EA020967B1 - Антагонисты рецептора 5-ht - Google Patents
Антагонисты рецептора 5-ht Download PDFInfo
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- EA020967B1 EA020967B1 EA201390312A EA201390312A EA020967B1 EA 020967 B1 EA020967 B1 EA 020967B1 EA 201390312 A EA201390312 A EA 201390312A EA 201390312 A EA201390312 A EA 201390312A EA 020967 B1 EA020967 B1 EA 020967B1
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- EA
- Eurasian Patent Office
- Prior art keywords
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10174880 | 2010-09-01 | ||
| PCT/EP2011/064906 WO2012028614A1 (en) | 2010-09-01 | 2011-08-30 | 5-ht2b receptor antagonists |
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| Publication Number | Publication Date |
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| EA201390312A1 EA201390312A1 (ru) | 2013-07-30 |
| EA020967B1 true EA020967B1 (ru) | 2015-03-31 |
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| EP (1) | EP2619180B1 (OSRAM) |
| JP (1) | JP5845263B2 (OSRAM) |
| KR (1) | KR101815123B1 (OSRAM) |
| CN (1) | CN103080089B (OSRAM) |
| AU (1) | AU2011298361B2 (OSRAM) |
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| ES (1) | ES2525515T3 (OSRAM) |
| MX (1) | MX2013002409A (OSRAM) |
| SG (1) | SG188233A1 (OSRAM) |
| WO (1) | WO2012028614A1 (OSRAM) |
| ZA (1) | ZA201301561B (OSRAM) |
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| EP2619180B1 (en) | 2010-09-01 | 2014-10-08 | Janssen Pharmaceutica, N.V. | 5-ht2b receptor antagonists |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| WO2015134503A1 (en) * | 2014-03-04 | 2015-09-11 | The Children's Hospital Of Philadelphia | Methods for managing care of patients predisposed to progressive mitral valve diseases |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076530A2 (en) * | 1981-10-01 | 1983-04-13 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| WO2001093849A2 (en) * | 2000-06-07 | 2001-12-13 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| US6444477B1 (en) * | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| CN1918157B (zh) * | 2004-01-07 | 2010-06-23 | ARYx医疗有限公司 | 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法 |
| EP1991545A2 (en) | 2005-12-23 | 2008-11-19 | AstraZeneca AB | Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines |
| EP2619180B1 (en) | 2010-09-01 | 2014-10-08 | Janssen Pharmaceutica, N.V. | 5-ht2b receptor antagonists |
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- 2011-08-30 EP EP11748693.6A patent/EP2619180B1/en active Active
- 2011-08-30 CN CN201180041597.9A patent/CN103080089B/zh not_active Expired - Fee Related
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- 2011-08-30 SG SG2013011929A patent/SG188233A1/en unknown
- 2011-08-30 BR BR112013004503A patent/BR112013004503A2/pt active Search and Examination
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- 2011-08-30 WO PCT/EP2011/064906 patent/WO2012028614A1/en not_active Ceased
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- 2011-08-30 ES ES11748693.6T patent/ES2525515T3/es active Active
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2013
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076530A2 (en) * | 1981-10-01 | 1983-04-13 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| WO2001093849A2 (en) * | 2000-06-07 | 2001-12-13 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
Non-Patent Citations (2)
| Title |
|---|
| COLLIN S. ET AL.: "Molecular structure of two gastrokinetic compounds, cisapride and R53757: comparison with dopaminergic D2 antagonists", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 214, 1 December 1989 (1989-12-01), pages 159-175, XP026535048, ISSN: 0022-2860, DOI: DOI:10.1016/0022-2860(89)80012-2 [retrieved on 1989-12-01], the whole document * |
| POISSONNET G. ET AL.: "Parsing Failed The emergence of selective 5-HT 2B antagonists structures, activities and potential therapeutic applications", MINI REVIEWS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 4, 1 March 2004 (2004-03-01), pages 325-330, XP009141939, ISSN: 1389-5575, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8703958B2 (en) | 2014-04-22 |
| CA2806647A1 (en) | 2012-03-08 |
| CA2806647C (en) | 2018-09-18 |
| ZA201301561B (en) | 2014-08-27 |
| AU2011298361B2 (en) | 2014-03-13 |
| EP2619180B1 (en) | 2014-10-08 |
| EA201390312A1 (ru) | 2013-07-30 |
| KR20130101503A (ko) | 2013-09-13 |
| CN103080089A (zh) | 2013-05-01 |
| KR101815123B1 (ko) | 2018-01-04 |
| US20140187585A1 (en) | 2014-07-03 |
| SG188233A1 (en) | 2013-04-30 |
| US20130172386A1 (en) | 2013-07-04 |
| WO2012028614A1 (en) | 2012-03-08 |
| JP2013536823A (ja) | 2013-09-26 |
| AU2011298361A1 (en) | 2013-02-14 |
| US9139523B2 (en) | 2015-09-22 |
| JP5845263B2 (ja) | 2016-01-20 |
| BR112013004503A2 (pt) | 2016-06-07 |
| MX2013002409A (es) | 2013-04-03 |
| ES2525515T3 (es) | 2014-12-23 |
| EP2619180A1 (en) | 2013-07-31 |
| HK1182097A1 (zh) | 2013-11-22 |
| CN103080089B (zh) | 2015-09-23 |
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