acceptor site splicing, a sequence encoding a leader sequence for secreting a polypeptide, a ribosome binding site, a polyadenylation sequence, a polylinker region for inserting a nucleic acid encoding a polypeptide to be expressed, and a selectable marker element. Each of these sequences is discussed below.

Optionally, the vector may contain a label encoding sequence, i. e. an oligonucleotide molecule located at the 5' or 3' end of the GIPR antigen-binding protein coding sequence; an oligonucleotide sequence encoding a poly-His (eg hexa-His) or another label such as FLAG®, HA (influenza hemagglutinin) or myc for which there are commercially available antibodies. This label is typically fused to the polypeptide upon expression of the polypeptide and may serve as a means to affinity purify or detect the antigen-binding protein for GIPR from the host cell. Affinity purification can be performed, for example, by column chromatography using antibodies to a given label as an affinity matrix. Optionally, the label can subsequently be removed from the purified GIPR antigen-binding protein in a variety of ways, such as using certain cleavage peptidases.

Flanking sequences can be homologous (i.e., from the same species and/or strain as the host cell), heterologous (i.e., from a different species and/or strain of the host cell), hybrid (i.e., a combination of flanking sequences from more than one source), synthetic or native. Therefore, the source of the flanking sequence can be any prokaryotic or eukaryotic organism, any vertebrate or invertebrate organism, or any plant, provided that the flanking sequence is functional in the host cell apparatus and can be activated by it.

Flanking sequences suitable for vectors can be obtained by any of several methods well known in the art. Typically, the flanking sequences used in the present invention will be previously identified by mapping and/or by restriction endonuclease digestion and thus can be isolated from an appropriate tissue source using suitable restriction endonucleases. In some cases, the complete nucleotide sequence of the flanking sequence may be known. In this case, the flanking sequence can be synthesized using the nucleic acid synthesis or cloning methods described herein.

If all or only part of the flanking sequence is known, then it can be obtained by polymerase chain reaction (PCR) and/or by screening the genomic library with a suitable probe, such as an oligonucleotide and/or a flanking sequence fragment from the same or another species. If the flanking sequence is not known, the DNA fragment containing the flanking sequence can be isolated from a longer piece of DNA, which may contain, for example, a coding sequence, or even another gene or genes. Isolation can be accomplished by restriction endonuclease digestion to obtain the proper DNA fragment, followed by isolation using agarose gel purification, Qiagen® column chromatography (Chatsworth, Calif.), or other methods known to one of skill in the art. The choice of suitable enzymes for this task will be readily apparent to those skilled in the art.

Typically, the origin of replication is part of these commercially acquired prokaryotic expression vectors, and such an origin contributes to amplification.

- 278 040374 plification of the vector in the host cell. If the chosen vector does not contain an origin of replication, it can be chemically synthesized from a known sequence and ligated into the vector. For example, the origin of replication from plasmid pBR322 (New England Biolabs, Beverly, Massachusetts) is suitable for most gram-negative bacteria, and different viral origins of replication are used for cloning vectors in mammalian cells (e.g., SV40, polyoma, adenovirus, vesicular stomatitis virus (VSV ) or papillomaviruses such as HPV or BPV). In general, the origin of replication component is generally not necessary for mammalian expression vectors (for example, the SV40 origin is often used only because it contains the early promoter of the virus). Typically, a transcription termination sequence is located 3' to the end of the polypeptide coding region and serves to terminate transcription. Typically, the transcription termination sequence in prokaryotic cells is a rich G-C fragment followed by a poly-T sequence. While this sequence is easy to clone from a library or even commercially available as part of a vector, it can also be easily synthesized using the nucleic acid synthesis methods provided herein.

The selection marker gene encodes a protein essential for the survival and growth of a host cell growing in a selective culture medium. Exemplary selection marker genes encode proteins that (a) confer resistance to antibiotics or other toxins, such as ampicillin, tetracycline, or kanamycin, to prokaryotic host cells; (b) supplement auxotrophic deficiencies of the cell; or (c) provide essential nutrients not available in complex or well-formulated media. Specific selectable markers are the kanamycin resistance gene, the ampicillin resistance gene, and the tetracycline resistance gene. Preferably, the neomycin resistance gene can also be used for selection in both prokaryotic and eukaryotic host cells.

Other selectable genes can be used to amplify the gene to be expressed. Amplification is a process in which genes necessary for the production of a protein critical for cell growth or survival are repeated sequentially on the chromosomes of successive generations of recombinant cells. Examples of suitable selectable markers for mammalian cells include dihydrofolate reductase (DHFR) and promoterless thymidine kinase genes. Mammalian cell transformants are grown under selection pressure, with only the transformants adapted to survive due to the presence of the selectable gene in the vector. The selection pressure is established by culturing the transformed cells under conditions in which the concentration of the selection agent in the medium is gradually increased, thereby allowing the amplification of both the selection gene and DNA that encodes another gene, such as an antigen-binding protein that binds to a GIPR polypeptide. As a result, an increased amount of a polypeptide, such as an antigen-binding protein, is synthesized from the amplified DNA.

Typically, the ribosome binding site is required to initiate mRNA translation and is characterized by a Shine-Dalgarno sequence (prokaryotes) or a Kozak sequence (eukaryotes). Typically, this element is located 3' to the promoter and 5' to the coding sequence for the polypeptide to be expressed.

In some cases, such as in which glycosylation is desired in the eukaryotic host cell expression system, different presequences or prosequences can be used to improve glycosylation or yield. For example, the peptidase cleavage site of a particular signal peptide may be altered, or prosequences may be added that may also affect glycosylation. The final protein product may have, at position -1 (relative to the first amino acid of the mature protein), one or more additional amino acids indicative of expression that cannot be completely removed. For example, the final protein product may have one or two amino acid residues attached to the amino terminus at the peptidase cleavage site. Alternatively, the use of certain enzymatic cleavage sites may result in a slightly truncated form of the desired polypeptide if enzymatic cleavage occurs in that region within the mature polypeptide.

Typically, expression and cloning will involve a promoter that is recognized by the host organism and is operably linked to a molecule encoding an antigen-binding protein for GIPR. Promoters are non-transcribed sequences located upstream of the start codon (i.e. at the 5' position) of a structural gene (typically between about 100 and 1000 bp (nucleotide base pairs)) that regulates transcription structural gene. Conventionally, promoters are grouped into one of two classes: inducible promoters and constitutive promoters. Inducible promoters, under their control, initiate increased levels of transcription from DNA in response to some change in culture conditions, such as the presence or absence of a nutrient, or a change in temperature. On the other hand, constitutive

- 279 040374 motors uniformly transcribe the gene with which they are functionally linked, i. there is little or no control of gene expression. A large number of promoters are well known and recognized by different potential host cells. A suitable promoter is operably linked to a DNA encoding a heavy chain or light chain containing an antigen-binding protein for GIPR by removing the promoter from the original DNA by restriction enzyme digestion and inserting the desired promoter sequence into the vector.

Suitable promoters for use with yeast host cells are also well known in the art. Yeast enhancers are preferably used with yeast promoters. Suitable promoters for use with mammalian host cells are well known and include, but are not limited to, promoters derived from the genomes of viruses such as polyoma virus, fowl pox virus, adenovirus (such as adenovirus 2), bovine papillomavirus , avian sarcoma virus, cytomegalovirus, retroviruses, hepatitis B virus, and simian virus 40 (SV40). Other suitable mammalian promoters include heterologous mammalian promoters such as heat shock promoters and the actin promoter.

An enhancer sequence can be inserted into a vector to increase the transcription of DNA encoding a light chain or a heavy chain containing an antigen-binding protein to GIPR by higher eukaryotes. Enhancers are cis-acting DNA elements, typically about 10-300 bp long, that act on a promoter to increase transcription. Enhancers are relatively orientation and position independent as they are found at both 5' and 3' positions with respect to the transcription unit. Several enhancer sequences are known to be available from mammalian genes (eg, globin, elastase, albumin, AFP, and insulin). However, as a rule, an enhancer from a virus is used. The SV40 enhancer, cytomegalovirus early promoter enhancer, polyoma enhancer, and adenovirus enhancers known in the art are typical elements that enhance the activation of eukaryotic promoters. Although the enhancer may be located in the vector either at the 5' position or 3' position relative to the coding sequence, as a rule, it is located in the site 5' from the promoter. A sequence encoding an appropriate native or heterologous signal sequence (leader sequence or signal peptide) may be inserted into an expression vector to promote extracellular secretion of the antibody. The choice of signal peptide or leader sequence depends on the type of host cells in which the antibody is produced, and a heterologous signal sequence can replace the native signal sequence. Examples of signal peptides that are functional in mammalian host cells include the following: the interleukin-7 (IL-7) signal sequence described in US Pat. No. 4,965,195; the signal sequence of the interleukin-2 receptor described in Cosman et al., 1984, Nature, 312:768; the signal peptide of the interleukin-4 receptor described in European patent No. 0367566; the signal peptide of the type I interleukin-1 receptor described in US patent No. 4968607; a type II interleukin-1 receptor signal peptide described in European Patent No. 0460846. In one embodiment, the leader sequence comprises SEQ ID NO: 3157 (MDMRVPAQLLGLLLLWLRGARC) which is encoded by SEQ ID NO: 3158 (atggacatga gagtgcctgc acagctgctg ggcctgctgc tgctgtggct gagagcg). In another embodiment, the leader sequence contains SEQ ID NO: 3159 (MAWALLLLTLLTQGTGSWA), which is encoded by SEQ ID NO: 3160 (atggcctggg ctctgctgct cctcaccctc ctcactcagg gcacagggtc ctgggcc).

The expression vectors provided may be constructed from a parent vector, such as a commercially available vector. Such vectors may or may not contain all of the desired flanking sequences. If the vector does not already contain one or more of the flanking sequences described herein, they can be separately obtained and ligated into the vector. The methods used to obtain each of the flanking sequences are well known to those skilled in the art.

Once the vector has been constructed and a nucleic acid molecule encoding a light chain, a heavy chain, or a light chain and a heavy chain containing an anti-GIPR antigen-binding protein sequence has been inserted at the appropriate site on the vector, the completed vector can be inserted into a suitable host cell for amplification. and/or expression of the polypeptide. Transformation of an antigen-binding protein expression vector into a host cell of choice can be accomplished by well-known methods including transfection, infection, calcium phosphate co-precipitation, electroporation, microinjection, lipofection, DEAE-dextran mediated transfection, or other known methods. The method chosen will depend in part on the type of host cell used. These methods and other suitable methods are well known to those skilled in the art and are given, for example, in Sambrook et al., 2001, supra.

When cultured under suitable conditions, the host cell synthesizes an antigen-binding protein, which can subsequently be assembled from the culture medium (if the host cell secretes it into the medium) or directly from the host cell producing it (if it is not secreted). Selection of an appropriate host cell will depend on various factors such as desired levels

- 280 040374 expression, polypeptide modifications that are desirable or necessary for activity (such as glycosylation or phosphorylation), and ease of folding into a biologically active molecule.

Mammalian cell lines suitable for expression as hosts are well known in the art and include, but are not limited to, American Type Culture Collection (ATCC) immortalized cell lines, including but not limited to Chinese ovarian cells. hamster kidney (CHO), HeLa cells, newborn hamster kidney (BHK) cells, monkey kidney (COS) cells, human hepatocellular carcinoma cells (eg, Hep G2) and a number of other cell lines. In some embodiments, cell lines can be selected by determining which cell lines have high expression levels and constitutively produce antigen-binding proteins with GIPR-binding properties. In another embodiment, a cell line can be selected from a B-lymphocyte lineage that does not produce its own antibody, but has the ability to produce and secrete a heterologous antibody.

In one embodiment, this invention relates to an antigen-binding protein produced by a cell expressing one or more of the polynucleotides listed in table. 2-5.

In one aspect, the GIPR binding protein is administered for long-term treatment. In another aspect, binding proteins are administered for short term treatment. Also provided are pharmaceutical compositions that contain an antigen-binding protein for GIPR and can be used in any of the preventive and therapeutic methods disclosed herein. One embodiment also provides a therapeutically effective amount of one or more antigen-binding proteins and a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative and/or adjuvant. Acceptable formulation materials are non-toxic to recipients at the dosages and concentrations used.

In some embodiments, the pharmaceutical composition may contain formulation materials to alter, maintain, or maintain, for example, pH, osmolarity, viscosity, clarity, color, isotonicity, odor, sterility, stability, dissolution or release rate, adsorption, or permeability of the composition. In such embodiments, suitable formulation materials include, but are not limited to, amino acids (such as glycine, glutamine, asparagine, arginine, or lysine); antimicrobials; antioxidants (such as ascorbic acid, sodium sulfite or sodium hydrogen sulfite); buffer solutions (such as borate, bicarbonate, Tris-HCl, citrates, phosphates or other organic acids); bulking agents (such as mannitol or glycine); chelating agents (such as ethylenediaminetetraacetic acid (EDTA)); complexing agents (such as caffeine, polyvinylpyrrolidone, beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin); fillers; monosaccharides; disaccharides and other carbohydrates (such as glucose, mannose or dextrins); proteins (such as serum albumin, gelatin, or immunoglobulins); dyes, flavors and diluents; emulsifying agents, hydrophilic polymers (such as polyvinylpyrrolidone); low molecular weight polypeptides; salt-forming counterions (such as sodium); preservatives (such as benzalkonium chloride, benzoic acid, salicylic acid, thimerosal, phenethyl alcohol, methylparaben, propylparaben, chlorhexidine, sorbic acid, or hydrogen peroxide); solvents (such as glycerin, propylene glycol or polyethylene glycol); sugar alcohols (such as mannitol or sorbitol); suspending agents; surfactants or wetting agents (such as pluronics, PEGs, sorbitan esters, polysorbates such as polysorbate 20, polysorbate, triton, tromethamine, lecithin, cholesterol, tyloxapal); substances that increase stability (such as sucrose or sorbitol); substances that increase tonicity (such as alkali metal halides, preferably sodium or potassium chloride, mannitol, sorbitol); means of delivery; diluents; excipients and/or pharmaceutical adjuvants. REMINGTON'S PHARMACEUTICAL SCIENCES, 18 Edition, (A.R. Genrmo, ed.), 1990, Mack Publishing Company provides additional details and options for suitable agents that may be included in pharmaceutical compositions.

In some embodiments, the optimal pharmaceutical composition will be determined by one of skill in the art depending on, for example, route of administration, delivery format, and desired dose, see, for example, REMINGTON'S PHARMACEUTICAL SCIENCES, supra. In some embodiments, such compositions can affect the physical condition, stability, in vivo release rate, and in vivo clearance rate of the disclosed antigen-binding proteins. In some embodiments, the primary excipient or carrier in the pharmaceutical composition may be either aqueous or non-aqueous in nature. For example, a suitable vehicle or carrier may be water for injection or physiological saline. In some embodiments, anti-GIPR antigen-binding protein compositions can be prepared for storage by mixing the composition of choice, having the desired purity, with optional formulation materials (REMINGTON'S PHARMACEUTICAL

SCIENCES, see above) as a lyophilized tablet or aqueous solution. Additionally, in some embodiments, the GIPR antigen-binding protein can be formulated as a lyophilisate using appropriate excipients such as sucrose.

Pharmaceutical compositions may be selected for parenteral delivery. Alternatively, the compositions may be selected for inhalation or for delivery through the digestive tract, for example, orally. The preparation of such pharmaceutically acceptable compositions is within the skill of the art.

The components of the composition are preferably present at concentrations that are acceptable to the site of administration. In some embodiments, buffer solutions are used to maintain the composition at physiological pH or at a slightly lower pH, typically a pH in the range of about 5 to about 8. parenteral administration of an aqueous solution containing the desired antigen-binding protein that binds human GIPR in a pharmaceutically acceptable carrier. A particularly suitable vehicle for parenteral injection is sterile distilled water in which the GIPR antigen-binding protein is prepared as a sterile, isotonic solution, properly stored. In some embodiments, the formulation may include formulating the desired molecule with a substance, such as injectable microspheres, biodegradable particles, polymeric compounds (such as polylactic acid or polyglycolic acid), granules, or liposomes, that can provide a controlled or sustained release of a product that can be delivered. through injection of a depot substance. In some embodiments, hyaluronic acid, which has the effect of promoting prolonged residence in the bloodstream, can also be used. In some embodiments, implantable drug delivery devices may be used to deliver the antigen binding protein. Some pharmaceutical compositions are formulated for inhalation. In some embodiments, the GIPR antigen-binding proteins are formulated as a dry, respirable powder. In specific embodiments, GIPR antigen-binding protein solutions for inhalation may also be formulated with an aerosol delivery propellant. In some embodiments, the implementation of the solutions can be sprayed. Inhalation administration and methods of preparation are further described in International Patent Application No. PCT/US94/001875, which is incorporated by reference and describes the inhalation delivery of chemically modified proteins. Some compositions may be administered orally. GIPR antigen-binding proteins administered in this manner may be formulated with or without carriers commonly used in formulating solid dosage forms such as tablets and capsules. In some embodiments, the capsule may be designed to release the active portion of the drug at the point in the gastrointestinal tract where bioavailability is maximized and first-stage degradation is minimal. Additional agents may be used to facilitate absorption of the antigen-binding protein to GIPR. Diluents, flavoring agents, low melting waxes, vegetable oils, lubricants, suspending agents, disintegrating agents and binders may also be used.

Some pharmaceutical compositions contain an effective amount of one or more anti-GIPR antigen-binding proteins in admixture with non-toxic excipients that are suitable for tablet formulation. Solutions may be prepared as a single dose by dissolving the tablets in sterile water or other suitable vehicle. Suitable fillers include, but are not limited to, inert diluents such as calcium carbonate, sodium carbonate or bicarbonate, lactose or calcium phosphate; or binding agents such as starch, gelatin or gum arabic; or lubricants such as magnesium stearate, stearic acid or talc.

Additional pharmaceutical compositions will be apparent to those skilled in the art, including formulations comprising GIPR binding proteins with delayed or controlled drug delivery. Also known to those skilled in the art are methods for preparing a number of other sustained or controlled delivery formulations, such as liposome carriers, biodegradable microparticles or porous granules, and injection of a sustained absorption agent. See, for example, International Patent Application No. PCT/US93/00829, which is incorporated by reference and describes the controlled release of porous polymeric microparticles for the delivery of pharmaceutical compositions. Sustained release formulations may include semi-permeable polymeric matrices in the form of molded articles such as films or microcapsules. Sustained release matrices may include polyesters, hydrogels, polylactides (as described in US Patent No. 3,773,919 and European Patent Application Publication EP No. 058481, each of which is incorporated by reference), copolymers of L-glutamic acid, and gamma ethyl-E -glutamate (Sidman et al., 1983, Biopolymers, 2:547-556), poly(2-282 040374 hydroxyethyl methacrylate) (Langer et al., 1981, J. Biomed. Mater. Res. 15:167-277 and Langer, 1982, Chem. Tech. 12:98-105), ethylene vinyl acetate (Langer et al., 1981, supra), or poly-O(-)-3-hydroxybutyric acid (EP Publication No. 133988 ). Sustained release compositions may also include liposomes, which can be prepared by any of several methods known in the art. See, for example, Eppstein et al., 1985, Proc. Natl. Acad. sci. U.S.A. 82:3688-3692; European Patent Application Publication No. EP 036676; EP 088046 and EP 143949 incorporated by reference.

Pharmaceutical compositions used for in vivo administration are generally provided as sterile preparations. Sterilization can be achieved by filtration with sterile filtration membranes. If the composition is lyophilized, sterilization by this method may be performed either before or after lyophilization and reconstitution. Compositions for parenteral administration may be stored in lyophilized form or in solution. Generally, parenteral compositions are placed in a container having a sterile entry port, such as an intravenous solution bag or vial, with a stopper pierceable by a hypodermic needle.

In some formulations, the antigen binding protein has a concentration of at least 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, or 150 mg/mL. In one embodiment, the pharmaceutical composition contains an antigen-binding protein, a buffer solution, and a polysorbate. In another embodiment, the pharmaceutical composition contains an antigen binding protein, a buffer solution, sucrose and a polysorbate. An example of a pharmaceutical composition is a composition containing 50-100 mg/ml antigen-binding protein, 5-20 mm sodium acetate, 5-10% wt./about. sucrose and 0.002-0.008% w/v. polysorbate. Some compositions, for example, contain 65-75 mg/ml antigen-binding protein in 9-11 mm sodium acetate buffer, 8-10% wt./about. sucrose and 0.0050.006% w/v. polysorbate. In some of these compositions, the pH is in the range of 4.5-6. Other compositions have a pH of 5.0-5.5 (for example, a pH of 5.0, 5.2 or 5.4).

Once the pharmaceutical composition has been formulated, it can be stored in sterile vials as a solution, suspension, gel, emulsion, solid, crystal, or as a dehydrated or lyophilized powder. Such formulations may be stored either in ready-to-use form or in a form (eg, lyophilized) that is reconstituted prior to administration. Also available are kits for producing a single dose form. Some kits contain a first container containing a dry protein and a second container containing an aqueous formulation. In some embodiments, kits are provided that contain single and multi-chamber pre-filled syringes (eg, liquid or lyophilized syringes). The therapeutically effective amount of a pharmaceutical composition containing an antigen-binding protein to GIPR to be used will depend, for example, on the therapeutic context and goals. Those skilled in the art will appreciate that suitable dosage levels for treatment will vary depending, in part, on the molecule delivered, the indication for which the GIPR antigen-binding protein is being used, the route of administration, and size (body weight, body surface, or organ size). ) and/or condition (age and general health) of the patient. In some embodiments, the practitioner may titrate the dose and change the route of administration to obtain the optimal therapeutic effect.

The frequency of dosing will depend on the pharmacokinetic parameters of the particular GIPR antigen-binding protein in the drug being used. Typically, the practitioner will administer the composition until the dose that results in the desired effect is reached. Therefore, the composition may be administered as a single dose, or as two or more doses (which may or may not contain the same amount of the desired molecule) over time, or as a continuous infusion through device or catheter implantation. Appropriate doses can be determined by applying appropriate dose-effect relationship data. In some embodiments, antigen-binding proteins may be administered to patients over an extended period of time. In some embodiments, the antigen binding protein is dosed every two weeks, every month, every two months, every three months, every four months, every five months, or every six months.

The method of administration of the pharmaceutical composition is in accordance with known methods, for example oral, through injection, intravenous, intraperitoneal, intracerebral (intraparenchymal), intracerebroventricular, intramuscular, intraocular, intraarterial, intraportal or intralesional way; using sustained release systems or by device implantation. In some embodiments, the compositions may be administered by bolus injection or over an extended period of time by infusion or by device implantation.

The composition may also be administered locally by implantation of a membrane, sponge or other suitable material into which the desired molecule has been imbibed or encapsulated. IN

- 283 040374 In some embodiments where device implantation is used, the device may be implanted in any suitable tissue or organ and delivery of the desired molecule may be by diffusion, timed release bolus, or continuous administration.

It may also be desirable to use pharmaceutical compositions of the antigen binding protein to GIPR ex vivo. In such cases, cells, tissues, or organs that have been removed from the patient are exposed to GIPR antigen-binding protein pharmaceutical compositions, after which the cells, tissues, and/or organs are subsequently implanted back into the patient's body.

The physician will be able to select the appropriate treatment rate and target lipid levels depending on the individual patient profile. One of the accepted standards for the treatment of hyperlipidemia is the National Cholesterol Education Expert Group (NCEP) Third Report on the Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Group III), Final Report, National Institutes of Health, NIH publication No. 02-5215 (2002), the printed publication of which is incorporated herein by reference in its entirety.

The effectiveness of a particular dose can be assessed by observing biomarkers or improvement in certain physiological parameters. Examples of suitable biomarkers include free cholesterol to plasma lipid, free cholesterol to membrane protein, phosphatidylcholine to sphingomyelin, or HDL-C levels.

Also provided herein are compositions comprising an anti-GIPR antigen-binding protein and one or more additional therapeutic agents, as well as methods in which such agents are administered simultaneously or sequentially with an anti-GIPR antigen-binding protein for use in the preventive and therapeutic methods described herein. . One or more additional agents may be co-formulated with the GIPR antigen-binding protein or may be co-administered with the GIPR antigen-binding protein. Generally, the therapeutic methods, compositions, and compounds can also be used in combination with other therapeutic agents in the treatment of various disease states, with the additional agents being administered simultaneously.

In one aspect, the invention relates to a method of treating a subject with a metabolic disorder comprising administering to the subject a therapeutically effective amount of a GLP-1 receptor agonist and a therapeutically effective amount of a GIPR antagonist that specifically binds to a protein having an amino acid sequence having at least 90% amino acid identity. sequences with the amino acid sequence GIPR. A GLP-1 receptor agonist refers to compounds having GLP-1 receptor activity. Such exemplary compounds include exendins, exendin analogs, exendin agonists, GLP-1(7-37), GLP-1(7-37) analogs, GLP-1(7-37) agonists, and the like. The GLP-1 receptor agonist compounds may optionally be amidated. The terms GLP-1 receptor agonist and GLP-1 receptor agonist compound have the same meaning.

The term exendin includes naturally occurring (or synthetic variants of naturally occurring) exendin peptides that are found in the salivary secretions of the Arizona gila-tooth (Heloderma suspectum). Exendins of particular interest include exendin-3 and exendin-4. Exendins, exendin analogs, and exendin agonists for use in the methods described herein may optionally be amidated and may also be in acid form, pharmaceutically acceptable salt form, or any other physiologically active form of the molecule.

In one embodiment, the molar ratio of GLP-1 receptor agonist to GIPR antagonist is about 1:1 to 1:110, 1:1 to 1:100, 1:1 to 1:75, 1:1 to 1: 50, 1:1 to 1:25, 1:1 to 1:10, 1:1 to 1:5, and 1:1. In one embodiment, the molar ratio of GIPR antagonist to GLP-1 receptor agonist is about 1:1 to 1:110, 1:1 to 1:100, 1:1 to 1:75, 1:1 to 1: 50, 1:1 to 1:25, 1:1 to 1:10, and 1:1 to 1:5.

In one embodiment, a GLP-1 receptor agonist is used in combination with a GIPR antagonist in therapeutically effective molar ratios between about 1:1.5 to 1:150, preferably 1:2 to 1:50.

In one embodiment, the GLP-1 receptor agonist and GIPR antagonist are present at doses that are at least about 1.1 to 1.4, 1.5, 2, 3, 4, 5, 6, 7, 8, 9 or 10 times lower than the doses of each individual compound required to treat the pathology and/or disease.

In one embodiment, the GLP-1 receptor agonist is GLP-1(7-37) or a GLP-1(7-37) analogue.

In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semiglutide, and taspoglutide.

In one aspect, the invention relates to a method of treatment comprising administering to a subject a therapeutically effective amount of at least one GLP-1 receptor agonist in combination with administering at least one GIPR antagonist which, when administered to a subject with metabolic symptoms, provides sustained positive effects.

In one embodiment, administration of at least one GLP-1 receptor agonist in combination with administration of at least one GIPR antagonist provides sustained beneficial effects for at least one symptom of a metabolic disorder.

In one embodiment, a therapeutically effective amount of a GLP-1 receptor agonist and a GIPR antagonist are combined prior to administration to a subject.

In one embodiment, a therapeutically effective amount of a GLP-1 receptor agonist and a GIPR antagonist are administered sequentially to a subject.

In one embodiment, the therapeutically effective amounts of the GLP-1 receptor agonist and the GIPR antagonist are synergistically effective amounts.

Exendin-4 (HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (SEQ ID NO: 3163)) is a peptide found in the saliva of the Arizona gila-tooth, Heloderma suspectum; and exendin-3 (HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (SEQ ID NO: 3164)) is a peptide found in the saliva of the Mexican gila-tooth, Heloderma horridum. Exendins share some amino acid sequence similarity with some members of the glucagon-like peptide (GLP) family. For example, exendin-4 shares about 53% sequence identity with glucagon-like peptide-1(GLP-1)(7-37) (HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG (SEQ ID NO: 3184)). However, exendin-4 is transcribed from a separate gene and not from the Arizona gila homologue of the mammalian proglucagon gene from which GLP-1 is expressed. In addition, exendin-4 is not a GLP-1 analogue (7-37) because the structure of the synthetic exendin-4 peptide was not created by sequential modification of the structure of GLP-1. Nielsen et al., Current Opinion in Investigational Drugs, 4(4):401-405 (2003). Synthetic exendin-4, also known as exenatide, is commercially available as BYETTA® (Amylin Pharmaceuticals, Inc. and Eli Lilly and Company). The formulation of exenatide administered once a week is described in WO 2005/102293, the disclosure of which is incorporated herein by reference.

An exendin analog refers to peptides that exhibit the biological activity of the parent exendin peptide, preferably having an activity equal to or better than the parent exendin peptide (e.g., exendin-4), or within five orders of magnitude (plus or minus) of the parent exendin peptide when assessed by known measurement methods in the art, such as receptor binding and/or competition assays as described, for example, Hargrove et al., Regulatory Peptides, 141:113-119 (2007), the disclosure of which is incorporated herein by reference. Preferably, the exendin analogs will bind in such assays with an affinity of less than 1 μM, and more preferably with an affinity of less than 3 nM, less than 1 nM, or less than 0.1 nM. The term exendin analog can also be referred to as an exendin agonist. In a preferred embodiment, the exendin analogue is an exendin-4 analogue. Exendin analogs also include peptides described herein that have been chemically derivatized or altered, e.g., peptides with non-natural amino acid residues (e.g., taurine, β-amino acids, γ-amino acids, and D-amino acids), with C-terminal modifications. functional group such as amides, esters, and with C-terminal ketone modifications and N-terminal functional group modifications such as acylated amines, Schiff bases or cyclization as found, for example, in the amino acid pyroglutamic acid. Exendin analogs may also contain other chemical moieties such as peptide mimetics.

Exemplary exendins and exendin analogues of exendin-4 (SEQ ID NO: 3163); exendin-3 (SEQ ID NO: 3164); Leu ¹⁴ -exendin-4 (SEQ ID NO: 3165); Leu ¹⁴ ,Phe ²⁵ -exendin-4 (SEQ ID NO: 3166); Leu ¹⁴ , Ala ¹⁹ , Phe ²⁵ -exendin-4 (SEQ ID NO: 3167); exendin-4(1-30) (SEQ ID NO: 3168); Leu ¹⁴ -exendin 4(1-30) (SEQ ID NO: 3169); Leu ¹⁴ ,Phe ²⁵ -exendin-4(1-30) (SeQ ID NO: 3170); Leu ¹⁴ ,Ala ¹⁹ ,Phe ²⁵ -exendin 4(1-3o) (SEQ ID NO: 3171); exendin-4(1-28) (SEQ ID NO: 3172); Leu ¹⁴ -exendin-4(1-28) (SEQ ID NO: 3173); Leu ¹⁴ ,Phe ²⁵ -exendin-4(1-28) (SEQ ID NO: 3174); Leu ¹⁴ , Ala ¹⁹ , Phe ²⁵ -exendin-4 (1-28) (SEQ ID NO: 3175); Leu ¹⁴ , Lys ^17I20 , Ala ¹⁹ , Glu ²¹ , Phe ²⁵ , Gln ²⁸ -exendin-4 (SEQ ID NO: 3176); Leu ¹⁴ , Lys ^17.20 , Ala ¹⁹ , Glu ²¹ , Gln ²⁸ -exendin-4 (SEQ ID NO: 3177); octyl-Glu ¹⁴ ,Gln ²⁸ -exendin-4 (SEQ ID NO: 3178); Leu ¹⁴ , Gln ²⁸ , octyl-Glu ³⁴ -exendin-4 (SEQ ID NO: 3179); Phe ⁴ , Leu ¹⁴ , Gln ²⁸ , Lys ³³ , Glu ³⁴ , Ile ^35I36 , Ser ³⁷ -exendin-4(1-37) (SEQ ID NO: 3180); Phe ⁴ , Leu ¹⁴ , Lys ^17I20 , Ala ¹⁹ , Glu ²¹ , Gln ²⁸ -exendin-4 (SEQ ID NO: 3181); Val ¹¹ , Ile ¹³ , Leu ¹⁴ , Ala ¹⁶ , Lys ²¹ , Phe ²⁵ -exendin-4 (SEQ ID NO: 3182); exendin-4-Lys ⁴⁰ (SEQ ID NO: 3183); lixisenatide (Sanofi-Aventis/Zealand Pharma); CJC-1134 (ConjuChem, Inc.); [N ^e -(17-carboxyheptadecanoic acid)Lys ²⁰ ]exendin-4-NH2 (SEQ ID NO: 3208); [N ^e -(17-carboxyheptadecanoyl)Lys ³² ]exendin-4-NH2 (SEQ ID NO: 3209); [desamino-His ¹ ,N ^e -(17-carboxyheptadecanoyl)Lys ²⁰ ]exendin-4-NH2 (SEQ ID NO: 3210); [Arg ^12.27 ,NLe ¹⁴ ,N ^e -(17-carboxyheptadecanoyl)Lys ³² ]exendin-4-NH2 (SEQ ID NO: 3211); [N ^e -(19-carboxynodecanoylamino)Lys ²⁰ ]-exendin-4NH2 (SEQ ID NO: 3212); [N ^e -(15-carboxypentadecanoylamino)Lys ²⁰ ]-exendin-4-NH ₂

- 285 040374 (SEQ ID NO: 3213); [N ^e -(13-carboxytridecanoylamino)Lys ²⁰ ]exendin-4-NH2 (SEQ ID NO: 3214); [N ^e -(11-carboxyundecanoyl-amino)Lys ²⁰ ]exendin-4-NH2 (SEQ ID NO: 3215); exendin-4-Lys ⁴⁰ (e-MPA)NH2 (SEQ ID NO: 3216); exendin-4-Lys ⁴⁰ (e-AEEA-AEEA-MPA)-NH2 (SEQ ID NO: 3217); exendin-4Lys ⁴⁰ (e-AEEA-MPA)-NH ₂ (SEQ ID NO: 3218); exendin-4-Lys ⁴⁰ (e-MPA)-albumin (SEQ ID NO: 3219); exendin-4-Lys ⁴⁰ (e-AEEA-AEEA-MPA)-albumin (SEQ ID NO: 3220); exendin-4-Lys ⁴⁰ (e-AEEA-MPA) albumin (SEQ ID NO: 3221), and the like. AEEA refers to [2-(2-amino)ethoxy)]acetic acid. EDA refers to ethylenediamine. MPA refers to maleimidopropionic acid. Exendins and exendin analogs may optionally be amidated.

In one embodiment, the GLP-1 receptor agonist compound is an exendin-4 analog that has at least 80% sequence identity with exendin-4 (SEQ ID NO: 3163); at least 85% sequence identity with exendin-4 (SEQ ID NO: 3163); at least 90% sequence identity with exendin-4 (SEQ ID NO: 3163); or at least 95% sequence identity with exendin-4 (SEQ ID NO: 3163).

Other exendins and exendin analogs suitable for the methods described in these documents include those described in WO 98/05351; W099/07404; W099/25727; W099/25728; W099/40788; WO00/41546; WO00/41548; W000/73331; WO 01/51078; WO 03/099314; US Pat. No. 6,956,026; 6506724; 6703359; 6858576; 6872700; 6902744; 7157555; 7223725; 7220721; US Publication No. 2003/0036504 and US Publication No. 2006/0094652, the disclosures of which are incorporated herein by reference in their entirety. GLP-1(7-37) analogs refer to peptides that exhibit biological activity similar to that of GLP-1(7-37) when assessed by measurement methods known in the art, such as receptor binding assays or assays for glucose levels in blood in vivo, as described, for example, Hargrove et al., Regulatory Peptides, 141:113-119 (2007), the disclosure of which is incorporated herein by reference. In one embodiment, the term GLP-1(7-37) analog refers to a peptide that has an amino acid sequence with 1, 2, 3, 4, 5, 6, 7, or 8 amino acid substitutions, insertions, deletions, or a combination of two or more of these compared with the amino acid sequence of GLP-1(7-37). In one embodiment, the GLP-1(7-37) analog is GLP-1(7-36)-NH2. GLP-1(7-37) analogs include amidated forms, acid form, pharmaceutically acceptable salt form, and any other physiologically active form of the molecule.

Illustrative analogues of GLP-1(7-37) and GLP-1(7-37) include GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH ₂ (SEQ ID NO: 3185); liraglutide (VICTOZA® from Novo Nordisk); albiglutide (SYNCRIA® from GlaxoSmithKline); taspoglutide (Hoffman La-Roche); dulaglutide (also known as LY2189265; Eli Lilly and Company); LY2428757 (Eli Lilly and Company); desamino-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (Nε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) (core peptide described as SEQ ID NO: 3222); deamino-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (Nε-octanoyl)-GLP-1(7-37) (SEQ ID NO: 3223); Arg ^26.34 , Lys ³⁸ (Nε-(ω-carboxypentadecanoyl))-GLP-1(7-38) (SEQ ID NO: 3224); Arg ^26.34 , Lys ³⁶ (Nε-(γ-Glu(Nα-hexadecanoyl)))-GLP-1(7-36) (core peptide described as SEQ ID NO: 3225); Aib ^8.35 , Arg ^26.34 , Phe ³¹ GLP-1(7-36)) (SEQ ID NO: 3186); HXaa ₈ EGTFTSDVSSYLEXaa ₂₂ Xaa ₂₃ AAKEFIXaa ₃₀ WLXaa ₃₃ Xaa ₃₄ G Xaa ₃₆ Xaa ₃₇ ; wherein Xaa ₃ is A, V or G; Xaa ₂₂ is G, K or E; Xaa ₂₃ is Q or K; Xaa ₃₀ is A or E; Xaa ₃₃ is V or K; Xaa ₃₄ is K, N, or R; Xaa ₃₆ is R or G; and Xaa ₃₇ is G, H, P, or absent (SEQ ID NO: 3187); Arg ³⁴ -GLP-1(7-37) (SEQ ID NO: 3188); Glu ³⁰ -GLP-1(7-37) (SEQ ID NO: 3189); Lys ²² -GLP-1(7-37) (SEQ ID NO: 3190); Gly ^8.36 , Glu ²² -GLP-1(7-37) (SEQ ID NO: 3191); Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1(7-37) (SEQ ID NO: 3192); Gly ^8.36 , Glu ²² , Lys ³³ , Asn ³⁴ -GLP-1(7-37) (SEQ ID NO: 3193); Val ⁸ ,Glu ²² ,Lys ³³ ,Asn ³⁴ ,Gly ³⁶ -GLP-1(7-37) (SEQ ID NO: 3194); Gly ^8.36 , Glu ²² , Pro ³⁷ -GLP-1(7-37) (SEQ ID NO: 3195); Val ⁸ ,Glu ²² ,Gly ³⁶ Pro ³⁷ -GLP-1(7-37) (SEQ ID NO: 3196); Gly ^8.36 , Glu ²² , Lys ³³ , Asn ³⁴ , Pro ³⁷ GLP-1(7-37) (SEQ ID NO: 3197); Val ⁸ , Glu ²² , Lys ³³ , Asn ³⁴ , Gly ³⁶ , Pro ³⁷ -GLP-1(7-37) (SEQ ID NO: 3198); Gly ^8.36 , Glu ²² -GLP-1(7-36) (SEQ ID NO: 3199); Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1(7-36) (SEQ ID NO: 3200); Val ⁸ ,Glu ²² ,Asn ³⁴ ,Gly ³⁶ -GLP-1(7-36) (SEQ ID NO: 3201); Gly ^8.36 ,Glu ²² ,Asn ³⁴ -GLP-1(7-36) (SEQ ID NO: 3202). Each of the GLP-1(7-37) and GLP-1(7-37) analogs may optionally be amidated. In one embodiment, the GLP-1(7-36) or GLP-1(7-37) analogs are covalently linked (directly or through a linking group) to the Fc portion of an immunoglobulin (e.g., IgG, IgE, IgG, and the like. ). For example, any of SEQ ID NOs: 25-40 may be covalently linked to an Fc portion of an immunoglobulin containing the sequence:

AESKYGPPCPPCPAPXaaieXaanXaaisGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQED PEVQFNWYVDGVEVHNAKTKPREEQFXaasoSTYRVVSVLTVLHQDWLNGKEYKCKVS NKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLS LSLGXaa23o;

wherein Xaa ₁₆ is P or E;

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Xaa ₁₇ is F, V or A;

Xaa ₁₈ is L, E or A;

Xaa ₈₀ is N or A and

Xaa ₂₃₀ is K or absent (SEQ ID NO: 3203).

The linking group can be any chemical moiety (eg, amino acids and/or chemical groups). In one embodiment, the connecting group is (-GGGGS-)x (SEQ ID NO: 3204) wherein x is 1, 2, 3, 4, 5, or 6; preferably 2, 3 or 4; more preferably 3.

In one embodiment, the GLP-1(7-37) analog covalently linked to the Fc portion of an immunoglobulin contains the amino acid sequence:

HGEGTFTSDVSSYLEEQAAKEFIAWLVKGGGGGGGSGGGGSGGGGSAESKYGPPCPPC PAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREP QVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF LYSR LTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG (SEQ Ш NO: 3205).

In another embodiment, GLP-1(7-37) or a GLP-1(7-37) analog can be covalently linked (directly or via a linking group) to one or two polyethylene glycol molecules. For example, a GLP-1(7-37) analogue may contain the amino acid sequence:

_HXaa8 EGTFTSDVS

SYLEXaa22QAAKEFIAWLXaa33KGGPSSGAPPPC ₄ 5C46-Z, wherein Xaa ₈ is D-Ala, G, V, L, I, S, or T; Xaa ₂₂ is G, E, D or K; Xaa ₃₃ is: V or I and Z is OH or NH2, (SEQ ID NO: 3206), and optionally (i) one polyethylene glycol component is covalently attached to C ₄₅ , (ii) one polyethylene glycol component is covalently attached to C ₄₆ or (iii) one polyethylene glycol component is covalently attached to C45 and one polyethylene glycol component is covalently attached to C ₄₆ .

In one embodiment, the GLP-1(7-37) analog is

HVEGTFTSDVSSYLEEQAAKEFI

AWLIKGGPSSGAPPPC45C ₄ 6-NH2 (SEQ GO NO: 3207) and optionally (i) one polyethylene glycol component covalently attached to C ₄ , (ii) one polyethylene glycol component covalently attached to C ₄₆ , or (iii) one polyethylene glycol component covalently attached to C ₄₅ and one polyethylene glycol component is covalently attached to C ₄₆ .

In one embodiment, the GLP-1 receptor agonist compound is a peptide that has at least 80% sequence identity with GLP-1(7-37) (SEQ ID NO: 3184); at least 85% sequence identity with GLP-1(7-37) (SEQ ID NO: 3184); at least 90% sequence identity with GLP-1(7-37) (SEQ ID NO: 3184) or at least 95% sequence identity with GLP-1(7-37) (SEQ ID NO: 3184). GLP-1 receptor agonist compounds can be prepared by methods well known in the art, such as peptide purification as described in Eng et al., J. Biol. Chem. 265:20259-62 (1990); standard methods of solid-phase peptide synthesis, as described in Raufman et al., J. Biol. Chem., 267:21432-37 (1992); recombinant DNA methods as described in Sambrook et al., Molecular Cloning: A Laboratory Manual, ^2nd Ed., Cold Spring Harbor (1989); and so on.

Table 7

Exemplary GLP-1 Agonist Sequences

SEQ ID NO: Subsequence Description 3163 HGEGTFTSDLSKQMEEEAVRLFIEWL KNGGPSSGAPPPS Exendin-4 3164 HSDGTFTSDLSKQMEEEAVRLFIEWL KNGGPSSGAPPPS Exendin-3 3165 HGEGTFTSDLSKQLEEEAVRLFIEWL KNGGPSSGAPPPS Eii ^and -exendin-4 3166 HGEGTFTSDLSKQLEEEAVRLFIEFLK NGGPSSGAPPPS Eee ¹⁴ , P11e ²⁵ -exendin-4

- 287 040374

3167 HGEGTFTSDLSKQLEEEAARLFIEFLK NGGPSSGAPPPS Eui ¹⁴ , A1a ¹⁹ , Pye ²⁵ -exendin-4 3168 HGEGTFTSDLSKQMEEEAVRLFIEWL KNGG exendin-4( 1 -3 0) 3169 HGEGTFTSDLSKQLEEEAVRLFIEWL KNGG Leu ¹⁴ -exendin-4(l-30) 3170 HGEGTFTSDLSKQLEEEAVRLFIEFLK NGG Eui ¹⁴ , Pye ²⁵ - exendin-4 (1 -3 0) 3171 HGEGTFTSDLSKQLEEEAARLFIEFLK NGG Eui ¹⁴ , A1a ¹⁹ , Pye ²⁵ -exendin-4(130) 3172 HGEGTFTSDLSKQMEEEAVRLFIEWL KN exendin-4( 1 -28) 3173 HGEGTFTSDLSKQLEEEAVRLFIEWL KN Eep ¹⁴ - exendin-4 (1-28) 3174 HGEGTFTSDLSKQLEEEAVRLFIEFLK N Eui ¹⁴ , Pye ²⁵ - exendin-4 (1-28) 3175 HGEGTFTSDLSKQLEEEAARLFIEFLK N Eui ¹⁴ , A1a ¹⁹ , Pye ²⁵ -exendin-4 (128) 3176 HGEGTFTSDLSKQLEEKAAKEFIEFLK QGGPSSGAPPPS Leu ¹⁴ , Lys ¹⁷ ' ²⁰ , Ala ¹⁹ , Glu ²¹ , Phe ²⁵ , Gl n ²⁸ -exendin-4 3177 HGEGTFTSDLSKQLEEKAAKEFIEWL KQGGPSSGAPPPS Leu ¹⁴ ,Lys ^{17 '20} ,Ala ¹⁹ ,Glu ²¹ ,Gln ²⁸ exendin-4 3178 HGEGTFTSDLSKQ(octylG)EEEAVRLF IEWLKQGGPSSGAPPPS octyl O1u ¹⁴ , O1p ²⁸ -exendin-4 3179 HGEGTFTSDLSKQLEEEAVRLFIEWL KQGGPSS(octylG)APPPS Leu ¹⁴ ,Gln ²⁸ ,oktylGly ³⁴ exendin-4 3180 HGEFTFTSDLSKQLEEEAVRLFIEWLK QGGPSKEIIS Phe ⁴ , Leu ¹⁴ , Gln ²⁸ , Lys ³³ , Glu ³⁴ , He ^35.36 , 8er ³⁷ -exendin-4 (1 -3 7) 3181 HGEFTFTSDDLSKQLEEKAAKEFIEWL KQGGPSSGAPPPS Phe ⁴ ,Leu ¹⁴ ,Lys ^{17 '20} ,Ala ¹⁹ ,Glu ²¹ ,Gl n ²⁸ -exendin-4 3182 HGEGTFTSDLVKILEAEAVRKFIEFLK NGGPSSGAPPPS Val ^u ,Ile ¹³ ,Leu ¹⁴ ,Ala ¹⁶ ,Lys ²¹ ,Phe ²⁵ -exendin-4 3183 HGEGTFTSDLSKQMEEEAVRLFIEWL KNGGPSSGAPPPSK exendin-4-Lys ⁴⁰ 3184 HAEGTFTSDVSSYLEGQAAKEFIAWL VKGRG GLP-l(7-37) 3185 HAEGTFTSDVSSYLEGQAAKEFIAWL VKGR GLP-l(7-36)-NH ₂ 3186 H(Aib)EGTFTSDVSSYLEGQAAREFIA FLVR(Aib)R Aib ⁸ ' ³⁵ ,Arg ²⁶ ' ³⁴ ,Phe ³¹ -GLP-l(736)) 3187 HXaa ₈ EGTFTSDVSSYLEXaa2 ₂ Xaa2 ₃ AA KEFI Xaa ₃ oWLXaa ₃₃ Xaa ₃ 4GXaa ₃ eXaa ₃ 7 wherein Xaa ₈ is A, V, or G Haagg is G, K, or E Xaa ₂₃ is Q or K Xaa ₃ o is is A or E Xaa ₃₃ is V or K Xaa ₃ 4 is K, N, or R Xaa ₃ b is R or G HXaa ₈ EGTFTSDVSSYLEXaa ₂ 2X aa ₂₃ AAKEFIXaa ₃ oWLXaa ₃₃ Xaa ₃ 4 G Xaa ₃ bXaa ₃ 7 wherein Xaa ₈ is A, V, or G Haagg is G, K, or E Haage is Q or K Xaa ₃ o is A or E

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and Haaz? is G, H, P, or absent Haazz represents V or K Haazd is K, N, or R Haase represents R or G and Haaz? is G, H, P, or absent 3188 HAEGTFT SD VS SYLEGQ AAKEFIAWL VRGRG Arg ³⁴ -GLP-l(7-37) 3189 HAEGTFTSDVSSYLEGQAAKEFIEWL VKGRG Glu ³⁰ -GLP-l(7-37) 3190 HAEGTFTSDVSSYLEKQAAKEFIAWL VKGRG Lys ²² -GLP-l(7-37) 3191 HGEGTFTSDVSSYLEEQ AAKEFIAWL VKGGG Gly ^8.36 ,Glu ²² -GLP-l(7-37) 3192 HVEGTFTSDVSSYLEEQ AAKEFIAWL VKGGG Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1 (7-3 7) 3193 HGEGTFTSDVSSYLEEQ AAKEFIAWL KNGGG Gly ^8.36 ,Glu ²² ,Lys ³³ ,Asn ³⁴ -GLP1(7-37) 3194 HVEGTFTSDVSSYLEEQ AAKEFIAWL KNGGG Val ⁸ ,Glu ²² ,Lys ³³ ,Asn ³⁴ ,Gly ³⁶ - GLP-l(7-37) 3195 HGEGTFTSDVSSYLEEQ AAKEFIAWL VKGGP Gly ⁸ ' ³⁶ ,Glu ²² ,Pro ³⁷ -GLP-1 (7-3 7) 3196 HVEGTFTSDVSSYLEEQ AAKEFIAWL VKGGP Val ⁸ ,Glu ²² ,Gly ³⁶ ,Pro ³⁷ -GLP-1 (737) 3197 HGEGTFTSDVSSYLEEQ AAKEFIAWL KNGGP Gly ⁸ ' ³⁶ ,Glu ²² ,Lys ³³ , Asn ³⁴ ,Pro ³⁷ - GLP-l(7-37) 3198 HVEGTFTSDVSSYLEEQ AAKEFIAWL KNGGP Val ⁸ ,Glu ²² ,Lys ³³ ,Asn ³⁴ ,Gly ³⁶ ,Pro ³⁷ -GLP-l(7-37) 3199 HGEGTFTSDVSSYLEEQ AAKEFIAWL VKGG Gly ^8.36 ,Glu ²² -GLP-l(7-36) 3200 HVEGTFTSDVSSYLEEQ AAKEFIAWL VKGG Val ⁸ ,Glu ²² ,Gly ³⁶ -GLP-1 (7-3 6) 3201 HVEGTFTSDVSSYLEEQ AAKEFIAWL VNGG Val ⁸ ,Glu ²² , Asn ³⁴ ,Gly ³⁶ -GLP-1 (736) 3202 HGEGTFTSDVSSYLEEQ AAKEFIAWL VNGG Gly ^8.36 , Glu ²² , Asn ³⁴ -GLP-1 (7-3 6) 3203 AESKYGPPCPPCPAPXaai ₆ Xaai7Xaai ₈ G GPSVFLFPPKPKDTLMISRTPEVTCVV VDVSQEDPEVQFNWYVDGVEVHNA KTKPREEQFXaasoSTYRVVSVLTVLH QDWLNGKEYKCKVSNKGLPSSIEKTI SKAKGQPREPQVYTLPPSQEEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLYSRLTVDK SRWQEGNVFSCSVMHEALHNHYTQK SLSLSLGXaa23o причем Xaai6 представляет собой P или E Хаап представляет собой F, V или A Xaais представляет собой L, E или A Fc part of immunoglobulin

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Xaaso is N or A and Haaso is K or absent 3204 (-GGGGS-)x where x is 1, 2, 3, 4, 5 or 6 Linker 3205 HGEGTFTSDVSSYLEEQAAKEFIAWL VKGGGGGGGSGGGGSGGGGSAESK YGPPCPPCPAPEAAGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSQEDPEVQ FNWYVDGVEVHNAKTKPREEQFNST YRVVSVLTVLHQDWLNGKEYKCKV SNKGLPSSIEKTISKAKGQPREPQVYT LPPSQEEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDG SFFLYSR LTVDKSRWQEGNVFSCSVMHEALHN HYTQKSLSLSLG Fc part of immunoglobulin 3206 HXaasEGTFTSDVS SYLEXaa22QAAKEFIAWLXaa ₃₃ KGGPS SGAPPPC45C46-Z, where Xaas is: D-Ala, G, V, L, I, S or T Haagg is G, E, D or K Xaa ₃₃ is: V or I and Z is OH or NH2 and optionally (i) one polyethylene glycol moiety is covalently attached to C45, (i) one polyethylene glycol moiety is covalently attached to C46, or (iii) one polyethylene glycol moiety is attached to C45 and one polyethylene glycol moiety is attached to C46. Analog GLP 3207 HVEGTFTSDVSSYLEEQAAKEFIAWLI KGGPSSGAPPPC45C46-NH2 and, optionally, wherein (i) one polyethylene glycol fragment covalently attached to C4, (d) one polyethylene glycol fragment covalently attached to C46, or (iii) one polyethylene glycol fragment attached to C45 and one polyethylene glycol fragment attached to C46 Analog GLP 3208 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPS [Na-(17-carboxyheptadecanoic acid)Eus ²⁰ ] exendin-4-MH2 3209 HGEGTFTSDLSKQMEEEAVRLFIEWL KNGGPKSGAPPPS [Na-(17-carboxyheptadecanoyl)Lys ³² ] exendin-4-MH2

