EA033291B1 - Dosage unit comprising ramipril and bisoprolol hemifumarate, process for the preparation thereof and method of treating hypertension - Google Patents
Dosage unit comprising ramipril and bisoprolol hemifumarate, process for the preparation thereof and method of treating hypertensionInfo
- Publication number
- EA033291B1 EA033291B1 EA201690395A EA201690395A EA033291B1 EA 033291 B1 EA033291 B1 EA 033291B1 EA 201690395 A EA201690395 A EA 201690395A EA 201690395 A EA201690395 A EA 201690395A EA 033291 B1 EA033291 B1 EA 033291B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dosage unit
- ramipril
- active ingredients
- preparation
- bisoprolol hemifumarate
- Prior art date
Links
- RZPZLFIUFMNCLY-WLHGVMLRSA-N (e)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol Chemical compound OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 RZPZLFIUFMNCLY-WLHGVMLRSA-N 0.000 title abstract 4
- 229960002781 bisoprolol Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 title abstract 4
- 229960003401 ramipril Drugs 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a dosage unit comprising ramipril or a pharmaceutically acceptable salt thereof and bisoprolol hemifumarate as active ingredients, wherein particles of said active ingredients are separated from each other in the dosage unit by that at least one of the two active ingredients is in form of granules or coated compacts, and wherein the dosage unit is in tablet or capsule form. The invention also relates to a process for the preparation of said dosage unit, a method of treating hypertension using the same and to the use of bisoprolol hemifumarate and ramipril or salts thereof for the preparation of said dosage unit. The invention allows to obtain a dosage unit comprising ramipril and bisoprolol hemifumarate as active ingredients, characterised with the stability of the active ingredients, the bioavailability similar to that measured in case of simultaneous administration of two corresponding mono compositions and the dissolution profile which does not change during storage.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1300496A HUP1300496A2 (en) | 2013-08-16 | 2013-08-16 | Stable pharmaceutical composition |
PCT/HU2014/000072 WO2015022560A1 (en) | 2013-08-16 | 2014-08-15 | Stable pharmaceutical composition containing bisoprolol and ramipril |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201690395A1 EA201690395A1 (en) | 2016-07-29 |
EA033291B1 true EA033291B1 (en) | 2019-09-30 |
Family
ID=89991232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690395A EA033291B1 (en) | 2013-08-16 | 2014-08-15 | Dosage unit comprising ramipril and bisoprolol hemifumarate, process for the preparation thereof and method of treating hypertension |
Country Status (3)
Country | Link |
---|---|
EA (1) | EA033291B1 (en) |
HU (2) | HUP1300496A2 (en) |
WO (2) | WO2015022559A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3501502A1 (en) * | 2017-12-20 | 2019-06-26 | Midas Pharma GmbH | Fixed dosed pharmaceutical compositions comprising amlodipine, ramipril and atorvastatin |
WO2021162562A2 (en) | 2020-02-10 | 2021-08-19 | Adamed Pharma S.A. | Stable ramipril composition and fixed dose composition comprising thereof |
CN115068434B (en) * | 2022-08-03 | 2023-05-09 | 昆山龙灯瑞迪制药有限公司 | Preparation method of ramipril tablet |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007056442A1 (en) * | 2005-11-07 | 2007-05-18 | King Pharmaceuticals Research & Development, Inc. | Compositions of stabilized ramipril in combination with another active agent |
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DE3174844D1 (en) | 1980-10-23 | 1986-07-24 | Schering Corp | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
DE3226768A1 (en) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF |
DE3739690A1 (en) | 1987-11-24 | 1989-06-08 | Hoechst Ag | STABILIZED MEDICINAL PRODUCTS, METHOD FOR THEIR PRODUCTION AND STABLE MEDICAL PREPARATIONS |
US20030215526A1 (en) | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
WO2003092729A1 (en) * | 2002-05-03 | 2003-11-13 | Hexal Ag | Stable pharmaceutical formulation for a combination of a statin and an ace inhibitor |
DK1635792T3 (en) | 2003-06-26 | 2009-06-15 | Teva Pharma | Stable pharmaceutical compositions of 2-aza-bicyclo-3.3.0-octane-3-carboxylic acid derivatives |
AU2003300692A1 (en) | 2003-10-30 | 2005-05-19 | Lupin Ltd. | Stable formulations of ace inhibitors and methods for preparation thereof |
GB2394660A (en) | 2003-12-17 | 2004-05-05 | Niche Generics Ltd | Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide |
EA011862B1 (en) | 2004-03-24 | 2009-06-30 | Актавис Груп Хф. | Formulations of ramipril |
ZA200704767B (en) | 2004-11-05 | 2008-08-27 | King Pharmaceuticals Res & Dev | Stabilized individually coated ramipril particles, compositions and methods |
CN100374462C (en) | 2005-11-21 | 2008-03-12 | 大连帝恩生物工程有限公司 | Gerobriecin pancrease glucagon peptidel (SGLP-1), its preparation and use |
US20070232680A1 (en) | 2006-04-04 | 2007-10-04 | Vijayabhaskar Bolugoddu | Preparation of ramipril and stable pharmaceutical compositions |
JP2009533461A (en) | 2006-04-19 | 2009-09-17 | テバ ファーマシューティカル インダストリーズ リミティド | Stable pharmaceutical composition of 2-aza-bicyclo [3.3.0] -octane-3-carboxylic acid derivative |
EP2034966A1 (en) | 2006-06-30 | 2009-03-18 | Alphapharm Pty Ltd. | A stabilised composition comprising ace inhibitors |
US20110086092A1 (en) | 2006-08-08 | 2011-04-14 | Accu-Break Technologies, Inc. | Pharmacuetical tablets containing a plurality of active ingredients |
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HU230877B1 (en) | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stable pharmaceutical combination |
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CN104254321A (en) | 2012-02-17 | 2014-12-31 | 埃吉斯药物私人有限公司 | Pharmaceutical formulation having improved stability |
-
2013
- 2013-08-16 HU HU1300496A patent/HUP1300496A2/en not_active Application Discontinuation
-
2014
- 2014-08-15 WO PCT/HU2014/000071 patent/WO2015022559A1/en active Application Filing
- 2014-08-15 HU HU1600414A patent/HU231052B1/en unknown
- 2014-08-15 EA EA201690395A patent/EA033291B1/en not_active IP Right Cessation
- 2014-08-15 WO PCT/HU2014/000072 patent/WO2015022560A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007056442A1 (en) * | 2005-11-07 | 2007-05-18 | King Pharmaceuticals Research & Development, Inc. | Compositions of stabilized ramipril in combination with another active agent |
Non-Patent Citations (3)
Title |
---|
FETZNER, A. BOHM, S. SCHREDER, S. SCHUBERT, R.: "Degradation of raw or film-incorporated @b-cyclodextrin by enzymes and colonic bacteria", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS., ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, vol. 58, no. 1, 1 July 2004 (2004-07-01), NL, pages 91 - 97, XP004519832, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2004.02.001 * |
FINSTERER JOSEF ; ST�LLBERGER CLAUDIA ; GELPI ELLEN: "Successful heart failure therapy in mitochondrial disorder with noncompaction cardiomyopathy", THE INTERNATIONAL JOURNAL OF CARDIAC IMAGING, KLUWER ACADEMIC PUBLISHERS, DO, vol. 22, no. 3-4, 25 February 2006 (2006-02-25), Do, pages 393 - 398, XP019392601, ISSN: 1573-0743, DOI: 10.1007/s10554-005-9073-4 * |
THERES H P, ET AL.: "Combined treatment with ramipril and metoprolol prevents changes in the creatine kinase isoenzyme system and improves hemodynamic function in rat hearts after myocardial infarction", CARDIOVASCULAR DRUGS AND THERAPY., KLUWER ACADEMIC PUBLISHERS, BOSTON., US, vol. 14, no. 6, 1 January 2000 (2000-01-01), US, pages 597 - 606, XP002983205, ISSN: 0920-3206, DOI: 10.1023/A:1007846311040 * |
Also Published As
Publication number | Publication date |
---|---|
WO2015022559A1 (en) | 2015-02-19 |
WO2015022560A8 (en) | 2015-05-14 |
EA201690395A1 (en) | 2016-07-29 |
HU231052B1 (en) | 2020-02-28 |
HUP1600414A2 (en) | 2016-09-28 |
WO2015022560A1 (en) | 2015-02-19 |
HUP1300496A2 (en) | 2015-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG TJ TM |