EA036438B1 - Применение производных пиридазина для предупреждения или лечения атаксического синдрома - Google Patents

Применение производных пиридазина для предупреждения или лечения атаксического синдрома Download PDF

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Publication number
EA036438B1
EA036438B1 EA201691566A EA201691566A EA036438B1 EA 036438 B1 EA036438 B1 EA 036438B1 EA 201691566 A EA201691566 A EA 201691566A EA 201691566 A EA201691566 A EA 201691566A EA 036438 B1 EA036438 B1 EA 036438B1
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EA
Eurasian Patent Office
Prior art keywords
hydroxypyridazin
ethyl
hydroxy
trifluoromethyl
phenyl
Prior art date
Application number
EA201691566A
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English (en)
Russian (ru)
Other versions
EA201691566A1 (ru
Inventor
Сара Олмонд
Original Assignee
Такеда Фармасьютикал Компани Лимитед.
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Application filed by Такеда Фармасьютикал Компани Лимитед. filed Critical Такеда Фармасьютикал Компани Лимитед.
Publication of EA201691566A1 publication Critical patent/EA201691566A1/ru
Publication of EA036438B1 publication Critical patent/EA036438B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201691566A 2014-03-06 2015-03-06 Применение производных пиридазина для предупреждения или лечения атаксического синдрома EA036438B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1403944.0A GB201403944D0 (en) 2014-03-06 2014-03-06 New use
PCT/GB2015/050654 WO2015132608A1 (en) 2014-03-06 2015-03-06 Pyridazine derivatives for use in the prevention or treatment of an ataxic disorder

Publications (2)

Publication Number Publication Date
EA201691566A1 EA201691566A1 (ru) 2016-12-30
EA036438B1 true EA036438B1 (ru) 2020-11-11

Family

ID=50554599

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691566A EA036438B1 (ru) 2014-03-06 2015-03-06 Применение производных пиридазина для предупреждения или лечения атаксического синдрома

Country Status (32)

Country Link
US (1) US20170014407A1 (enExample)
EP (1) EP3113778B1 (enExample)
JP (1) JP6510549B2 (enExample)
KR (1) KR20160126081A (enExample)
CN (1) CN106102743A (enExample)
AU (1) AU2015225954B2 (enExample)
CA (1) CA2940342A1 (enExample)
CL (1) CL2016002151A1 (enExample)
CY (1) CY1120573T1 (enExample)
DK (1) DK3113778T3 (enExample)
EA (1) EA036438B1 (enExample)
ES (1) ES2676905T3 (enExample)
GB (1) GB201403944D0 (enExample)
GE (1) GEP20196984B (enExample)
HR (1) HRP20181082T1 (enExample)
IL (1) IL247435A0 (enExample)
LT (1) LT3113778T (enExample)
MA (1) MA39315A1 (enExample)
MX (1) MX2016010524A (enExample)
MY (1) MY202127A (enExample)
PH (1) PH12016501751A1 (enExample)
PL (1) PL3113778T3 (enExample)
PT (1) PT3113778T (enExample)
RS (1) RS57594B1 (enExample)
SG (1) SG11201607106YA (enExample)
SI (1) SI3113778T1 (enExample)
SM (1) SMT201800367T1 (enExample)
TR (1) TR201809537T4 (enExample)
TW (1) TW201534591A (enExample)
UA (1) UA123352C2 (enExample)
WO (1) WO2015132608A1 (enExample)
ZA (1) ZA201604611B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
GB201222711D0 (en) 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
US10118917B2 (en) 2014-04-29 2018-11-06 E I Du Pont De Nemours And Company Pyridazinone herbicides
TWI785022B (zh) 2017-03-28 2022-12-01 美商富曼西公司 新穎噠嗪酮類除草劑
US11213030B2 (en) 2017-06-30 2022-01-04 Fmc Corporation 4-(3,4-dihydronaphth-1-yl or 2H-chromen-4-yl)-5-hydroxy-2H-pyradizin-3-ones as herbicides
CN112569217B (zh) * 2019-09-30 2022-04-22 厦门大学 戊酸衍生物在治疗遗传性小脑共济失调中的应用
JP2021138648A (ja) 2020-03-04 2021-09-16 武田薬品工業株式会社 経口固形製剤
CA3209781A1 (en) 2021-03-01 2022-09-09 Takeda Pharmaceuticals Company Limited Use of luvadaxistat for the treatment of cognitive impairment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003047558A2 (en) * 2001-12-03 2003-06-12 Genset S.A. Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors
US20130052281A1 (en) * 2011-08-22 2013-02-28 Takeda Pharmaceutical Company Limited Novel compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE321553T1 (de) * 1998-06-10 2006-04-15 Meiji Seika Kaisha Arzneimittel für hinterstrangataxie und zusammensetzung zur behandlung von hinterstrangataxie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003047558A2 (en) * 2001-12-03 2003-06-12 Genset S.A. Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors
US20130052281A1 (en) * 2011-08-22 2013-02-28 Takeda Pharmaceutical Company Limited Novel compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALMOND, S.L. ; FRADLEY, R.L. ; ARMSTRONG, E.J. ; HEAVENS, R.B. ; RUTTER, A.R. ; NEWMAN, R.J. ; CHIU, C. ; KONNO, R. ; HUTSON, P.H.: "Behavioral and biochemical characterization of a mutant mouse strain lacking d-amino acid oxidase activity and its implications for schizophrenia", MOLECULAR AND CELLULAR NEUROSCIENCES., SAN DIEGO, US, vol. 32, no. 4, 1 August 2006 (2006-08-01), US, pages 324 - 334, XP024908147, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2006.05.003 *
HASHIMOTO, A. ; YOSHIKAWA, M. ; NIWA, A. ; KONNO, R.: "Mice lacking d-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1033, no. 2, 8 February 2005 (2005-02-08), NL, pages 210 - 215, XP027735997, ISSN: 0006-8993 *

Also Published As

Publication number Publication date
CA2940342A1 (en) 2015-09-11
SMT201800367T1 (it) 2018-09-13
GB201403944D0 (en) 2014-04-23
JP6510549B2 (ja) 2019-05-08
MA39315A1 (fr) 2017-09-29
AU2015225954B2 (en) 2020-06-18
RS57594B1 (sr) 2018-11-30
SG11201607106YA (en) 2016-09-29
TW201534591A (zh) 2015-09-16
PL3113778T3 (pl) 2018-11-30
KR20160126081A (ko) 2016-11-01
DK3113778T3 (en) 2018-07-30
JP2017507156A (ja) 2017-03-16
TR201809537T4 (tr) 2018-07-23
EP3113778B1 (en) 2018-06-06
ES2676905T3 (es) 2018-07-26
LT3113778T (lt) 2018-08-27
AU2015225954A1 (en) 2016-07-07
GEP20196984B (en) 2019-06-25
MX2016010524A (es) 2016-10-31
CN106102743A (zh) 2016-11-09
SI3113778T1 (en) 2018-08-31
CL2016002151A1 (es) 2016-12-30
EA201691566A1 (ru) 2016-12-30
PH12016501751A1 (en) 2017-02-06
MY202127A (en) 2024-04-05
UA123352C2 (uk) 2021-03-24
IL247435A0 (en) 2016-11-30
PT3113778T (pt) 2018-07-11
WO2015132608A1 (en) 2015-09-11
ZA201604611B (en) 2017-09-27
EP3113778A1 (en) 2017-01-11
CY1120573T1 (el) 2019-07-10
HRP20181082T1 (hr) 2018-09-07
US20170014407A1 (en) 2017-01-19

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