DK4048278T3 - Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion - Google Patents

Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion Download PDF

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Publication number
DK4048278T3
DK4048278T3 DK20807558.0T DK20807558T DK4048278T3 DK 4048278 T3 DK4048278 T3 DK 4048278T3 DK 20807558 T DK20807558 T DK 20807558T DK 4048278 T3 DK4048278 T3 DK 4048278T3
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Denmark
Prior art keywords
malignants
morpholinoazetidin
dioxopiperidin
isoindoline
hematologic
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DK20807558.0T
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English (en)
Inventor
Maria Soraya Carrancio Anton
Tonia J Buchholz
Shailaja Kasibhatla
Antonia Lopez-Girona
Rama Krishna Narla
Michael Pourdehnad
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Celgene Corp
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Publication of DK4048278T3 publication Critical patent/DK4048278T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK20807558.0T 2019-10-21 2020-10-20 Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion DK4048278T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962924028P 2019-10-21 2019-10-21
PCT/US2020/056408 WO2021080935A1 (en) 2019-10-21 2020-10-20 Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benz yl)amino)isoindoline-1,3-dione

Publications (1)

Publication Number Publication Date
DK4048278T3 true DK4048278T3 (da) 2024-01-08

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ID=73449175

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20807558.0T DK4048278T3 (da) 2019-10-21 2020-10-20 Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion

Country Status (21)

Country Link
US (2) US11666579B2 (da)
EP (1) EP4048278B1 (da)
JP (1) JP2022552882A (da)
KR (1) KR20220103722A (da)
CN (2) CN115087448A (da)
AU (1) AU2020372330A1 (da)
BR (1) BR112022007417A2 (da)
CA (1) CA3154504A1 (da)
DK (1) DK4048278T3 (da)
ES (1) ES2967929T3 (da)
FI (1) FI4048278T3 (da)
HR (1) HRP20231487T1 (da)
HU (1) HUE064768T2 (da)
IL (1) IL292266A (da)
LT (1) LT4048278T (da)
MX (1) MX2022004683A (da)
PL (1) PL4048278T3 (da)
PT (1) PT4048278T (da)
RS (1) RS64936B1 (da)
SI (1) SI4048278T1 (da)
WO (1) WO2021080935A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20231487T1 (hr) * 2019-10-21 2024-03-01 Celgene Corporation Postupci za liječenje hematoloških malignosti uporabom 2-(2,6-dioksopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)benzil)amino)izoindolin-1,3-diona

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205268B (zh) * 2014-10-30 2021-01-26 康朴生物医药技术(上海)有限公司 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
FI3784663T3 (fi) * 2018-04-23 2023-10-06 Celgene Corp Substituoituja 4-aminoisoindoliini-1,3-dioniyhdisteitä ja niiden käyttö lymfooman hoitamiseksi
AR119715A1 (es) * 2019-04-12 2022-01-05 Celgene Corp Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona
HRP20231487T1 (hr) * 2019-10-21 2024-03-01 Celgene Corporation Postupci za liječenje hematoloških malignosti uporabom 2-(2,6-dioksopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)benzil)amino)izoindolin-1,3-diona

Also Published As

Publication number Publication date
PT4048278T (pt) 2024-01-12
EP4048278B1 (en) 2023-11-01
CN115919871A (zh) 2023-04-07
US20210113577A1 (en) 2021-04-22
JP2022552882A (ja) 2022-12-20
LT4048278T (lt) 2023-12-11
FI4048278T3 (fi) 2023-12-19
US20230277548A1 (en) 2023-09-07
EP4048278A1 (en) 2022-08-31
SI4048278T1 (sl) 2024-01-31
CA3154504A1 (en) 2021-04-29
PL4048278T3 (pl) 2024-03-18
ES2967929T3 (es) 2024-05-06
RS64936B1 (sr) 2024-01-31
US11666579B2 (en) 2023-06-06
HRP20231487T1 (hr) 2024-03-01
CN115087448A (zh) 2022-09-20
KR20220103722A (ko) 2022-07-22
AU2020372330A1 (en) 2022-05-19
BR112022007417A2 (pt) 2022-07-12
MX2022004683A (es) 2022-05-10
WO2021080935A1 (en) 2021-04-29
IL292266A (en) 2022-06-01
HUE064768T2 (hu) 2024-04-28

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