DK589586A - EXPRESSION AND DIAGNOSTIC USE OF GAG-CODED PEPTIDES IMMUNOLOGICALLY REACTIVE WITH LOW ANTIBODIES. - Google Patents

EXPRESSION AND DIAGNOSTIC USE OF GAG-CODED PEPTIDES IMMUNOLOGICALLY REACTIVE WITH LOW ANTIBODIES.

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Publication number
DK589586A
DK589586A DK589586A DK589586A DK589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A
Authority
DK
Denmark
Prior art keywords
lav
gag
immunologically reactive
expression
operon
Prior art date
Application number
DK589586A
Other languages
Danish (da)
Other versions
DK589586D0 (en
DK168892B1 (en
Inventor
Susan Mitsue Watanabe
Wesley Cosand
Susan Mcardle
Bruce Mcfarland Travis
Pamela June Ward
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1986/000716 external-priority patent/WO1986006099A1/en
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of DK589586D0 publication Critical patent/DK589586D0/en
Publication of DK589586A publication Critical patent/DK589586A/en
Application granted granted Critical
Publication of DK168892B1 publication Critical patent/DK168892B1/en

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Immunologically reactive gag proteins of LAV are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid which contains prokaryotic transcriptional and translational signals for expression, followed downstream by a DNA sequence which comprises a part of the gag region of LAV. Preferred expression signals are selected from an inducible operon and/or an operon which can be repressed, such as the trp operon. The gag proteins are isolated from the bacterial host and used in diagnostic analyses which detect the presence of LAV antigens or LAV antibodies which are immunologically reactive with LAV. In addition, the proteins which are prepared in the process in question are used as a vaccine against infection which is caused by the virus for the acquired immunodeficiency syndrome (AIDS).
DK589586A 1985-04-08 1986-12-08 DNA sequence which encodes proteins which are immunologically reactive with antibodies against LAV/HTLV- III, a recombinant plasmid which contains the DNA, a bacterial cell which is transformed with a plasmid, a process for preparing the protein, and the use of the protein in analyses DK168892B1 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US72123785A 1985-04-08 1985-04-08
US72123785 1985-04-08
US75376985A 1985-07-10 1985-07-10
US75376985 1985-07-10
US76346085A 1985-08-07 1985-08-07
US76346085 1985-08-07
US82882886A 1986-02-12 1986-02-12
US82882886 1986-02-12
US8600716 1986-04-07
PCT/US1986/000716 WO1986006099A1 (en) 1985-04-08 1986-04-07 EXPRESSION AND DIAGNOSTIC USE OF gag ENCODED PEPTIDES WHICH ARE IMMUNOLOGICALLY REACTIVE WITH ANTIBODIES TO LAV

Publications (3)

Publication Number Publication Date
DK589586D0 DK589586D0 (en) 1986-12-08
DK589586A true DK589586A (en) 1987-02-09
DK168892B1 DK168892B1 (en) 1994-07-04

Family

ID=27536422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK589586A DK168892B1 (en) 1985-04-08 1986-12-08 DNA sequence which encodes proteins which are immunologically reactive with antibodies against LAV/HTLV- III, a recombinant plasmid which contains the DNA, a bacterial cell which is transformed with a plasmid, a process for preparing the protein, and the use of the protein in analyses

Country Status (2)

Country Link
DK (1) DK168892B1 (en)
NO (1) NO864901L (en)

Also Published As

Publication number Publication date
DK589586D0 (en) 1986-12-08
NO864901L (en) 1987-02-05
DK168892B1 (en) 1994-07-04
NO864901D0 (en) 1986-12-05

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed