DK65882A - Fremgangsmaade til fremstilling af substituerede phosphonamider - Google Patents

Fremgangsmaade til fremstilling af substituerede phosphonamider

Info

Publication number
DK65882A
DK65882A DK65882A DK65882A DK65882A DK 65882 A DK65882 A DK 65882A DK 65882 A DK65882 A DK 65882A DK 65882 A DK65882 A DK 65882A DK 65882 A DK65882 A DK 65882A
Authority
DK
Denmark
Prior art keywords
phosphonamids
substituted
procedure
preparation
substituted phosphonamids
Prior art date
Application number
DK65882A
Other languages
Danish (da)
English (en)
Inventor
W J Greenlee
E E Harris
A A Patchett
E D Thorsett
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK65882A publication Critical patent/DK65882A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK65882A 1981-02-17 1982-02-16 Fremgangsmaade til fremstilling af substituerede phosphonamider DK65882A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23533681A 1981-02-17 1981-02-17
US06/318,221 US4379146A (en) 1981-02-17 1981-11-05 Substituted phosphonamides as antihypertensives

Publications (1)

Publication Number Publication Date
DK65882A true DK65882A (da) 1982-08-18

Family

ID=26928818

Family Applications (1)

Application Number Title Priority Date Filing Date
DK65882A DK65882A (da) 1981-02-17 1982-02-16 Fremgangsmaade til fremstilling af substituerede phosphonamider

Country Status (6)

Country Link
US (1) US4379146A (es)
EP (1) EP0058427A3 (es)
DK (1) DK65882A (es)
ES (1) ES509653A0 (es)
GR (1) GR74785B (es)
PT (1) PT74444B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
ATE22692T1 (de) * 1981-08-03 1986-10-15 Squibb & Sons Inc Phosphonamidate verbindungen.
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4716155A (en) * 1981-12-24 1987-12-29 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and hypotensive use thereof
EP0085488B1 (en) * 1982-01-23 1990-03-28 Ajinomoto Co., Inc. Amino acid derivatives and antihypertensive drugs containing them
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560681A (en) * 1982-04-22 1985-12-24 E. R. Squibb & Sons, Inc. Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4448772A (en) * 1982-04-22 1984-05-15 E. R. Squibb & Sons, Inc. Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4460579A (en) * 1983-02-28 1984-07-17 E. R. Squibb & Sons, Inc. Thiazine and thiazepine containing compounds
US4555579A (en) * 1983-03-24 1985-11-26 E. R. Squibb & Sons, Inc. Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors
US4598071A (en) * 1983-03-28 1986-07-01 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic acid derivatives having anti-hypertensive properties
US4533661A (en) * 1983-03-28 1985-08-06 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity
US4567167A (en) * 1983-03-28 1986-01-28 E. R. Squibb & Sons, Inc. Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activity
US4558034A (en) * 1984-01-31 1985-12-10 The Board Of Trustees Of The University Of Kentucky Inhibitors of bacterial collagenase
US5189030A (en) * 1985-06-11 1993-02-23 Ciba-Geigy Corporation 1-amino-2-phenylethanephosphonic acids as microbiocides
DE3669512D1 (de) * 1985-06-11 1990-04-19 Ciba Geigy Ag Mikrobizide mittel.
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4931430A (en) * 1987-12-14 1990-06-05 E. R. Squibb & Sons, Inc. Method for preventing or treating anxiety employing an ACE inhibitor
EP0376040A3 (en) * 1988-12-27 1990-09-12 American Cyanamid Company N-phosphinyl di-and tripeptides as renin inhibitors
US5189023A (en) * 1990-09-04 1993-02-23 American Cyanamid Company Renin inhibitors
US5098889A (en) * 1990-09-17 1992-03-24 E. R. Squibb & Sons, Inc. Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors
US5032578A (en) * 1990-09-17 1991-07-16 E. R. Squibb & Sons, Inc. Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
JPH05105698A (ja) * 1991-06-13 1993-04-27 Takeda Chem Ind Ltd ホスホン酸誘導体、その製造法および用途
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
EP1115396A4 (en) * 1998-09-25 2002-05-22 Sunol Molecular Corp PHARMACEUTICALLY ACTIVE COMPOUNDS, AND METHODS OF USE THEREOF

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151172A (en) * 1977-08-11 1979-04-24 E. R. Squibb & Sons, Inc. Phosphonoacyl prolines and related compounds
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
US4168267A (en) * 1978-10-23 1979-09-18 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl prolines

Also Published As

Publication number Publication date
ES8307263A1 (es) 1983-07-01
EP0058427A2 (en) 1982-08-25
GR74785B (es) 1984-07-12
PT74444A (en) 1982-03-01
ES509653A0 (es) 1983-07-01
PT74444B (en) 1985-01-04
EP0058427A3 (en) 1983-10-05
US4379146A (en) 1983-04-05

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Legal Events

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ARF Application refused