DK373584D0 - IMPLANT CONTAINING A REGULATORY PEPTID AND PROCEDURE FOR DTS MANUFACTURING - Google Patents

IMPLANT CONTAINING A REGULATORY PEPTID AND PROCEDURE FOR DTS MANUFACTURING

Info

Publication number
DK373584D0
DK373584D0 DK373584A DK373584A DK373584D0 DK 373584 D0 DK373584 D0 DK 373584D0 DK 373584 A DK373584 A DK 373584A DK 373584 A DK373584 A DK 373584A DK 373584 D0 DK373584 D0 DK 373584D0
Authority
DK
Denmark
Prior art keywords
peptid
dts
regulatory
procedure
manufacturing
Prior art date
Application number
DK373584A
Other languages
Danish (da)
Other versions
DK373584A (en
Inventor
Wolfgang Koenig
Heinz-Ruediger Seidel
Juergen Kurt Sandow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833336197 external-priority patent/DE3336197A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK373584D0 publication Critical patent/DK373584D0/en
Publication of DK373584A publication Critical patent/DK373584A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK373584A 1983-08-02 1984-08-01 IMPLANT CONTAINING A REGULATORY PEPTID AND PROCEDURE FOR ITS MANUFACTURING DK373584A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3327856 1983-08-02
DE19833336197 DE3336197A1 (en) 1983-10-05 1983-10-05 Pharmaceutical products containing regulatory peptides and having protracted release, and process for the production thereof

Publications (2)

Publication Number Publication Date
DK373584D0 true DK373584D0 (en) 1984-08-01
DK373584A DK373584A (en) 1985-02-03

Family

ID=25812846

Family Applications (1)

Application Number Title Priority Date Filing Date
DK373584A DK373584A (en) 1983-08-02 1984-08-01 IMPLANT CONTAINING A REGULATORY PEPTID AND PROCEDURE FOR ITS MANUFACTURING

Country Status (8)

Country Link
EP (1) EP0133988A2 (en)
AU (1) AU567572B2 (en)
DK (1) DK373584A (en)
ES (1) ES534745A0 (en)
GR (1) GR82450B (en)
HU (1) HUT35524A (en)
IL (1) IL72546A0 (en)
PT (1) PT79007B (en)

Families Citing this family (628)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3413608A1 (en) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt IMPLANTABLE PREPARATIONS OF REGULATORY PEPTIDES WITH CONTROLLED RELEASE AND METHOD FOR THE PRODUCTION THEREOF
IL79134A (en) * 1985-07-29 1991-06-10 American Cyanamid Co Continuous release peptide implants for parenteral administration
US5137874A (en) * 1985-07-29 1992-08-11 American Cyanamid Co. Partially coated C10 -C20 fatty acid salts of peptides having molecular weights up to about 5,000
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
DE3855869T2 (en) 1987-02-20 1997-10-02 Genentech Inc Methods and preparations for the use of HIV env polypeptides and antibodies
DE3712095A1 (en) * 1987-04-10 1988-10-20 Lentia Gmbh BINDER-FREE GRANULES WITH DELAYED DELIVERY OF ACTIVE SUBSTANCES
DE3811231A1 (en) * 1988-04-02 1989-10-12 Beiersdorf Ag Surgical implants
EP0423484B1 (en) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Tablet with sustained release
US5470582A (en) * 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
JP2651320B2 (en) * 1992-07-16 1997-09-10 田辺製薬株式会社 Method for producing sustained-release microsphere preparation
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5708142A (en) 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
DE4423131A1 (en) * 1994-07-01 1996-01-04 Bayer Ag New hIL-4 mutant proteins as antagonists or partial agonists of human interleukin 4
US6093697A (en) * 1994-11-07 2000-07-25 The University Of Virginia Patent Foundation Synthetic insulin mimetic substances
US5674888A (en) * 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US6020473A (en) * 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
US7005505B1 (en) 1995-08-25 2006-02-28 Genentech, Inc. Variants of vascular endothelial cell growth factor
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
WO1998011913A1 (en) * 1996-09-16 1998-03-26 Dalhousie University Use of igf-i for the treatment of polycystic kidney disease and related indications
EP2230307A1 (en) 1996-10-25 2010-09-22 Human Genome Sciences, Inc. Neutrokine alpha
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
EP2332975A1 (en) 1997-05-30 2011-06-15 Human Genome Sciences, Inc. Human proteins
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
ATE442385T1 (en) 1997-09-17 2009-09-15 Human Genome Sciences Inc INTERLEUKIN-17 RECEPTOR-LIKE PROTEIN
US5906979A (en) * 1998-01-27 1999-05-25 Insmed Pharmaceuticals, Inc. Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility
EP2050762A3 (en) 1998-03-10 2009-07-08 Genentech, Inc. Human cornichon-like protein and nucleic acids encoding it
EP1064382B1 (en) 1998-03-17 2008-08-20 Genentech, Inc. Polypeptides homologous to vegf and bmp1
EP1982990A1 (en) 1998-03-19 2008-10-22 Human Genome Sciences, Inc. Cytokine receptor common gamma chain like
US5973119A (en) * 1998-06-05 1999-10-26 Amgen Inc. Cyclin E genes and proteins
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6303749B1 (en) 1999-01-29 2001-10-16 Amgen Inc. Agouti and agouti-related peptide analogs
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
SI2332976T1 (en) 1999-02-03 2014-08-29 Amgen Inc. Novel polypeptides involved in immune response
US7708993B2 (en) 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
CA2363779A1 (en) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Human endokine alpha and methods of use
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
KR100674528B1 (en) 1999-06-28 2007-01-29 제넨테크, 인크. Methods for Making Apo-2 Ligand Using Divalent Metal Ions
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7408047B1 (en) 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
EP1276849A4 (en) 2000-04-12 2004-06-09 Human Genome Sciences Inc Albumin fusion proteins
WO2001096528A2 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
EP2077276A1 (en) 2000-06-23 2009-07-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogensis
EP2042597B1 (en) 2000-06-23 2014-05-07 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2002000724A2 (en) 2000-06-28 2002-01-03 Amgen, Inc. Thymic stromal lymphopoietin receptor molecules and uses thereof
JP4236925B2 (en) 2000-11-28 2009-03-11 アムジエン・インコーポレーテツド Novel polypeptides involved in immune responses
US6989247B2 (en) 2000-11-28 2006-01-24 Celltech R & D, Inc. Compositions and methods for diagnosing or treating psoriasis
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
AUPR546801A0 (en) 2001-06-05 2001-06-28 Commonwealth Scientific And Industrial Research Organisation Recombinant antibodies
PL222211B1 (en) 2001-06-26 2016-07-29 Amgen Fremont Inc Antibodies to opgl
US7767786B2 (en) 2001-08-24 2010-08-03 Neuren Pharmaceuticals Ltd. Neural regeneration peptides and methods for their use in treatment of neural injury or degeneration
CN1575338B (en) 2001-08-29 2012-05-16 杰南技术公司 Bv8 nucleic acids and polypeptides with mitogenic activity
EP2050460A1 (en) 2001-09-24 2009-04-22 Imperial Innovations Limited PYY and agonists thereof for modification of feeding behaviour
EP2348043A1 (en) 2001-10-02 2011-07-27 Genentech, Inc. APO-2 ligand variants and uses thereof
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
EP2316485A1 (en) 2001-10-12 2011-05-04 Schering Corporation Use of bispecific antibodies to regulate immune responses
EP1450847B1 (en) 2001-11-13 2010-09-29 Genentech, Inc. APO2 ligand/ TRAIL formulations and uses thereof
EP2277889B1 (en) 2001-12-21 2014-07-09 Human Genome Sciences, Inc. Fusion proteins of albumin and interferon beta
JP4733922B2 (en) 2002-01-10 2011-07-27 インペリアル・イノベ−ションズ・リミテッド Correction of eating behavior
US8058233B2 (en) 2002-01-10 2011-11-15 Oregon Health And Science University Modification of feeding behavior using PYY and GLP-1
US7662924B2 (en) 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
PL375041A1 (en) 2002-04-05 2005-11-14 Amgen Inc. Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors
ATE512989T1 (en) 2002-04-15 2011-07-15 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING SCDB LIBRARIES
AU2003235833A1 (en) 2002-04-26 2003-11-10 Chugai Seiyaku Kabushiki Kaisha Method of screening agonistic antibody
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
EP2305710A3 (en) 2002-06-03 2013-05-29 Genentech, Inc. Synthetic antibody phage libraries
CA2489348A1 (en) 2002-06-24 2003-12-31 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof
NZ593428A (en) 2002-09-06 2013-01-25 Amgen Inc Therapeutic human anti-il-1r1 monoclonal antibody
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
WO2004034988A2 (en) 2002-10-16 2004-04-29 Amgen Inc. Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors
AU2003298816C1 (en) 2002-12-02 2010-12-16 Amgen Fremont, Inc. Antibodies directed to Tumor Necrosis Factor and uses thereof
WO2004060911A2 (en) 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
