CO7350656A2 - Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis - Google Patents

Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis

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Publication number
CO7350656A2
CO7350656A2 CO15081680A CO15081680A CO7350656A2 CO 7350656 A2 CO7350656 A2 CO 7350656A2 CO 15081680 A CO15081680 A CO 15081680A CO 15081680 A CO15081680 A CO 15081680A CO 7350656 A2 CO7350656 A2 CO 7350656A2
Authority
CO
Colombia
Prior art keywords
ntzx
mbdz
treatment
composition
pharmaceutical combination
Prior art date
Application number
CO15081680A
Other languages
Spanish (es)
Inventor
Esteban Alejandro; Fiore
Original Assignee
Rhein Siegfried Sa De Cv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54010752&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7350656(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhein Siegfried Sa De Cv filed Critical Rhein Siegfried Sa De Cv
Priority to CO15081680A priority Critical patent/CO7350656A2/en
Publication of CO7350656A2 publication Critical patent/CO7350656A2/en

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Abstract

La presente invención se refiere a una composición farmacéutica sinérgica para el tratamiento de parasitosis humana de Mebendazol (MBDZ) con Nitazoxanida (NTZX), que amplía significativamente el espectro del MBDZ contra protozoos y refuerza la acción antihelmíntica de la NTZX. Además, al usar dicha combinación farmacéutica de MBDZ y NTZX, la acción sistémica del metabolito activo de la NTZX, la Tizoxanida, y el tratamiento de algunas formas sistémicas de parasitosis, mantienen los mismos efectos de los principios activos individuales. También, la combinación farmacéutica sinérgica de MBDZ con NTZX logra un mayor espectro antiparasitario, mientras mantienen la eficacia y los perfiles de seguridad de ambos principios activos por separado. Todos estos efectos permiten que la combinación farmacéutica de la presente invención se diferencie del resto de los tratamientos antiparasitarios clásicos que tienen espectros más acotados. Los efectos sinérgicos de la combinación farmacéutica MBDZ y NTZX son, por consiguiente, el objeto principal de la presente invención.The present invention relates to a pharmaceutical pharmaceutical composition for the treatment of human parasitosis of Mebendazole (MBDZ) with Nitazoxanide (NTZX), which significantly broadens the spectrum of the MBDZ against protozoa and reinforces the action ; n antihelmintic of the NTZX. In addition, when using such a pharmaceutical combination of MBDZ and NTZX, the systemic action of the active metabolite of NTZX, Thizoxanide, and the treatment of some systematic forms of parasitosis, maintain the same effects of individual active ingredients. Also, the synergistic pharmaceutical combination of MBDZ with NTZX achieves a greater antiparasitic spectrum, while maintaining the efficacy and safety profiles of both active ingredients separately. All these effects allow the pharmaceutical combination of the present invention to be differentiated from the rest of the classic antiparasitic treatments that have more narrow spectra. The synergistic effects of the pharmaceutical combination MBDZ and NTZX are, therefore, the main object of the present invention.

CO15081680A 2015-04-13 2015-04-13 Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis CO7350656A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CO15081680A CO7350656A2 (en) 2015-04-13 2015-04-13 Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CO15081680A CO7350656A2 (en) 2015-04-13 2015-04-13 Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis

Publications (1)

Publication Number Publication Date
CO7350656A2 true CO7350656A2 (en) 2015-08-10

Family

ID=54010752

Family Applications (1)

Application Number Title Priority Date Filing Date
CO15081680A CO7350656A2 (en) 2015-04-13 2015-04-13 Synergistic composition of nitazoxanide and mebendazole, processes to prepare it and the use of said composition for the treatment of human parasitosis

Country Status (1)

Country Link
CO (1) CO7350656A2 (en)

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