DK456681A - PROCEDURE FOR PREPARING 6-AMINOPENCILLANIC ACID DERIVATIVES - Google Patents
PROCEDURE FOR PREPARING 6-AMINOPENCILLANIC ACID DERIVATIVESInfo
- Publication number
- DK456681A DK456681A DK456681A DK456681A DK456681A DK 456681 A DK456681 A DK 456681A DK 456681 A DK456681 A DK 456681A DK 456681 A DK456681 A DK 456681A DK 456681 A DK456681 A DK 456681A
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- formula
- ester
- pharmaceutically compatible
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measurement Of Force In General (AREA)
- Gear-Shifting Mechanisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1. Claims (for the Contracting States : CH, IT, LI, LU, NL, SE) A process for the manufacture of 6-aminopenicillanic acid derivatives of the general formula see diagramm : EP0049891,P5,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of pharmaceutically compatible salts of these compounds, characterized by hydrogenating a compound of the general formula see diagramm : EP0049891,P5,F2 in which R has the significance given above and R**1 signifies a hydrogenolytically cleavable group, or a salt of such a compound in the presence of palladium/carbon, whereafter, if desired, an ester of formula I obtained is subjected to an ester cleavage, if desired a carboxylic acid of formula I obtained is treated with an agent yielding the ester group R and, if desired, a compound of formula I obtained is converted into a pharmaceutically compatible salt thereof. 1. Claims (for the Contracting State : AT) A process for the manufacture of 6-aminopenicillanic acid derivatives of the general formula see diagramm : EP0049891,P5,F4 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of pharmaceutically compatible salts of these compounds, characterized by hydrogenating a compound of the general formula see diagramm : EP0049891,P6,F1 in which R has the significance given above and R**1 signifies a hydrogenolytically cleavable group, or a salt of such a compound in the presence of palladium/carbon, whereafter, if desired, an ester of formula I obtained is subjected to an ester cleavage, if desired a carboxylic acid of formula I obtained is treated with an agent yielding the ester group R and, if desired, a compound of formula I obtained is converted into a pharmaceutically compatible salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH770080 | 1980-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK456681A true DK456681A (en) | 1982-04-16 |
Family
ID=4329211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK456681A DK456681A (en) | 1980-10-15 | 1981-10-14 | PROCEDURE FOR PREPARING 6-AMINOPENCILLANIC ACID DERIVATIVES |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0049891B1 (en) |
| JP (1) | JPS5795991A (en) |
| KR (1) | KR830007668A (en) |
| AT (1) | ATE11540T1 (en) |
| CA (1) | CA1171407A (en) |
| DK (1) | DK456681A (en) |
| ES (1) | ES8206529A1 (en) |
| FI (1) | FI813202L (en) |
| GR (1) | GR75822B (en) |
| PT (1) | PT73822B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
| US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7216268A (en) * | 1971-12-16 | 1973-06-19 |
-
1981
- 1981-10-12 EP EP81108244A patent/EP0049891B1/en not_active Expired
- 1981-10-12 AT AT81108244T patent/ATE11540T1/en not_active IP Right Cessation
- 1981-10-13 GR GR66262A patent/GR75822B/el unknown
- 1981-10-14 FI FI813202A patent/FI813202L/en not_active Application Discontinuation
- 1981-10-14 PT PT73822A patent/PT73822B/en unknown
- 1981-10-14 DK DK456681A patent/DK456681A/en not_active Application Discontinuation
- 1981-10-14 KR KR1019810003874A patent/KR830007668A/en unknown
- 1981-10-14 ES ES506236A patent/ES8206529A1/en not_active Expired
- 1981-10-14 JP JP56162882A patent/JPS5795991A/en active Pending
- 1981-10-14 CA CA000387840A patent/CA1171407A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATE11540T1 (en) | 1985-02-15 |
| GR75822B (en) | 1984-08-02 |
| EP0049891B1 (en) | 1985-01-30 |
| ES506236A0 (en) | 1982-08-16 |
| JPS5795991A (en) | 1982-06-15 |
| KR830007668A (en) | 1983-11-04 |
| PT73822B (en) | 1983-11-07 |
| PT73822A (en) | 1981-11-01 |
| CA1171407A (en) | 1984-07-24 |
| EP0049891A1 (en) | 1982-04-21 |
| FI813202L (en) | 1982-04-16 |
| ES8206529A1 (en) | 1982-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |