EA025997B1 - Composition for producing a disinfectant having a washing effect - Google Patents

Abstract

The invention is related to the field of health service, veterinary, food industry, and can be used also at catering and retail facilities, at markets, food production units, transport, at greenhouse facilities and in other sectors of economical activities and veterinary-sanitary supervision. The objective of the invention is development of a disinfecting composition having a washing effect, increased bactericide activity (against bacteria, including tuberculosis mycobacteria, viruses, fungi, sporocidal infections) and improved stability of working solutions (during 30 days as compared to 7 days of the prior art) with simultaneous broadening of the area of application of said disinfectant, which would provide sterilizing and pre-sterilizing treatment of medical articles and disinfection of surfaces, equipment and rooms in health service organizations of any profile; in veterinary, food industry and in other sectors of economical activities. The objective of the invention is attained by provision of a composition for producing a disinfectant with a washing effect for disinfection, sterilization and pre-sterilization cleaning including an organic acid, a quaternary ammonium salt, a surfactant, a complexing agent and water, characterized in that the complexing agent is selected from a group of compounds including nitrilotriacetic acid, trilon B, organic derivatives of phosphonic acid selected from hydroxy-ethane-1,1-diphosphonic acid, hydroxy-ethyl-amine-dimethylene-phosphonic acid, phosphon-hydroxyacetic acid or mixtures thereof, and the surfactant comprises mixture of an alkyl glycoside of C-Crow and an ethoxylated alcohol of C-Cwith different ethoxylation degrees (from 3 to 10 moles of ethylene per mole of alcohol) (1-50:1-50), the composition including also an alkaline buffering agent, with the following proportion of components, wt.%: organic acid: 2-35; quaternary ammonium salt: 3-40; surfactant: 3-15; complexing agent: 0.05-1.0; buffering agent: 0.01-2.0; water: balance to 100.

Description

The invention relates to the development of a new means for disinfection, sterilization and pre-sterilization cleaning, which also has a washing effect. The product is effective against bacteria, viruses, spores, fungi of various etiologies and can be used for disinfection (including combined with pre-sterilization cleaning) and sterilization of medical devices; for disinfection of surfaces and equipment in healthcare organizations of any specialization; in veterinary medicine, food industry, public catering, trade, markets, food units, transport, in greenhouse-greenhouse farms and other objects of economic activity and veterinary and sanitary supervision.

An antiseptic agent is known [1], including the active substance - a quaternary ammonium salt (alkylamino-propyldimethylbenzylammonium chloride, alkyldimethylbenzylammonium chloride or alkyltrimethylammonium chloride), mineral or organic acid (boric, salicylic, benzoic, ethyl alcohol, or tartaric , dimethyl sulfoxide or water).

However, the above remedy is not effective enough in relation to pathogens of intestinal infections and other representatives of gram-negative microflora - constant and transit contaminants of various environmental objects.

Known disinfectant [2], which is used in veterinary disinfection for sanitation of livestock and poultry facilities. The composition of the disinfectant includes a 30% aqueous solution of acetic acid, alkylbenzyldimethylammonium chloride, sodium carbonate, boric acid and trisodium phosphate in a certain ratio of components.

The disadvantage of this drug is the low bactericidal activity; the disinfectant has a high exposure time, which significantly degrades labor productivity. Only a 3% concentration at an exposure time of 3 hours causes 100% death of sanitary-indicative microorganisms (E. coli, staphylococcus and streptococcus). The drug is a dangerous substance when inhaled, has an irritating effect on the mucous membranes of the eyes and upper respiratory tract.

Also known is a composition for producing a disinfectant containing hydrogen peroxide, lactic acid, catamine, Trilon B, citric acid, sodium diphosphate and water [3], which is used to disinfect equipment, pipelines, surfaces at food processing enterprises, as well as for veterinary disinfection. The disadvantage of the drug is the low stability of working solutions (7 days), the drug is ineffective against spores and is characterized by significant corrosion activity with respect to metals.

As an analogue of the claimed object, an antiseptic agent is also known [4], which is used in agriculture (mainly in veterinary medicine), containing a quaternary ammonium salt, mineral or organic acid, and a solvent. As a quaternary ammonium salt, it contains alkylbenzyl dimethyl ammonium chloride (benzalkonium chloride), or dialkyl dimethyl ammonium chloride, or dodecyldimethyl ethyl benzyl ammonium chloride, or cetyl trimethyl ammonium bromide, or cetyl trimethyl ammonium chloride, hydrochloric acid, hydrochloric acid, hydrochloric acid, or hydrochloric acid as a solvent, the product contains water or a 1-15% solution of glycol in water or a 1-10% solution of ethyl or isopropyl alcohol. The disadvantage of the above drug is the low microbiological activity of the agent for viral and spore-forming infections.

There is a method of increasing the bactericidal effectiveness of a disinfecting cleaning composition [5] by including in the composition of the composition an effective amount of a mixture of a nonionic surfactant (alkyl glycoside) and a quaternary ammonium salt. In the study of the microbiological activity of the above aqueous disinfecting cleansing composition, it was found that it does not have sporocidal activity.

The closest in technical essence and the achieved result to the proposed composition (prototype) is a German-made product [6] of the following composition: quaternary ammonium salt (or a mixture thereof): 1-50%, organic acid: 1-50%, surfactant (alkanoic acid ester): 0.1-5.0%, complexing agent: 1-50%, active additive (aliphatic alcohols, glycols, polyglycols): 1-50%, antifoam, perfume, preservative, solvent: up to 100%.

Following the description of the prototype, this composition is used only for chemical-thermal treatment of medical devices. The disadvantage of the drug (prototype) is the lower antimicrobial activity (effective 0.2-2 wt.% Solutions; not effective against spores) compared with the claimed composition; lower stability (activity) of working solutions; a narrower scope is machine disinfection of medical devices by the method of chemical thermal treatment.

The objective of the invention is to develop a composition for disinfection with a washing effect, with increased bactericidal activity (against bacteria, including mycobacterium tuberculosis, viruses, fungi, sporocidal infections) and increased stability (activity) of working solutions (within 30 days against 7 days in a known composition), while expanding the scope of application of 1,025,997 of the specified funds, which would allow for sterilization and pre-sterilization cleaning of medical devices, as well as disinfection tion of surfaces, equipment and facilities in health organizations of any specialization; in veterinary medicine, food industry and other objects of economic activity.

This object is achieved in that the composition for obtaining a disinfectant with a detergent effect for disinfection, sterilization and pre-sterilization cleaning, including organic acid, quaternary ammonium salt, surfactant, complexing agent, water, characterized in that the complexing agent is selected from the group compounds representing nitrilotriacetic acid, trilon B, organic derivatives of phosphonic acid selected from hydroxy-ethane-1,1-diphosphonic acid, hyd oksietilamindimetilenfosfonovuyu acid fosfonogidroksiuksusnuyu acid or mixtures thereof, as well as a number of alkylglycoside surfactant mixture of C ₆ -C _9, ethoxylated alcohol series and C ₁₀ -C _18, with various degrees of ethoxylation (from 3 to 10 moles of ethylene oxide per mole of alcohol) (1-50 : 1-50), the composition also contains an alkaline buffering agent in the following ratio of components, wt.%:

organic acid: 2-35; Quaternary ammonium salt: 3-40; surfactant: 3-15; complexing agent: 0.05-1.0; buffering agent: 0.01-2.0; water: up to 100.

As an organic acid, the product contains glycolic, or acetic, or lactic, or citric, or propionic, or malic, or succinic, or tartaric, or dehydroacetic, or benzoic, or formic, or sorbic acid.

As the quaternary ammonium salt means comprises alkilbenzildimetilammonium chloride (benzalkonium chloride) or dialkildimetilammonium chloride dodetsildimetiletilbenzilammonium chloride didodetsildipropilenammonium tsetiltrimetilammonium chloride or bromide, tsetiltrimetilammonium chloride didetsildipropilenammonium chloride kokofraktsionirovanny benzyldimethylammonium chloride, dikokoalkildimetilammoniya chloride, hexadecyltrimethylammonium chloride.

As a complexing agent, the agent contains organic compounds: organic derivatives of phosphonic acid, such as 1-hydroxy-ethane-1,1-diphosphonic acid, hydroxyethylamine dimethylene phosphonic acid, phosphonohydroxyacetic acid, nitrilotriacetic acid, trilon B (ethylenediaminetetraacetic acid) or sodium combination complexing agents.

As a surfactant, the product contains a mixture of 1-50 wt.% (Alkyl glycoside): 1-50 wt.% (Ethoxylated fatty alcohol). As the alkyl glycoside, hexyl-D-glucoside, octyl-D-glucoside, heptyl-D-glucoside, nonyl-D-glucoside or a mixture thereof can be used. Ethoxylated fatty alcohols of the C ₁₀ -C ₁₈ series with varying degrees of ethoxylation (from 3-10 mol of ethylene oxide per mole of alcohol) or a mixture thereof can be used as ethoxylated fatty alcohol.

Caustic soda is used as the alkaline buffering agent.

The inventive tool with a detergent effect for disinfection, sterilization and PSO is prepared by mechanical mixing of these components in a specific order. The tool is a concentrate, which is diluted before use to concentrations of 0.1-7.0 wt.%.

The invention is illustrated by the following examples.

Example 1

We prepare the product concentrate by mixing organic acid (glycolic) - 35 wt.%, Quaternary ammonium salt (benzalkonium chloride) - 40 wt.%, Surfactant (mixture of 1 wt.% (Alkyl glycoside (hexyl-D-glycoside)): 1 wt.% (С ₉ -СЦ-ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 15 wt.%, Complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 1.0 wt.%, alkaline buffering agent - 2.0 wt.% and water up to 100 wt.%.

Example 2

We prepare the product concentrate by mixing organic acid (glycolic) - 2 wt.%, Quaternary ammonium salt (benzalkonium chloride) - 3 wt.%, Surfactant (mixture of 50 wt.% (Alkyl glycoside (hexyl-D-glycoside)): 50 wt.% (С ₉ -СЦ-ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 3 wt.%, Complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.05 wt.%, alkaline buffering agent - 0.01 wt.% and water up to 100 wt.%.

Example 3

We prepare the product concentrate by mixing organic acid (glycolic) - 17 wt.%, Quaternary ammonium salt (alkylbenzyldimethylammonium chloride (benzalkonium chloride)) - 12 wt.%, Surfactant (mixture 1-50 wt.% (Hexyl-D- glycoside): 1-50 wt.% (С _9- ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 5 wt.%, complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt. %, alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

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Example 4

We prepare the product concentrate by mixing organic acid (lactic) - 17 wt.%, Quaternary ammonium salt (didecyldipropylene ammonium chloride) - 12 wt.%, Surfactant (mixture 1-50 wt.% (Octyl-D-glycoside): 1 -50 wt.% C ₁₂ -C ₁₄ -ethoxylated fatty alcohol, ethoxylation degree 3-10) - 5 wt.%, Complexing agent (trilon B) - 0.1 wt.%, Alkaline buffering agent - 0.7 wt.% And water up to 100 wt.%.

Example 5

We prepare the product concentrate by mixing organic acid (acetic) - 17 wt.%, Quaternary ammonium salt (cetyltrimethylammonium bromide) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside (hexyl-D-glycoside) ): 1-50 wt.% (Ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 5 wt.%, Complexing agent (hydroxyethylamine-dimethylene phosphonic acid) - 0.1 wt.%, Alkaline buffering agent - 0.7 wt. % and water up to 100 wt.%.

Example 6

We prepare the product concentrate by mixing organic acid (citric) - 17 wt.%, Quaternary ammonium salt (didodecyl-dipropyleneammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside (heptyl-D- glycoside)): 1-50 wt.% (Scc-ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 5 wt.%, complexing agent (phosphonohydroxyacetic acid) - 0.1 wt.%, alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

Example 7

We prepare the product concentrate by mixing organic acid (propionic) - 17 wt.%, Quaternary ammonium salt (cetyltrimethylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside (nonyl-D-glycoside) ): 1-50 wt.% (Сш-С ^ ethoxylated fatty alcohol, degree of ethoxylation 3-10)) - 5 wt.%, Complexing agent (nitrilotriacetic acid) - 0.1 wt.%, Alkaline buffering agent - 0, 7 wt.% And water up to 100 wt.%.

Example 8

We prepare the product concentrate by mixing organic acid (malic) - 17 wt.%, Quaternary ammonium salt (dodecyldimethylethylbenzylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside (decyl-D-glycoside) ): 1-50 wt.% (C ₁₆ -C ₁₈ ethoxylated fatty alcohol, ethoxylation degree 3-10) - 5 wt.%, Complexing agent (150 wt.% Nitrilotriacetic acid: 1-50 wt.% 1-hydroxy-ethane -1,1-diphosphonic acid) - 0.1 wt.%, Alkaline buffering agent -0.7 wt.% And water up to 100 wt.%.

Example 9

We prepare the product concentrate by mixing organic acid (succinic) - 17 wt.%, Quaternary ammonium salt (dialkyl dimethyl ammonium chloride) - 12 wt.%, Surfactant (mixture 1-50 wt.% (Decyl-D-glycoside (1- 50 wt.%), Nonyl-D-glycoside (1-50 wt.%)): 1-50 wt.% (С ₁₀ -С ₁₂ (1-50 wt.%): С1 ₆ -С1 ₈ (1- 50 wt.%) Ethoxylated fatty alcohols, degree of ethoxylation 3-10)) - 5 wt.%, Complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, Alkaline buffering agent - 0 , 7 wt.% And water up to 100 wt.%.

Example 10

We prepare the product concentrate by mixing organic acid (tartaric) - 17 wt.%, Quaternary ammonium salt (1-50 wt.% Dialkyldimethylammonium chloride: 1-50 wt.% Dodecyldimethyl-ethylbenzylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (alkyl glycoside): 1-50 wt.% (ethoxylated fatty alcohol)) - 5 wt.%, complexing agent (1-hydroxyethane-1,1-diphosphonic acid) - 0.1 wt.% alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

Example 11

We prepare the product concentrate by mixing organic acid (dehydroacetic) - 17 wt.%, Quaternary ammonium salt (cocofractionated benzyldimethylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside): 1-50 wt. wt.% (ethoxylated fatty alcohol)) - 5 wt.%, complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, alkaline buffering agent - 0.7 wt.% and water to 100 wt.%.

Example 12

We prepare the product concentrate by mixing organic acid (benzoic) - 17 wt.%, Quaternary ammonium salt (dicocoalkyl dimethylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside): 1-50 wt. % (ethoxylated fatty alcohol)) - 5 wt.%, complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

Example 13

We prepare the product concentrate by mixing organic acid (formic) - 17 wt.%, Quaternary ammonium salt (hexadecyltrimethylammonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside): 1-50 wt. % (ethoxylated fatty alcohol)) - 5 wt.%, complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, alkaline buffering agent - 3,025,997, 0.7 wt.% and water up to 100 wt.%.

Example 14

We prepare the product concentrate by mixing organic acid (sorbic acid) - 17 wt.%, Quaternary ammonium salt (benzalkonium chloride) - 12 wt.%, Surfactant (mixture of 1-50 wt.% (Alkyl glycoside): 1-50 wt. % (ethoxylated fatty alcohol)) - 5 wt.%, complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

Example 15

We prepare the product concentrate by mixing organic acid (1-50 wt.% Sorbic: 1-50 wt.% Formic) - 17 wt.%, Quaternary ammonium salt (benzalkonium chloride) - 12 wt.%, Surfactant (mixture 1 -50 wt.% (Alkyl glycoside): 1-50 wt.% (Ethoxylated fatty alcohol)) - 5 wt.%, Complexing agent (1-hydroxy-ethane-1,1-diphosphonic acid) - 0.1 wt.%, alkaline buffering agent - 0.7 wt.% and water up to 100 wt.%.

The inventive tool was tested in accordance with the current legislation of the Republic of Belarus and the Customs Union in an accredited laboratory.

The tool has bactericidal, virucidal, fungicidal and sporocidal activity when used in the modes regulated by this table.

The research results are shown in the table.

The effectiveness of the drug against microorganisms

Type of infection Exposition (minutes) Concentration, means, mass. % Achieved results one 2 3 4 Mycobacteria (tuberculosis) 60 thirty KO 2.0 E. coli pseudomonads, staphylococcus, shigella, salmonella thirty oh 1 + Candidates thirty KO + Aspergillus 60 thirty 3.0 5,0 + Spores (Bacillus) thirty 7.0 + Viruses (including pathogens enterovirus infections, including causative agents of poliomyelitis, as well as herpes simplex, influenza) thirty 0.25 4- Pre-sterilization cleaning up 10 0.25 +

The author found that as a result of the synergistic effect of the interaction of HOUR and the specified surfactant, in the presence of an organic acid in the composition, the antimicrobial activity of the agent is significantly increased compared to the prototype due to increased bactericidal activity (the agent is effective against bacteria, including mycobacterium tuberculosis, viruses, fungi , dispute), which entails the expansion of its scope (sterilization and pre-sterilization cleaning of medical devices). The presence of caustic soda in the composition as a buffering agent significantly increases the stability (activity) of the working solutions of the agent for up to 30 days due to the formation of buffering systems from organic acids and their sodium salts.

The advantages of the claimed funds in comparison with the prototype and analogues are:

1) the effectiveness of the drug is not only against fungi, viruses, mycobacteria, but also against spores, which allows it to be used not only for disinfection, but also sterilization (increasing bactericidal activity allows you to expand the scope, including sterilization);

2) all working solutions of the claimed funds remain active for 30 days, with a known composition - 7 days (improving the economic characteristics of the funds);

3) as a complexing agent, the author uses organic derivatives of phosphonic acid, the introduction of which enhances the disinfecting effect of the composition;

4) only chemical treatment of instruments, in contrast to the chemical-thermal treatment claimed in the prototype (the cost of the disinfection process);

5) the possibility of using the product not only for disinfection of tools, but also surfaces (expanding the scope);

6) the possibility of using the product not only for disinfection, but also for pre-sterilization cleaning (expanding the scope);

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7) reducing the amount of complexing agent (improving the economic characteristics of the tool)

8) the proposed composition of the disinfectant with a detergent effect expands the range and resources of disinfectants.

Information sources.

1. A.S. USSR No. 1459005, MKI A61 2/18, 1987.

2. Patent KI 2252035 C2, MKI A61 2/18, 2000.

3. Patent No. 13828 C1, MKI A61 2/16, 2010.

4. Patent KI 2118174 C1, MKI A61 2/16, 2/18 A61K 31/14, 1998.

5. Patent KI 2093550 C11 I3 / 48, C11 I1: 62, C11 I3: 22, 1997.

6. Patent EP 1454638 B1, 2010.

Claims (3)

CLAIM 1. A composition for producing a disinfectant with a detergent effect for disinfection, sterilization and pre-sterilization cleaning, including organic acid, quaternary ammonium salt, surfactant, complexing agent, water, characterized in that the complexing agent is selected from the group of compounds representing nitrilotriacetic acid, trilon B, organic phosphonic acid derivatives selected from hydroxyethane-1,1-diphosphonic acid, hydroxyethylamine dimethylene phosphonic acid that, phosphonohydroxyacetic acid or mixtures thereof, and as a surfactant, a mixture of alkyl glycoside of series C ₆ -C ₉ and ethoxylated alcohol of series C ₁₀ -C ₁₈ with various degrees of ethoxylation (from 3 to 10 mol of ethylene oxide per mole of alcohol) (1-50: 1-50), the composition also contains an alkaline buffering agent in the following ratio of components, wt.%: organic acid: 2-35; Quaternary ammonium salt: 3-40; surfactant: 3-15; complexing agent: 0.05-1.0; buffering agent: 0.01-2.0; water: up to 100. 2. The composition according to claim 1, characterized in that the organic acid contains glycolic, or acetic, or lactic, or citric, or propionic, or malic, or amber, or tartaric, or dehydroacetal, or benzoic, or formic, or sorbic acid or mixtures thereof. 3. Composition according to claim 1, characterized in that as the quaternary ammonium salt comprises alkilbenzildimetilammonium chloride (benzalkonium chloride) or dialkildimetilammonium chloride dodetsildimetiletilbenzilammonium chloride or didodetsildimetilammonium chloride didodetsildipropilenammonium tsetiltrimetilammonium chloride or bromide, or chloride tsetiltrimetilammonium, didetsildipropilenammonium chloride, benzyldimethylammonium chloride kokofraktsionirovanny , dicocoalkyl dimethyl ammonium chloride, hexadecyl trimethyl ammonium chloride or mixtures thereof.