DK497682A - Fremgangsmaade til fremstilling af 7-oxabicycloheptan- og 7-oxabicycloheptenprostaglandinanaloge - Google Patents
Fremgangsmaade til fremstilling af 7-oxabicycloheptan- og 7-oxabicycloheptenprostaglandinanaloge Download PDFInfo
- Publication number
- DK497682A DK497682A DK497682A DK497682A DK497682A DK 497682 A DK497682 A DK 497682A DK 497682 A DK497682 A DK 497682A DK 497682 A DK497682 A DK 497682A DK 497682 A DK497682 A DK 497682A
- Authority
- DK
- Denmark
- Prior art keywords
- oxabicycloheptenprostaglandinanalogue
- oxabicycloheptan
- preparing
- procedure
- Prior art date
Links
- DYWAPFDKPAHSED-UHFFFAOYSA-N 2-cycloheptyloxepane Chemical compound C1CCCCCC1C1OCCCCC1 DYWAPFDKPAHSED-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31951181A | 1981-11-09 | 1981-11-09 | |
| US06/378,547 US4537981A (en) | 1981-11-09 | 1982-05-17 | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK497682A true DK497682A (da) | 1983-05-10 |
Family
ID=26982040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK497682A DK497682A (da) | 1981-11-09 | 1982-11-08 | Fremgangsmaade til fremstilling af 7-oxabicycloheptan- og 7-oxabicycloheptenprostaglandinanaloge |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4537981A (pt) |
| EP (1) | EP0079694B1 (pt) |
| KR (1) | KR890000185B1 (pt) |
| AU (1) | AU569464B2 (pt) |
| CA (1) | CA1215063A (pt) |
| DE (1) | DE3276317D1 (pt) |
| DK (1) | DK497682A (pt) |
| GR (1) | GR76780B (pt) |
| IE (1) | IE54086B1 (pt) |
| IL (1) | IL66989A0 (pt) |
| NZ (1) | NZ202138A (pt) |
| PH (1) | PH22106A (pt) |
| PT (1) | PT75811B (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837234A (en) * | 1981-12-23 | 1989-06-06 | National Research Development Corporation | Prostaglandins |
| DE3280020D1 (en) * | 1981-12-23 | 1989-12-21 | Nat Res Dev | Prostaglandins |
| US4614825A (en) * | 1982-05-17 | 1986-09-30 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane and 7-oxabicycloheptene compounds |
| US4474972A (en) * | 1983-03-14 | 1984-10-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same |
| US4536514A (en) * | 1984-04-06 | 1985-08-20 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease |
| US4661506A (en) * | 1984-11-30 | 1987-04-28 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted ox prostaglandin analogs |
| US4588743A (en) * | 1985-01-22 | 1986-05-13 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease |
| US4591603A (en) * | 1985-02-25 | 1986-05-27 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
| US4611007A (en) * | 1985-04-22 | 1986-09-09 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
| US4654366A (en) * | 1986-02-14 | 1987-03-31 | E. R. Squibb & Sons, Inc. | Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful as anti-thrombotic agents |
| US4931460A (en) * | 1987-09-17 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Post-ischemic myocardial dysfunction using thromboxane A2 antagonists |
| US4900723A (en) * | 1988-04-29 | 1990-02-13 | E. R. Squibb & Sons, Inc. | Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination |
| US4925873A (en) * | 1988-09-01 | 1990-05-15 | E. R. Squibb & Sons, Inc. | Method of treating skin injuries using thromboxane A2 receptor antagonists |
| US4839384A (en) * | 1988-10-07 | 1989-06-13 | E. R. Squibb & Sons, Inc. | Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist |
| CA2006086A1 (en) * | 1989-01-17 | 1990-07-17 | A. K. Gunnar Aberg | Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist |
| CA2007896A1 (en) * | 1989-02-06 | 1990-08-06 | A.K. Gunnar Aberg | Method of treating hypertension using a thromboxane a2 receptor antagonist and new combinations |
| CA2012852A1 (en) * | 1989-05-01 | 1990-11-01 | Miguel A. Ondetti | Method of inhibiting vasospasm and platelet aggregation resulting from angioplasty using thromboxane a receptor antagonists |
| US5093329A (en) * | 1990-03-12 | 1992-03-03 | Allergan, Inc. | Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives |
| ZA911453B (en) * | 1990-03-19 | 1991-11-27 | Squibb & Sons Inc | Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromoboxane,a2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation |
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
| JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| US9693998B2 (en) | 2014-05-16 | 2017-07-04 | Cumberland Pharmaceuticals, Inc. | Compositions and methods of treating cardiac fibrosis with ifetroban |
| CN107708692A (zh) | 2015-06-30 | 2018-02-16 | 坎伯兰医药品股份有限公司 | Aerd/哮喘中的血栓烷受体拮抗剂 |
| CN109152767B (zh) | 2016-05-11 | 2022-10-21 | 坎伯兰医药品股份有限公司 | 用血栓烷-a2受体拮抗剂治疗肌营养不良的组合物和方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4088779A (en) * | 1973-05-18 | 1978-05-09 | Ciba-Geigy Corporation | 9-Oxaprostaglandins |
| DE2357953A1 (de) * | 1973-11-21 | 1975-05-28 | Hoechst Ag | Neue, natuerlich nicht vorkommende analoga von prostansaeuren und verfahren zu ihrer herstellung |
| US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
| US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
| US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
| US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
| US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
| US4436934A (en) * | 1981-02-05 | 1984-03-13 | Iowa State University Research Foundation, Inc. | Bicyclic prostaglandin analogs and method of synthesis |
| US4416896A (en) * | 1982-05-17 | 1983-11-22 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease |
| US4456615A (en) * | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
| US4456616A (en) * | 1982-12-27 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
-
1982
- 1982-05-17 US US06/378,547 patent/US4537981A/en not_active Expired - Fee Related
- 1982-10-08 CA CA000413160A patent/CA1215063A/en not_active Expired
- 1982-10-12 NZ NZ202138A patent/NZ202138A/en unknown
- 1982-10-14 PH PH27983A patent/PH22106A/en unknown
- 1982-10-14 AU AU89359/82A patent/AU569464B2/en not_active Ceased
- 1982-10-15 IL IL66989A patent/IL66989A0/xx not_active IP Right Cessation
- 1982-10-22 EP EP82305634A patent/EP0079694B1/en not_active Expired
- 1982-10-22 DE DE8282305634T patent/DE3276317D1/de not_active Expired
- 1982-11-05 IE IE2648/82A patent/IE54086B1/en not_active IP Right Cessation
- 1982-11-08 PT PT75811A patent/PT75811B/pt not_active IP Right Cessation
- 1982-11-08 DK DK497682A patent/DK497682A/da not_active Application Discontinuation
- 1982-11-08 KR KR8205040A patent/KR890000185B1/ko active
- 1982-11-08 GR GR69754A patent/GR76780B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR890000185B1 (ko) | 1989-03-09 |
| AU8935982A (en) | 1983-05-19 |
| AU569464B2 (en) | 1988-02-04 |
| IL66989A0 (en) | 1983-02-23 |
| US4537981A (en) | 1985-08-27 |
| PT75811B (en) | 1985-07-26 |
| EP0079694B1 (en) | 1987-05-13 |
| IE822648L (en) | 1983-05-09 |
| CA1215063A (en) | 1986-12-09 |
| EP0079694A1 (en) | 1983-05-25 |
| PT75811A (en) | 1982-12-01 |
| DE3276317D1 (en) | 1987-06-19 |
| GR76780B (pt) | 1984-09-04 |
| NZ202138A (en) | 1986-03-14 |
| PH22106A (en) | 1988-06-01 |
| IE54086B1 (en) | 1989-06-07 |
| KR840002400A (ko) | 1984-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK497682A (da) | Fremgangsmaade til fremstilling af 7-oxabicycloheptan- og 7-oxabicycloheptenprostaglandinanaloge | |
| DK162647C (da) | Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner | |
| DK280182A (da) | Fremgangsmaade til fremstilling af n-aryl-piperazinalkanamider | |
| DK260682A (da) | Fremgangsmaade til fremstilling af partikelformige geler | |
| DK444682A (da) | Fremgangsmaade til fremstilling af peptider | |
| DK81082A (da) | Fremgangsmaade til fremstilling af polypeptider | |
| DK606084D0 (da) | Fremgangsmaade til fremstilling af 2-fluor-17beta-oestradiol | |
| DK79882A (da) | Fremgangsmaade til fremstilling af substituerede n-(4-indolyl-piperidino-alkyl)-benzimidazoloner | |
| DK153282A (da) | Fremgangsmaade til fremstilling af bismethinisoindoliner | |
| DK386784D0 (da) | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner | |
| DK239382A (da) | Fremgangsmaade til fremstilling af anthracyclinglycosider | |
| DK158682A (da) | Fremgangsmaade til fremstilling af azopigmentpraeparater og disses anvendelse | |
| DK312082A (da) | Fremgangsmaade til fremstilling af benzothiazolsulfonamidderivater | |
| DK305982A (da) | Fremgangsmaade til fremstilling af amidobenzamider | |
| DK160829C (da) | Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner | |
| DK156085A (da) | Fremgangsmaade til fremstilling af acetoxyazetidinoner | |
| DK553582A (da) | Fremgangsmaade til fremstilling af naphthoxyalkylaminer | |
| DK370582A (da) | Fremgangsmaade til fremstilling af 2-beta-d-ribofuranosylthiazol-4-carboxamid | |
| DK451883D0 (da) | Fremgangsmade til fremstilling af 4-methyl-5-alkylthiometyl-imidazoler | |
| DK37890D0 (da) | Fremgangsmaade til fremstilling af 6-deoxyanthracycliner | |
| DK5782A (da) | Fremgangsmaade til fremstilling af 3-picolin | |
| DK231482A (da) | Fremgangsmaade til fremstilling af beta-lactamringholdige derivater | |
| DK145182A (da) | Fremgangsmaade til fremstilling af amino-pyridiner | |
| DK215082A (da) | Fremgangsmaade til fremstilling af 2-iminotiazolidinderivater | |
| DK290682A (da) | Fremgangsmaade til fremstilling af 24-cyclopropylcholen-3beta,22-dioler og estere deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |