DK3749334T3 - Allogen hæmatopoietisk stamcelletransplantation - Google Patents

Allogen hæmatopoietisk stamcelletransplantation Download PDF

Info

Publication number
DK3749334T3
DK3749334T3 DK19750722.1T DK19750722T DK3749334T3 DK 3749334 T3 DK3749334 T3 DK 3749334T3 DK 19750722 T DK19750722 T DK 19750722T DK 3749334 T3 DK3749334 T3 DK 3749334T3
Authority
DK
Denmark
Prior art keywords
stem cell
hematopoietic stem
cell transplantation
allogenic hematopoietic
allogenic
Prior art date
Application number
DK19750722.1T
Other languages
Danish (da)
English (en)
Inventor
Everett Hurteau Meyer
Robert S Negrin
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK3749334T3 publication Critical patent/DK3749334T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK19750722.1T 2018-02-08 2019-02-07 Allogen hæmatopoietisk stamcelletransplantation DK3749334T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862628015P 2018-02-08 2018-02-08
PCT/US2019/017017 WO2019157158A2 (en) 2018-02-08 2019-02-07 Methods for allogenic hematopoietic stem cell transplantation

Publications (1)

Publication Number Publication Date
DK3749334T3 true DK3749334T3 (da) 2025-02-17

Family

ID=67549051

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19750722.1T DK3749334T3 (da) 2018-02-08 2019-02-07 Allogen hæmatopoietisk stamcelletransplantation

Country Status (10)

Country Link
US (5) US11952588B2 (https=)
EP (2) EP4529957A3 (https=)
JP (2) JP7422667B2 (https=)
CN (1) CN111971052B (https=)
AU (2) AU2019218792A1 (https=)
CA (1) CA3090175A1 (https=)
DK (1) DK3749334T3 (https=)
ES (1) ES3012854T3 (https=)
PL (1) PL3749334T3 (https=)
WO (1) WO2019157158A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3749334T3 (da) 2018-02-08 2025-02-17 Univ Leland Stanford Junior Allogen hæmatopoietisk stamcelletransplantation
KR20200130324A (ko) 2018-02-23 2020-11-18 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 Cd83-결합 키메라 항원 수용체
JP7701908B2 (ja) * 2019-08-16 2025-07-02 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 抗ｃｄ３８キメラ抗原受容体を発現する制御性ｔ細胞
CN117177748A (zh) * 2020-11-04 2023-12-05 浩康生物系统公司 用于异基因造血干细胞移植的方法
WO2022098926A1 (en) * 2020-11-04 2022-05-12 Orca Biosystems, Inc. Methods for allogeneic hematopoietic stem cell transplantation
AU2022245339A1 (en) * 2021-03-25 2023-08-31 Cellenkos, Inc. Populations of enriched regulatory t cells and methods for producing same
EP4426318A4 (en) * 2021-11-04 2025-11-19 Orca Biosystems Inc THERAPEUTIC COMPOSITIONS AND TRANSPLANTATION PROCESSES OF ALLOGENEIC HEMATOPOIETIC CELLS
AU2023252879A1 (en) * 2022-04-15 2024-11-21 Orca Biosystems, Inc. Methods for allogeneic hematopoietic stem cell transplantation
EP4709398A2 (en) * 2023-05-09 2026-03-18 The McLean Hospital Corporation Intra-striatal co-transplantation of autologous treg and mda cells in parkinson's disease cell therapy

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107483A0 (en) 1993-11-03 1994-02-27 Yeda Res & Dev Bone marrow transplantation
US20050163760A1 (en) 2001-12-06 2005-07-28 Nathalie Cartier-Lacave Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders
JP4988172B2 (ja) 2005-06-24 2012-08-01 株式会社日立製作所 固体酸化物形燃料電池発電システム
EP1928479B1 (en) 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
US8632768B2 (en) 2008-05-30 2014-01-21 University Of Louisville Research Foundation, Inc. Human facilitating cells
US11291686B2 (en) 2008-05-30 2022-04-05 University Of Louisville Research Foundation, Inc. Human facilitating cells
WO2010022341A1 (en) 2008-08-21 2010-02-25 The United State Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of enriching and using regulatory t cells
JP5756017B2 (ja) 2008-11-07 2015-07-29 サニーブルック ヘルス サイエンシズ センター ヒト前駆ｔ細胞
EP2461828B1 (en) 2009-07-31 2017-06-21 President and Fellows of Harvard College Programming of cells for tolerogenic therapies
EP2378287A1 (en) 2010-04-15 2011-10-19 TXCell New method for isolating Tr1 cells
MX370404B (es) 2011-12-22 2019-12-11 Yeda Res & Dev Uso de una terapia de combinación para inducir un injerto estable y a largo plazo.
WO2013130499A1 (en) 2012-02-29 2013-09-06 University Of Virginia Patent Foundation Compositions and methods for cxcr4 signaling and umbilical cord blood stem cell engraftment
WO2013173076A1 (en) * 2012-05-04 2013-11-21 University Of Southern California Methods and compositions for generating and using allogeneic suppressor cells
US9376663B2 (en) 2013-04-02 2016-06-28 New York University GPR15-mediated homing and uses thereof
US11850592B2 (en) 2017-11-13 2023-12-26 Owl biomedical, Inc. Particle manipulation system with multisort valve
MX389160B (es) * 2013-10-31 2025-03-20 Hutchinson Fred Cancer Res Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas.
US20170073406A1 (en) 2014-05-06 2017-03-16 Scholar Rock, Inc. Compositions and methods for growth factor modulation
CA3197849A1 (en) 2014-12-29 2016-07-07 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
MX2017011194A (es) 2015-03-03 2018-04-10 Kymab Ltd Anticuerpos, usos y métodos.
JP7062290B2 (ja) 2015-07-31 2022-05-06 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． がんに対する免疫チェックポイント阻害剤との併用療法における造血幹細胞
CN115137752A (zh) 2015-08-25 2022-10-04 Uab研究基金会 用于干细胞移植的方法
KR102768442B1 (ko) 2015-09-07 2025-02-17 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 CD8+CD45RClow TREGS의 신규한 아집단 및 이들의 용도
CA3003923A1 (en) 2015-11-05 2017-05-11 Glycostem Therapeutics B.V. Composition for use in immunotherapy
US20190032013A1 (en) 2016-01-29 2019-01-31 Tract Therapeutics, Inc. Immune cell selection, expansion, and use
WO2017143219A2 (en) 2016-02-18 2017-08-24 Viera Bioscience, Inc. Stimulation of therapeutic angiogenesis by t regulatory cells
IL261750B2 (en) 2016-03-14 2024-07-01 Millennium Pharm Inc Method of preventing graft versus host disease
WO2018106610A1 (en) 2016-12-05 2018-06-14 The Regents Of The University Of California Immunomagnetic bead-based method to enrich stem cells from whole hematopoietic tissue
SG11201908271WA (en) 2017-03-14 2019-10-30 Juno Therapeutics Inc Methods for cryogenic storage
EP3595683A1 (en) 2017-03-15 2020-01-22 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
US11662343B2 (en) 2017-04-07 2023-05-30 The Council Of The Queensland Institute Of Medical Research Cellular populations and uses thereof
EP3450981A1 (en) 2017-08-28 2019-03-06 Trizell GmbH Btnl8 as a marker for tregs
DK3749334T3 (da) 2018-02-08 2025-02-17 Univ Leland Stanford Junior Allogen hæmatopoietisk stamcelletransplantation
WO2019178106A1 (en) 2018-03-12 2019-09-19 Medeor Therapeutics, Inc. Methods for treating non-cancerous disorders using hematopoietic cells
US10842821B2 (en) 2018-04-05 2020-11-24 Medeor Therapeutics, Inc. Cellular compositions derived from prior organ donors and methods of manufacture and use thereof
US10881692B2 (en) 2018-04-05 2021-01-05 Medeor Therapeutics, Inc. Compositions for establishing mixed chimerism and methods of manufacture thereof
WO2020247341A1 (en) 2019-06-06 2020-12-10 Medeor Therapeutics, Inc. Methods of making cellular products by post-mortem mobilization and harvesting of hematopoietic cells
WO2022098926A1 (en) 2020-11-04 2022-05-12 Orca Biosystems, Inc. Methods for allogeneic hematopoietic stem cell transplantation

Also Published As

Publication number Publication date
US20220380729A1 (en) 2022-12-01
CN111971052A (zh) 2020-11-20
JP2024041938A (ja) 2024-03-27
JP2021512903A (ja) 2021-05-20
US20210030797A1 (en) 2021-02-04
EP3749334A2 (en) 2020-12-16
US20240344027A1 (en) 2024-10-17
EP4529957A2 (en) 2025-04-02
JP7422667B2 (ja) 2024-01-26
WO2019157158A3 (en) 2020-04-30
US11447747B2 (en) 2022-09-20
US20210002613A1 (en) 2021-01-07
ES3012854T3 (en) 2025-04-10
PL3749334T3 (pl) 2025-04-07
JP7652949B2 (ja) 2025-03-27
CA3090175A1 (en) 2019-08-15
EP3749334A4 (en) 2021-11-17
WO2019157158A2 (en) 2019-08-15
AU2025271013A1 (en) 2025-12-11
AU2019218792A1 (en) 2020-09-03
US20210015862A1 (en) 2021-01-21
US11952588B2 (en) 2024-04-09
EP4529957A3 (en) 2025-04-30
CN111971052B (zh) 2024-07-05
EP3749334B1 (en) 2024-12-11

Similar Documents

Publication Publication Date Title
DK3749334T3 (da) Allogen hæmatopoietisk stamcelletransplantation
IL285580A (en) Cryopreservation of stem cells
IL281113A (en) Genetically engineered hematopoietic stem cells and uses thereof
NO2025012I1 (no) Autologous anti-CD19-transduced CD3+ cells (brexucabtagene autoleucel)
IL271441A (en) Flow cells
IL283607A (en) Immunotherapies using enhanced ipsc derived effector cells
EP3455344A4 (en) Hematopoietic stem / precursor cells
IL282637A (en) Methods for allogeneic transplantation of hematopoietic stem cells
IL269203A (en) Compositions and methods for selective elimination and replacement of hematopoietic stem cells
IL289124A (en) Flow cells
EP4021180A4 (en) CELL CRYOPRESERVATION MEDIUM
EP3510145A4 (en) IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS
DE102019100477A8 (de) Sram-speicher
EP3448982A4 (en) CELL CULTURE MEDIUM
HUE054615T2 (hu) Kompozíció alkalmazásra hematopoetikus õssejtek átoltási hatékonyságának növelésében transzplantáció után
EP3647407A4 (en) CELL CULTURE DEVICE
EP3538115A4 (en) STEM CELL-DERIVED SWAN CELLS
KR102318115B9 (ko) 세포 대량배양 시스템
IL285083A (en) Culture media for pluripotent stem cells
IL260858B (en) Mesenchymal stem cells as vaccine adjuvants and methods for using the same
EP3655523C0 (en) CELL CULTURE MATERIALS
IL284066A (en) Flow cells
DK3325612T3 (da) Fremgangsmåder og sammensætninger til stamcelletransplantation
EP3448986A4 (en) CELL CULTURE
EP3698756A4 (en) STENT IMPLANT