- 290 040374

3210 GEGTFTSDLSKQMEEEAVKLFIEWLK NGGPSSGAPPPS [desamino-Hi s\N ^e -( 17carboxyheptadecanoyl)Ey8 ²⁰ ] exendin-4-MH2 3211 HGEGTFTSDLSRQNorLeEEEAVRLFIE WLRNGGPKSGAPPPS [Arg ¹² ' ²⁷ ,NLe ¹⁴ ,N-(17carboxyheptadecanoyl)Ey8 ³² ] exendin-4-MH2 3212 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPS [Na-(19-carboxynodecanoylamino)Ey8 ²⁰ ]exendin-4-18[H2 3213 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPS [Ni-(15-carboxypentadecanoylamino)E y8 ²⁰ ]-exenidn-4-LIII2 3214 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPS [Na-(13-carboxytridecanoylamino)Ey8 ²⁰ ]exendin-4-HH2 3215 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPS [Na-(11-carboxyundecanoylamino)Ey8 ²⁰ exendin-4-18[H2 3216 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-MPA)-MH2 3217 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-AEEA-AEEA-MPA)-NH ₂ 3218 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-AEEA-MPA)-NH ₂ 3219 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-MPA)albumin 3220 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-AEEAAAEA-MPA)-albumin 3221 HGEGTFTSDLSKQMEEEAVKLFIEWL KNGGPSSGAPPPSK exendin-4-Ey8 ⁴⁰ (e-AEEA-MPA)-albumin 3222 AEGTFTSD VS S YLEGQ AAREFIAWLV KGRG ae3aMUHO-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (Na-(YO1u(Na-hexadecanoyl)))-OEP1(7-37) (core peptide described as SEQ III NO: 3222) 3223 AEGTFTSD VS S YLEGQ AAREFIAWLV KGRG fle3aMHHO-His ⁷ ,Arg ²⁶ ,Lys ³⁴ (Noctanoyl)-OEP-1 (7-3 7) 3224 HAEGTFTSDVSSYLEGQAAREFIAWL VRGRGK Arg ²⁶ ' ³⁴ , Lys ³⁸ (N-(cocarboxypentadecanoyl))-OEP1(7-38) 3225 HAEGTFTSDVSSYLEGQAAREFIAWL VRGRGK Arg ²⁶ ' ³⁴ , Lys ³⁶ (N-(Y-Glu(N-ahexad ecanoyl)))-OEP-1 (7-3 6) (core peptide described as SEQ III NO: 3225)

AEEA refers to [2-(2-amino)ethoxy)]acetic acid. EDA refers to ethylenediamine.

MPA refers to maleimidopropionic acid.

The disclosure also provides pharmaceutical compositions comprising the GLP-1 receptor agonist compounds described herein and a pharmaceutically acceptable carrier. The GLP-1 receptor agonist compounds may be present in the pharmaceutical composition in a therapeutically effective amount and may be present in an amount that provides the minimum blood plasma level of the GLP-1 receptor agonist compound necessary for therapeutic efficacy. Such pharmaceutical compositions are known in the art and are described, for example, in US patent No. 7521423; 7456254; WO2000/037098; WO2005/021022; WO2005/102293; W02006/068910; WO 2006/125763; W02009/068910; US Publication No. 2004/0106547 and the like, the disclosure of which is incorporated herein by reference. Pharmaceutical compositions containing the GLP-1 receptor agonist compounds described herein may be provided for peripheral administration, such as parenteral (eg, subcutaneous, intravenous, intramuscular), continuous infusion (eg, intravenous drip, intravenous bolus, intravenous infusion ) nasal or oral administration. Suitable pharmaceutically acceptable carriers and formulations thereof are described in standard formulation textbooks such as Remington's Pharmaceutical Sciences by Martin; and Wang et al., Journal of Parenteral Science and Technology, Technical Report No. 10, Supp. 42:2S (1988). The GLP-1 receptor agonist compounds described herein may be provided as parenteral formulations for injection or infusion. For example, they can be suspended in water; an inert oil such as vegetable oil (eg sesame, peanut, olive oil, etc.) or other pharmaceutically acceptable carrier. In one embodiment, the compounds are suspended in an aqueous vehicle,

- 291 040374 for example in isotonic buffer solution with a pH of from about 3.0 to 8.0 or from about 3.0 to 5.0. The compositions may be sterilized by conventional sterilization techniques or may be sterile filtered. The compositions may contain pharmaceutically acceptable adjuvants necessary to approximate physiological conditions, such as pH buffering agents.

Suitable buffers include, for example, acetic acid buffers. A sustained release repository or depot formulation may be used such that therapeutically effective amounts of the drug are delivered to the bloodstream over many hours or days following subcutaneous injection, transdermal injection, or other delivery method. The desired isotonicity can be achieved using sodium chloride or other pharmaceutically acceptable agents such as dextrose, boric acid, sodium tartrate, propylene glycol, polyols (such as mannitol and sorbitol) or other inorganic or organic solutes. In one embodiment, for intravenous infusion, the composition may contain (1) a GLP-1 receptor agonist compound, (2) sterile water, and optionally (3) sodium chloride, dextrose, or a combination thereof.

Carriers or excipients may also be used to facilitate administration of GLP-1 receptor agonist compounds. Examples of carriers and excipients include calcium carbonate, calcium phosphate, various sugars such as lactose, glucose or sucrose or types of starch, cellulose derivatives, gelatin, vegetable oils, polyethylene glycols, and physiologically compatible solvents. The GLP-1 receptor agonist compounds may also be formulated as pharmaceutically acceptable salts (eg, acid addition salts) and/or complexes thereof. Pharmaceutically acceptable salts are non-toxic salts at the concentration at which they are administered. Pharmaceutically acceptable salts include acid addition salts such as those containing sulfate, hydrochloride, phosphate, sulfamate, acetate, citrate, lactate, tartrate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, cyclohexylsulfamate, and quinate. Pharmaceutically acceptable salts can be derived from acids such as hydrochloric acid, sulfuric acid, phosphoric acid, sulfamic acid, acetic acid, citric acid, lactic acid, tartaric acid, malonic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, ptoluenesulfonic acid, cyclohexylsulfamic acid and quinic acid. Such salts can be prepared, for example, by reacting the free acid or base forms of the product with one or more equivalents of the appropriate base or acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water, which is then removed. in vacuo, or by lyophilization, or by exchanging ions of an existing salt for another ion on a suitable ion exchange resin. Exemplary pharmaceutical compositions of GLP-1 receptor agonist compounds are described in US Pat. Nos. 7,521,423; 7,456,254; US Publications No. 2004/0106547, WO 2006/068910, WO 2006/125763 and the like, the disclosures of which are incorporated herein by reference.

A therapeutically effective amount of the GLP-1 receptor agonist compounds described herein for use in the methods described herein is typically from about 0.01 μg to about 5 mg; about 0.1 µg to about 2.5 mg; about 1 μg to about 1 mg; about 1 to about 50 micrograms; or about 1 to about 25 micrograms. Alternatively, a therapeutically effective amount of the GLP-1 receptor agonist compounds may be from about 0.001 to about 100 micrograms, based on a patient weight of 70 kg; or from about 0.01 to about 50 micrograms based on a patient weight of 70 kg. These therapeutically effective doses may be administered once a day, twice a day, three times a day, once a week, every other week, or once a month, depending on the formulation. The precise dose to be administered is determined, for example, by the formulation, such as an immediate release formulation or an extended release formulation. For transdermal, nasal, or oral dosage forms, the dose may be increased by about 5-fold and about 10-fold. In some embodiments, the GLP-1 receptor agonist will be administered concurrently with the GIPR antigen-binding protein. In one embodiment, the GLP-1 receptor agonist will be administered after the antigen-binding protein to GIPR. In one embodiment, the GLP-1 receptor agonist will be administered prior to the GIPR antigen binding protein. In some embodiments, the subject or patient will already be treated with a GLP-1 receptor agonist before being further treated with an anti-GIPR antigen-binding protein. Antigen binding proteins to GIPR, which are given in this document, are suitable for the detection of GIPR in biological samples. For example, GIPR antigen-binding proteins can be used in diagnostic assays, eg, binding assays to detect and/or quantify GIPR expressed in serum.

The antigen-binding proteins described herein can be used for diagnostic purposes to detect, diagnose, or monitor diseases and/or conditions associated with GIPR. Using the proposed disclosed antigen-binding proteins, the presence of GIPR in a sample can be determined using classical immunohistological methods known to those skilled in the art (e.g., Tijssen, 1993, Practice and Theory of Enzyme Immunoassays, Vol 15 (Eds R.H. Burdon and P.H. van Knippenberg, Elsevier , Amsterdam); Zola, 1987,

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Monoclonal Antibodies: A Manual of Techniques, p. 147-158 (CRC Press, Inc.); Jalkanen et al., 1985, J. Cell.

Biol. 101:976-985; Jalkanen et al., 1987, J. Cell Biol. 105:3087-3096). GIPR detection can be performed in vivo or in vitro.

The diagnostic applications provided herein include the use of antigen-binding proteins to detect GIPR expression. Examples of methods used to determine the presence of GIPR include immunoassay methods such as enzyme-linked immunoassay (ELISA) and radioimmunoassay (RIA).

For diagnostic applications, the antigen binding protein will typically be labeled with a detectable labeling group. Suitable labeling groups include, but are not limited to, radioisotopes or radionuclides (e.g. ³ H, ¹⁴ C, ¹⁵ N, ³⁵ S, ⁹⁰ Y, ⁹⁹ Tc, ⁿ¹ In, ¹²⁵ I, ¹³¹ I), fluorescent groups ( e.g., FITC, rhodamine, lanthanide complex phosphors), enzyme groups (e.g., horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase), chemiluminescent groups, biotinyl groups, or specified polypeptide epitopes recognized by a secondary reporter (e.g., paired leucine sequences). zippers, binding sites for secondary antibodies, metal binding domains, epitope tags). In some embodiments, the implementation of the labeling group is attached to the antigen binding protein using spacer legs of various lengths to reduce possible steric mismatch. Various methods for labeling proteins are known and can be used in the art. In other embodiments, the GIPR antigen-binding protein is isolated and measured using methods known in the art. See, for example, Harlow and Lane, 1988, Antibodies: A Laboratory Manual, New York: Cold Spring Harbor (ed. 1991 and periodic supplements); John E. Coligan, ed., 1993, Current Protocols In Immunology New York: John Wiley & Sons.

In another aspect of the invention, detection of the presence of a molecule of interest that competes for GIPR binding with the proposed antigen-binding proteins is provided. An example of one such assay involves detecting the amount of free antigen-binding protein in a solution containing some GIPR in the presence or absence of the molecule of interest. An increase in free antigen-binding protein (ie, antigen-binding protein that is not bound to GIPR) would indicate that the molecule of interest is able to compete for GIPR binding with the antigen-binding protein. In one embodiment, the antigen binding protein is labeled with a labeling group. Alternatively, the test molecule is labeled and the amount of free test molecule is monitored in the presence and absence of the antigen-binding protein.

GIPR binding proteins can be used to treat, diagnose or improve a metabolic pathology or disorder. In one embodiment, the metabolic disorder being treated is diabetes, such as type 2 diabetes. In another embodiment, the metabolic pathology or disorder is obesity. In other embodiments, the metabolic pathology or disorder is dyslipidemia, elevated glucose levels, elevated insulin levels, or diabetic nephropathy. For example, a metabolic pathology or disorder that may be treatable or ameliorated with a GIPR binding peptide includes a condition in which a person has a fasting blood glucose level of 125 mg/dL or higher, such as 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200 or greater than 200 mg/dl. Blood glucose levels can be determined in a fed or fasting state, or randomly. A metabolic pathology or disorder may also include a pathology in which a subject is at increased risk of developing a metabolic pathology. For a human, such conditions include a fasting blood glucose level of 100 mg/dl. Pathologies that can be treated using a pharmaceutical composition containing a GIPR binding protein can also be found in the American Diabetes Association Standards of Care in Diabetes Care-2011, American Diabetes Association, Diabetes Care, Vol. 34, no. Supplement 1, S11-S61, 2010, is incorporated herein by reference in its entirety.

When used, a metabolic disorder or pathology such as type 2 diabetes, elevated glucose levels, elevated insulin levels, dyslipidemia, obesity, or diabetic nephropathy can be treated by administering a therapeutically effective dose of GIPR binding protein to a patient in need thereof. The introduction can be performed as described herein, for example, by intravenous (IV) injection, intraperitoneal (IP) injection, subcutaneous injection, intramuscular injection or orally in the form of a tablet or liquid dosage form. In some situations, a therapeutically effective or preferred dose of GIPR binding protein may be determined by the clinician. The therapeutically effective dose of the GIPR binding protein will depend, among other things, on the schedule of administration, the single dose of the agent administered, whether the GIPR binding protein is administered in combination with other therapeutic agents, the immune status, and the health of the recipient. The term therapeutically effective dose, as used herein, means the amount of GIPR binding protein that elicits a biological or drug response in a tissue system, animal, or human being sought by a researcher, physician

- 293 040374 or other clinician, which includes alleviating or improving the symptoms of the disease or disorder being treated, i.e. an amount of GIPR binding protein that maintains an observed level of one or more of the desired biological or drug response, such as lowering blood glucose, insulin, triglyceride, or cholesterol levels; weight loss; or improvement in glucose tolerance, energy expenditure, or insulin sensitivity.

It should be noted that the therapeutically effective dose of GIPR binding protein may also vary depending on the desired result. Thus, for example, in situations where a lower blood glucose level is required, the dose of GIPR binding protein will be correspondingly higher than the dose at which a relatively lower blood glucose level is desired. Conversely, in situations where a higher blood glucose level is required, the dose of GIPR binding protein will be correspondingly lower than the dose at which a relatively higher blood glucose level is desired. In various embodiments, a human subject having a blood glucose level of 100 mg/dL or greater may be treated with a GIPR binding protein.

In one embodiment, the method of this disclosure includes initially measuring a baseline level of one or more metabolically important compounds such as glucose, insulin, cholesterol, lipid in a subject. The subject is then administered a pharmaceutical composition containing a GIPR binding protein. After the desired period of time, the level of one or more metabolically important compounds (eg, blood glucose, insulin, cholesterol, lipid) in the subject is again measured. The two levels can then be compared to determine the relative change in a metabolically important compound in a subject. Depending on the outcome of this comparison, a different dosage of the pharmaceutical composition containing the GIPR binding protein may be administered to achieve the desired level of one or more metabolically important compounds. It is noted that a pharmaceutical composition containing a GIPR binding protein may be co-administered with another compound. The identity and properties of the compound co-administered with the GIPR binding protein will depend on the nature of the pathology being treated or ameliorated. A non-limiting list of examples of compounds that can be administered in combination with a pharmaceutical composition containing a GIPR binding protein includes rosiglitizone, pioglithizone, repaglinide, nateglitinide, metformin, exenatide, stiagliptin, pramlintide, glipizide, glimepriridecarbase, and miglitol.

Kits are also provided for carrying out the disclosed methods. Such kits may contain a pharmaceutical composition such as those described herein, including nucleic acids encoding the peptides or proteins provided herein, vectors and cells containing such nucleic acids, and pharmaceutical compositions containing such compounds containing the nucleic acid. which can be provided in a sterile container. Optionally, instructions on how to use the provided pharmaceutical composition to treat a metabolic disorder may also be included or provided to the patient or healthcare provider.

In one aspect, the kit contains (a) a pharmaceutical composition containing a therapeutically effective amount of a GIPR binding protein; and (b) one or more containers for the pharmaceutical composition. Such a kit may also contain instructions for its use; the instructions may be tailored to the particular metabolic disorder being treated. The instructions may describe the use and nature of the materials supplied in the kit. In some embodiments, the kits contain instructions for a patient to administer for the treatment of a metabolic disorder such as elevated glucose levels, elevated insulin levels, obesity, type 2 diabetes, dyslipidemia, or diabetic nephropathy.

The instructions may be printed on a substrate such as paper or plastic, etc., and may be present in kits as a leaflet, as a label on the kit's container or components (eg, attached to the package), and the like. In other embodiments, the instructions are in the form of an electronically stored data file provided on a suitable computer-readable storage medium, such as a CD-ROM, floppy disk, etc. In still other embodiments, the actual instructions are not in the kit, but a means is provided to obtain instructions from a remote source, such as the Internet. An example of this embodiment is a set that contains a web address from which instructions can be viewed and/or from which instructions can be downloaded.

It is often desirable that some or all of the kit components be packaged in suitable packaging to maintain sterility. The kit components may be packaged in a kit containment element to form a single, easy-to-use unit, where the kit containment element, such as a box or similar structure, may or may not be a sealed container, for example, to further maintain the sterility of some or all of the kit components.

Example 1

Preparation of anti-mouse GIPR antibody.

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Immunizations were performed on 129X BL/6 mice from Charles River with GeneGun pooled DNA (pTT5:E3K-muGIPR-E3K and pTT5:Mut1-mGIPR-Mut1) and CA-64. B cells were harvested from the highest titer mice and hybridized with Sp2/0-Ag14 cells to create hybridomas. Antibodies were obtained from hybridomas cultured in HYPERFlask containers at 37°C. The antibody was purified from culture media by affinity chromatography (FF protein A, high salt/pH method), followed by buffer exchange (UV/DF, ultrafiltration/diafiltration). N-terminal sequencing of the variable domains was performed using hybridomas. RNA was isolated from hybridoma lysitis and converted to cDNA by cloning TOPO-TA RACE PCR products. The light chain and heavy chain sequences were confirmed by LC/MS (liquid chromatography/mass spectrometry). The initial isotype of hybridoma antibodies was mouse IgG2a. The subtype was changed to aglycosylated muIgG1 (mutation N297 on G) to render the effector molecules non-functional. The recombinant sequence was cloned by GeneArt seamless cloning into pTT5 and pSLX240 for transient expression in mammalian 293-6E and stable expression in mammalian CHO S, respectively. Expression was performed for 6 days in shake flasks at 36°C. Culture media were collected for purification. All protein lots were purified by affinity chromatography (Mab Select SuRe) followed by cation exchange (SP Sepharose HP) and final buffer exchange (UV/DF) into A5.2Su buffer. Protein analysis (SEC) indicated that all batches contained >98% of the main peak, with <1% of high molecular weight species.

Example 2

In FIG. 1 provides an overview of the pharmacodynamic analysis for tested anti-mouse GIPR antibodies. Seven-week-old male C57BL/6 mice with high fat diet (HFD) obesity were purchased from Jackson Labs. After acquisition, mice were maintained on a high fat diet with Research Diets D12492 (60 kcal% fat) (Research diet) for one to two weeks. Mice were randomized by body weight and injected intraperitoneally with test anti-GIPR antibody or vehicle (10 mM acetate, 150 mM NaCl, pH 5.0) the day before the intraperitoneal glucose tolerance test (IPGTT). Mice were kept from eating for 7 h and IPGTT was performed immediately after administration of exogenous GIP [D-Ala2]-GIP (50 nmol/kg, Phoenix Pharmaceuticals) administered intraperitoneally. Blood samples were taken from the tail vein at the indicated times. Glucose was measured using an AlphaTrak glucometer (Abbott). Blood insulin levels were determined using the EIA Insulin ultra-sensitive kit (mouse) (ALPCO Diagnostics). The results are shown in FIG. 2 and show that the anti-mouse GIPR antibody 2.63.1 antagonizes GIP-induced insulin secretion.

2. 63.1 contains a light chain with the following sequence:

MKLPVRLLVL

SNGDTYLHWY

MFWIPASSSD

LQKPGQSPKL

VVMTQTPLSL

LIYKVSNRFS

PVSLGDQASI SCRSSQSLVH

GVPDRFSGSG

SGTDFTTLKIS

RVEAADLGVY

FCSQSTHVPP

FTFGGGTKLE

IKRAD AARTU

SIFPPSEQL

TSGGASVVCF

LNNFYPKDIN

VKWKIDGSER

QNGVLNSWTD

QDSKDSTYSM

SSTLTLTKDE YERHNSYTCE ATHKTSTSPIVKSFNRNEC (SEQ ID NO: 3161) and 2.63.1 contains a heavy chain with the following sequence:

MGWSYIILFL VATATDVHSQ

NWMHWVKQRP RQGLEWIGEI

VQLQQPGAEL NPSNGRSNYN

VKPGASVKLS

EKFKTKATLT

CRASGYTFTS

VDKSSSTAYM

QLSSLTSEDS AVYYCARFYY

GTSWFAYWGQ

GTLVAVSAAK

TTPPSVYPLA

PGSAAQTNSM VTLGCLVKGY

FPEPVTVTWN

SGSLSSGVHT

FPAVLQSDLY

TLSSSVTVPS STWPSETVTC NVAHPASSTK VDKKIVPRDC GCKPCICTVP EVSSVFIFPP

KPKDVLTITL TPKVTCVVVD ISKDDPEVQF SWFVDDVEVH TAQTQPREEQ

FASTFRSVSE LPIMHQDWLN GKEFKCRVNS

AAFPAPIEKT ISKTKGRPKA

PQVYTIPPPK

EQMAKDKVSL

TCMITDFFPE DITVEWQWNG QPAENYKNTQ

PIMDTDGSYF VYSKLNVQKS NWEAGNTFTC SVLHEGLHNHHTEKSLSHSP GK (SEQ IDNO: 3162).

In one embodiment, the invention provides an anti-mouse GIPR antibody comprising a light chain comprising SEQ ID NO: 3161 and a heavy chain comprising SEQ ID NO: 3162. In one embodiment, the invention relates to an anti-mouse GIPR antibody comprising a light chain variable region. chain from SEQ ID NO: 3161 and the heavy chain variable region from SEQ ID NO: 3162. In one embodiment, the invention provides an anti-mouse GIPR antibody comprising CDRL1, CDRL2 and CDRL3 from SEQ ID NO: 3161 and CDRH1, CDRH2 and CDRH3 from SEQ ID NO: 3162.

Example 3

In FIG. 3 provides an overview of the study used to determine the effects of permanent

- 295 040374 diet-induced obese (DIO) mice with antibody 2.63.1. Male C57BL/6 DIO mice, 18 weeks of age, treated with Research Diets D12492 (60 kcal% fat) were randomized into groups. The treatment was carried out twice a week intraperitoneally for 6 weeks. Blood glucose levels were measured from a tail vein microsample using a glucometer (Abbott) after mice were fasted for 4 hours. Insulin levels were determined using a mouse insulin wide range ELISA (ALPCO Diagnostics). Triglyceride levels were measured using the Infinity Triglyceride Assay Kit (Thermo Scientific). Total cholesterol was measured using the Infinity total cholesterol kit (Thermo Scientific). The tissue composition of the body was determined using a small-sized analyzer of the total tissue composition of the body (Bruker).

For the intraperitoneal glucose tolerance test (IPGTT), mice were fasted for 4 hours. Glucose levels were measured and blood samples were taken from the tail vein prior to IPGTT. IPGTT was performed by intraperitoneal injection of glucose (1 g/kg body weight). Glucose levels were measured 20, 40 and 60 minutes after glucose administration using a glucometer (Abbott). All data are presented in Fig. 4-13. Fig. 4 - antibody 2.63.1 to GIPR leads to a decrease in body weight gain.

In FIG. 5 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in a reduction in fat mass. In FIG. 6 shows that anti-mouse GIPR treatment with antibody 2.63.1 results in a decrease in epididymal white adipose tissue mass. In FIG. 7 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in a decrease in fasting glucose levels. In FIG. 8 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in lower insulin levels. In FIG. 9 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in improved glucose tolerance. In FIG. 10 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in a decrease in total serum cholesterol. In FIG. 11 shows that anti-mouse GIPR treatment with antibody 2.63.1 results in a reduction in hepatocyte microvesicular alteration and corresponding lipid accumulation. In FIG. 12 shows that treatment of anti-mouse GIPR with antibody 2.63.1 results in a decrease in liver weight and triglycerides. Fig. 13 shows reduction of inflammation and reduction of adipocytes surrounded by infiltrating macrophages in epididymal white adipose tissue by anti-mouse GIPR antibody 2.63.1.

After euthanasia, the liver and epididymal fat were removed and weighed using a scale. One piece of each tissue was fixed in 10% buffered formalin for 24 hours. Sectioning and tissue staining were performed as shown in FIG. 11 and 13.

Example 4

Obtaining anti-GIPR antibodies.

Mouse lines.

Fully human anti-human GIPR antibodies were generated by immunization of XENOMOUSE® transgenic mice (US Pat. :13-21; Mendez et al., 1997, Nature Genetics, 15:146-156; Green and Jakobovitis, 1998, J. Ex. Med., 188:483495; Kellerman and Green, Current Opinion in Biotechnology 13, 593- 597, 2002). Animals from the XENOMOUSE® XMG2-K, XMG2-KL, XMG4-K and XMG4-KL lines were used for all immunizations.

Immunizations.

Several immunogens and immunization routes have been used to generate immune responses to human GIPR. For genetic immunizations, mice were immunized 12-14 times over 6-8 weeks using the Helios Gene Gun system according to the manufacturer's instructions (BioRad, Hercules, CA). Briefly, expression vectors encoding wild-type human or rhesus monkey GIPRs were coated with gold beads (BioRad, Hercules, Calif.) and inserted into the epidermis of a shaved mouse or rat abdomen. For soluble protein immunization, mice were immunized with recombinant human GIPR protein presenting the complete N-terminal extracellular domain (1-139). Animals were immunized with recombinant protein mixed with Alum and CpG-ODN 10 times over 4-6 weeks using subcutaneous injections. The initial dose contained 10 micrograms, while subsequent doses contained 5-10 micrograms. GIPR-specific serum titers were monitored by live cell FACS analysis on an Accuri flow cytometer (BD Biosciences) using transiently transfected 293T cells or stably transfected CHO cells. Animals with the highest antigen-specific serum titers against human and rhesus monkey GIPR were sacrificed and used to create hybridomas (Kohler and Milstein, 1975).

Creation of a hybrid.

Animals having suitable serum titers were identified and lymphocytes were obtained from the spleen and/or draining lymph nodes. Pooled lymphocytes (from each immunization group) were separated from lymphoid tissue by trituration in a suitable medium (eg, Dulbecco's Modified Eagle's Medium (DMEM), Invitrogen, Carlsbad, CA). Using standard methods, B-lymphocytes were selected and expanded, and they were hybridized with a suitable hybridization partner using methods known in the art.

Example 5

Binding analysis for GIPR Engineering Panel and Coefficient of Variation (CV) Fixes using MASS-1.

MASS-1, SPR Affinity Sensor - High Throughput Amine and Amine Binding Kit was obtained from Sierra Sensors (Greenville, Rhode Island). Surfactant P-20, 10 mM sodium acetate, pH 4.0 and 10 mM glycine, pH 1.5, were from Biacore, Inc. (Piscataway, New Jersey). Phosphate buffered saline (PBS, 1X, no calcium chloride, no magnesium chloride) was from Gibco. Bovine serum albumin (BSA, fraction V, free of IgG) was from Sigma. Goat antihuFc antibody was from Jackson ImmunoResearch Inc. (West Grove, Pennsylvania).

Immobilization of goat anti-huFc antibody on the surface of the sensor chip was performed according to the manufacturer's instructions. Briefly, the carboxyl groups on the surfaces of the sensor chip were activated by injecting 100 µl of a mixture containing 75 mg/ml N-ethyl-N'-(dimethylaminopropyl)carbodiimide (EDC) and 1.9 mg/ml N-hydroxysuccinimide (NHS) at 12 5 µl/min. Goat anti-huFc antibody was diluted in 10 mM sodium acetate, pH 4.0 to 20 µg/mL and applied to activated chip surfaces (flow cell channel 1-8/A and B) at 12.5 µL/min for 8 min. . Excess reactive groups on the surfaces were deactivated by injecting 100 μl of 1 M ethanolamine. The final level of immobilization was 4000-5000 resonance units (PE).

Binding assays were performed on the surface with immobilized goat anti-huFc antibody using MASS-1. The experiment was carried out at 25°C. The working buffer of the instrument was 0.005% P20/PBS. Goat anti-huFc capture antibody was covalently attached to the surface of the sensor chip through a standard amine bond in flow cell channels 1-8/A and B. Anti-huGIPR antibodies were diluted in sample buffer (0.1 mg/mL BSA, 0.005% P20, PBS) to 10 nM, then captured in channel B of the flow cells. Channel A was the control surface without injection of anti-huGIPR antibody. Channel B acquisition response range was approximately 100-400 PE. Then 200 nM huGIPRECD was passed at a flow rate of 25 μl/min for 3 min through goat anti-huFc antibody capturing huGIPR antibody. After 6 minutes of dissociation, each surface was repaired by injecting 10 mM glycine, pH 1.5, for 30 seconds. Sensorgrams were analyzed using the MASS-1 software (AnalyserR2, version 0.1.6.5).

Each anti-huGIPR antibody sample was captured on the surface of a MASS-1 sensor chip coated with goat anti-huFc antibody. 200 nM huGIPR ECD was applied to the surfaces of the captured samples. After 6 minutes of dissociation, each surface was repaired by injection of 10 mM glycine, pH 1.5. The obtained sensograms showed the binding of huGIPR ECD to an anti-huGIPR antibody of the 6H1 family, see table. 8 and FIG. 15.

In table. Figure 8 summarizes the dissociation rate constant (kd) for samples of the 6H1 family.

Name At iPS Table 8 Protein batch kd [1/s] 21-143_6Н1.005 iPS:359879 PL-42048 9DE-04 21-143_6Н1.006 iPS:361069 PL-42049 l,9E-04 21-143_6Н1.007 iPS:361073 PL-42050 7.6E-04 21-143_6Н1.008 iPS:361077 PL-42051 4.9E-04 21-143_6Н1.009 iPS:361853 PL-42052 7.0E-04 21-143 6H1 iPS:335940 PL-42053 8.3E-04 control 4V 1.007 iPS:336119 PL-40272 l,4E-03

Sensorgrams were analyzed using the MASS-1 software (AnalyserR2, version 0.1.6.5). The graph summarizes the calculated dissociation rate constant (1/s) for test samples binding to huGIPR ECD. The results are shown in FIG. 14A-14Q and 15.

Example 6

Description of the biological assay used to characterize the activity of the tested group of substances.

The cAMP assay (No. 62AM4PEC CISBIO) was used to determine the activity of anti-GIPR antibodies. 293T cells were grown in suspension and transiently transfected with human GIPR using Lipofectamine 2000 (No. 11668027 Life Technologies). 24 hours after transfection, the antibody was titrated from high to low concentration in black 384-well plates (No. 3712 Corning Life Sciences) with a final volume of 10 µl/well in assay buffer (DMEM No. D5671 Sigma supplemented with 15 mM HEPES and 0.1% bovine serum albumin). The GIPR-transfected cells were then added to the assay plate at 10,000 cells/well (10 μl/well) in the presence of 1:40 cAMP-d2 (component of the CISBIO kit). Analytical plates were incubated for 30 min at 37°C, 5% CO ₂ .

- 297 040374

Human GIP working stock (No. 027-02 Phoenix Pharmaceuticals) was prepared in assay buffer at 175 pM and 2.8 mM IBMX and 10 µl/well of this solution was added to assay plates. The plates were then incubated at 37°C, 5% CO ₂ for 30 min. Anti-cAMP-Eu3+ cryptate (component of CISBIO kit) was prepared as 1:40 in conjugation and lysis buffer (component of CISBIO kit) and 15 µl/well of this solution was added to assay plates and incubated for 1 h at room temperature. Time-resolved homogeneous fluorescence data were then acquired on a Tecan Genios Pro multi-mode microplate reader using an excitation wavelength of 320 nM, a delay time of 150 μs, and an integration time of 50 μs. Light emission was then detected at both 620 nM and 665 nM. The data collected was then reported as the FRET ratio for A665/A620 multiplied by a factor of 10,000 according to the CISBIO kit package insert. Percent inhibition of hGIP binding to transiently expressed GIPR was calculated by subtracting the ratio of FRET cells plus hGIP (f1) from the ratio of FRET cells plus antibody plus hGIP (f2) divided by the ratio of FRET cells plus hGIP (f1) subtracted from the ratio of FRET (f3) only cells multiplied by 100: % inhibition = [(f2-f1) / (f3-f1)] x 100. IC60 values are shown in FIG. 14Q-14Q, and the results of cAMP are shown in table. 9.

cAMP analysis Table 9 cAMP analysis GIPR Pers. (Conc. GIPR macaque rhesus mat @ 60% (Conc. mAt @ 60% inhibition in inhibition in iPS_________Design kd [1/s]______nM)_______ nM) ____________ 1 4Н9.004 iPS:336079 4Н9.004 1DE-03 0.12 0.43 iPS:359783 4H9.004.001 1.8E-03 0.51 0.43 iPS:360931 4H9.004.002 1.4E-03 0.75 0.76 iPS:360938 4H9.004.003 1.5E-03 0.59 0.50 iPS:360945 4H9.004.004 1.6E-03 0.81 0.44 iPS:360951 4H9.004.005 1.6E-03 0.27 0.65

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iPS:359763 4H9.004.006 4.2E-03 1.15__________________ 0.35________________ 2 4B1 iPS:335916 4B1 l,7E-03 0.93 0.67 iPS:360957 4B1.010 3.8E-03 2.46 1.14 iPS:360964 4B1.011 l,2E-03 1.34 0.51 iPS:360970 4B1.012 3.0E-03 4.77 1.01 iPS:360976 4B1.013 3.4E-03 4.50 1.35 iPS:360980 4B1.014 2.8E-03 2.46 0.95 iPS:359787 4B1.015 5.6E-03 2.65 0.84 iPS:360984 4BL016 ZDE-OZ 4.87________________ 1.57_________________ 3 18F2 iPS:335924 18F2 l,5E-03 0.72 0.80 iPS:360988 18F2.002 3.8E-03 3.59 2.23 iPS:360997 18F2.003 2.4E-03 6.69 2.01 iPS:361001 18F2.004 5.8E-03 7.04 2.72 iPS:361007 18F2.005 l,4E-03 1.62 1.13 iPS:361011 18F2.006 l,4E-03 1.59 0.52 iPS:361015 18F2.007 3.7E-03 2.72 1.94 iPS:361019 18F2.008 l,2E-03 4.89 1.76 iPS:361023 18F2.009 2.4E-03 2.23 1.28 iPS:361030 18F2.010 3.7E-03 5.73 1.75 iPS:360537 18F2.011 No > [at] > [at] binding tested tested iPS:361037 18F2.012 2.8E-03 7.87 1.88 iPS:361847 18F2.013 2.8E-03 > [at] > [at] tested tested 4 2F11 iPS:335943 2F11 No > [at] > [at] binding tested tested iPS:359942 2F11.002 6.0E-02 103.22 39.97 iPS:361041 2F11.003 9.8E-03 4.79 1.79 iPS:361045 2F11.004 5.3E-02 108.57 35.51 iPS:361051 2F11.005 3.6E-02 84.34 68.57 iPS:361057 2F11.006 1,1E-O2 1.33 1.30 iPS:361061 2F11.007 l,2E-02 2.20 1.82 iPS:361065 2F11.008 3.0E-02 153.65 57.35 iPS:359951 2F11.009 3.6E-02 147.64 36.91 iPS:359958 2F11.010 4.3E-02 15.94________________ 8.24________________ 5 6H1 iPS:335940 6H1 8.3E-04 0.21 iPS:359867 6H1.002 7.6E-04 0.22 0.31 iPS:359871 6H1.003 3.7E-04 0.31 0.18 iPS:359875 6H1.004 l,2E-04 0.12 0.79 iPS:359879 6H1.005 9.1E-O4 0.80 0.49 iPS:361069 6H1.006 l,9E-04 0.59 0.47

-299 040374

iPS:361073 iPS:361077 iPS:361853 6H1.007 6H1.008 6H1.009 7.6E-04 4.9E-04 7.0E-04 0.80 0.60 0.23_________________ 0.55 0.44 0.15________________ 6 6A5 iPS:336090 6A5.004 3.6E-04 0.60 0.76 iPS:361081 6A5.004.001 2.8E-03 0.27 0.90 iPS:361087 6A5.004.002 2.2E-03 0.15 0.88 iPS:361093 6A5.004.003 l,5E-03 0.42 0.78 iPS:361097 6A5.004.004 3.6E-03 0.76 0.97 iPS:361103 6A5.004.005 7.7E-04 0.28 0.62 iPS:361107 6A5.004.006 l,8E-03 0.28 0.77 iPS:361111 6A5.004.007 2.3E-03 0.39 0.61 iPS:361115 6A5.004.008 l,7E-03 0.53 0.82 iPS:361122 6A5.004.009 No > [at] 23.34 binding tested iPS:359898 6A5.004.010 4.6E-03 1.75 081 iPS:359892 6A5.004.011 2.7E-03 1.51__________________ 7 5G12 iPS :362053 5G12.005.001 8.2E-02 15.1 10.9 iPS:336069 5G12.006 7.3E-03 0.6 0.8 iPS:361129 5G12.006.001 8DE-03 1.8 0.9 iPS:361138 5G12.006.002 8DE-03 2.1 1.0 iPS:361142 5G12.006.003 6.2E-03 > [at] > [at] tested tested iPS:359921 5G12.006.004 no sample no sample iPS:361146 5G12.006.005 7.8E-03 26.1 5.3 iPS:361153 5G12.006.006 7.2E-03 1.0____________________ 0.9__________________ 8 2A11 iPS:335959 2A11 no sample no sample iPS:359569 2A11.002 3.0E-03 > [at] > [at] tested tested iPS:335967 2A11.003 No > [at] > [at] binding tested tested iPS:361160 2A11.004 No > [at] > [at] binding tested tested iPS:361167 2A11.005 No > [at] > [at] binding tested tested 9 2G10LC1 iPS:336043 2G10LC1 1.6E-03 0.80 0.67 iPS:361174 2G10_LC1.003 1.1E-03 0.57 0.85 iPS:361180 2G10LC1.004 1.2E-03 0.31 0.58 iPS:361187 2G10LC1.005 8.5E-04 0.72 0.43 iPS:361194 2G10LC1.006 1.0E-03 1.04 0.52 iPS:359611 2G10LC1.007 2.8E-02 68.24 16.31 iPS:359617 2G10LC1.008 2.4E-02 11.93 4.00 iPS:361198 2G10_LC1.009 1.5E-03 2.78 0.71

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iPS:361204 2G10LC1.010 l,4E-03 1.83___________ 0.86________________ 10 17H11 iPS:336101 17H11.004 1,OE-O3 0.27 0.27 iPS:359623 17H11.004,001 9.3E-04 0.27___________ 0.22________________ eleven 18E3 iPS:336026 18E3 3.2E-03 0.31 0.25 iPS:359646 18E3.002 3.3E-03 0.45 0.16 iPS:361208 18E3.003 3.4E-03 0.29 0.12 iPS:359630 18E3.004 3.5E-03 0.31 0.06 iPS:359639 18E3.005 2.8E-03 0.29 0.10 iPS:361212 18E3.006 3.8E-03 0.06 0.12 iPS:361216 18E3.007 3.6E-03 0.07 0.24 iPS:361220 18E3.008 3.2E-03 0.25___________ 0.37________________ 12 5C2 iPS:335972 5C2 2.4E-03 1.30 0.53 iPS:361224 5C2.006 3.2E-02 > [at] > [at] tested tested iPS:361231 5C2.007 2.9E-03 0.28 0.66 iPS:361238 5C2.008 3.0E-02 > [at] > [at] tested tested iPS:359687 5C2.009 2.3E-03 1.27 0.60 iPS:361242 5C2.010 2.6E-02 > [at] > [at] tested tested iPS:361249 5C2.011 2.6E-02 > [at] > [at] tested tested iPS:361256 5C2.012 2.7E-03 1.56 0.65 iPS:361263 5C2.013 l,5E-02 12.01 7.02 iPS:361270 5C2.014 2.5E-03 1.10 0.54 iPS:359671 5C2.015 2.8E-02 > [at] > [at] tested tested iPS:359680 5C2.016 2.9E-02 > LAtj > [at] tested tested 13 11C1 iPS:335988 11C1 4.3E-03 1.24 0.65 iPS:361277 11C1.002 3.5E-03 0.40 0.39 iPS:361284 11C1.003 3.7E-03 0.73 0.48 iPS:361291 11C1.004 3.5E-03 0.29 0.33 iPS:359714 11C1.005 3.9E-03 0.43 0.42 iPS:361295 11C1.006 4.1E-O3 0.48 0.51 iPS:361299 11C1.007 4.1E-O3 0.25 0.40 iPS:361303 11C1.008 3.7E-03 0.15 0.43 iPS:359705 11C1.009 5.3E-02 > [at] > [at] tested tested iPS:361307 11C1.010 3.6E-02 LAtj > [at] tested tested 14 13H12 iPS:335980 13H12 1.5E-O3 0.93 0.67 iPS:361314 13H12.002 1.1E-O3 2.18 0.95 iPS:359746 13H12.003 2.0E-03 2,P 0.83

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iPS:361321 13H12.004 l,8E-03 3.38 0.56 iPS:359739 13H12.005 2.7E-02 > [at] > [at] tested tested iPS:361328 13H12.006 6.3E-04 1.87_________________ 0.92___________ 15 12H11 iPS:335996 12H11 2.9E-03 3.17 0.79 iPS:361332 12H11.002 3.4E-03 1.01 0.45 iPS:361339 12H11.003 3.9E-03 0.71 0.60 iPS:361346 12H11.004 > [at] > [at] tested tested iPS:361353 12H11.005 3.8E-03 1.28 0.61 iPS:36136O 12H11.006 3.6E-03 0.47 0.59 iPS:361367 12H11.007 3.0E-03 0.76 0.56 iPS:361374 12H11.008 2DE-03 0.95 0.56 iPS:361381 12H11.009 2.4E-03 0.77 0.60 iPS:361385 12H11.010 2.6E-03 1.09 0.71 iPS:361389 12H11.011 3.3E-03 0.56 0.47 iPS:361393 12H11.012 l,3E-03 0.43 0.57 iPS:361397 12H11.013 3.7E-02 > [at] > [at] tested tested iPS:361404 12H11.014 3.6E-02 > [at] > [at] tested tested 16 2C2 iPS:336177 2C2.005 7DE-04 0.89 0.61 iPS:361408 2C2.005.001 l,6E-03 0.73 0.96 iPS:361414 2C2.005.002 l,5E-03 0.94 0.95 iPS:36142O 2C2.005.003 l,0E-03 0.86 1.23 iPS:361426 2C2.005.004 l,5E-03 0.97 1.26 iPS:361432 2C2.005.005 l,6E-03 0.07 0.85 iPS:361438 2C2.005.006 l,2E-03 0.69 0.97 iPS:361444 2C2.005.007 l,2E-03 0.62 0.76 iPS:36145O 2C2.005.008 l,2E-03 0.78 0.65 iPS:361456 2C2.005.009 l,4E-03 0.82 0.68 iPS:361462 2C2.005.010 l,4E-03 0.76 0.58 iPS:361468 2C2.005.011 l,6E-03 0.75 0.49 iPS:361474 2C2.005.012 l,5E-03 0.69 0.50 iPS:36148O 2C2.005.013 2.7E-03 1.33 1.23 iPS:361487 2C2.005.014 2.8E-03 2.23 1.14 iPS:361857 2C2.005.015 1DE-03 3.07_________________ 0.83____________ 17 17B11 iPS:336171 17B11.002 ZDE-OZ <0.1nM 0.21 iPS:361493 17B11.002.001 2.8E-03 0.06 0.29 iPS:361501 17B11.002.002 3.0E-03 0.11 0.00 iPS:361505 17B11.002.003 2DE-03 0.09 0.08 iPS:361509 17B11.002.004 2.6E-03 0.82 0.17 iPS:361516 17B11.002.005 3.2E-03 0.22 0.08 iPS:360584 17B11.002.006 3.6E-03 0.17 0.00 iPS:361520 17B11.002.007 l,4E-02 0.96 0.90 iPS:360572 17B11.002.008 l,9E-02 6.37 7.89

Example 7

In FIG. 16 provides an overview of the mouse pharmacodynamic analysis for the tested anti-GIPR antibodies. Male C57BL/6 DIO mice at 16 weeks of age were purchased from Jackson Laboratories. After acquisition, mice were maintained on a high fat diet (60 kcal% fat, Research Diets) for 2 weeks prior to pharmacological study. Four days before the start of treatment, after 4 hours of fasting fasting, glucose and insulin were measured. Body weight was determined twice a week during the week before treatment and on the day of treatment. Mice were randomized into groups and received one of the following therapies: 1) vehicle (10 mM acetate, 150 mM NaCl, pH 5.0), 2) 0.008 mg/kg 5G12.006, 3) 0.04 mg/kg 5G12 .006, 4) 0.2 mg/kg 5G12.006, 5) 1 mg/kg 5G12.006, 6) 5 mg/kg 5G12.006. All drugs were administered intraperitoneally once a week for 4 weeks. Body weight was measured twice a week. The results are shown in FIG. 17. Anti-GIPR antibody

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5G12.006 binds to both mouse and human GIPR.

Example 8

The study scheme is shown in Fig. 18. Male diet-induced obesity C57BL/6 mice (Jackson Lab), aged 18 weeks at start (12 weeks on a high fat diet) were randomized based on body weight. Mice were dosed every week for 4 weeks. Body weights were determined twice a week; non-fasting glucose measurement was performed on day 18, and fasting insulin measurement was performed on day 29. Blood collection after euthanasia was performed to measure total cholesterol and triglycerides. An intraperitoneal glucose tolerance test (IPGTT) was performed on day 25 with a preliminary 4-hour fast with 1 g/kg glucose. After 4 weeks, the study was terminated followed by a 4-hour fast. Serum samples were collected and the livers were weighed. Blood was collected from the tail vein or by cardiac puncture after euthanasia. Serum samples were obtained by centrifugation of blood collection tubes at 10,000 rpm. Serum insulin levels were determined using ELISA, which determines a wide range of mouse insulin levels (ALPCO Diagnostics). Triglyceride levels were measured using the Infinity Triglyceride Assay Kit (Thermo Scientific). Total cholesterol was measured using the Infinity total cholesterol kit (Thermo Scientific). After euthanasia, the liver and epididymal fat were removed and weighed using a scale. In FIG. 19 shows that GIPR treatment with the 5G12.006 antibody results in a reduction in body weight gain. In FIG. 20 shows that GIPR treatment with the 5G12.006 antibody results in improved glucose tolerance. In FIG. 21 shows that GIPR treatment with the 5G12.006 antibody results in a decrease in glucose and insulin levels. In FIG. 22 shows that GIPR treatment with 5G12.006 resulted in a decrease in liver weight. In FIG. 23 shows that the GIPR antibody 5G12.006 reduces total cholesterol levels.

Example 9

In FIG. 24 provides an overview of a study used to determine the effects of chronic treatment of diet-induced obese (DIO) mice with mouse anti-mouse GIPR Ab (2.63.1.) in combination with GLP-1R agonist liraglutide. Male C57BL/6 DIO mice were purchased from Jackson Laboratories. Mice were housed separately and continued to be maintained on a high fat diet (60 kcal% fat, Research Diets). Mice at 35 weeks of age were randomized into groups and received one of the following: A) vehicle (10 mM acetate, 9% sucrose, pH 5.2, and saline); B) 2.63.1 (30 mg/kg, twice a week); C) liraglutide (0.3 mg/kg, once a day) and D) 2.63.1 (30 mg/kg, twice a week) and liraglutide (0.3 mg/kg, once a day). All drugs were administered intraperitoneally.

Blood samples were taken from the tail vein or by cardiac puncture after euthanasia. Serum insulin levels were determined using ELISA, which determines a wide range of mouse insulin levels (ALPCO Diagnostics). Serum leptin levels were measured using the BioVendor mouse and rat leptin ELISA kit. Triglyceride levels were measured using the Infinity Triglyceride Assay Kit (Thermo Scientific). Total cholesterol was measured using the Infinity total cholesterol kit (Thermo Scientific). After euthanasia, the liver, epididymal fat and inguinal fat were removed and weighed using a scale.

The tissue composition of the body was determined using a small-sized analyzer of the total tissue composition of the body (Bruker).

For the oral glucose tolerance test (OGTT), mice were fasted for 4 hours. Glucose levels were measured and blood samples were taken from the tail vein before OGTT was administered. A bolus of glucose (2 g/kg) was administered orally with a gastric tube. Glucose levels were measured 15, 30 and 60 minutes after glucose administration using a glucometer (Abbott).

In FIG. 25-34 show that treatment with anti-mouse GIPR (antibody 2.63.1) alone prevented weight gain, reduced glucose and insulin levels. In addition, a dramatic weight loss was observed when treated with 2.63.1 in combination with liraglutide. The effect is greater than cumulative because the weight loss from the combination treatment was greater than the sum of the weight loss provided by each agent alone, indicating an asynergic effect. The reduced body weight was predominantly the result of fat loss. Mice had improved glucose and insulin levels and improved glucose tolerance when treated with liraglutide and the combination alone. The mice also had significantly reduced serum total cholesterol levels.

Example 10

In FIG. 35 provides an overview of a study used to determine the effects of chronic treatment of diet-induced obese (DIO) mice with mouse anti-mouse GIPR Ab (2.63.1.) in combination with GLP-1R agonist liraglutide, dulaglutide, or IV extendin. Male C57BL/6 DIO mice were purchased from Jackson Laboratories. Mice were housed separately and continued to be maintained on a high fat diet (60 kcal% fat, Research Diets) after acquisition. Mice at 37 weeks of age were randomized into groups and received one of the following: A) vehicle (10 mM acetate, 9% sucrose, pH 5.2 once a week and saline once a day); B) 2.63.1 (25 mg/kg, once a week); C) dulaglutide (1 mg/kg, twice a day

- 303 040374 week); D) 2.63.1 (25 mg/kg, once a week) and dulaglutide (1 mg/kg, twice a week); E) liraglutide (0.3 mg/kg, once a day), F: 2.63.1 (25 mg/kg, once a week) and liraglutide (0.3 mg/kg, once a day), G : extendin IV (0.01 mg/kg, once a day); H: 2.63.1 (25 mg/kg, once a week) and extendin

IV (0.01 mg/kg, once a day). All drugs were administered intraperitoneally.

Blood samples were taken from the tail vein, or by cardiac puncture after euthanasia. Serum insulin levels were determined using ELISA, which determines a wide range of mouse insulin levels (ALPCO Diagnostics). Triglyceride levels were measured using the Infinity Triglyceride Assay Kit (Thermo Scientific). Total cholesterol was measured using the Infinity total cholesterol kit (Thermo Scientific).

The tissue composition of the body was determined using a small-sized analyzer of the total tissue composition of the body (Bruker).

For the oral glucose tolerance test, mice were fasted for 4 hours. Glucose levels were measured and blood samples were taken from the tail vein prior to OGTT. A bolus of glucose (2 g/kg) was administered orally with a gastric tube. Glucose levels were measured 15, 30 and 60 minutes after glucose administration using a glucometer (Abbott).

This study demonstrates that GIPR Ab 2.63.1 has a synergistic effect on body weight loss and fat loss along with the GLP-1R agonists tested: liraglutide, dulaglutide, and exendin IV (FIGS. 35-40).

Example 11.

In FIG. 41 provides an overview of a study used to determine the effects of chronic treatment of diet-induced obese (DIO) mice pretreated with liraglutide with anti-mouse GIPR (Am 2.63.1). Male C57BL/6 DIO mice (17 weeks of age) treated with Research Diets D12492 (60 kcal% fat) for 13 weeks were randomized to groups. During phase 1 (pre-treatment phase), animals were dosed intraperitoneally daily for 2 weeks with either 1) saline (0.9% sodium chloride), 2) liraglutide (BAChem cat. no. H-6724-0005) 0.05 mg/ kg, 3) liraglutide 0.3 mg/kg or 4) liraglutide 0.3 mg/kg in combination with a weekly dose of mouse anti-mouse GIPR (Ab 2.63.1) in vehicle (10 mM acetate, 9% sucrose, pH 5 ,2) 25 mg/kg; the other groups (1-3) received a weekly dose of vehicle. During phase 2 (experimental phase), treatment with mouse anti-mouse GIPR Ab (2.63.1) was started in animals that had been pre-treated with liraglutide. Blood glucose levels were measured from a retroorbital sinus sample using a glucometer (Abbott) after mice were fasted for 4 hours before phase 1, at the end of phase 1, and at the end of the experiment. Insulin levels were determined using ELISA, which determines a wide range of mouse insulin levels (ALPCO Diagnostics). Food intake was averaged over 3 days at the beginning of phase 1, the beginning of phase 2, and the end of phase 2. At autopsy, white adipose tissue (epididymis and inguinal) was collected along with blood after euthanasia. Plasma was analyzed on an Olympus chemical analyzer for liver enzymes, cholesterol, triglycerides, and NEFA. Plasma was analyzed in a multiplex mouse metabolism assay (MMHMAG-44K - EMD Millipore) for mouse hormones. These data indicate that the weight loss effect of anti-GIPR can be observed in animals already treated with a GLP-1R agonist (FIGS. 42-47).

Example 12.

A non-human primate (NHP) model was used to confirm the effect of a GIPR antagonist Ab (antibody) alone or in combination with a GLP1R agonist.

Previously unexperimented, male, spontaneously obese cynomolgus monkeys (Macaca fascicularis) were acclimatized and prepared for experimental manipulations, which were divided into four final treatment groups of n = 10 monkeys each:

Species: Macaca fascicularis.

Body weight: >7.0 kg.

BMI range (body mass index): >41 kg/m ² .

Age range: 10-15 years old.

Source: KBI colony.

Number and sex: 40/males.

Animals were dosed with GIPR Ab antagonist vehicle 2G10_LC1.006 (2G10), dulaglutide, a GLP1R agonist, or a combination of 2G10_LC1.006 and dulaglutide (co-administration), followed by a specific dosing regimen as shown in FIG. 48.

Dulaglutide was administered to the respective groups on a loading dose regimen for 18 days prior to treatment with 2G10_LC1.006. Groups not receiving dulaglutide were treated with dulaglutide buffer during this time.

The main endpoints of the study were body weight, food intake and post-treatment OGTT. Clinical chemistry parameters were also analyzed (FIGS. 48-57). For spontaneously obese cynomolgus monkeys not previously experimented with, weekly treatment with 2G10 for 5 weeks demonstrates a reduction in fasting body weight and triglycerides, as well as preventing the increase in fasting insulin, as well as AUC (area under the curve) glucose and insulin during OGTT. Additionally, body weight, insulin and triglyceride levels were reduced in the 2G10 and dulaglutide treated group compared to the dulaglutide treated group alone.

Example 13

The 2G10_LC1.006 mAb (known as 2G10 below in the figures) was expressed in 293-6E cells. The protein was purified using a SelectSure mAb column and further purified on a size exclusion chromatography column. The purified mAb was digested with immobilized papain at 37° C. for 4 h. The digested Fab and Fc were separated using a SelectSure mAb column. The Fab fragment was further purified on a size exclusion chromatography column.

A caspase-3 cleavage site was introduced into the hinge region for the following antibodies to ensure efficient Fc cleavage: 2C2.005.014 (known as 2C2 below and in the figures), 6H1.004 (known as 6H1 below and in the figures) and 17H11.004.001 ( known as 17H11 below and in the figures). Antibodies were expressed in 293-6E cells and purified with the Select Sure mAb. The purified mAb was digested with caspase-3 at 4°C overnight. Fc, uncleaved mAb and caspase-3 were removed using the His-Trap cascade and a SelectSure mAb column. The Fab fragment was further purified on a size exclusion chromatography column.

Human GIPR ECD (amino acids 24-138) and a truncated version of human GIPR ECD (amino acids 24-123) were expressed in E. coli as inclusion bodies. The inclusion body was solubilized and flipped. The flipped human GCDR ECD was purified on a size exclusion chromatography column and a MonoQ column and further purified on a size exclusion chromatography column.

1. Comprehensive purification and crystallization.

The following huGIPR-Fab complexes were formed by mixing Fab fragments and an excess molar amount of huGIPR:

1) Human ECD GIPR (24-138) with Fab 2G10,

2) Human ECD GIPR (24-138) with Fab 2C2,

3) Human ECD GIPR (24-138) with Fab 6H1,

4) Human GIPR ECD (24-123) with Fab 17H11.

The complexes were incubated on ice for 30 min and purified on a Supderdex 75 16/600 column. Purified complexes were concentrated to 10-15 mg/ml and screened on commercial high-throughput crystallization screens. Crystals were examined under the following conditions for each complex:

huGIPR ECD (24-138) with Fab 2G10: 10% PEG4000 and 20% isopropanol;

huGIPR ECD (24-138) with Fab 2C2: 20-35% PEG4000, 0.2 M MgCl ₂ , 0.1 M Hepes or Tris pH 7.0-8.5;

huGIPR ECD (24-138) with Fab 6H1: 20% PEG4000, 0.1 M Na Citrate, pH 5.5 18% isopropanol;

huGIPR ECD (24-123) with Fab 17H11: 20% PEG4000, 18-20% isopropanol, 0.1 M Na Citrate pH 5.5 or 0.1 M MES, pH 6.0.

2. Data collection and structure resolution.

The crystals were flash frozen in liquid nitrogen with either 25% glycerol supplemented with well solution or oil as a cryoprotectant.

High resolution datasets were collected at Advanced Light Source, Lawrence Berkeley National Laboratory (Berkeley, California) and Advanced Photon Source, Argonne National Laboratory (Chicago, Illinois). The data was processed using XDS and scaled using AIMLESS in the CCP4 software package.

Structure resolution was performed by molecular replacement using the PHASER program, using the published huGIPR ECD domain structure (PDB code: 4HJ0), and the constant and variable domains of the Fab structure (Amgen internal data) as a search model. Iterative structure refinement was done with REFMAC5 in CCP4 or Phenix.refine, and model building was done in COOT.

Interface analysis was performed using the PISA, AREAMOL, and NCONTACT programs in the CCP4 package. The figures were prepared with Pymol.

3. Results.

A. General structure of huGIPR-Fab complexes.

The huGIPR-Fab 2G10 complex was crystallized and a structure with a resolution of 1.9 A was obtained. There are two pairs of huGIPR-Fab 2G10 complexes in the asymmetric element (FIG. 57). Each complex consists of one huGIPR ECD molecule and one Fab 2G10 fragment. The huGIPR molecule uses a typical αββα fold similar to other class B GPCR ECD domains such as GCGR and GLP1R. Fab 2G10 uses all six heavy chain and light chain CDR loops to interact with the huGIPR ECD domain (FIG. 58A). The interface on the huGIPR ECD includes α1, β1-β2 loop, β3-β4 loop, e4-aC loop, and aC. Note that the segment aC is not ordered in the previously resolved structure of the complex

- 305 040374

GIPR-GIP. The area of the solvent-accessible surface involved in the interaction on huGIPR is 1184 A ² , of which 917 A ² is contributed by the 2G10 heavy chain and 267 A ² by the light chain.

The co-crystal structure of the huGIPR-Fab 2C2 complex was obtained at a resolution of 2.3 A. There are two pairs of huGIPR-Fab 2C2 complexes in the asymmetric element (Fig. 59). Each complex consists of one huGIPR ECD molecule and one Fab 2C2 fragment. Fab 2C2 uses heavy chain CDRs H1 and H3 and light chain CDRs L2 to interact with the huGIPR ECD domain (FIG. 60A). The huGIPR ECD domain interface includes α1, a β1-β2 loop, a β3-β4 loop, and a long loop after β4. Helix aC is disordered in the huGIPR-Fab 2C2 complex (FIG. 60B). The total area of the solvent-accessible surface involved in the interaction between huGIPR and Fab 2C2 is 1078 A ² , of which 806 A ² contributes to the 2C2 heavy chain and 272 A ² to the light chain.

The structure of the huGIPR-Fab 6H1 complex was obtained at a resolution of 2.65 A. There is one pair of the huGIPR-Fab 6H1 complex in the asymmetric element (Fig. 61). Fab 6H1 uses all six heavy chain and light chain CDR loops to interact with the huGIPR ECD domain (FIG. 62A). The interface on the huGIPR ECD domain includes α1, the β1-β2 loop, the β3-β4 loop, and a small portion of the loop after β4 (FIG. 62B). The aC helix is disordered in the huGIPR-Fab 6H1 complex. The total area of the solvent-accessible surface involved in the interaction between huGIPR and Fab 6H1 is 784 A ² , of which 505 A ² contributes to the heavy chain of Fab 6H1 and 279 A ² to the light chain. The structure of the huGIPR-Fab 17H11 complex was obtained at a resolution of 1.6 A. There is one pair of the huGIPR-Fab 17H11 complex in the asymmetric element (Fig. 63). Fab 17H11 uses all six heavy chain and light chain CDR loops to interact with the huGIPR ECD domain (FIG. 64A). The interface on the huGIPR ECD domain includes α1, the β1-β2 loop, the β3-β4 loop, and part of the loop after β4. The total area of the solvent-accessible surface involved in the interaction between huGIPR and Fab 17H11 is 739 A ² , of which 299 A ² contributes to the heavy chain of Fab 17H11 and 440 A ² to the light chain.

B. Interface analysis.

Two different methods were used to determine interface residues.

In the first method, interface residues were determined using the difference in interaction with the solvent. Solvent-accessible surface area (ASA) was calculated for each residue in the hdGIPR ECD domain in the complex and compared with the solvent-accessible surface area of the corresponding residue removed from the complex. All amino acids with different ASAs are considered interface residues.

In the second method, interface residues were chosen that had at least one atom within a predetermined distance near its partner protein. Based on the distance, two shells were identified.

1) The nuclear interaction shell includes all residues with a distance shorter than 5.0 A.

2) The boundary shell includes all residues with a distance greater than 5.0 A but shorter than 8.0 A near the partner protein.

A complete list of amino acid residues for human ECD GIPR that interact with four Fabs are listed in the following tables.

Tab. 10. GIPR ECD epitope residues in GIPR-Fab 2G10 complex determined by difference in solvent interaction and distance truncation method.

Tab. 11. GIPR ECD epitope residues in the GIPR-Fab 2C2 complex determined by solvent interaction difference and distance truncation method.

Tab. 12. GIPR ECD epitope residues in the GIPR-Fab 6H1 complex determined by solvent interaction difference and distance truncation method.

Tab. 13: GIPR ECD epitope residues in the GIPR-Fab 17H11 complex determined by solvent interaction difference and distance truncation method.

Important residues on human ECD GCDR that form either a hydrogen bond or an ionic bond with Fab are summarized in Table 1. 14.

Using similar methods, paratope residues were determined for each of the antibodies and the results were summarized in the following tables.

Tab. 15. Fab 2G10 paratope residues determined by solvent interaction difference and distance truncation method.

Tab. 16. Fab 2C2 paratope residues determined by solvent interaction difference and distance truncation method.

Tab. 17. Fab 6H1 paratope residues determined by solvent interaction difference and distance truncation method.

Tab. 18. Fab 17H11 paratope residues determined by solvent interaction difference and distance truncation method.

The Gipg013 antibody epitope (Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor. Ravn, et al. J. Biol. Chem. 2013 Jul 5; 288(27):19760-72) was analyzed based on the published structure of 4HJ0 using the same methods.

The results are summarized in table. 19.

In FIG. 65 shows the epitope of four antibodies (2G10, 2C2, 6H1 and 17H11) and a previously published antibody Gipg013 (PDB 4HJ0) on the surface of the human GIPR ECD domain.

The high resolution crystal structure allowed identification of the interface between the huGIPR ECD and four antibodies. Using two different methods, specific amino acid residues involved in recognition were mapped. The required space and the nature of the interaction for each remainder of the interface are established.

Table 10

GIPR ECD epitope residues in GIPR-Fab 2G10 complex, determined by difference in _______ solvent interaction and distance truncation method ______

GIPR residues within 5A 2G10 GIPR residues within 8A 2G10 Remains of GIPR, identified by difference no ASA thirty GLN 29 GLY thirty GLN 31 THR thirty GLN 31 THR 32 ALA 31 THR 32 ALA 33 GLY 32 ALA 33 GLY 34 GLU 33 GLY 34 GLU 35 LEU 34 GLU 35 LEU 36 TYR 35 LEU 36 TYR 37 GLN 36 TYR 37 GLN 39 TRP 37 GLN 39 TRP 66 A.S.P. 38 ARG 66 A.S.P. 67 MET 39 TRP 67 MET 68 TYR 40 GLU 68 TYR 87 TYR 43 ARG 87 TYR 88 LEU 65 PHE 88 LEU 89 PRO 66 A.S.P. 89 PRO 90 TRP 67 MET 90 TRP 101 ARG 68 TYR 101 ARG 113 ARG 69 VAL 113 ARG 115 HIS 71 TRP 115 HIS 119 GLU 85 PRO 119 GLU 123 LYS 87 TYR 120 ASN 125 GLU 88 LEU 123 LYS 128 LEU 89 PRO 125 GLU 129 A.S.P. 90 TRP 128 LEU 132 ARG 101 ARG 129 A.S.P. 133 LEU 111 LEU 132 ARG 112 TRP 133 LEU 113 ARG 115 HIS 116 THR 118 CYS 119 GLU 120 ASN 122 GLU 123 LYS 124 ASN 125 GLU 126 ALA 128 LEU 129 A.S.P. 130 GLN 131 ALA 132 ARG 133 LEU 134 ILE

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Table 11

GIPR ECD epitope residues in the GIPR-Fab 2C2 complex determined by difference in solvent interaction and distance truncation method

GIPR residues within 5A 2C2 GIPR remnants within 8A 2C2 Remains of GIPR, identified by difference no ASA 31 THR thirty GLN 32 ALA 32 ALA 31 THR 35 LEU 35 LEU 32 ALA 36 TYR 36 TYR 33 GLY 39 TRP 39 TRP 34 GLU 62 ASN 62 ASN 35 LEU 64 SER 64 SER 36 TYR 65 PHE 65 PHE 39 TRP 66 A.S.P. 66 A.S.P. 40 GLU 67 MET 67 MET 43 ARG 68 TYR 68 TYR 47 GLN 87 TYR 71 TRP 60 ALA 88 LEU 87 TYR 61 CYS 89 PRO 88 LEU 62 ASN 90 TRP 89 PRO 63 GLY 101 ARG 90 TRP 64 SER 104 GLY 101 ARG 65 PHE 105 SER 104 GLY 66 A.S.P. 106 A.S.P. 105 SER 67 MET 108 GLN 106 A.S.P. 68 TYR 109 TRP 108 GLN 69 VAL BUT GLY 109 TRP 71 TRP 111 LEU BUT GLY 77 ASN 112 TRP 111 LEU 85 PRO 113 ARG 112 TRP 87 TYR 114 A.S.P. 113 ARG 88 LEU 115 HIS 114 A.S.P. 89 PRO 116 THR 115 HIS 90 TRP 118 CYS 116 THR 99 VAL 119 GLU 119 GLU 100 LEU 120 ASN 101 ARG 102 GLN 103 CYS 104 GLY 105 SER 106 A.S.P. 107 GLY 108 GLN 109 TRP BY GLY 111 LEU 112 TRP 113 ARG 114 A.S.P. 115 HIS 116 THR 117 GLN 118 CYS 119 GLU 120 ASN 121 PRO

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Table 12

GIPR ECD epitope residues in the GIPR-Fab 6H1 complex determined by solvent interaction difference and distance truncation method

GIPR residues within 5A 6H1 Remains of GIPR within 8A 6H1 Remains of GIPR, identified by difference no ASA 32 ALA 32 ALA 32 ALA 33 GLY 33 GLY 33 GLY 34 GLU 34 GLU 34 GLU 36 TYR 35 LEU 35 LEU 37 GLN 36 TYR 36 TYR 40 GLU 37 GLN 37 GLN 43 ARG 38 ARG 39 TRP 35 LEU 39 TRP 40 GLU 39 TRP 40 GLU 43 ARG 66 A.S.P. 43 ARG 66 A.S.P. 67 MET 67 MET 67 MET 87 TYR 65 PHE 68 TYR 88 LEU 66 A.S.P. 87 TYR 89 PRO 68 TYR 88 LEU 90 TRP 85 PRO 89 PRO 111 LEU 87 TYR 90 TRP 112 TRP 88 LEU 111 LEU 115 HIS 89 PRO 112 TRP 119 GLU 90 TRP 113 ARG 120 ASN 111 LEU 115 HIS 112 TRP 118 CYS 113 ARG 119 GLU 114 A.S.P. 120 ASN 115 HIS 118 CYS 119 GLU 120 ASN 121 PRO

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Table 13

GIPR ECD epitope residues in the GIPR-Fab 17H11 complex, determined by the difference in _____ solvent interaction and truncation method. distances_____

Remains GIPR identified with Remains GIPR in Remains GIPR's using the difference in within 5А 17Н11 within 8A 17H11 ASA thirty GLN thirty GLN thirty GLN 31 THR 31 THR 31 THR 32 ALA 32 ALA 32 ALA 33 GLY 33 GLY 33 GLY 35 LEU 34 GLU 34 GLU 36 TYR 35 LEU 35 LEU 37 GLN 36 TYR 36 TYR 39 TRP 37 GLN 37 GLN 40 GLU 38 ARG 39 TRP 43 ARG 39 TRP 40 GLU 66 A.S.P. 40 GLU 43 ARG 67 MET 43 ARG 66 A.S.P. 68 TYR 65 PHE 67 MET 87 TYR 66 A.S.P. 68 TYR 88 LEU 67 MET 87 TYR 89 PRO 68 TYR 88 LEU 90 TRP 69 VAL 89 PRO 113 ARG 71 TRP 90 TRP 115 HIS 85 PRO 111 LEU 119 GLU 87 TYR 112 TRP 88 LEU 113 ARG 89 PRO 114 A.S.P. 90 TRP 115 HIS 99 VAL 116 THR 101 ARG 119 GLU 111 LEU 120 ASN 113 ARG 114 A.S.P. 115 HIS 116 THR 118 CYS 119 GLU 120 ASN

