DK563585A - EXTENDED EFFECTS OF IMMUNOTOXINS CONTAINING A GLYCOPEPTIDE COMPONENT WHICH INACTIVES RIBOSOMES AND MODIFIED IN ITS POLYSACCHARIDE UNITS AND PROCEDURES FOR THE PREPARATION OF IMMUNOTOXINES - Google Patents

EXTENDED EFFECTS OF IMMUNOTOXINS CONTAINING A GLYCOPEPTIDE COMPONENT WHICH INACTIVES RIBOSOMES AND MODIFIED IN ITS POLYSACCHARIDE UNITS AND PROCEDURES FOR THE PREPARATION OF IMMUNOTOXINES Download PDF

Info

Publication number
DK563585A
DK563585A DK563585A DK563585A DK563585A DK 563585 A DK563585 A DK 563585A DK 563585 A DK563585 A DK 563585A DK 563585 A DK563585 A DK 563585A DK 563585 A DK563585 A DK 563585A
Authority
DK
Denmark
Prior art keywords
immunotoxines
inactives
ribosomes
procedures
modified
Prior art date
Application number
DK563585A
Other languages
Danish (da)
Other versions
DK563585D0 (en
Inventor
Franz Jansen
Pierre Gros
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK563585D0 publication Critical patent/DK563585D0/en
Publication of DK563585A publication Critical patent/DK563585A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Prolonged-acting immunotoxin consisting of a conjugate in which an antibody or antibody fragment is coupled, via a covalent structure containing a disulphide group or a thioether group, to a ribosome-inactivating glycoprotein having a prolonged action obtained by oxidation of its saccharide moieties with periodate ions.
DK563585A 1985-02-13 1985-12-05 EXTENDED EFFECTS OF IMMUNOTOXINS CONTAINING A GLYCOPEPTIDE COMPONENT WHICH INACTIVES RIBOSOMES AND MODIFIED IN ITS POLYSACCHARIDE UNITS AND PROCEDURES FOR THE PREPARATION OF IMMUNOTOXINES DK563585A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8502068A FR2577135B1 (en) 1985-02-13 1985-02-13 LONG-TERM ACTION IMMUNOTOXINS COMPRISING A GLYCOPEPTITIDE CONSTITUENT MODIFYING RIBOSOMES MODIFIED ON ITS POLYSACCHARIDE PATTERNS

Publications (2)

Publication Number Publication Date
DK563585D0 DK563585D0 (en) 1985-12-05
DK563585A true DK563585A (en) 1986-08-14

Family

ID=9316241

Family Applications (1)

Application Number Title Priority Date Filing Date
DK563585A DK563585A (en) 1985-02-13 1985-12-05 EXTENDED EFFECTS OF IMMUNOTOXINS CONTAINING A GLYCOPEPTIDE COMPONENT WHICH INACTIVES RIBOSOMES AND MODIFIED IN ITS POLYSACCHARIDE UNITS AND PROCEDURES FOR THE PREPARATION OF IMMUNOTOXINES

Country Status (14)

Country Link
EP (1) EP0192002B1 (en)
JP (1) JPH0725701B2 (en)
KR (1) KR930003333B1 (en)
AT (1) ATE75487T1 (en)
AU (1) AU591077B2 (en)
CA (1) CA1264667A (en)
DE (1) DE3585951D1 (en)
DK (1) DK563585A (en)
FR (1) FR2577135B1 (en)
GR (1) GR852914B (en)
IE (1) IE59909B1 (en)
NZ (1) NZ214482A (en)
PT (1) PT81623B (en)
ZA (1) ZA859299B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2566271B1 (en) * 1984-06-20 1986-11-07 Sanofi Sa NOVEL CYTOTOXIC CONJUGATES FOR USE IN THERAPEUTICS AND PROCESS FOR OBTAINING SAME
FR2573656B1 (en) * 1984-11-29 1987-02-27 Sanofi Sa MEDICINAL PRODUCT COMPRISING A COMBINATION OF AT LEAST ONE IMMUNOTOXIN AND AT LEAST ONE MANNOSE-CONTAINING POLYMER
ATE81467T1 (en) * 1987-02-24 1992-10-15 Xoma Corp IMMUNOSUPPRESSION IN IMMUNOTOXIN-BASED TREATMENT OF HUMANS.
US4981979A (en) * 1987-09-10 1991-01-01 Neorx Corporation Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
IT1249051B (en) * 1991-02-26 1995-02-11 Italfarmaco Spa IMMUNOTOXIN FROM ANTI-CD5 MONOCLONAL ANTIBODIES
US5376546A (en) * 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL47372A (en) * 1975-05-27 1979-10-31 Yeda Res & Dev Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same
FR2437213A1 (en) * 1978-09-28 1980-04-25 Cm Ind CYTOTOXIC PRODUCTS FORMED BY COVALENT BINDING OF THE CHAIN TO RICIN WITH AN ANTIBODY AND THEIR PREPARATION METHOD
JPS5616418A (en) * 1979-07-20 1981-02-17 Teijin Ltd Antitumor protein complex and its preparation
EP0044167A3 (en) * 1980-07-14 1982-04-21 The Regents Of The University Of California Antibody targeted cytotoxic agent
FR2504010B1 (en) * 1981-04-15 1985-10-25 Sanofi Sa ANTI-CANCER MEDICINAL PRODUCTS CONTAINING THE RICIN-ASSOCIATED CHAIN ASSOCIATED WITH ANTIMELANOMA ANTIBODY AND PROCESS FOR THEIR PREPARATION
JPS5843926A (en) * 1981-09-08 1983-03-14 Suntory Ltd Selective carcinostatic agent
FR2516794B1 (en) * 1981-11-20 1985-10-25 Sanofi Sa NOVEL CANCER DRUGS FOR THE TREATMENT OF LEUKEMIA T CONTAINING RICIN AND A SPECIFIC MONOCLONAL ANTIBODY
CA1203164A (en) * 1982-03-09 1986-04-15 Thomas J. Mckearn Antibody conjugates
PT80662B (en) * 1984-06-20 1986-12-09 Sanofi Sa Process to obtain anti-tumoral glycoprotein modified on its glycidic portions

Also Published As

Publication number Publication date
JPS61200925A (en) 1986-09-05
JPH0725701B2 (en) 1995-03-22
ZA859299B (en) 1986-08-27
NZ214482A (en) 1989-08-29
CA1264667A (en) 1990-01-23
DK563585D0 (en) 1985-12-05
PT81623B (en) 1988-04-21
KR930003333B1 (en) 1993-04-26
FR2577135A1 (en) 1986-08-14
GR852914B (en) 1986-04-07
KR860006482A (en) 1986-09-11
DE3585951D1 (en) 1992-06-04
AU5078385A (en) 1986-08-14
IE59909B1 (en) 1994-04-20
ATE75487T1 (en) 1992-05-15
EP0192002A1 (en) 1986-08-27
EP0192002B1 (en) 1992-04-29
IE853071L (en) 1986-08-13
PT81623A (en) 1986-01-01
FR2577135B1 (en) 1989-12-15
AU591077B2 (en) 1989-11-30

Similar Documents

Publication Publication Date Title
MX9102535A (en) LIQUID COMPOSITIONS OF SACARALOSA CONCENTRATE.
DK593285A (en) POLYSACCHARIDE CONNECTION AND PROCEDURES FOR PRODUCING THEREOF
DK100887A (en) AMINO ACID DERIVATIVES
DK563585D0 (en) EXTENDED EFFECTS OF IMMUNOTOXINS CONTAINING A GLYCOPEPTIDE COMPONENT WHICH INACTIVES RIBOSOMES AND MODIFIED IN ITS POLYSACCHARIDE UNITS AND PROCEDURES FOR THE PREPARATION OF IMMUNOTOXINES
DK1191852T3 (en) Device for processing a slaughter product
FI923155A (en) GELGUMMI FOER ICKE-SPROEDA GELER
ATE137242T1 (en) COVALENT-THER LIPIDENUCLEOSIDE CONJUGATES
KR870000941A (en) Light irradiation therapy and beauty device
SE8600998D0 (en) PARENTERAL PHENYTOIN PREPARATION
NZ221065A (en) Conjugates of antibodies and toxins with sulphur-containing linking groups
DE3750025D1 (en) Cytostatic anthracycline derivatives.
NZ235316A (en) Vaccine containing capsular polysaccharide conjugated to recombinant c protein of a group b streptococcus, production and use against b streptococcus infection
DE3688137D1 (en) RICIN ANTIBODY CONJUGATES.
DK1037642T3 (en) Modified polysaccharides with altered biological recognition
IT8721474A0 (en) TAURINE DERIVATIVES.
ES1006576U (en) Double balloon catheter for percutaneous valvuloplasty guide. (Machine-translation by Google Translate, not legally binding)
ES1000902U (en) Skewer-support-piece for portaprecios (Machine-translation by Google Translate, not legally binding)
ES279345U (en) Perfected lantern (Machine-translation by Google Translate, not legally binding)
SE8603683L (en) LIGHTING MARKING DEVICE
RO102805A2 (en) Vitaminised composition for children
ES248334U (en) Security device in the positional fixation of elements linked sliding. (Machine-translation by Google Translate, not legally binding)
KR890012643A (en) Alternative to bioenergy source by Leucine
ES1011770U (en) Lamp for indirect light. (Machine-translation by Google Translate, not legally binding)
PT7986U (en) FIXATION OF PROTEIN CAPILLARY BY INTEGRATION WITH NATURAL POINT

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment