DK3887033T3 - Chelatdannende materiale i fast fase, metode til fremstilling heraf og anvendelse heraf til oprensning af proteiner - Google Patents
Chelatdannende materiale i fast fase, metode til fremstilling heraf og anvendelse heraf til oprensning af proteiner Download PDFInfo
- Publication number
- DK3887033T3 DK3887033T3 DK19820999.1T DK19820999T DK3887033T3 DK 3887033 T3 DK3887033 T3 DK 3887033T3 DK 19820999 T DK19820999 T DK 19820999T DK 3887033 T3 DK3887033 T3 DK 3887033T3
- Authority
- DK
- Denmark
- Prior art keywords
- proteins
- purification
- production
- solid phase
- chelating material
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000007790 solid phase Substances 0.000 title 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/288—Polar phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3265—Non-macromolecular compounds with an organic functional group containing a metal, e.g. a metal affinity ligand
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862772206P | 2018-11-28 | 2018-11-28 | |
| PCT/EP2019/082224 WO2020109162A1 (en) | 2018-11-28 | 2019-11-22 | Solid-phase chelator material, method for producing thereof and use thereof for the purification of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3887033T3 true DK3887033T3 (da) | 2024-08-12 |
Family
ID=68887375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19820999.1T DK3887033T3 (da) | 2018-11-28 | 2019-11-22 | Chelatdannende materiale i fast fase, metode til fremstilling heraf og anvendelse heraf til oprensning af proteiner |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220023851A1 (da) |
| EP (1) | EP3887033B1 (da) |
| JP (1) | JP7544704B2 (da) |
| CN (1) | CN113164915A (da) |
| CA (1) | CA3121103C (da) |
| DK (1) | DK3887033T3 (da) |
| WO (1) | WO2020109162A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023044368A1 (en) * | 2021-09-17 | 2023-03-23 | Doublerainbow Biosciences Inc. | Method for producing glycosylated therapeutics by using an immobilized enzyme preparation |
| CN115350682A (zh) * | 2022-08-16 | 2022-11-18 | 青海师范大学 | 一种富含羧基的凹凸棒复合材料及其制备方法和应用 |
| WO2024056508A1 (en) | 2022-09-15 | 2024-03-21 | Cube Biotech Gmbh | In vitro diagnostic method for detecting the presence of a target by using stabilized membrane proteins |
| WO2024127796A1 (ja) * | 2022-12-13 | 2024-06-20 | 公益財団法人かずさＤｎａ研究所 | ペプチド含有試料の調製方法 |
| EP4417697A1 (en) | 2023-02-17 | 2024-08-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Modular conjugation system |
| CN116063733A (zh) * | 2023-02-20 | 2023-05-05 | 苏州赛分科技股份有限公司 | 一种基于ted的高耐受金属螯合试剂亲和填料及其制备方法和应用 |
| CN117169393B (zh) * | 2023-11-03 | 2024-03-19 | 杭州湃肽生化科技有限公司 | 一种植物组织中环肽的检测方法 |
| CN117339580B (zh) * | 2023-12-05 | 2024-04-02 | 凯莱英生命科学技术(天津)有限公司 | 螯合载体、其制备方法及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| CA1304886C (en) | 1986-07-10 | 1992-07-07 | Heinz Dobeli | Metal chelate resins |
| GB8923843D0 (en) | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
| GB9404208D0 (en) * | 1994-03-04 | 1994-04-20 | Nycomed Salutar Inc | Chelants |
| CA2277372C (en) | 1998-07-13 | 2011-03-15 | Tran Quang Minh | Affinity immobilised metal resins |
| US6623655B1 (en) | 2000-04-24 | 2003-09-23 | Sigma-Aldrich Co. | Metal chelating compositions |
| SE0303532D0 (sv) * | 2003-12-23 | 2003-12-23 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US20050208118A1 (en) * | 2004-03-18 | 2005-09-22 | Takemoto Arnold C | Preparations of encapsulated bioavailable chelating agents for detoxifying humans and animals |
| DE102004038134B4 (de) * | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| JP2008508333A (ja) | 2004-08-05 | 2008-03-21 | ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン | 標的分子の改変および組織化のための多価キレーター |
| EP2164591B1 (en) | 2007-07-09 | 2013-05-08 | GE Healthcare Bio-Sciences AB | Method for preparation of a biomolecule adsorbent |
| EP2022561A1 (en) | 2007-08-06 | 2009-02-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Immobilisation of chelating groups for immobilised metal ion chromatography (IMAC) |
| EP2183049B2 (en) | 2007-08-06 | 2019-03-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of immobilized chelator for purification of recombinant proteins by immobilized metal ion chromatography and method of purifying recombinant proteins |
| GB0901207D0 (en) * | 2009-01-26 | 2009-03-11 | Innospec Ltd | Chelating agents and methods relating thereto |
| EP2576502B1 (en) | 2010-06-01 | 2020-08-05 | Cytiva BioProcess R&D AB | Novel chelator and use thereof |
| EP2995323B1 (de) * | 2014-09-15 | 2019-02-27 | Evonik Degussa GmbH | Aminopolycarboxylsäuren als Prozesshilfsmittel bei der Superabsorberherstellung |
| WO2017046625A1 (en) | 2015-06-25 | 2017-03-23 | Cube Biotech Gmbh | New chelators for affinity purification of recombinant proteins |
-
2019
- 2019-11-22 EP EP19820999.1A patent/EP3887033B1/en active Active
- 2019-11-22 JP JP2021530306A patent/JP7544704B2/ja active Active
- 2019-11-22 DK DK19820999.1T patent/DK3887033T3/da active
- 2019-11-22 WO PCT/EP2019/082224 patent/WO2020109162A1/en unknown
- 2019-11-22 CN CN201980078337.5A patent/CN113164915A/zh active Pending
- 2019-11-22 CA CA3121103A patent/CA3121103C/en active Active
- 2019-11-22 US US17/296,928 patent/US20220023851A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3121103C (en) | 2023-10-10 |
| WO2020109162A1 (en) | 2020-06-04 |
| JP2022509239A (ja) | 2022-01-20 |
| CA3121103A1 (en) | 2020-06-04 |
| JP7544704B2 (ja) | 2024-09-03 |
| US20220023851A1 (en) | 2022-01-27 |
| CN113164915A (zh) | 2021-07-23 |
| EP3887033B1 (en) | 2024-07-24 |
| EP3887033A1 (en) | 2021-10-06 |
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