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Table 14

List of interface remnant interactions

Interactions between Fab 2G10 heavy chain and huGIPR

Interactions in the form of a hydrogen bond huGIPR | Rust. | 2G10HC

TYR 36 [OH] | 2.8 GLN 100 [OE1] ARG FROM [NH1] | 3.1 | ASN 31[OD1] ARG FROM [NH2] 3.1 SER 30[O] LYS123[NZ] | 2.9 | ASP 54 [ 0 ] ARG 132 [NH2] | 1 3.2 | LYS 58 [ 0 ] 1

Ionic bonds huGIPR | Rust. | 2G10HC

HIS115[NE2] | 3.0 | ASP 54 [OD2] GLU 125 [OE1] | 3.4 | LYS 58 [NZ] ASP 129 [OD1] | 2.9 | LYS 58 [NZ] ASP 129 [OD2] | 3.1 | LYS 58 [NZ]

Interactions between Fab 2G10 light chain and huGIPR

Hydrogen bonds huGIPR | Rust. | 2G10LC

ALA 32 [N] | 3.4 | ASN 93[OD1]

ALA 32 [ N ] I 3.0 I ASN 92 [ O ]

GLY 33 [N] I 2.4 I ASN 92 [O]

GLN 37 [OE1] I 3.2 | ASN 32[ND2]'I

Interactions between Fab 2C2 heavy chain and huGIPR

Hydrogen bonds huGIPR I Rust. | 2S2 NS

ARG FROM [O] I 3.3 I TYR 32 [OH] LEU 111 [O] I 3.5 I ARG 98 [NH2] ASP 66 [OD2] I 2.7 | TYR 113 [OH]

ARG 113 [NH2]| 2.6 | GLY 100 [O]

Interactions between Fab 2C2 light chain and huGIPR

Hydrogen bonds huGIPR | Rust. | 2С2 LC

SER 57[OG] | 3.1 | ASP 106[OD1] GLY 58[N] | 2.8 | ASP 106[OD2] ARG 55 [NE] | 2.6 GLN 108 [OE1] TYR 50 [OH] 3.2 ARG 101 [NH2] GLN 54 [OE1] 3.5 | ASN 62[ND2] PRO 56 [ 0 ] | 3.0 |GLN 108 [NE2] VAL 59 [O ] | 3.1 :GLN 108 [NE2]

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Interactions between Fab 6H1 heavy chain and huGIPR

Hydrogen bonds huGIPR | Rust. | 6N1 NS ---------------------+-------+-----------------LEU111 [About] | 3.8 | TYR 31 [OH]

Interactions between Fab 6H1 light chain and huGIPR huGIPR I Rust. | 6Н1 LC

GLU 34 [N] I 3.6 I L:ASN 92 [O]

Interactions between Fab 17H11 heavy chain and huGIPR

Hydrogen bonds huGIPR | Rust. | 17N11NS

GLN 37 [NE2] | 3.3 | SER 31 [O] ARG 43 [NH2] | 3.8 | TYR 33 [OH] GLU 40 [OE2] | 3.0 | TYR 33 [OH]

Interactions between Fab 17H11 light chain and huGIPR

Hydrogen bonds huGIPR | Rust. | 17H11LC ------------------+-------+----------------ALA 32 [N ] | 3.0 | GLN 55 [OE1] GLN 30 [O] I 3.9 I TYR 49 [OH]

Fab 2G10 paratope residues determined by solvent interaction difference and distance truncation method

Table 15

2G10 Heavy chain 2 G10 Light chain Truncation 5 A Truncation distance 8A Difference no ASA Truncation 5 A Truncation distance 8A ASA difference number remainder number remainder number remainder number remainder number remainder number remainder thirty SER 28 THR thirty SER thirty SER 29 VAL thirty SER 31 ASN 29 RNE 31 ASN 32 ASN thirty SER 31 SER 32 TYR thirty SER 32 TYR 49 TYR 31 SER 32 ASN 52 TRP 31 ASN 51 ILE 91 TYR 32 ASN 49 TYR 53 RNE 32 TYR 52 TRP 92 ASN 33 LEU 91 TYR 54 A.S.P. 33 GLY 53 PHE 93 ASN 46 LEU 92 ASN 55 ALA 50 ALA 54 A.S.P. 94 TRP 49 TYR 93 ASN 56 SER 51 ILE 55 ALA 96 LEU 50 GLY 94 TRP 57 A.S.P. 52 TRP 56 SER 53 THR 96 LEU 58 LYS 53 PHE 57 A.S.P. 90 GLN 59 TYR 54 A.S.P. 58 LYS 91 TYR 60 TYR 55 ALA 59 TYR 92 ASN 65 LYS 56 SER 60 TYR 93 ASN 66 GLY 57 A.S.P. 65 LYS 94 TRP 67 ARG 58 LYS 66 GLY 95 PRO 69 THR 59 TYR 67 ARG 96 LEU 70 ILE 60 TYR 68 PHE 71 SER 61 ALA 69 THR 84 ASN 62 A.S.P. 71 SER 100 GLN 64 VAL 72 ARG 101 ALA 65 LYS 84 ASN 102 ILE 66 GLY 100 GLN 103 PHE 67 ARG 101 ALA 105 VAL 68 PHE 102 ILE 69 THR 103 PHE 70 ILE 105 VAL 71 SER 106 VAL 72 ARG 73 A.S.P. 74 ASN 75 SER 82 GLN 84 ASN 85 SER 98 ARG 99 A.S.P. 100 GLN 101 ALA 102 ILE 103 PHE 104 GLY 105 VAL 106 VAL 108 A.S.P.

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Fab 2C2 paratope residues determined by solvent interaction difference and distance truncation method

Table 16

2S2 Heavy chain 2C2 Light chain Truncation 5 A Truncation distance 8A Difference no ASA Truncation distance 5A Truncation distance 8A Difference no ASA number remainder number remainder number remainder number remainder number remainder number remainder 2 MET 1 GLN 2 MET 47 LEU 32 GLN 47 LEU 26 GLY 2 MET 26 GLY 50 TYR 33 THR 50 TYR 27 TYR 25 SER 27 TYR 54 GLN 35 ASN 54 GLN 28 THR 26 GLY 28 THR 55 ARG 37 TYR 55 ARG 32 TYR 27 TYR thirty THR 56 PRO 46 LYS 56 PRO 98 ARG 28 THR 32 TYR 57 SER 47 LEU 57 SER 100 GLY 29 PHE 98 ARG 58 GLY 48 LEU 58 GLY 101 A.S.P. thirty THR 100 GLY 59 VAL 49 ILE 59 VAL 102 TYR 31 GLY 101 A.S.P. 61 A.S.P. 50 TYR 61 A.S.P. 104 RNU 32 TYR 102 TYR 51 THR 105 GLY 54 ASN 104 PHE 53 ASN 107 TYR 98 ARG 105 GLY 54 GLN BY HIS 99 GLY 107 TYR 55 ARG 111 TYR 100 GLY 110 HIS 56 PRO 112 TYR 101 A.S.P. 111 TYR 57 SER 113 TYR 102 TYR 112 TYR 58 GLY 116 A.S.P. 103 VAL 113 TYR 59 VAL 104 PHE 116 A.S.P. 60 PRO 105 GLY 61 A.S.P. 106 THR 62 ARG 107 TYR 63 PHE 108 ARG 109 PRO BY HIS 111 TYR 112 TYR 113 TYR 114 GLY 115 MET 116 A.S.P. 117 VAL 118 TRP

Fab 6H1 paratope residues determined by solvent interaction difference and distance truncation method

Table 17

6H1 Heavy chain 6H1 Light chain Truncation 5 A Truncation distance 8A Difference no ASA Truncation distance 5A Truncation distance 8A Difference no ASA number remainder number remainder number remainder number remainder number remainder number remainder 28 THR 26 GLY 28 THR 32 TYR 29 ILE 32 TYR 31 TYR 27 RNU thirty SER 49 TYR thirty ARG 49 TYR 32 RNU 28 THR 31 TYR 50 GLY 31 A.S.P. 50 GLY 52 TRP 29 RNE 32 PHE 53 SER 32 TYR 53 SER 53 TYR thirty SER 52 TRP 55 GLN 33 LEU 55 GLN 98 ARG 31 TYR 53 TYR 91 HIS 46 LEU 91 HIS 100 GLY 32 RNE 77 ASN 92 ASN 48 ILE 92 ASN 101 THR 52 TRP 98 ARG 93 ASN 49 TYR 93 ASN 102 ILE 53 TYR 100 GLY 94 TYR 50 GLY 94 TYR 103 RNE 54 A.S.P. 101 THR 51 ALA 96 PHE 105 VAL 56 SER 102 ILE 52 SER 106 LEU 57 ASN 103 PHE 53 SER 59 TYR 105 VAL 54 LEU 74 ASN 106 LEU 55 GLN 77 ASN 109 A.S.P. 56 SER 98 ARG 90 GLN 99 A.S.P. 91 HIS 100 GLY 92 ASN 101 THR 93 ASN 102 ILE 94 TYR 103 PHE 96 PHE 104 GLY 105 VAL 106 LEU 107 LEU 109 A.S.P. BY TYR

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Table 18

Fab 17H11 paratope residues determined by solvent interaction difference and distance truncation method

17H11 Heavy chain 17H11 Light chain Truncation 5 A Truncation distance 8A Difference no ASA Truncation 5 A Truncation distance 8A Difference no ASA number remainder number remainder number remainder number remainder number remainder number remainder 31 SER thirty SER 31 SER thirty ILE 27 GLN thirty ILE 32 TYR 31 SER 32 TYR 31 ILE 28 GLY 31 ILE 33 TYR 32 TYR 33 TYR 32 TRP 29 LEU 32 TRP 52 TYR 33 TYR 52 TYR 46 LEU thirty ILE 46 LEU 97 ARG 52 TYR 97 ARG 49 TYR 31 ILE 49 TYR 98 A.S.P. 97 ARG 98 A.S.P. 52 SER 32 TRP 50 ALA 99 VAL 98 A.S.P. 99 VAL 53 SER 34 ALA 52 SER 100 ALA 99 VAL 100 ALA 54 LEU 46 LEU 53 SER 101 VAL 100 ALA 101 VAL 55 GLN 47 LEU 54 LEU 102 ALA 101 VAL 102 ALA 56 SER 48 ILE 55 GLN 105 A.S.P. 102 ALA 105 A.S.P. 67 SER 49 TYR 56 SER 103 GLY 91 THR 50 ALA 66 GLY 104 PHE 92 ASN 51 ALA 67 SER 105 A.S.P. 52 SER 91 THR 106 TYR 53 SER 92 ASN 54 LEU 55 GLN 56 SER 57 GLY 65 SER 66 GLY 67 SER 68 GLY 71 PHE 90 GLN 91 THR 92 ASN 93 SER 94 PHE

Table 19

GIPR ECD paratope residues in GIPR-Fab Gipg013 (PDB 4HJ0) complex determined by difference in solvent interaction and distance truncation method

GIPR Remains within 5A Gipg013 GIPR residues within 8 A Gipg013 Remains of GIPR, identified by difference no ASA number remainder number remainder number remainder 32 ALA 31 THR 32 ALA 33 GLY 32 ALA 33 GLY 35 LEU 33 GLY 35 LEU 36 TYR 34 GLU 36 TYR 37 GLN 35 LEU 37 GLN 39 TRP 36 TYR 39 TRP 40 GLU 37 GLN 40 GLU 43 ARG 38 ARG 43 ARG 47 GLN 39 TRP 44 ARG 65 PHE 40 GLU 47 GLN 66 A.S.P. 41 ARG 65 PHE 67 MET 43 ARG 66 A.S.P. 68 TYR 44 ARG 67 MET 87 TYR 47 GLN 68 TYR 88 LEU 64 SER 87 TYR 89 PRO 65 PHE 88 LEU 90 TRP 66 A.S.P. 89 PRO 113 ARG 67 MET 90 TRP 115 HIS 68 TYR 111 LEU 119 GLU 69 VAL 113 ARG 121 PRO 71 TRP 115 HIS 122 GLU 85 PRO 119 GLU 87 TYR 121 PRO 88 LEU 122 GLU 89 PRO 90 TRP 91 HIS 99 VAL 101 ARG 108 GLN 111 LEU 112 TRP 113 ARG 114 A.S.P. 115 HIS 116 THR 117 GLN 118 CYS 119 GLU 120 ASN 121 PRO 122 GLU

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Claims (11)

CLAIM 1. An isolated antigen-binding protein that specifically binds to a human gastric inhibitory peptide receptor (GIPR) polypeptide, wherein said antigen-binding protein is an antibody or a fragment of such an antibody, wherein the antibody comprises CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, wherein said CDRL1 has SEQ ID NO: 702, said CDRL2 has SEQ ID NO: 859, said CDRL3 has SEQ ID NO: 1016, said CDRH1 has SEQ ID NO: 1173, said CDRH2 has SEQ ID NO: 1330, and said CDRH3 has SEQ ID NO: 1330 NO: 1487. 2. The isolated antigen binding protein of claim 1, wherein said human GIPR has a sequence containing a sequence selected from the group consisting of SEQ ID NO: 3141, SEQ ID NO: 3143, and SEQ ID NO: 3145. 3. The isolated antigen-binding protein of claim 2, wherein said antigen-binding protein is a monoclonal antibody, a polyclonal antibody, a recombinant antibody, a human antibody, a humanized antibody, a chimeric antibody, or a fragment of such an antibody. 4. The isolated antigen-binding protein of claim 3, wherein said antibody fragment is a Fab fragment, a Fab' fragment, or an F(ab') _{2 fragment} . 5. An isolated antigen-binding protein according to claim 3, wherein said antigen-binding protein is a human antibody. 6. An isolated antigen-binding protein according to claim 3, wherein said antigen-binding protein is a monoclonal antibody. 7. An isolated antigen-binding protein according to claim 3, characterized in that said antigen-binding protein belongs to the IgG1-, IgG2-IgG3- or IgG4-type. 8. An isolated antigen-binding protein according to claim 7, characterized in that said antigen-binding protein is of the IgG1 or IgG2 type. 9. The isolated antigen-binding protein of claim 3, wherein said antigen-binding protein inhibits binding of GIP to the extracellular portion of human GIPR. 10. An isolated antigen-binding protein according to claim 3, characterized in that said antigen-binding protein is an antibody or fragment thereof, and wherein said antibody or fragment thereof comprises a light chain variable region comprising SEQ ID NO: 74 and a heavy chain variable region, containing SEQ ID NO: 231. 11. An isolated antigen-binding protein according to claim 3, characterized in that said antigen-binding protein is an antibody, and said antibody contains a light chain containing SEQ ID NO: 388 and a heavy chain containing SEQ ID NO: 545. Grouping mice by body weight Vehicle or antibody administration ♦ : Day 1: dose Mouse pharmacodynamic assay for anti-GIPR antibody testing Study design Mice: C57BL/6 diet-induced obesity from Jackson Labs, aged 18 weeks Assay: Test anti-GIPR antibodies for inhibition of insulin secretion induced by exogenous GIP ([D-Ala2]GIP) and glucose Data collection - Insulin (T = 0.30 min after a dose of [D-Ala2]-GIP and glucose) - Glucose (T = 0.60 min after a dose of [D-Ala2]-GIP and glucose) Study groups - Negative Control: Vehicle, [D-Ala2]-GIP (50 nM/kg) - Antibody 2.63.1 in the amount of 25, 5, 1.0.2, 0.04 mg/kg - Positive Control: Vehicle, no [D-Ala2]-GIP Draw blood for baseline glucose/ fasting insulin, then: exposure Glucose administration (2 g/ blood ^sampling °P per blood sampling per kg mice) and [D-Ala2]-GIP insulin glucose 7 hours 30 minutes 30 minutes Day 2: analysis Day 3: insulin measurement Fig. 1 - 315 040374 Antibody 2.63.1 to GIPR antagonizes GIP-induced insulin secretion Glucose I ha ha Oh 600 400 200 O60 D1 Carrier + [D-Ala2]-GIP2.63.1 (25 mg/kg) + Q[D-Ala2]-GIP Cl 2.63.1 (5 mg/kg) + [D-Ala2]-GIP O 2.63.1 (1 mg/kg) + [D-Ala2]-GIP SZ 2.63.1 (0.2 mg/kg) + [D-Ala2]-GIP U 2.63.1 (0.04 mg/kg) + [D-Ala2]-GIP And only the carrier Time (min) after a dose of [D-Ala2]-GIP Time (min) after a dose of [D-Ala2]-GIP G~T Carrier + [D-Ala2]-GIP2.63.1 (25 mg/kg) + And [D-Ala2]-GIP P 2.63.1 (5 mg/kg) + [D-Ala2]-GIR O 2.63.1 (1 mg/kg) + [D-Ala2]-GIR O 2.63.1 (0.2 mg/kg) + [D-Ala2]-GIR LJ 2.63.1 (0.04 mg/kg) + [D-Ala2]-GIP And only the carrier Fig. 2 Chronic treatment of diet-induced obese mice with anti-GIPR antibody 2.63.1 Study design Diet-induced obese C57BL/6 male mice (Jackson Labs) at 18 weeks of age at baseline (on a high-fat diet for 12 weeks) Mice were randomized based on their body weight, glucose and insulin (10 am, fasted for 4 hours) Weekly measurement of body weight; fasting glucose was measured at baseline and at week 3, week 4, and week 5 Blood was collected at baseline and at week 3. Blood collection after euthanasia to measure insulin, total cholesterol and triglycerides An intraperitoneal glucose tolerance test (IPTG) was performed at week 4, with a preliminary 4 hour fast, using 1 g/kg glucose. Body composition analysis for fat/no fat mass was performed at baseline and week 4.5 At week 6.5, the study was terminated. Blood collection after euthanasia Liver and epididymal white adipose tissue mass (EpiWAT) Liver harvest and EpiWAT for pathology assessment Termination of the study Body Composition