DK589586A - EXPRESSION AND DIAGNOSTIC USE OF GAG-CODED PEPTIDES IMMUNOLOGICALLY REACTIVE WITH LOW ANTIBODIES. - Google Patents
EXPRESSION AND DIAGNOSTIC USE OF GAG-CODED PEPTIDES IMMUNOLOGICALLY REACTIVE WITH LOW ANTIBODIES.Info
- Publication number
- DK589586A DK589586A DK589586A DK589586A DK589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A DK 589586 A DK589586 A DK 589586A
- Authority
- DK
- Denmark
- Prior art keywords
- lav
- gag
- immunologically reactive
- expression
- operon
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Immunologically reactive gag proteins of LAV are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid which contains prokaryotic transcriptional and translational signals for expression, followed downstream by a DNA sequence which comprises a part of the gag region of LAV. Preferred expression signals are selected from an inducible operon and/or an operon which can be repressed, such as the trp operon. The gag proteins are isolated from the bacterial host and used in diagnostic analyses which detect the presence of LAV antigens or LAV antibodies which are immunologically reactive with LAV. In addition, the proteins which are prepared in the process in question are used as a vaccine against infection which is caused by the virus for the acquired immunodeficiency syndrome (AIDS).
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72123785A | 1985-04-08 | 1985-04-08 | |
US72123785 | 1985-04-08 | ||
US75376985A | 1985-07-10 | 1985-07-10 | |
US75376985 | 1985-07-10 | ||
US76346085A | 1985-08-07 | 1985-08-07 | |
US76346085 | 1985-08-07 | ||
US82882886A | 1986-02-12 | 1986-02-12 | |
US82882886 | 1986-02-12 | ||
US8600716 | 1986-04-07 | ||
PCT/US1986/000716 WO1986006099A1 (en) | 1985-04-08 | 1986-04-07 | EXPRESSION AND DIAGNOSTIC USE OF gag ENCODED PEPTIDES WHICH ARE IMMUNOLOGICALLY REACTIVE WITH ANTIBODIES TO LAV |
Publications (3)
Publication Number | Publication Date |
---|---|
DK589586D0 DK589586D0 (en) | 1986-12-08 |
DK589586A true DK589586A (en) | 1987-02-09 |
DK168892B1 DK168892B1 (en) | 1994-07-04 |
Family
ID=27536422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK589586A DK168892B1 (en) | 1985-04-08 | 1986-12-08 | DNA sequence which encodes proteins which are immunologically reactive with antibodies against LAV/HTLV- III, a recombinant plasmid which contains the DNA, a bacterial cell which is transformed with a plasmid, a process for preparing the protein, and the use of the protein in analyses |
Country Status (2)
Country | Link |
---|---|
DK (1) | DK168892B1 (en) |
NO (1) | NO864901L (en) |
-
1986
- 1986-12-05 NO NO864901A patent/NO864901L/en unknown
- 1986-12-08 DK DK589586A patent/DK168892B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK589586D0 (en) | 1986-12-08 |
NO864901L (en) | 1987-02-05 |
DK168892B1 (en) | 1994-07-04 |
NO864901D0 (en) | 1986-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |