DOP2013000016A - CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES - Google Patents

CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES

Info

Publication number
DOP2013000016A
DOP2013000016A DO2013000016A DO2013000016A DOP2013000016A DO P2013000016 A DOP2013000016 A DO P2013000016A DO 2013000016 A DO2013000016 A DO 2013000016A DO 2013000016 A DO2013000016 A DO 2013000016A DO P2013000016 A DOP2013000016 A DO P2013000016A
Authority
DO
Dominican Republic
Prior art keywords
docetaxel
dimetoxi
crystal forms
preparation procedures
solvates
Prior art date
Application number
DO2013000016A
Other languages
Spanish (es)
Inventor
Patricia Rortais
Pascal Billot
Marielle Dufraigne
Hagit Elmaleh
Alexandre Giuliani
Fabrice Mangin
Lionel Zaske
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39712334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2013000016(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of DOP2013000016A publication Critical patent/DOP2013000016A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Formas anhidras, solvatos y hetero-solvatos etanólicos, hidratos de dimetoxi5 docetaxel o (2R,3 S)-3-terc-butoxicarbonilamino-2-hidroxi-3-feni I-propionato de 4-acetoxi-2 Z -benzoiloxi-5 Z ,20-epoxi-1 -hidroxi-7 Z , 1 O Z -dimetoxi-9-oxo-tax-1 1 -en13Z-ilo y su preparación.Anhydrous forms, solvates and ethanolic hetero-solvates, dimethoxy5 docetaxel hydrates or (2R, 3 S) -3-tert-butoxycarbonylamino-2-hydroxy-3-feni I-propionate of 4-acetoxy-2 Z-benzoyloxy-5 Z , 20-epoxy-1-hydroxy-7 Z, 1 OZ-dimethoxy-9-oxo-tax-1 1 -en13Z-yl and its preparation.

DO2013000016A 2008-01-17 2013-01-15 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES DOP2013000016A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800243A FR2926551A1 (en) 2008-01-17 2008-01-17 CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING SAME

Publications (1)

Publication Number Publication Date
DOP2013000016A true DOP2013000016A (en) 2013-06-15

Family

ID=39712334

Family Applications (3)

Application Number Title Priority Date Filing Date
DO2010000211A DOP2010000211A (en) 2008-01-17 2010-07-07 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES
DO2013000016A DOP2013000016A (en) 2008-01-17 2013-01-15 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES
DO2013000212A DOP2013000212A (en) 2008-01-17 2013-09-25 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DO2010000211A DOP2010000211A (en) 2008-01-17 2010-07-07 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES

Family Applications After (1)

Application Number Title Priority Date Filing Date
DO2013000212A DOP2013000212A (en) 2008-01-17 2013-09-25 CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES

Country Status (42)

Country Link
US (5) US8378128B2 (en)
EP (2) EP2719694A1 (en)
JP (3) JP5932219B2 (en)
KR (3) KR20100103614A (en)
CN (3) CN104130220A (en)
AR (1) AR070175A1 (en)
AU (1) AU2009227081B2 (en)
BR (1) BRPI0906518A2 (en)
CA (1) CA2712373C (en)
CL (1) CL2009000094A1 (en)
CO (1) CO6351784A2 (en)
CR (1) CR11532A (en)
CY (1) CY1119129T1 (en)
DK (1) DK2247582T3 (en)
DO (3) DOP2010000211A (en)
EA (1) EA017670B1 (en)
EC (1) ECSP10010324A (en)
ES (1) ES2606228T3 (en)
FR (1) FR2926551A1 (en)
HK (1) HK1150603A1 (en)
HN (1) HN2010001435A (en)
HR (1) HRP20161655T1 (en)
HU (1) HUE032150T2 (en)
IL (2) IL207031A (en)
LT (1) LT2247582T (en)
MA (1) MA32086B1 (en)
ME (2) ME02694B (en)
MX (1) MX2010007840A (en)
MY (1) MY159362A (en)
NI (4) NI201001033A (en)
NZ (3) NZ598289A (en)
PL (1) PL2247582T3 (en)
PT (1) PT2247582T (en)
RS (1) RS55519B1 (en)
SG (1) SG179446A1 (en)
SI (1) SI2247582T1 (en)
TN (1) TN2010000284A1 (en)
TW (3) TW201444814A (en)
UA (1) UA105896C2 (en)
UY (1) UY31602A1 (en)
WO (1) WO2009115655A2 (en)
ZA (1) ZA201105206B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2779009A1 (en) 2009-10-29 2011-05-05 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
JP2014514306A (en) * 2011-04-12 2014-06-19 プラス・ケミカルス・エスアー Solid form of cabazitaxel and method for producing the same
TWI526437B (en) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 Crystalline forms of cabazitaxel
WO2013069027A1 (en) 2011-09-26 2013-05-16 Fresenius Kabi Oncology Ltd. Processes for the preparation of cabazitaxel involving c(7) -oh and c(13) -oh silylation or just c(7) -oh silylation
CN102503913B (en) * 2011-10-20 2014-03-26 江苏红豆杉生物科技股份有限公司 Preparation method for dimethoxy taxanes compound monocrystal directly used for X-ray single crystal diffraction analysis
WO2013065070A1 (en) 2011-11-01 2013-05-10 Fresenius Kabi Encology Ltd. Amorphous form of cabazitaxel and process for its preparation
ES2716799T3 (en) 2011-11-28 2019-06-17 Fresenius Kabi Oncology Ltd Crystal form of cabazitaxel and process for the preparation of it
EP2791122B1 (en) 2011-12-13 2019-01-23 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
US9403785B2 (en) 2012-01-03 2016-08-02 Shilpa Medicare Limited Process for preparing amorphous cabazitaxel
US9394266B2 (en) 2012-03-08 2016-07-19 IVAX International GmbH Solid state forms of cabazitaxel and processes for preparation thereof
CN102675257B (en) * 2012-05-10 2014-07-02 上海金和生物技术有限公司 Cabazitaxel crystal and preparation method thereof
CN102746258B (en) * 2012-07-25 2015-02-04 重庆泰濠制药有限公司 Crystal forms of cabazitaxel and preparation method thereof
CN104583189A (en) 2012-07-31 2015-04-29 永信药品工业股份有限公司 Amorphous cabazitaxel
EP2884963B1 (en) 2012-08-15 2017-12-27 Yung Shin Pharm. Ind. Co. Ltd. Stable pharmaceutical formulation of cabazitaxel
CN103664836B (en) * 2012-09-20 2016-04-20 齐鲁制药有限公司 Crystal form A of 7 β, 10 β-dimethoxy docetaxel deuterated acetone compound and preparation method thereof
CN102898406B (en) * 2012-11-02 2014-12-03 上海金和生物技术有限公司 Cabazitaxel crystal and preparation method thereof
CN103058960B (en) * 2012-12-12 2014-12-10 江苏奥赛康药业股份有限公司 Cabazitaxel polymorphic form and preparation method thereof
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
KR101429543B1 (en) * 2012-12-13 2014-08-14 주식회사 삼양바이오팜 A novel crystal form of cabazitaxel and a method for preparing the same
CN103910697B (en) * 2012-12-30 2016-08-03 上海医药工业研究院 Cabazitaxel acetic acid compound and crystallization thereof
CN103910696B (en) * 2012-12-30 2016-01-20 上海医药工业研究院 Cabazitaxel isopropyl ether compound and crystallization thereof
CN103910698B (en) * 2012-12-30 2016-01-20 上海医药工业研究院 Cabazitaxel acetone compound and crystallization thereof
EP2938605A4 (en) * 2012-12-31 2016-10-26 Shilpa Medicare Ltd Process for preparing amorphous cabazitaxel
WO2014115168A2 (en) * 2013-01-23 2014-07-31 Leiutis Pharmaceuticals Private Limited Novel solvate forms of cabazitaxel and process for preparation thereof
WO2014128728A2 (en) * 2013-02-25 2014-08-28 Laurus Labs Private Limited Solid forms of cabazitaxel and processes for preparation thereof
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
WO2015000165A1 (en) * 2013-07-04 2015-01-08 北京新天宇科技开发有限公司 Stable transformation product of dimethoxy docetaxel mono-acetonate and crystalline forms thereof, and methods for preparation of same
CN103450119B (en) * 2013-09-24 2015-06-17 天津炜捷制药有限公司 Cabazitaxel with crystal form W and method for preparing same
EP2865675A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
CN103601704B (en) * 2013-11-22 2015-05-06 石家庄智恒医药科技有限公司 Preparation method of amorphous cabazitaxel
CN104945453B (en) * 2014-03-28 2018-06-26 江苏天士力帝益药业有限公司 The polymorph of pyrazole derivatives
US10188626B2 (en) 2015-11-03 2019-01-29 Cipla Limited Stabilized cabazitaxel formulations
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) * 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (en) * 1995-03-27 1996-10-01 Aventis Pharma Sa NEW TAXOIDS, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
FR2745814B1 (en) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2771092B1 (en) 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF DERIVATIVES OF THE TAXOID CLASS
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
PL368945A1 (en) * 2001-11-30 2005-04-04 Bristol-Myers Squibb Company Paclitaxel solvates
FR2859996B1 (en) * 2003-09-19 2006-02-03 Aventis Pharma Sa ACETONIC SOLVAT OF DIMETHOXY DOCETAXEL AND PROCESS FOR PREPARING THE SAME
WO2007044950A2 (en) * 2005-10-12 2007-04-19 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
TWI394765B (en) * 2008-12-12 2013-05-01 Ind Tech Res Inst Flame-retardant waterborne polyurethane dispersion
CA2779009A1 (en) 2009-10-29 2011-05-05 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
TWI526437B (en) 2011-09-09 2016-03-21 台灣神隆股份有限公司 Crystalline forms of cabazitaxel
ES2716799T3 (en) 2011-11-28 2019-06-17 Fresenius Kabi Oncology Ltd Crystal form of cabazitaxel and process for the preparation of it
EP2791122B1 (en) 2011-12-13 2019-01-23 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same

Also Published As

Publication number Publication date
EP2247582A2 (en) 2010-11-10
KR20150042302A (en) 2015-04-20
KR20100103614A (en) 2010-09-27
US20140350272A1 (en) 2014-11-27
EP2247582B1 (en) 2016-09-07
SI2247582T1 (en) 2017-03-31
HRP20161655T1 (en) 2017-01-27
NZ603797A (en) 2013-05-31
UY31602A1 (en) 2009-08-31
DOP2013000212A (en) 2014-01-31
JP2014074054A (en) 2014-04-24
NI201001032A (en) 2011-04-26
US10160739B2 (en) 2018-12-25
NI201001031A (en) 2011-04-26
CN104130221A (en) 2014-11-05
TW201444814A (en) 2014-12-01
EA201070856A1 (en) 2011-02-28
TW201444813A (en) 2014-12-01
US20110144362A1 (en) 2011-06-16
MA32086B1 (en) 2011-02-01
JP2015163626A (en) 2015-09-10
US20190144406A1 (en) 2019-05-16
NZ586829A (en) 2012-05-25
MY159362A (en) 2016-12-30
NZ598289A (en) 2013-06-28
CA2712373A1 (en) 2009-09-24
JP5932219B2 (en) 2016-06-08
IL207031A0 (en) 2010-12-30
AU2009227081A1 (en) 2009-09-24
TN2010000284A1 (en) 2011-11-11
CA2712373C (en) 2016-06-14
AU2009227081B2 (en) 2013-11-14
CY1119129T1 (en) 2018-02-14
CO6351784A2 (en) 2011-12-20
JP2011509980A (en) 2011-03-31
PT2247582T (en) 2016-11-16
CN104130220A (en) 2014-11-05
ME02694B (en) 2017-10-20
CL2009000094A1 (en) 2010-02-12
NI201001033A (en) 2011-04-26
LT2247582T (en) 2017-01-25
SG179446A1 (en) 2012-04-27
EP2719694A1 (en) 2014-04-16
KR20150042303A (en) 2015-04-20
MX2010007840A (en) 2010-08-04
BRPI0906518A2 (en) 2015-07-14
DOP2010000211A (en) 2010-07-31
NI201000103A (en) 2011-04-26
US8846959B2 (en) 2014-09-30
CN101918385A (en) 2010-12-15
HUE032150T2 (en) 2017-08-28
US20180002302A1 (en) 2018-01-04
WO2009115655A3 (en) 2010-04-01
WO2009115655A2 (en) 2009-09-24
DK2247582T3 (en) 2017-01-02
EA017670B1 (en) 2013-02-28
UA105896C2 (en) 2014-07-10
IL229239A0 (en) 2013-12-31
US20130178639A1 (en) 2013-07-11
ES2606228T3 (en) 2017-03-23
FR2926551A1 (en) 2009-07-24
TW200944510A (en) 2009-11-01
TWI477492B (en) 2015-03-21
HN2010001435A (en) 2014-02-03
CN101918385B (en) 2014-07-02
AR070175A1 (en) 2010-03-17
RS55519B1 (en) 2017-05-31
ECSP10010324A (en) 2010-08-31
PL2247582T3 (en) 2017-04-28
IL207031A (en) 2017-11-30
ME01009B (en) 2012-10-20
ZA201105206B (en) 2013-05-29
US8378128B2 (en) 2013-02-19
HK1150603A1 (en) 2012-01-06
CR11532A (en) 2010-11-22

Similar Documents

Publication Publication Date Title
DOP2013000016A (en) CRYSTAL FORMS OF DIMETOXI-DOCETAXEL AND ITS PREPARATION PROCEDURES
CR20120158A (en) IMINOTIADIAZINE DIÒXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE.
ECSP12012011A (en) CERTAIN TRIAZOLOPIRIDINS AND TRIAZOLOPIRAZINS, COMPOSITIONS OF THESE AND THEIR EMPLOYMENT METHODS
UY34484A (en) BENZOTIENILO-PIRROLOTRIAZINAS DISUSTITUIDAS AND ITS USES
AR059978A1 (en) PHARMACEUTICAL COMPOSITIONS
EA201270619A1 (en) USE OF BETANEHOL FOR THE TREATMENT OF XEROSTOMY
EA201171367A1 (en) VINYLINDASOLYL COMPOUNDS
MX2009008430A (en) Anti-robo4 antibodies and uses therefor.
UY33826A (en) UNION PROTEINS WITH TRIVARIABLE DOMAINS AND ITS USES
CR20150247A (en) ANTIHEMAGLUTININE ANTIBODIES AND METHODS OF USE
EA201270149A1 (en) BACE INHIBITORS
GT200800190A (en) NEW SYNTHESIS PROCEDURE FOR THE STRONTIUM RANELATE AND ITS HYDRATS
CR10955A (en) NEW AGOMELATINE SYNTHESIS PROCEDURE
AR074222A1 (en) CARBOXYAMIDE LANTIBIOTIC DERIVATIVES WITH IMPROVED ANTIBACTERIAL ACTIVITY, PROCEDURE FOR OBTAINING YOUR PHARMACEUTICAL COMPOSITIONS CARBOXAMIDE DERIVATIVES AND USE OF THEM
BRPI0814772A2 (en) INDAZOES REPLACED BY 5-PYRIDINONE
GT201000037A (en) CYCLIC DEPSIPEPTIDES
CR10960A (en) NEW AGOMELATINE SYNTHESIS PROCEDURE
CR10934A (en) NEW AGOMELATINE SYNTHESIS PROCEDURE
MA32474B1 (en) New derivatives of (piperazinil major) -1-Alkon and their use p75 inhibitors
UY32654A (en) COMPOUNDS 1- (2-RENT-2,3-DIHIDRO-BENZOFURAN-4-IL) -PIRROLIDIN-3-ILAMINOACILO
CL2012000355A1 (en) Compounds derived from 4-amino-butenamide; pharmaceutical composition; and use in the treatment of COPD.
CO6561812A2 (en) DERIVATIVES OF 2-ALDOXIMINO-5-FLUOROPIRIMIDINA
CL2009000317A1 (en) Compounds derived from substituted 3-alkyl-piperazine; pharmaceutical composition; and its use in the treatment of depression and anxiety.
UA110458C2 (en) Inhibitors ns5a vgs
CL2010001424A1 (en) Compounds derived from azacarbolines; intermediate compounds; pharmaceutical composition; preparation procedure; and its use in the treatment of cancer.