DOP2006000185A - BENZOATE SALT OF 4- (5-METHYLLOZAZOLO [4,5-B] PIRIDIN-2-IL) -1,4-DIAZABICICLO [3,2,2] NONANO - Google Patents

BENZOATE SALT OF 4- (5-METHYLLOZAZOLO [4,5-B] PIRIDIN-2-IL) -1,4-DIAZABICICLO [3,2,2] NONANO

Info

Publication number
DOP2006000185A
DOP2006000185A DO2006000185A DO2006000185A DOP2006000185A DO P2006000185 A DOP2006000185 A DO P2006000185A DO 2006000185 A DO2006000185 A DO 2006000185A DO 2006000185 A DO2006000185 A DO 2006000185A DO P2006000185 A DOP2006000185 A DO P2006000185A
Authority
DO
Dominican Republic
Prior art keywords
nonano
benzoate salt
methyllozazolo
diazabiciclo
piridin
Prior art date
Application number
DO2006000185A
Other languages
Spanish (es)
Inventor
Allen Jocab Duplantier
Kenneth George Kraus
Bruuce Nelsen Rogers
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of DOP2006000185A publication Critical patent/DOP2006000185A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona una sal benzoato de formula 1: Formula I La formula I es tambien conocida como 4-(5-metiloxazolo[4,5-b]piridin-2-il)-1,4-diazabiciclo[3.2.2]nonano. La sal benzoato de la invención es util en el tratamiento de esquizofrenia y enfermedad de Alzheimer. Es particularmente util en el tratamiento de deficit cognitivos asociados a esquizofrenia, sintomas de deficit cognitivo y de atención de la enfermedad de Alzheimer y neurodegeneracibn asociada a la enfermedad de Alzheimer.The present invention provides a benzoate salt of formula 1: Formula I Formula I is also known as 4- (5-methyloxazolo [4,5-b] pyridin-2-yl) -1,4-diazabicyclo [3.2.2] nonano. The benzoate salt of the invention is useful in the treatment of schizophrenia and Alzheimer's disease. It is particularly useful in the treatment of cognitive deficits associated with schizophrenia, symptoms of cognitive deficit and attention to Alzheimer's disease and neurodegeneration associated with Alzheimer's disease.

DO2006000185A 2005-08-08 2006-08-08 BENZOATE SALT OF 4- (5-METHYLLOZAZOLO [4,5-B] PIRIDIN-2-IL) -1,4-DIAZABICICLO [3,2,2] NONANO DOP2006000185A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70660105P 2005-08-08 2005-08-08

Publications (1)

Publication Number Publication Date
DOP2006000185A true DOP2006000185A (en) 2007-03-31

Family

ID=37398316

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2006000185A DOP2006000185A (en) 2005-08-08 2006-08-08 BENZOATE SALT OF 4- (5-METHYLLOZAZOLO [4,5-B] PIRIDIN-2-IL) -1,4-DIAZABICICLO [3,2,2] NONANO

Country Status (6)

Country Link
AR (1) AR055111A1 (en)
DO (1) DOP2006000185A (en)
NL (1) NL1032286C2 (en)
TW (1) TW200738734A (en)
UY (1) UY29731A1 (en)
WO (1) WO2007017750A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009113950A1 (en) * 2008-03-10 2009-09-17 Astrazeneca Ab Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
AU2017384392B2 (en) 2016-12-20 2023-05-25 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
JP7236389B2 (en) 2016-12-20 2023-03-09 エルテーエス ローマン テラピー－ジステーメ アーゲー Transdermal therapeutic system containing asenapine
CN107188900B (en) * 2017-05-27 2019-09-06 北京师范大学 The ligand compound of alpha 7 nicotinic acetylcholine receptors and its application
EP3644973B1 (en) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer
BR112020026099A2 (en) 2018-06-20 2021-03-23 Lts Lohmann Therapie-Systeme Ag transdermal therapeutic system containing asenapine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
JP2007516275A (en) * 2003-12-23 2007-06-21 ファイザー・プロダクツ・インク Therapeutic combinations for cognitive enhancement and psychotic disorders

Also Published As

Publication number Publication date
WO2007017750A1 (en) 2007-02-15
UY29731A1 (en) 2007-03-30
NL1032286A1 (en) 2007-02-09
NL1032286C2 (en) 2007-08-07
AR055111A1 (en) 2007-08-08
TW200738734A (en) 2007-10-16

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