DK4107252T3 - Fremgangsmåde til fremstillingen af aav - Google Patents
Fremgangsmåde til fremstillingen af aav Download PDFInfo
- Publication number
- DK4107252T3 DK4107252T3 DK21811385.0T DK21811385T DK4107252T3 DK 4107252 T3 DK4107252 T3 DK 4107252T3 DK 21811385 T DK21811385 T DK 21811385T DK 4107252 T3 DK4107252 T3 DK 4107252T3
- Authority
- DK
- Denmark
- Prior art keywords
- aav
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20209811.7A EP4006141A1 (en) | 2020-11-25 | 2020-11-25 | Method for the production of aav |
| PCT/EP2021/082615 WO2022112218A1 (en) | 2020-11-25 | 2021-11-23 | Method for the production of aav |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4107252T3 true DK4107252T3 (da) | 2025-03-17 |
Family
ID=73597941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21811385.0T DK4107252T3 (da) | 2020-11-25 | 2021-11-23 | Fremgangsmåde til fremstillingen af aav |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20240263148A1 (https=) |
| EP (3) | EP4006141A1 (https=) |
| JP (2) | JP7601339B2 (https=) |
| KR (1) | KR102700433B1 (https=) |
| CN (1) | CN116209748A (https=) |
| AU (1) | AU2021388811B2 (https=) |
| CA (1) | CA3174017C (https=) |
| DK (1) | DK4107252T3 (https=) |
| ES (1) | ES3017247T3 (https=) |
| FI (1) | FI4107252T3 (https=) |
| IL (1) | IL296770B2 (https=) |
| MX (1) | MX2022013385A (https=) |
| PT (1) | PT4107252T (https=) |
| WO (1) | WO2022112218A1 (https=) |
| ZA (1) | ZA202210745B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022373653A1 (en) * | 2021-10-18 | 2024-05-02 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| CN119137263A (zh) * | 2022-03-07 | 2024-12-13 | 奥特吉尼克斯制药公司 | 改进的分批aav产生系统和方法 |
| EP4532737A1 (en) * | 2022-06-03 | 2025-04-09 | F. Hoffmann-La Roche AG | Method for producing recombinant aav particles |
| KR20260048589A (ko) | 2023-08-29 | 2026-04-10 | 후지필름 가부시키가이샤 | 바이러스의 제조 방법 및 세포로의 핵산 도입 방법 |
| WO2025171001A1 (en) | 2024-02-06 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for improved production of aav viral vectors |
| WO2025168663A1 (en) | 2024-02-09 | 2025-08-14 | F. Hoffmann-La Roche Ag | Method for producing recombinant adeno-associated viral particles |
| EP4606816A1 (en) | 2024-02-26 | 2025-08-27 | Universitat Autónoma De Barcelona (UAB) | Method for production of gene therapy vehicles in mammalian cells |
| WO2025226558A1 (en) | 2024-04-22 | 2025-10-30 | Ultragenyx Pharmaceutical Inc. | Multi-step filtration and clarification methods for recombinant adeno-associated virus purification |
| WO2025252480A1 (en) | 2024-06-07 | 2025-12-11 | F. Hoffmann-La Roche Ag | Method for purifying plasmid dna |
| WO2026010979A2 (en) * | 2024-07-01 | 2026-01-08 | Genzyme Corporation | Perfusion in production bioreactors |
| US20260022401A1 (en) | 2024-07-22 | 2026-01-22 | Hoffmann-La Roche Inc. | Novel AAV rep ORFs and Rep polypeptides |
| WO2026037757A1 (en) | 2024-08-13 | 2026-02-19 | F. Hoffmann-La Roche Ag | Modified aav particles |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020168342A1 (en) * | 1994-11-03 | 2002-11-14 | Cell Genesys, Inc. | Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods |
| US6995006B2 (en) * | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| AU764130B2 (en) * | 1998-10-27 | 2003-08-14 | Crucell Holland B.V. | Improved AAV vector production |
| US6844192B2 (en) * | 2001-06-29 | 2005-01-18 | Wake Forest University | Adenovirus E4 protein variants for virus production |
| WO2017180724A1 (en) * | 2016-04-12 | 2017-10-19 | Artemis Biosystems, Inc. | Perfusion filtration systems |
| EP3456822A1 (en) * | 2017-09-19 | 2019-03-20 | CEVEC Pharmaceuticals GmbH | Inducible aav rep genes |
| US20220098556A1 (en) * | 2019-01-25 | 2022-03-31 | Biogen Ma Inc. | Seed culture process for aav production |
| EP3962536A1 (en) * | 2019-04-29 | 2022-03-09 | Voyager Therapeutics, Inc. | Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors |
-
2020
- 2020-11-25 EP EP20209811.7A patent/EP4006141A1/en not_active Withdrawn
-
2021
- 2021-11-23 AU AU2021388811A patent/AU2021388811B2/en active Active
- 2021-11-23 CN CN202180045906.3A patent/CN116209748A/zh active Pending
- 2021-11-23 PT PT218113850T patent/PT4107252T/pt unknown
- 2021-11-23 WO PCT/EP2021/082615 patent/WO2022112218A1/en not_active Ceased
- 2021-11-23 ES ES21811385T patent/ES3017247T3/es active Active
- 2021-11-23 CA CA3174017A patent/CA3174017C/en active Active
- 2021-11-23 US US18/005,027 patent/US20240263148A1/en active Pending
- 2021-11-23 FI FIEP21811385.0T patent/FI4107252T3/fi active
- 2021-11-23 MX MX2022013385A patent/MX2022013385A/es unknown
- 2021-11-23 EP EP25158433.0A patent/EP4596674A3/en active Pending
- 2021-11-23 EP EP21811385.0A patent/EP4107252B1/en active Active
- 2021-11-23 DK DK21811385.0T patent/DK4107252T3/da active
- 2021-11-23 IL IL296770A patent/IL296770B2/en unknown
- 2021-11-23 JP JP2022569478A patent/JP7601339B2/ja active Active
- 2021-11-23 KR KR1020227040149A patent/KR102700433B1/ko active Active
-
2022
- 2022-09-28 ZA ZA2022/10745A patent/ZA202210745B/en unknown
-
2024
- 2024-07-11 JP JP2024111946A patent/JP2024144435A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024144435A (ja) | 2024-10-11 |
| IL296770B1 (en) | 2025-06-01 |
| FI4107252T3 (fi) | 2025-03-26 |
| WO2022112218A1 (en) | 2022-06-02 |
| CN116209748A (zh) | 2023-06-02 |
| EP4596674A2 (en) | 2025-08-06 |
| US20240263148A1 (en) | 2024-08-08 |
| JP2023518919A (ja) | 2023-05-08 |
| KR102700433B1 (ko) | 2024-08-30 |
| KR20220164801A (ko) | 2022-12-13 |
| EP4596674A3 (en) | 2025-10-22 |
| EP4107252B1 (en) | 2025-02-19 |
| ZA202210745B (en) | 2023-05-31 |
| AU2021388811A1 (en) | 2022-11-03 |
| EP4006141A1 (en) | 2022-06-01 |
| CA3174017C (en) | 2025-05-06 |
| JP7601339B2 (ja) | 2024-12-17 |
| EP4107252A1 (en) | 2022-12-28 |
| IL296770A (en) | 2022-11-01 |
| PT4107252T (pt) | 2025-03-14 |
| CA3174017A1 (en) | 2022-06-02 |
| MX2022013385A (es) | 2022-11-30 |
| AU2021388811B2 (en) | 2023-02-23 |
| ES3017247T3 (en) | 2025-05-12 |
| IL296770B2 (en) | 2025-10-01 |
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