DK52292D0 - hirudin - Google Patents

hirudin

Info

Publication number
DK52292D0
DK52292D0 DK92522A DK52292A DK52292D0 DK 52292 D0 DK52292 D0 DK 52292D0 DK 92522 A DK92522 A DK 92522A DK 52292 A DK52292 A DK 52292A DK 52292 D0 DK52292 D0 DK 52292D0
Authority
DK
Denmark
Prior art keywords
new
derivs
terminally
fusion proteins
hirudin
Prior art date
Application number
DK92522A
Other languages
Danish (da)
Other versions
DK52292A (en
DK172210B1 (en
Inventor
Paul Habermann
Friedrich Wengenmayer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK52292A publication Critical patent/DK52292A/en
Publication of DK52292D0 publication Critical patent/DK52292D0/en
Application granted granted Critical
Publication of DK172210B1 publication Critical patent/DK172210B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Fusion proteins in which the C- or N-terminal essentially corresponds to the first 100 units of interleukin 2 are new. Also new are gene structures coding for the above fusion proteins, vectors containing these gene structures, and hot cells containing these vectors. Hirudin derivs. with an amino acide sequence begining N-terminally with Pro are new and claimed. Human interleukin 2 derivs. contg. Asp. C-terminally are new and claimed.
DK052292A 1985-11-27 1992-04-21 hirudin DK172210B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853541856 DE3541856A1 (en) 1985-11-27 1985-11-27 EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3541856 1985-11-27

Publications (3)

Publication Number Publication Date
DK52292A DK52292A (en) 1992-04-21
DK52292D0 true DK52292D0 (en) 1992-04-21
DK172210B1 DK172210B1 (en) 1998-01-05

Family

ID=6286938

Family Applications (2)

Application Number Title Priority Date Filing Date
DK568586A DK172064B1 (en) 1985-11-27 1986-11-26 Fusion protein, its preparation and use, gene structure encoding the fusion protein, vector containing the gene structure, and host cell containing the vector
DK052292A DK172210B1 (en) 1985-11-27 1992-04-21 hirudin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK568586A DK172064B1 (en) 1985-11-27 1986-11-26 Fusion protein, its preparation and use, gene structure encoding the fusion protein, vector containing the gene structure, and host cell containing the vector

Country Status (17)

Country Link
EP (3) EP0468539B1 (en)
JP (1) JP2566933B2 (en)
KR (1) KR950000300B1 (en)
AT (2) ATE127841T1 (en)
AU (1) AU595262B2 (en)
CA (1) CA1341203C (en)
DE (4) DE3541856A1 (en)
DK (2) DK172064B1 (en)
ES (3) ES2032378T3 (en)
FI (1) FI93471C (en)
GR (1) GR3005042T3 (en)
HU (1) HU203579B (en)
IE (1) IE59488B1 (en)
IL (1) IL80755A0 (en)
NO (1) NO176481C (en)
PT (1) PT83813B (en)
ZA (1) ZA868943B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125021A (en) * 1955-11-14 1964-03-17 Smooth
EP0168342B1 (en) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Process for the preparation of thrombin inhibitors
DE3545568A1 (en) * 1985-12-21 1987-07-16 Hoechst Ag GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
DE3819079A1 (en) * 1988-06-04 1989-12-07 Hoechst Ag HIRUDINE DERIVATIVES WITH DELAYED EFFECT
DE3835815A1 (en) * 1988-10-21 1990-04-26 Hoechst Ag NEW ISOHIRUDINE
DE3844211A1 (en) * 1988-12-29 1990-07-05 Hoechst Ag NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
WO1991000912A1 (en) * 1989-07-07 1991-01-24 Massachusetts Institute Of Technology Production and use of hybrid protease inhibitors
CU22222A1 (en) * 1989-08-03 1995-01-31 Cigb PROCEDURE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS PRODUCED IN A FUSION FORM IN ESCHERICHIA COLI, ITS USE, EXPRESSION VECTORS AND RECOMBINANT STRAINS
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
DE3942580A1 (en) * 1989-12-22 1991-06-27 Basf Ag METHOD FOR PRODUCING HIRUDINE
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
DE4140381A1 (en) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De NEW SYNTHETIC ISOHIRUDINE WITH IMPROVED STABILITY
DE4404168A1 (en) * 1994-02-10 1995-08-17 Hoechst Ag Hirudin derivatives and process for their preparation
DK0821006T3 (en) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulin derivatives with increased zinc binding
DE19726167B4 (en) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
DE10033195A1 (en) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunctional fusion proteins from hirudin and TAP
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
KR101820024B1 (en) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 Combination of an insulin and a GLP-1 agonist
ES2534191T3 (en) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
HUE037735T2 (en) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION COMPRISING desPro36Exendin-4(1-39)-Lys6-NH2 AND METHIONINE
BR112013004756B1 (en) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland use of ave0010 for the manufacture of a medication for the treatment of type 2 diabetes mellitus
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (en) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Pharmaceutical combination for use in glycemic control in patients with type 2 diabetes mellitus
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
JP6970615B2 (en) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Insulin glargine / lixisenatide fixed ratio prescription
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
KR20200080748A (en) 2018-12-27 2020-07-07 주식회사 폴루스 A Method for Purifying Proinsulin Using Anion Exchange Chromatography
KR20200080747A (en) 2018-12-27 2020-07-07 주식회사 폴루스 An Enzymatic Conversion Composition for Producing Insulin from Proinsulin and a Method for Producing Insulin from Proinsulin Using the Same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
DK108685A (en) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co GROWTH FACTOR I
CA1341414C (en) * 1984-03-27 2002-12-31 Paul Tolstoshev Expression vectors of hirudine, transformed cells and process for the preparation of hirudine
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
DE3429430A1 (en) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt GENE TECHNOLOGICAL METHOD FOR PRODUCING HIRUDINE AND MEANS FOR IMPLEMENTING THIS METHOD
DE3526995A1 (en) * 1985-07-27 1987-02-05 Hoechst Ag FUSION PROTEINS, METHOD FOR THEIR PRODUCTION AND THEIR USE
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
CA1297003C (en) * 1985-09-20 1992-03-10 Jack H. Nunberg Composition and method for treating animals

Also Published As

Publication number Publication date
DK52292A (en) 1992-04-21
ATE122397T1 (en) 1995-05-15
EP0468539B1 (en) 1995-09-13
GR3005042T3 (en) 1993-05-24
PT83813B (en) 1989-06-30
DE3650396D1 (en) 1995-10-19
FI93471B (en) 1994-12-30
DK568586A (en) 1987-05-28
ES2032378T3 (en) 1993-02-16
EP0464867A1 (en) 1992-01-08
ATE127841T1 (en) 1995-09-15
PT83813A (en) 1986-12-01
DE3650322D1 (en) 1995-06-14
NO176481B (en) 1995-01-02
DE3541856A1 (en) 1987-06-04
FI864798A (en) 1987-05-28
NO176481C (en) 1995-04-12
EP0227938B1 (en) 1992-04-15
IL80755A0 (en) 1987-02-27
ES2073081T3 (en) 1995-08-01
DK568586D0 (en) 1986-11-26
KR950000300B1 (en) 1995-01-13
CA1341203C (en) 2001-03-13
EP0468539A1 (en) 1992-01-29
JP2566933B2 (en) 1996-12-25
JPS62143696A (en) 1987-06-26
EP0464867B1 (en) 1995-05-10
ZA868943B (en) 1987-07-29
AU6569386A (en) 1987-06-04
HU203579B (en) 1991-08-28
DK172064B1 (en) 1997-10-06
KR870005098A (en) 1987-06-04
FI93471C (en) 1995-04-10
ES2077747T3 (en) 1995-12-01
EP0227938A2 (en) 1987-07-08
FI864798A0 (en) 1986-11-25
AU595262B2 (en) 1990-03-29
IE59488B1 (en) 1994-03-09
DE3684892D1 (en) 1992-05-21
HUT43642A (en) 1987-11-30
IE863119L (en) 1987-05-27
EP0227938A3 (en) 1988-11-23
NO864759D0 (en) 1986-11-26
DK172210B1 (en) 1998-01-05

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired