EA037533B9 - 6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[4,3-f]ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER - Google Patents

6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[4,3-f]ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER

Info

Publication number
EA037533B9
EA037533B9 EA201990943A EA201990943A EA037533B9 EA 037533 B9 EA037533 B9 EA 037533B9 EA 201990943 A EA201990943 A EA 201990943A EA 201990943 A EA201990943 A EA 201990943A EA 037533 B9 EA037533 B9 EA 037533B9
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
treatment
pyrazolo
tetrahydro
derivatives useful
Prior art date
Application number
EA201990943A
Other languages
Russian (ru)
Other versions
EA201990943A1 (en
EA037533B1 (en
Inventor
Джеймс Стюарт Скотт
Бернар Кристоф Барлаам
Бин ЯН
Томас Эндрю Мосс
Саманта Джейн Хьюз
Йоханнес Вилхелмус Мария Ниссинк
Даниэль Хильбранд О'Донован
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Priority claimed from PCT/EP2017/076191 external-priority patent/WO2018077630A1/en
Publication of EA201990943A1 publication Critical patent/EA201990943A1/en
Publication of EA037533B1 publication Critical patent/EA037533B1/en
Publication of EA037533B9 publication Critical patent/EA037533B9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The invention relates to compounds of Formula (ID)wherein R1, R14, Q and Y are as defined in the claims, to pharmaceutically acceptable salts thereof and to the use thereof in the prevention or treatment of cancer in a warm-blooded animal.
EA201990943A 2016-12-16 2017-10-13 6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[4,3-f]ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER EA037533B9 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435159P 2016-12-16 2016-12-16
PCT/EP2017/076191 WO2018077630A1 (en) 2016-10-24 2017-10-13 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer

Publications (3)

Publication Number Publication Date
EA201990943A1 EA201990943A1 (en) 2019-10-31
EA037533B1 EA037533B1 (en) 2021-04-09
EA037533B9 true EA037533B9 (en) 2021-05-27

Family

ID=68319033

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990943A EA037533B9 (en) 2016-12-16 2017-10-13 6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[4,3-f]ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER

Country Status (1)

Country Link
EA (1) EA037533B9 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097072A1 (en) * 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
WO2016202161A1 (en) * 2015-06-16 2016-12-22 江苏恒瑞医药股份有限公司 Piperidine derivative and preparation method and pharmaceutical use thereof
WO2017174757A1 (en) * 2016-04-08 2017-10-12 F. Hoffmann-La Roche Ag Tetrahydroisoquinoline estrogen receptor modulators and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097072A1 (en) * 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
WO2016202161A1 (en) * 2015-06-16 2016-12-22 江苏恒瑞医药股份有限公司 Piperidine derivative and preparation method and pharmaceutical use thereof
WO2017174757A1 (en) * 2016-04-08 2017-10-12 F. Hoffmann-La Roche Ag Tetrahydroisoquinoline estrogen receptor modulators and uses thereof

Also Published As

Publication number Publication date
EA201990943A1 (en) 2019-10-31
EA037533B1 (en) 2021-04-09

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Legal Events

Date Code Title Description
TH4A Publication of the corrected specification to eurasian patent