DOP2015000068A - SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS - Google Patents

SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS

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Publication number
DOP2015000068A
DOP2015000068A DO2015000068A DO2015000068A DOP2015000068A DO P2015000068 A DOP2015000068 A DO P2015000068A DO 2015000068 A DO2015000068 A DO 2015000068A DO 2015000068 A DO2015000068 A DO 2015000068A DO P2015000068 A DOP2015000068 A DO P2015000068A
Authority
DO
Dominican Republic
Prior art keywords
ntzx
mbdz
composition
treatment
pharmaceutical combination
Prior art date
Application number
DO2015000068A
Other languages
Spanish (es)
Inventor
Esteban Alejandro Fiore
Original Assignee
Rhein Siegfried Sa De Cv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhein Siegfried Sa De Cv filed Critical Rhein Siegfried Sa De Cv
Priority to DO2015000068A priority Critical patent/DOP2015000068A/en
Publication of DOP2015000068A publication Critical patent/DOP2015000068A/en

Links

Abstract

La presente invención se refiere a una composición farmacéutica sinérgica para el tratamiento de parasitosis humana de Mebendazol (MBDZ) con Nitazoxanida (NTZX), que amplía significativamente el espectro del MBDZ contra protozoos y refuerza la acción antihelmíntica de la NTZX. Además, al usar dicha combinación farmacéutica de MBDZ y NTZX, la acción sistémica del metabolito activo de la NTZX, la Tizoxanida, y el tratamiento de algunas formas sistémicas de parasitosis, mantienen los mismos efectos de los principios activos individuales. También, la combinación farmacéutica sinérgica de MBDZ con NTZX logra un mayor espectro antiparasitario, mientras mantienen la eficacia y los perfiles de seguridad de ambos principios activos por separado. Todos estos efectos permiten que la combinación farmacéutica de la presente invención se diferencie del resto de los tratamientos antiparasitarios clásicos que tienen espectros más acotados. Los efectos sinérgicos de la combinación farmacéutica MBDZ y NTZX son, por consiguiente, el objeto principal de la presente invención.The present invention relates to a synergistic pharmaceutical composition for the treatment of human parasitosis of Mebendazole (MBDZ) with Nitazoxanide (NTZX), which significantly broadens the spectrum of the MBDZ against protozoa and reinforces the anthelmintic action of NTZX. Furthermore, by using said pharmaceutical combination of MBDZ and NTZX, the systemic action of the active metabolite of NTZX, Tizoxanide, and the treatment of some systemic forms of parasitosis, maintain the same effects of individual active ingredients. Also, the synergistic pharmaceutical combination of MBDZ with NTZX achieves a greater antiparasitic spectrum, while maintaining the efficacy and safety profiles of both active ingredients separately. All these effects allow the pharmaceutical combination of the present invention to be distinguished from the rest of the classic antiparasitic treatments that have more narrow spectra. The synergistic effects of the pharmaceutical combination MBDZ and NTZX are, therefore, the main object of the present invention.

DO2015000068A 2015-03-20 2015-03-20 SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS DOP2015000068A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DO2015000068A DOP2015000068A (en) 2015-03-20 2015-03-20 SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DO2015000068A DOP2015000068A (en) 2015-03-20 2015-03-20 SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS

Publications (1)

Publication Number Publication Date
DOP2015000068A true DOP2015000068A (en) 2015-05-31

Family

ID=53274302

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2015000068A DOP2015000068A (en) 2015-03-20 2015-03-20 SYNERGIC COMPOSITION OF NITAZOXANIDA AND MEBENDAZOL, PROCESSES TO PREPARE IT AND THE USE OF SUCH COMPOSITION FOR THE TREATMENT OF HUMAN PARASITOSIS

Country Status (1)

Country Link
DO (1) DOP2015000068A (en)

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