GB0300571D0 (en) 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
EP1592387A4 (en) 2003-01-24 2009-05-06 Elan Pharm Inc Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
JP4912144B2 (en) 2003-03-12 2012-04-11 ジェネンテック, インコーポレイテッド Use of BV8 and / or EG-VEGF to promote hematopoiesis
AU2004224390A1 (en) 2003-03-19 2004-10-07 Abgenix, Inc. Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof
US7375076B2 (en) 2003-05-20 2008-05-20 The Regents Of The University Of Michigan Methods of reducing vascular permeability in tissue by inhibition of tissue plasminogen activator (tPA) and tPA inhibitors useful therein
BRPI0411852A (en) 2003-06-27 2006-05-23 Abgenix Inc antibodies directed to epidermal growth factor receptor deletion mutants and their uses
JP5105874B2 (en) 2003-07-18 2012-12-26 アムジエン・インコーポレーテツド Specific binding factor for hepatocyte growth factor
NZ545940A (en) 2003-09-12 2009-12-24 Tercica Inc Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency
WO2005035753A1 (en) 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
AU2003271186A1 (en) 2003-10-14 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
EP1684791A4 (en) 2003-10-27 2009-07-01 Amgen Inc Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
AU2005211362B2 (en) 2004-02-02 2008-03-13 Ambrx, Inc. Modified human interferon polypeptides and their uses
AU2005319099B2 (en) 2004-02-02 2010-09-16 Ambrx, Inc. Modified human growth hormone
WO2005076843A2 (en) 2004-02-06 2005-08-25 Elan Pharmaceuticals, Inc. Methods and compositions for treating tumors and metastatic disease
US7807176B2 (en) 2004-03-19 2010-10-05 Genomidea, Inc. Polypeptide promoting vascular endothelial cell growth
CA2564989C (en) 2004-03-19 2014-05-27 Amgen, Inc. Reducing the risk of human and anti-human antibodies through v gene manipulation
MY162179A (en) 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
AU2005247943A1 (en) 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
CA2567405A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
CA2568952C (en) 2004-06-18 2019-05-21 Ambrx, Inc. Novel antigen-binding polypeptides and their uses
ATE501252T1 (en) 2004-06-22 2011-03-15 Univ Illinois METHOD FOR INHIBITING TUMOR CELL GROWTH USING FOXM1 SIRNS
ES2395094T3 (en) 2004-06-24 2013-02-08 Biogen Idec Ma Inc. Treatment of conditions that involve demyelination
ME00226B (en) 2004-07-15 2011-02-10 Medarex Llc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
WO2006015373A2 (en) 2004-08-04 2006-02-09 Amgen Inc Antibodies to dkk-1
CA2577442A1 (en) 2004-08-17 2006-03-02 The Johns Hopkins University Pde5 inhibitor compositions and methods for treating cardiac indications
CN101072580B (en) 2004-10-06 2012-08-22 农业生物技术有限公司 Antibody production method
EP1810687A4 (en) 2004-10-15 2009-04-01 Univ Mie Liver regeneration/repair controlling agent
WO2006055638A2 (en) 2004-11-17 2006-05-26 Abgenix, Inc. Fully human monoclonal antibodies to il-13
US8642596B2 (en) 2004-12-06 2014-02-04 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
ATE504602T1 (en) 2004-12-20 2011-04-15 Amgen Fremont Inc BINDING PROTEINS SPECIFIC TO HUMAN MATRIPTASE
AU2005319382B2 (en) 2004-12-21 2011-04-07 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
JP5425398B2 (en) 2004-12-22 2014-02-26 アンブレツクス・インコーポレイテツド Compositions comprising unnatural amino acids and polypeptides, methods relating to unnatural amino acids and polypeptides, and uses of unnatural amino acids and polypeptides
EP1851245B1 (en) 2005-01-26 2012-10-10 Amgen Fremont Inc. Antibodies against interleukin-1 beta
DK2824183T3 (en) 2005-04-08 2020-09-28 Chugai Pharmaceutical Co Ltd Process for the production of bispecific antibodies
US20080009546A1 (en) 2005-05-06 2008-01-10 Chevron U.S.A. Inc. Diamondoid derivatives possessing therapeutic activity in the treatment of neurologic disorders
CA2605508A1 (en) 2005-05-12 2006-11-23 Wisconsin Alumni Research Foundation Blockade of pin1 prevents cytokine production by activated immune cells
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20090028854A1 (en) 2005-06-10 2009-01-29 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 SITE-DIRECTED MUTANT
JP5068167B2 (en) 2005-06-10 2012-11-07 中外製薬株式会社 Stabilizer for protein preparation containing meglumine and use thereof
ES2776657T3 (en) 2005-06-14 2020-07-31 Amgen Inc Self-buffering protein formulations
PT2314623E (en) 2005-06-21 2012-10-02 Xoma Technology Ltd Il-1beta binding antibodies and fragments thereof
MX2008000253A (en) 2005-07-08 2008-04-02 Biogen Idec Inc Sp35 antibodies and uses thereof.
EP2388277A3 (en) 2005-07-18 2013-03-20 Amgen, Inc Human anti-B7RP1 neutralizing antibodies
CN101600475A (en) 2005-07-27 2009-12-09 佛罗里达大学研究基金会有限公司 Revise the miniaturization compound and the use thereof of protein false folding
KR20140077946A (en) 2005-10-13 2014-06-24 휴먼 게놈 사이언시즈, 인코포레이티드 Methods and compositions for use in treatment of patients with autoantibody positive diseases
CA2625773C (en) 2005-10-14 2015-05-12 Fukuoka University Inhibition of interleukin-6 (il-6) receptor promotes pancreatic islet transplantation
BRPI0617664B8 (en) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd use of an antibody recognizing IL-6 for the production of a pharmaceutical composition to treat myocardial infarction or suppress left ventricular remodeling after myocardial infarction
MX2008005764A (en) 2005-11-04 2008-11-18 Biogen Idec Inc Methods for promoting neurite outgrowth and survival of dopaminergic neurons.
JP2009515897A (en) 2005-11-10 2009-04-16 キュラジェン コーポレイション Methods of treating ovarian and renal cancer using antibodies to immunoglobulin domains of murine domain and mucin domain 1 (TIM-1) antigen
EP1964574B1 (en) 2005-11-14 2016-09-07 Cellmid Limited Method for treatment or prevention of disease associated with functional disorder of regulatory t cell
AR056806A1 (en) 2005-11-14 2007-10-24 Amgen Inc RANKL- PTH / PTHRP ANTIBODY CHEMICAL MOLECULES
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization AGENTS TO DELETE INDUCTION OF CYTOTOXIC T LYMPHOCYTES
EP1951890A4 (en) 2005-11-16 2009-06-24 Ambrx Inc Methods and compositions comprising non-natural amino acids
WO2007061029A1 (en) 2005-11-25 2007-05-31 Keio University Therapeutic agent for prostate cancer
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
JP5312039B2 (en) 2005-12-02 2013-10-09 バイオジェン・アイデック・エムエイ・インコーポレイテッド Treatment of conditions involving demyelination
US8158588B2 (en) 2005-12-05 2012-04-17 Simon Delagrave Loop-variant PDZ domains as biotherapeutics, diagnostics and research reagents
RS52357B (en) 2005-12-13 2012-12-31 Medimmune Limited Binding proteins specific for insulin-like growth factors and uses thereof
WO2007068895A1 (en) 2005-12-15 2007-06-21 Astrazeneca Ab Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
EP1981525B1 (en) 2005-12-30 2015-01-21 Zensun (Shanghai) Science and Technology Limited Extended release of neuregulin for improved cardiac function
CN101405389A (en) 2006-01-17 2009-04-08 生物载体株式会社 Novel protein expression system
CN103215293B (en) 2006-01-27 2015-10-28 比奥根Ma公司 NOGO receptor antagonist
EP1990060B1 (en) 2006-01-27 2016-09-28 Keio University Therapeutic agents for diseases associated involving choroidal neovascularization
WO2007116962A1 (en) 2006-04-07 2007-10-18 Osaka University Muscle regeneration promoter
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
EP2035030A2 (en) 2006-05-17 2009-03-18 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
ES2429225T3 (en) 2006-05-17 2013-11-13 The Ludwig Institute For Cancer Research Anti-VEGF-B antibodies for the treatment or prophylaxis of type II diabetes or metabolic syndrome
EP2049570B1 (en) 2006-06-01 2016-08-10 President and Fellows of Harvard College Purification of a bivalently active antibody using a non-chromatographic method
CN101500608A (en) 2006-06-08 2009-08-05 中外制药株式会社 Preventive or remedy for inflammatory disease
TW200808351A (en) 2006-07-13 2008-02-16 Chugai Pharmaceutical Co Ltd Cell death-inducing agents
JP5175729B2 (en) 2006-07-21 2013-04-03 中外製薬株式会社 Kidney disease treatment
US20100105610A1 (en) 2006-07-28 2010-04-29 Children's Memorial Hospital Methods of Inhibiting Tumor Cell Aggressiveness Using the Microenvironment of Human Embryonic Stem Cells
CL2007002225A1 (en) 2006-08-03 2008-04-18 Astrazeneca Ab SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A
EP2054437A2 (en) 2006-08-07 2009-05-06 Teva Biopharmaceuticals USA, Inc. Albumin-insulin fusion proteins
EP2615108B1 (en) 2006-09-08 2016-10-26 Ambrx, Inc. Modified human plasma polypeptide or fc scaffolds and thier uses
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
MX2009004757A (en) 2006-11-14 2009-05-21 Genentech Inc Modulators of neuronal regeneration.
PT2121751T (en) 2006-12-08 2017-04-18 Lexicon Pharmaceuticals Inc Monoclonal antibodies against angptl3
TWI428346B (en) 2006-12-13 2014-03-01 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
RU2554747C9 (en) 2006-12-20 2015-10-20 Ксома (Сша) Ллс Method of treating il-1beta-dependent diseases
DK2740744T3 (en) 2007-01-09 2018-04-23 Biogen Ma Inc Sp35 antibodies and uses thereof
TWI438208B (en) 2007-01-23 2014-05-21 Chugai Pharmaceutical Co Ltd Agents for suppressing chronic rejection reaction
GEP20135853B (en) 2007-02-02 2013-06-25 Univ Pierre And Marie Curie Method of myelination and oligodendrocyte differentiation promotion
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US7947646B2 (en) 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
CL2008000719A1 (en) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO
ATE554785T1 (en) 2007-03-30 2012-05-15 Ambrx Inc MODIFIED FGF-21 POLYPEPTIDES AND THEIR USE
WO2008140026A1 (en) 2007-05-11 2008-11-20 Bizen Chemical Co., Ltd. Novel leukotriene receptor antagonist
EP1995227A1 (en) 2007-05-24 2008-11-26 Chevron USA, Inc. Spiro and other derivatives of diamondoids posessing therapeutic activity in the treatment of viral disorders
EP1994927A1 (en) 2007-05-24 2008-11-26 Chevron USA, Inc. Diamondoid derivatives possessing therapeutic activity in the treatment of viral disorders
MX2009013765A (en) 2007-06-27 2010-02-01 Auckland Uniservices Ltd Polypeptides and polynucleotides for artemin and related ligands, and methods of use thereof.
EP2174667B1 (en) 2007-07-26 2017-01-04 Osaka University Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient
CL2008002444A1 (en) 2007-08-21 2009-09-04 Amgen Inc Antibody or fragment thereof that binds to human c-fms protein; nucleic acid molecule that encodes it; vector and host cell; production method; pharmaceutical composition comprising it; and its use to treat or prevent a condition associated with c-fms in a patient.
JOP20080381B1 (en) 2007-08-23 2023-03-28 Amgen Inc Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9)
EP2615114B1 (en) 2007-08-23 2022-04-06 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
US20090156488A1 (en) 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
EP2040075A1 (en) 2007-09-24 2009-03-25 Julius-Maximilians-Universität Würzburg Compounds and markers for surface-enhanced raman scattering
MX2010003380A (en) 2007-09-26 2010-10-15 U3 Pharma Gmbh Heparin-binding epidermal growth factor-like growth factor antigen binding proteins.
EP2196220B1 (en) 2007-10-02 2014-12-03 Chugai Seiyaku Kabushiki Kaisha Inhibting anti-IL-6 receptor antibody for treating graft-versus-host disease
ME01026B (en) 2007-11-16 2012-10-20 Univ Rockefeller Antibodies specific for the protofibril form of beta-amyloid protein
EP2930182A1 (en) 2007-11-20 2015-10-14 Ambrx, Inc. Modified insulin polypeptides and their uses
BRPI0821110B8 (en) 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anti-nr10/il31ra neutralizing antibody, pharmaceutical composition comprising said antibody and use thereof
MY185647A (en) 2007-12-05 2021-05-27 Chugai Pharmaceutical Co Ltd Therapeutic agent for pruritus
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
PT2391650E (en) 2007-12-20 2015-01-14 Xoma Us Llc Methods for the treatment of gout
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
JOP20190083A1 (en) 2008-06-04 2017-06-16 Amgen Inc Fgf21 mutant fusion polypeptides and uses thereof
CA2728243C (en) 2008-06-05 2020-03-10 National Cancer Center Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
EP2307381B1 (en) 2008-06-09 2021-01-13 Ludwig-Maximilians-Universität München New drugs for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
EP2671891A3 (en) 2008-06-27 2014-03-05 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
DK2982695T3 (en) 2008-07-09 2019-05-13 Biogen Ma Inc COMPOSITIONS CONCERNING ANTIBODIES AGAINST LINGO OR FRAGMENTS THEREOF
US10138283B2 (en) 2008-07-23 2018-11-27 Ambrx, Inc. Modified bovine G-CSF polypeptides and their uses
KR20110051245A (en) 2008-09-10 2011-05-17 제넨테크, 인크. Methods for inhibiting ocular angiogenesis
EP2927244A1 (en) 2008-09-19 2015-10-07 MedImmune, LLC Antibodies directed to DLL4 and uses thereof
MX2011003196A (en) 2008-09-26 2011-04-27 Ambrx Inc Non-natural amino acid replication-dependent microorganisms and vaccines.
CN102232085A (en) 2008-09-26 2011-11-02 Ambrx公司 Modified animal erythropoietin polypeptides and their uses
EA032727B1 (en) 2008-10-10 2019-07-31 Амген Инк. Fgf21 mutant proteolysis-resistant polypeptide and use thereof
JP2012504969A (en) 2008-10-10 2012-03-01 アナフォア インコーポレイテッド Polypeptides that bind to TRAIL-R1 and TRAIL-R2
AU2009308293B2 (en) 2008-10-22 2015-02-05 Genentech, Inc. Modulation of axon degeneration
PE20120206A1 (en) 2008-11-26 2012-03-09 Amgen Inc ACTIVIN IIB RECEPTOR POLYPEPTIDE VARIANTS
US20120087870A1 (en) 2008-12-19 2012-04-12 Hentges Francois Novel caviidae allergens and uses thereof
WO2010072684A1 (en) 2008-12-22 2010-07-01 Universität Regensburg Norrin in the treatment of diseases associated with an increased tgf-beta activity
JO3382B1 (en) 2008-12-23 2019-03-13 Amgen Inc Human cgrp receptor binding antibodies
EP2379595A2 (en) 2008-12-23 2011-10-26 AstraZeneca AB Targeted binding agents directed to 5 1 and uses thereof
US9139809B2 (en) 2009-01-08 2015-09-22 Albert Einstein College Of Medicine Of Yeshiva University Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
US20110294733A1 (en) 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
EP2396035A4 (en) 2009-02-12 2012-09-12 Human Genome Sciences Inc Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance
CN102369211B (en) 2009-02-13 2015-04-29 诺华股份有限公司 Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof
KR20110136819A (en) 2009-02-27 2011-12-21 시가 테크놀로지스, 인크. Thienopyridine derivatives for the treatment and prevention of dengue virus infections
JP2010210772A (en) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd Method of manufacturing liquid crystal display device
US9724337B2 (en) 2009-04-21 2017-08-08 University Of Kentucky Research Foundation AG-205 for the treatment of breast cancer
HRP20240135T1 (en) 2009-05-05 2024-04-12 Amgen Inc. Fgf21 mutants and uses thereof
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
EP2260857A1 (en) 2009-06-11 2010-12-15 Alfact Innovation Novel applications of HIP/PAP or derivatives thereof
IN2012DN00352A (en) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
WO2010148142A1 (en) 2009-06-17 2010-12-23 Amgen Inc. Chimeric fgf19 polypeptides and uses thereof
SG10201404340TA (en) 2009-07-31 2014-10-30 Shin Maeda Cancer metastasis inhibitor
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
EP2305285A1 (en) 2009-09-29 2011-04-06 Julius-Maximilians-Universität Würzburg Means and methods for treating ischemic conditions
EP2305810A1 (en) 2009-10-02 2011-04-06 Technische Universität München miRNAs in the treatment of fibrosis
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
CN102711772A (en) 2009-10-16 2012-10-03 奥克兰联合服务有限公司 Anti-neoplastic uses of artemin antagonists
US9068019B2 (en) 2009-10-19 2015-06-30 Hanall Biopharma Co., Ltd. Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
CN104043126A (en) 2009-10-22 2014-09-17 霍夫曼-拉罗奇有限公司 Modulation of axon degeneration
BR112012010202A2 (en) 2009-11-02 2015-09-22 Univ Washington dimeric polypeptide hybrid nuclease molecule, pharmaceutical composition nucleic acid molecule recombinant expression vector transformed host cell method for preparing the nuclease molecule and method for treating or preventing a condition associated with an abnormal immune
EP2742949A1 (en) 2009-11-13 2014-06-18 Puget Sound Blood Center Factor VIII B cell epitope variants having reduced immunogenicity
NZ599405A (en) 2009-11-24 2014-09-26 Medimmune Ltd Targeted binding agents against b7-h1
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
JP2013512672A (en) 2009-12-02 2013-04-18 アムジエン・インコーポレーテツド Human FGFR1c, human β-croto-, and binding proteins that bind to both human FGFR1c and human β-croto-
UA109888C2 (en) 2009-12-07 2015-10-26 ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES
MX349301B (en) 2009-12-21 2017-07-21 Ambrx Inc Modified bovine somatotropin polypeptides and their uses.
BR112012015597A2 (en) 2009-12-21 2017-01-31 Ambrx Inc modified porcine somatotropin peptides and their uses
EP2525792A1 (en) 2010-01-19 2012-11-28 Medizinische Universität Wien Pharmaceutical compositions comprising lignans and their derivatives for the medical management of angiogenesis and hypovascularity
JP6046493B2 (en) 2010-01-27 2016-12-14 チルドレンズ メディカル センター コーポレーション Proangin-1 angiogenesis-promoting fragments and uses thereof
EP2533859B1 (en) 2010-02-10 2016-04-06 Nayacure Therapeutics Ltd Pharmaceutical compositions for the treatment and prevention of cancer
US9233087B2 (en) 2010-02-19 2016-01-12 Siga Technologies, Inc Inhibitors and methods of inhibiting bacterial and viral pathogens
WO2011119906A1 (en) 2010-03-26 2011-09-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HUMAN POLYOMAVIRUS 6 (HPyV6) AND HUMAN POLYOMAVIRUS 7 (HPyV7)
JPWO2011118804A1 (en) 2010-03-26 2013-07-04 国立大学法人徳島大学 Novel anti-CD98 antibody and its use
AU2011239689A1 (en) 2010-04-15 2012-11-08 Amgen Inc. Human FGF receptor and beta-Klotho binding proteins
US20130116304A1 (en) 2010-04-19 2013-05-09 Ernst R. Werner Tmem195 encodes for tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity
WO2011139594A2 (en) 2010-04-27 2011-11-10 Medtronic, Inc. Artificial bursa for intra-articular drug delivery
WO2011139595A2 (en) 2010-04-27 2011-11-10 Medtronic, Inc. Elongated biodegradable depot for sustained drug release to treat chronic pelvic pain
EP3181692A1 (en) 2010-05-07 2017-06-21 Centre National De La Recherche Scientifique Ucp1 (thermogenin) - inducing agents for use in the treatment of a disorder of the energy homeostasis
CA2800065A1 (en) 2010-05-21 2011-11-24 Peptimed, Inc. Reagents and methods for treating cancer
EP4115906A1 (en) 2010-05-28 2023-01-11 Chugai Seiyaku Kabushiki Kaisha Antitumor t cell response enhancer
JP5904552B2 (en) 2010-05-28 2016-04-13 国立研究開発法人国立がん研究センター Pancreatic cancer treatment
ES2486321T3 (en) 2010-06-18 2014-08-18 Xiberscience Gmbh Peptides as active agents to stabilize biological barriers
HUE045845T2 (en) 2010-08-17 2021-12-28 Ambrx Inc Modified relaxin polypeptides and their uses
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
AR083006A1 (en) 2010-09-23 2013-01-23 Lilly Co Eli FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME
EP2623592B1 (en) 2010-09-28 2019-05-15 NB Health Laboratory Co. Ltd. Anti-human ccr7 antibodies, hybridoma, medicinal composition, and antibody-immobilized carrier
EP2632481A1 (en) 2010-10-25 2013-09-04 Regents Of The University Of Minnesota Therapeutic composition for treatment of glioblastoma
TWI636994B (en) 2010-10-27 2018-10-01 安美基公司 Dkk1 antibodies and methods of use
AU2011323508B2 (en) 2010-11-01 2017-04-27 Peptimed, Inc. Compositions of a peptide targeting system for treating cancer
TR201802772T4 (en) 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Multi-specific antigen binding molecule with alternative function for the function of blood coagulation factor VIII.
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
RU2013123793A (en) 2010-11-24 2014-12-27 Лексикон Фармасьютикалз, Инк. ANTIBODIES RELATING TO NOTUM PECTINACETHYLESTERASE
CA2819501C (en) 2010-11-30 2020-03-31 The Johns Hopkins University Hybrid cyclic libraries and screens thereof
AR084053A1 (en) 2010-11-30 2013-04-17 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT THAT INDUCES CYTOTOXICITY
DK2657252T3 (en) 2010-12-23 2017-05-08 Hanall Biopharma Co Ltd MODIFIED HUMAN TUMOR CANCER FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF AND METHOD OF PRODUCING THEREOF
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
WO2012102679A1 (en) 2011-01-24 2012-08-02 National University Of Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
EP2667715B1 (en) 2011-01-27 2017-07-19 Neuren Pharmaceuticals Limited Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid
WO2012118903A2 (en) 2011-03-01 2012-09-07 Amgen Inc. Bispecific binding agents
RU2013141611A (en) 2011-03-10 2015-04-20 Дженентек, Инк. TREATMENT OF DISEASES WITH AN CHANGED VASCULAR FUNCTION OF VESSELS
KR20140027211A (en) 2011-04-04 2014-03-06 유니버시티 오브 아이오와 리써치 파운데이션 Methods of improving vaccine immunogenicity
CN103619881B (en) 2011-04-07 2017-07-28 安姆根有限公司 New EGFR associated proteins
CN103533951B (en) 2011-04-08 2017-04-19 安姆根有限公司 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
PL2704737T3 (en) 2011-04-29 2018-07-31 University Of Washington Therapeutic nuclease compositions and methods
JP2014513128A (en) 2011-05-03 2014-05-29 ジェネンテック, インコーポレイテッド Vascular disruptors and their use
JOP20200043A1 (en) 2011-05-10 2017-06-16 Amgen Inc Methods of treating or preventing cholesterol related disorders
EP2707718A1 (en) 2011-05-10 2014-03-19 Amgen Inc. Method of identifying compounds that specifically modulate the interaction of fgfr1 and beta-klotho
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
EA032666B1 (en) 2011-06-14 2019-06-28 Бикам Фармасьютикалз, Инк. Opsin-binding ligands and methods of use thereof
CA2838340A1 (en) 2011-06-17 2012-12-20 Amgen Inc. Method of treating or ameliorating metabolic disorders using clec-2
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
CA2843369A1 (en) 2011-08-16 2013-02-21 Evotec (Munchen) Gmbh Markers for susceptibility to an inhibitor of an src-family kinase
US9745288B2 (en) 2011-08-16 2017-08-29 Indiana University Research And Technology Corporation Compounds and methods for treating cancer by inhibiting the urokinase receptor
EP2744828A4 (en) 2011-08-16 2014-12-31 Univ Emory Jaml specific binding agents, antibodies, and uses related thereto
US20140213512A1 (en) 2011-08-31 2014-07-31 Amgen Inc. Method of Treating or Ameliorating Type 1 Diabetes Using FGF21
WO2013039916A1 (en) 2011-09-12 2013-03-21 The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Compositions for and methods of treatment and enhanced detection of non-pituitary tumors
MX353958B (en) 2011-09-22 2018-02-07 Amgen Inc Cd27l antigen binding proteins.
TW201315742A (en) 2011-09-26 2013-04-16 Novartis Ag Dual fuction proteins for treating metabolic disorders
US9006400B2 (en) 2011-09-26 2015-04-14 Novartis Ag Fibroblast growth factor-21-Fc fusion proteins
KR102239138B1 (en) 2011-09-30 2021-04-12 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule inducing immune response to target antigen
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun (Shanghai)Science & Technology Limited Compositions and methods for treating heart failure
US8906860B2 (en) 2011-10-14 2014-12-09 The Board Of Trustees Of The University Of Illinois Methods and compositions inhibiting tumor cell proliferation
WO2013056255A1 (en) 2011-10-14 2013-04-18 The Board Of Trustees Of The University Of Illinois Methods and compositions for inhibiting tumor cell proliferation
EP2768307B1 (en) 2011-10-19 2020-03-18 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
AU2012340174A1 (en) 2011-11-16 2014-05-29 Amgen Inc. Methods of treating epidermal growth factor deletion mutant VIII related disorders
GR1007832B (en) 2011-11-21 2013-02-14 Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, Activin neutralisers and uses thereof for treatment of diseases associated with aberrant "host defence response" activation
US9353063B2 (en) 2011-11-30 2016-05-31 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
CA2862746A1 (en) 2011-12-01 2013-06-06 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
EP2601941A1 (en) 2011-12-06 2013-06-12 Ludwig-Maximilians-Universität München Beta-O/S/N fatty acid based compounds as antibacterial and antiprotozoal agents
CA2858572C (en) 2011-12-08 2023-01-17 Amgen Inc. Human lcat antigen binding proteins and their use in therapy
WO2013083810A1 (en) 2011-12-09 2013-06-13 F. Hoffmann-La Roche Ag Identification of non-responders to her2 inhibitors
SG11201403367YA (en) 2011-12-19 2014-07-30 Amgen Inc Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
US20150017157A1 (en) 2011-12-19 2015-01-15 Xoma (Us) Llc Methods for treating acne
WO2013106489A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Humanized antibodies with ultralong cdr3s
WO2013106485A2 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
US9512212B2 (en) 2012-01-11 2016-12-06 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Bispecific antibody fragments for neurological disease proteins and methods of use
US9714276B2 (en) 2012-01-26 2017-07-25 Amgen Inc. Growth differentiation factor 15 (GDF-15) polypeptides
EP2626066A1 (en) 2012-02-10 2013-08-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Combination therapy comprising selective VEGFR-2 inhibitors and MEK inhibitors
AU2013221475B2 (en) 2012-02-17 2016-10-20 Kineta Four Llc Antiviral drugs for treatment of Arenavirus infection
US9879012B2 (en) 2012-03-29 2018-01-30 Regents Of The University Of Colorado, A Body Corporate Click nucleic acids
US20150118237A1 (en) 2012-04-23 2015-04-30 Genefrontier Corporation Anti-human cd69 antibody, and use thereof for medical purposes
EA039663B1 (en) 2012-05-03 2022-02-24 Амген Инк. Use of an anti-pcsk9 antibody for lowering serum cholesterol ldl and treating cholesterol related disorders
JO3623B1 (en) 2012-05-18 2020-08-27 Amgen Inc St2 antigen binding proteins
EP2666775A1 (en) 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
US9844582B2 (en) 2012-05-22 2017-12-19 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
EP2852584B1 (en) 2012-05-22 2018-02-28 F. Hoffmann-La Roche AG Substituted dipyridylamines and uses thereof
MX2014014234A (en) 2012-05-22 2015-05-07 Genentech Inc N-substituted benzamides and their use in the treatment of pain.
AU2013285537B2 (en) 2012-07-02 2017-10-12 Medizinische Universitat Wien Complement split product C4d for the treatment of inflammatory conditions
CA2878478A1 (en) 2012-07-06 2014-01-09 Genentech, Inc. N-substituted benzamides and methods of use thereof
EP2687225A1 (en) 2012-07-19 2014-01-22 Alfact Innovation HIP/PAP protein and derivatives thereof for use in treating cancer
EP2695950A1 (en) 2012-08-10 2014-02-12 Blackfield AG Markers for responsiveness to an inhibitor of the fibroblast growth factor receptor
EP2887942A4 (en) 2012-08-21 2016-08-31 Genesys Res Inst Compositions and methods for treating or preventing anthracycline induced cardiotoxicity
BR112015006737A2 (en) 2012-09-27 2017-07-04 Hoffmann La Roche substituted sulfonamide compounds
JP6336459B2 (en) 2012-10-17 2018-06-06 バスキュラー バイオジェニックス リミテッド Treatment method using adenovirus
US9309318B2 (en) 2012-10-17 2016-04-12 Amgen, Inc. Compositions relating to anti-IL-21 receptor antibodies
CN108424453B (en) 2012-11-09 2021-08-06 基因先端领域株式会社 anti-ADAM 28 antibodies for the treatment of cancer
UY35148A (en) 2012-11-21 2014-05-30 Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
MX363188B (en) 2012-11-30 2019-03-13 Hoffmann La Roche Identification of patients in need of pd-l1 inhibitor cotherapy.
TW201425336A (en) 2012-12-07 2014-07-01 Amgen Inc BCMA antigen binding proteins
BR112015016395A2 (en) 2013-01-18 2017-07-11 Hoffmann La Roche 3-substituted pyrazoles and use as dlk inhibitors
ES2728936T3 (en) 2013-01-25 2019-10-29 Amgen Inc Antibodies directed against CDH19 for melanoma
JO3519B1 (en) 2013-01-25 2020-07-05 Amgen Inc Antibody constructs for CDH19 and CD3
MX2015009901A (en) 2013-02-01 2016-04-06 Santa Maria Biotherapeutics Inc Administration of an anti-activin-a compound to a subject.
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (en) 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
WO2014153037A1 (en) 2013-03-14 2014-09-25 Genentech, Inc. Substituted triazolopyridines and methods of use thereof
US20140271629A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
US9850297B2 (en) 2013-03-15 2017-12-26 Amgen Inc. Secreted frizzle-related protein 5 (SFRP5) binding proteins
AU2014236867A1 (en) 2013-03-15 2015-09-24 Amgen Inc. Methods and compositions relating to anti-CCR7 antigen binding proteins
AP2015008732A0 (en) 2013-03-15 2015-09-30 Amgen Inc Human pac1 antibodies
AR095596A1 (en) 2013-03-15 2015-10-28 Amgen Res (Munich) Gmbh UNIQUE CHAIN UNION MOLECULES UNDERSTANDING N-TERMINAL ABP
US9708375B2 (en) 2013-03-15 2017-07-18 Amgen Inc. Inhibitory polypeptides specific to WNT inhibitors
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
US9474792B2 (en) 2013-03-15 2016-10-25 Amgen Inc. Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
CN105164114B (en) 2013-05-01 2018-03-23 豪夫迈·罗氏有限公司 The miazines and their purposes of the Heterocyclylalkyl substitution of C connections
CN110003178B (en) 2013-05-01 2022-02-25 豪夫迈·罗氏有限公司 Diheteroaryl compounds and uses thereof
US10501803B2 (en) 2013-05-21 2019-12-10 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Isoforms of GATA6 and NKX2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy
BR112015029293A2 (en) 2013-05-22 2018-04-24 Zensun Shanghai Science & Tech Ltd method and kit for preventing, treating or delaying a cardiovascular disease or disorder in a mammal
US20160130585A1 (en) 2013-05-28 2016-05-12 The Johns Hopkins University Aptamers for the treatment of sickle cell disease
EA201592285A1 (en) 2013-05-30 2016-05-31 Байоджен Ма Инк. ANTIGENSYCLING PROTEINS TO ONCOSTATIN M RECEPTOR
EP2810648A1 (en) 2013-06-04 2014-12-10 Daniel Rauh Targeting domain-domain interaction for the identification of kinase modulators
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
EP2835135A3 (en) 2013-06-19 2015-06-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Means and methods for treating pseudomonas infection
WO2014207213A1 (en) 2013-06-28 2014-12-31 Medizinische Universität Innsbruck Novel inhibitors of protein kinase c epsilon signaling
AU2013396206B2 (en) 2013-06-28 2019-11-14 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
EP3693397A1 (en) 2013-07-11 2020-08-12 The Scripps Research Institute Coiled coil immunoglobulin fusion proteins and compositions thereof
EP3022224A2 (en) 2013-07-18 2016-05-25 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
EA202092386A1 (en) 2013-07-31 2021-04-30 Эмджен Инк. CONSTRUCTIONS BASED ON DIFFERENTIATION AND GROWTH FACTOR 15 (GDF15)
WO2015022326A1 (en) 2013-08-12 2015-02-19 Xiber Science Gmbh Peptides as active agents for treating primary graft dysfunction
TW201605896A (en) 2013-08-30 2016-02-16 安美基股份有限公司 GITR antigen binding proteins
EP3712166A1 (en) 2013-09-05 2020-09-23 Amgen Inc. Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
CA2923835C (en) 2013-09-11 2022-11-29 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
AR097648A1 (en) 2013-09-13 2016-04-06 Amgen Inc COMBINATION OF EPIGENETIC FACTORS AND BIESPECTIVE COMPOUNDS THAT HAVE LIKE DIANA CD33 AND CD3 IN THE TREATMENT OF MYELOID LEUKEMIA
WO2015038938A1 (en) 2013-09-13 2015-03-19 The California Institute For Biomedical Research Modified therapeutic agents and compositions thereof
AU2014320262B2 (en) 2013-09-16 2019-06-13 Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh Mutant calreticulin for the diagnosis of myeloid malignancies
JP6445440B2 (en) 2013-09-20 2018-12-26 中外製薬株式会社 Treatment of bleeding disorders with anti-protein C antibodies
DK3049521T3 (en) 2013-09-25 2019-04-23 Univ Cornell Compounds for inducing antitumor immunity and methods thereof
DK3052102T3 (en) 2013-10-04 2020-03-09 Aptose Biosciences Inc CANCER TREATMENT COMPOSITIONS
PL3055302T3 (en) 2013-10-11 2019-05-31 Hoffmann La Roche Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators
CA2927525C (en) 2013-10-15 2023-01-31 Genefrontier Corporation Human antibody against aggrecanase-type adamts species for therapeutics of aggrecanase-related diseases
US20150238631A1 (en) 2013-10-15 2015-08-27 The California Institute For Biomedical Research Chimeric antigen receptor t cell switches and uses thereof
KR102339240B1 (en) 2013-10-15 2021-12-15 더 스크립스 리서치 인스티튜트 Peptidic chimeric antigen receptor t cell switches and uses thereof
EP3057605A1 (en) 2013-10-18 2016-08-24 Novartis AG Methods of treating diabetes and related disorders
US10988745B2 (en) 2013-10-31 2021-04-27 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
EP4212180A1 (en) 2013-12-18 2023-07-19 The Scripps Research Institute Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
MX2016008110A (en) 2013-12-20 2016-08-19 Hoffmann La Roche Pyrazole derivatives and uses thereof as inhibitors of dlk.
CN103965357B (en) 2013-12-31 2016-08-17 嘉和生物药业有限公司 A kind of anti-human RANKL antibody
WO2015110930A1 (en) 2014-01-24 2015-07-30 Pfizer Inc. Modified interleukin 21 receptor proteins
WO2015120187A1 (en) 2014-02-05 2015-08-13 The University Of Chicago Chimeric antigen receptors recognizing cancer-spevific tn glycopeptide variants
WO2015121457A1 (en) 2014-02-13 2015-08-20 Westphal Sören Fgf-8 for use in treating diseases or disorders of energy homeostasis
US9701743B2 (en) 2014-02-20 2017-07-11 Allergan, Inc. Complement component C5 antibodies
JP6643244B2 (en) 2014-02-27 2020-02-12 アラーガン、インコーポレイテッドAllergan,Incorporated Complement factor Bb antibody
CA2941716A1 (en) 2014-03-07 2015-09-11 The Johns Hopkins University Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
US10507227B2 (en) 2014-04-15 2019-12-17 The Hospital For Sick Children Cationic antimicrobial peptides
EP3143143A1 (en) 2014-05-15 2017-03-22 CeMM - Forschungszentrum für Molekulare Medizin GmbH Antagonists of slc38a9 and their use in therapy
WO2015179415A1 (en) 2014-05-19 2015-11-26 Novartis Ag Methods of treating anorexia
EP2947460A1 (en) 2014-05-22 2015-11-25 Medizinische Universität Wien Personalized therapy of inflammation-associated cancer using methods of assessing the susceptibility of a subject to the treatment with EGFR inhibitors/antagonists
US11357748B2 (en) 2014-05-30 2022-06-14 The Johns Hopkins University Methods for treating mendelian disorders of the epigenetic machinery
SG10201703965SA (en) 2014-06-03 2017-06-29 Xbiotech Inc Compositions and methods for treating and preventing staphylococcus aureus infections
BR112016028567A2 (en) 2014-06-09 2018-01-30 Kyowa Hakko Kirin Co Ltd method for using anti-fgf23 ligand and for treating fgf23-related disease and / or condition and increasing bone remodeling
BR112016029211A2 (en) 2014-06-13 2018-01-30 Amgen Inc composition, method for inhibiting solid tumor growth in an individual, method for producing a protein, method for inhibiting, reducing or treating cachexia in an individual, method for treating obesity or an obesity-associated disease and kit
TW201625299A (en) 2014-06-20 2016-07-16 Chugai Pharmaceutical Co Ltd Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii
CN106715418A (en) 2014-07-07 2017-05-24 基因泰克公司 Therapeutic compounds and methods of use thereof
US10166304B2 (en) 2014-07-11 2019-01-01 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
JP6749312B2 (en) 2014-07-31 2020-09-02 アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH Optimized interspecific bispecific single chain antibody constructs
AR101669A1 (en) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh ANTIBODY CONSTRUCTS FOR CDH19 AND CD3
US20170216403A1 (en) 2014-08-12 2017-08-03 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
DK3180018T3 (en) 2014-08-12 2019-10-28 Massachusetts Inst Technology Synergistic tumor treatment with IL-2 and integrin-binding Fc fusion protein
EA201790434A1 (en) 2014-08-22 2017-07-31 Окленд Юнисервисиз Лимитед CHANNEL MODULATORS
EP3186378A1 (en) 2014-08-27 2017-07-05 Peptimed, Inc. Anti-tumor compositions and methods
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
CN113855806A (en) 2014-10-21 2021-12-31 赛生药品股份国际有限公司 Treatment of cancer with immunostimulants
EA036697B1 (en) 2014-10-24 2020-12-09 Бристол-Майерс Сквибб Компани Modified fgf-21 polypeptides and uses thereof
WO2016069889A1 (en) 2014-10-31 2016-05-06 Resolve Therapeutics, Llc Therapeutic nuclease-transferrin fusions and methods
WO2016079321A1 (en) 2014-11-20 2016-05-26 Cemm Forschungszentrum Für Molekulare Medizin Gmbh Antagonists of setdb2 for use in the therapy of infectious diseases
EP3085709B1 (en) 2014-12-28 2019-08-21 Genor Biopharma Co., Ltd Humanized anti-human rankl antibody, pharmaceutical composition and use thereof
JP6912386B2 (en) 2015-01-26 2021-08-04 ザ ユニバーシティー オブ シカゴ CAR T cells that recognize cancer-specific IL13Rα2
JP7264592B2 (en) 2015-01-26 2023-04-25 ザ ユニバーシティー オブ シカゴ IL13Rα2 BINDING AGENTS AND THEIR USE IN CANCER THERAPY
WO2016135139A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 2,3-dihydrocyclopenta[b]quinoline derivatives as mth1 inhibitors for the therapy of cancer
WO2016135140A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 4-aminoquinazoline derivatives as mth1 inhibitors for the therapy of cancer
WO2016135137A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Substituted 4-(phenylamino)quinoline derivatives as mth1 inhibitors for the therapy of cancer
AU2016223584B2 (en) 2015-02-23 2020-11-19 Enrico GIRAUDO Non-natural Semaphorins 3 and their medical use
WO2016135138A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer
TWI805046B (en) 2015-02-27 2023-06-11 日商中外製藥股份有限公司 Use of IL-6 receptor antibody for preparing pharmaceutical composition
WO2016142310A1 (en) 2015-03-09 2016-09-15 F. Hoffmann-La Roche Ag Tricyclic dlk inhibitors and uses thereof
WO2016154621A1 (en) 2015-03-26 2016-09-29 The California Institute For Biomedical Research SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF
MX2017012966A (en) 2015-04-10 2018-06-06 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells.
US11091546B2 (en) 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
EP4276116A3 (en) 2015-04-17 2024-01-17 Amgen Research (Munich) GmbH Bispecific antibody constructs for cdh3 and cd3
US10864190B2 (en) 2015-04-22 2020-12-15 CeMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH Combination of an antiandrogen with a vitamin K antagonist or with a gamma-glutamyl carboxylase inhibitor for the therapy of androgen receptor positive cancer
US20180146703A1 (en) * 2015-05-15 2018-05-31 The Johns Hopkins University Novel fluoride prenatal dietary supplement
MX2017014715A (en) 2015-05-22 2018-03-16 Genentech Inc Substituted benzamides and methods of use thereof.
US20160361380A1 (en) 2015-06-12 2016-12-15 Nymox Corporation Combination compositions for treating disorders requiring removal or destruction of unwanted cellular proliferations
CN107921098A (en) 2015-06-17 2018-04-17 加州生物医学研究所 Therapeutic agent of modification and combinations thereof
WO2017007955A1 (en) 2015-07-07 2017-01-12 The Research Foundation For The State University Of New York Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
US10842763B2 (en) 2015-07-31 2020-11-24 The Johns Hopkins University Methods for cancer and immunotherapy using prodrugs of glutamine analogs
WO2017023791A1 (en) 2015-07-31 2017-02-09 The Johns Hopkins University Glutamine antagonists for the treatment of cognitive deficits
TWI796283B (en) 2015-07-31 2023-03-21 德商安美基研究(慕尼黑)公司 Antibody constructs for msln and cd3
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究(慕尼黑)公司 Antibody constructs for flt3 and cd3
SI3328827T1 (en) 2015-07-31 2023-11-30 The Johns Hopkins University Prodrugs of glutamine analogs
CN108135875B (en) 2015-07-31 2021-12-31 约翰霍普金斯大学 Methods and compositions for treating metabolic reprogramming disorders
TWI717375B (en) 2015-07-31 2021-02-01 德商安美基研究(慕尼黑)公司 Antibody constructs for cd70 and cd3
TWI744242B (en) 2015-07-31 2021-11-01 德商安美基研究(慕尼黑)公司 Antibody constructs for egfrviii and cd3
TWI793062B (en) 2015-07-31 2023-02-21 德商安美基研究(慕尼黑)公司 Antibody constructs for dll3 and cd3
JO3620B1 (en) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh Immune-checkpoint inhibitors for use in the treatment of blood-borne cancers cancers
JP2018526371A (en) 2015-08-27 2018-09-13 ジェネンテック, インコーポレイテッド Therapeutic compounds and methods of use thereof
AU2016315889A1 (en) 2015-09-04 2018-03-22 The California Institute For Biomedical Research Insulin immunoglobulin fusion proteins
US20180280474A1 (en) 2015-10-01 2018-10-04 Amgen Inc. Treatment of bile acid disorders
WO2017079215A1 (en) 2015-11-03 2017-05-11 Glycomimetics, Inc. Methods and compositions for the production of monoclonal antibodies, hematopoietic stem cells, and methods of using the same
CA3004680A1 (en) 2015-11-13 2017-05-18 Mavalon Therapeutics Limited Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group ii metabotropic glutamate receptors
JP6925278B2 (en) 2015-11-18 2021-08-25 中外製薬株式会社 Method of enhancing humoral immune response
EP3378487B1 (en) 2015-11-18 2022-03-16 Chugai Seiyaku Kabushiki Kaisha Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
MA43304A (en) 2015-11-25 2018-10-03 Genentech Inc SUBSTITUTE BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS
WO2017096262A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
DK3387019T3 (en) 2015-12-09 2022-01-10 Scripps Research Inst RELAXIN-IMMUNOGLOBULIN INFUSION PROTEINS AND METHODS OF USE
WO2017097986A1 (en) 2015-12-09 2017-06-15 Medizinische Universität Wien Monomaleimide-functionalized platinum compounds for cancer therapy
PE20181327A1 (en) 2015-12-23 2018-08-20 Amgen Inc METHOD TO TREAT OR IMPROVE METABOLIC DISORDERS WITH GASTRIC INHIBITOR PEPTIDE RECEPTOR BINDING PROTEINS (GIPR) IN COMBINATION WITH GLP-1 AGONISTS
JP6954842B2 (en) 2015-12-25 2021-10-27 中外製薬株式会社 Antibodies with enhanced activity and methods for modifying them
JP2019508383A (en) 2016-01-15 2019-03-28 ウニベルジテート ハンブルグUniversitaet Hamburg Flavonoid-type compound having O-rhamnosyl residue
JOP20170017B1 (en) 2016-01-25 2021-08-17 Amgen Res Munich Gmbh Pharmaceutical composition comprising bispecific antibody constructs
EA039859B1 (en) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
EP3411404B1 (en) 2016-02-03 2022-11-09 Amgen Research (Munich) GmbH Psma and cd3 bispecific t cell engaging antibody constructs
KR20180103084A (en) 2016-02-03 2018-09-18 암젠 리서치 (뮌헨) 게엠베하 BCMA and CD3 bispecific T cell engrafting antibody constructs
US10098909B2 (en) 2016-02-05 2018-10-16 University Of South Florida Ionic cocrystal of lithium, lispro, for the treatment of fragile X syndrome
RU2732502C2 (en) 2016-02-10 2020-09-18 Ратгерс, Де Стейт Юниверсити Оф Нью Джерси Novel monoclonal antibodies to lam and pim6/lam for diagnosing and treating infections caused by mycobacterium tuberculosis
CA3013988A1 (en) 2016-02-15 2017-08-24 Cemm-Forschungszentrum Fur Molekulare Medizin Gmbh Taf1 inhibitors for the therapy of cancer
EP3216458A1 (en) 2016-03-07 2017-09-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Modified vascular endothelial growth factor a (vegf-a) and its medical use
TW202342540A (en) 2016-03-14 2023-11-01 日商中外製藥股份有限公司 Cell injury inducing therapeutic drug for use in cancer therapy
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
GB2555264A (en) 2016-04-15 2018-04-25 Univ Oxford Innovation Ltd Adenosine receptor modulators for the treatment of circadian rhythm disorders
KR20180133198A (en) 2016-05-04 2018-12-13 암젠 인크 Interleukin-2 mutein for proliferation of T-regulatory cells
US10183058B2 (en) 2016-06-17 2019-01-22 Nymox Corporation Method of preventing or reducing the progression of prostate cancer
MA45554A (en) 2016-07-01 2019-05-08 Resolve Therapeutics Llc OPTIMIZED BINUCLEASE FUSIONS.
US10300145B2 (en) 2016-07-15 2019-05-28 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
WO2018015410A1 (en) 2016-07-20 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic proline compounds
WO2018015411A1 (en) 2016-07-20 2018-01-25 F. Hoffmann-La Roche Ag Sulfonylcycloalkyl carboxamide compounds as trpa1 modulators
US10172910B2 (en) 2016-07-28 2019-01-08 Nymox Corporation Method of preventing or reducing the incidence of acute urinary retention
US20200030295A1 (en) 2016-08-02 2020-01-30 Friedrich-Alexander-Universität Erlangen-Nürnberg Heterocyclic diamidines
CN110214021A (en) 2016-08-08 2019-09-06 安进公司 Improve the method for connective tissue attachment using anti-hardened proteins antibody
JP7071959B2 (en) 2016-08-12 2022-05-19 エフ.ホフマン-ラ ロシュ アーゲー Sulfonylpyridyl TRP inhibitor
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
US10532081B2 (en) 2016-09-07 2020-01-14 Nymox Corporation Method of ameliorating or preventing the worsening or the progression of symptoms of BPH
CA3032046A1 (en) 2016-09-16 2018-03-22 Research Triangle Institute Tetrahydroisoquinoline kappa opioid antagonists
JP7349359B2 (en) 2016-10-17 2023-09-22 エフ. ホフマン-ラ ロシュ アーゲー Bicyclic pyridone lactams and methods of using them.
AU2017345479B2 (en) 2016-10-19 2024-03-21 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
AU2017359288A1 (en) 2016-11-14 2019-05-30 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Combination of a BRD4 inhibitor and an antifolate for the therapy of cancer
WO2018096159A1 (en) 2016-11-28 2018-05-31 F. Hoffmann-La Roche Ag Oxadiazolones as transient receptor potential channel inhibitors
JP7166252B2 (en) 2016-11-30 2022-11-07 メディツィーニシェ・ウニヴェルジテート・インスブルック 3-amino-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-ones as cyclin-dependent kinase inhibitors
US11071721B2 (en) 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
WO2018128454A1 (en) 2017-01-06 2018-07-12 에이비엘바이오 주식회사 ANTI-α-SYN ANTIBODY AND USE THEREOF
US10603358B2 (en) 2017-01-10 2020-03-31 Nodus Therapeutics Combination tumor treatment with an integrin-binding-Fc fusion protein and immune stimulator
US10350266B2 (en) 2017-01-10 2019-07-16 Nodus Therapeutics, Inc. Method of treating cancer with a multiple integrin binding Fc fusion protein
EP3568143B1 (en) 2017-01-11 2023-12-13 Paracelsus Medizinische Privatuniversität Salzburg - Privatstiftung Mesenchymal stem cell-derived extracellular vesicles and their medical use
JOP20190177A1 (en) 2017-01-17 2019-07-16 Amgen Inc Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)
JOP20190189A1 (en) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh Low ph pharmaceutical composition comprising t cell engaging antibody constructs
CA3052639A1 (en) 2017-02-08 2018-08-16 Bristol-Myers Squibb Company Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
US10335453B2 (en) 2017-03-01 2019-07-02 Nymox Corporation Compositions and methods for improving sexual function
US11021529B2 (en) 2017-03-03 2021-06-01 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
JP7178357B2 (en) 2017-03-07 2022-11-25 エフ.ホフマン-ラ ロシュ アーゲー Oxadiazole transient receptor potential channel inhibitor
WO2018175707A1 (en) 2017-03-24 2018-09-27 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
JP7185884B2 (en) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター METHOD FOR PREDICTING AND DETERMINING THERAPEUTIC EFFECT OF IL-6 AND NEUTROPHIL-RELATED DISEASE
WO2018204907A1 (en) 2017-05-05 2018-11-08 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
AU2018265615A1 (en) 2017-05-12 2019-10-03 Domain Therapeutics Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors
CA3062749A1 (en) 2017-05-12 2018-11-15 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Compounds for use in the treatment or prevention of melanoma
JOP20190259A1 (en) 2017-05-31 2019-10-31 Amgen Inc Anti-jagged1 antigen binding proteins
WO2018236904A1 (en) 2017-06-19 2018-12-27 Surface Oncology, Inc. Combination of anti-cd47 antibodies and cell death-inducing agents, and uses thereof
BR112019024410A2 (en) 2017-06-20 2020-07-14 Amgen Inc. method of treating or improving metabolic disorders using gastric inhibitory peptide receptor (gipr) binding proteins in combination with glp 1 agonists
MX2020000342A (en) 2017-07-11 2020-08-17 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof.
CA3185865A1 (en) 2017-07-14 2019-01-17 F. Hoffmann-La Roche Ag Bicyclic ketone compounds and methods of use thereof
CA3070089A1 (en) 2017-07-19 2019-01-24 Auckland Uniservices Limited Cytokine modulation
WO2019032827A1 (en) 2017-08-09 2019-02-14 Massachusetts Institute Of Technology Albumin binding peptide conjugates and methods thereof
SG11202001311VA (en) 2017-08-22 2020-03-30 Sanabio Llc Soluble interferon receptors and uses thereof
KR20200055037A (en) 2017-09-19 2020-05-20 메사추세츠 인스티튜트 오브 테크놀로지 Compositions and uses for chimeric antigen receptor T cell therapy
SG11202003114UA (en) 2017-10-04 2020-05-28 Amgen Inc Transthyretin immunoglobulin fusions
KR20200070297A (en) 2017-10-11 2020-06-17 에프. 호프만-라 로슈 아게 Bicyclic compounds for use as RIP1 kinase inhibitors
KR20200074160A (en) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 Pharmaceutical composition for inhibiting post-surgical adhesion containing anti-IL-6 receptor antibody
EP3704132A4 (en) 2017-10-30 2021-07-28 Enterin, Inc. New squalamine solid forms and methods of making the same
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
PE20211247A1 (en) 2017-10-31 2021-07-13 Hoffmann La Roche SULFONES AND BICYCLE SULFOXIDES AND METHODS OF USING THEM
WO2019100052A2 (en) 2017-11-20 2019-05-23 Compass Therapeutics Llc Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
WO2019110139A1 (en) 2017-12-05 2019-06-13 Eth Zurich New compounds for use as a therapeutically active substance and in particular for use in the treatment of tumors
EP3724229A1 (en) 2017-12-11 2020-10-21 Amgen Inc. Continuous manufacturing process for bispecific antibody products
KR20200101954A (en) 2017-12-19 2020-08-28 메사추세츠 인스티튜트 오브 테크놀로지 Antigen-adjuvant coupling reagents and methods of use
WO2019131988A1 (en) 2017-12-28 2019-07-04 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
TW201940518A (en) 2017-12-29 2019-10-16 美商安進公司 Bispecific antibody construct directed to MUC17 and CD3
US20210363238A1 (en) 2018-01-31 2021-11-25 Motokazu Kato Therapeutic agent for asthma containing il-6 inhibitor
WO2019155427A1 (en) 2018-02-09 2019-08-15 Nestlé Skin Health Sa Nemolizumab in the treatment of atopic dermatitis with moderate to severe excoriation
AR114585A1 (en) 2018-02-20 2020-09-23 Hoffmann La Roche PROCESS FOR PREPARING ANTAGONIST COMPOUNDS OF POTENTIAL TRANSIENT CHANNELS OF THE 1-ARYLSULFONYL-PYRROLIDIN-2-CARBOXAMIDE RECEPTOR AND CRYSTALLINE FORMS THEREOF
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
KR102411489B1 (en) 2018-03-14 2022-06-23 서피스 온콜로지, 인크. Antibodies that bind to CD39 and uses thereof
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
US11332524B2 (en) 2018-03-22 2022-05-17 Surface Oncology, Inc. Anti-IL-27 antibodies and uses thereof
KR20200138254A (en) 2018-03-30 2020-12-09 암젠 인크 C-terminal antibody variant
US10947251B2 (en) 2018-03-30 2021-03-16 Genentech, Inc. Therapeutic compounds and methods of use thereof
CA3096146A1 (en) 2018-04-06 2019-10-10 Zilentin AG Bumetanide derivatives for the therapy of hyperhidrosis
US20210163406A1 (en) 2018-04-06 2021-06-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bumetanide Derivatives for the Therapy of Stroke and Other Neurological Diseases/Disorders Involving NKCCs
CR20200510A (en) 2018-04-09 2020-11-26 Amgen Inc Growth differentiation factor 15 fusion proteins
WO2019200357A1 (en) 2018-04-12 2019-10-17 Surface Oncology, Inc. Biomarker for cd47 targeting therapeutics and uses therefor
US10907161B2 (en) 2018-04-19 2021-02-02 Checkmate Pharmaceuticals, Inc. Synthetic RIG-I-like receptor agonists
CN112074519A (en) 2018-04-20 2020-12-11 豪夫迈·罗氏有限公司 N- [ 4-oxo-2, 3-dihydro-1, 5-benzoxazepin-3-yl ] -5, 6-dihydro-4H-pyrrolo [1,2-B ] pyrazole-2-carboxamide derivatives and related compounds as RIP1 kinase inhibitors for the treatment of e.g. Irritable Bowel Syndrome (IBS)
WO2019207051A1 (en) 2018-04-25 2019-10-31 Università Degli Studi Di Torino Medical use of combinations of non-natural semaphorins 3 and antimetabolites
WO2019226658A1 (en) 2018-05-21 2019-11-28 Compass Therapeutics Llc Multispecific antigen-binding compositions and methods of use
WO2019226617A1 (en) 2018-05-21 2019-11-28 Compass Therapeutics Llc Compositions and methods for enhancing the killing of target cells by nk cells
TW202003490A (en) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use thereof
WO2019225787A1 (en) 2018-05-24 2019-11-28 에이비엘바이오 주식회사 Anti-b7-h3 antibody and use thereof
WO2020011938A1 (en) 2018-07-11 2020-01-16 Medizinische Universität Wien Glucocorticoids for the topical treatment of autoimmune gastritis
US20220275043A1 (en) 2018-07-17 2022-09-01 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
US20210388089A1 (en) 2018-08-09 2021-12-16 Compass Therapeutics Llc Antigen binding agents that bind cd277 and uses thereof
WO2020033925A2 (en) 2018-08-09 2020-02-13 Compass Therapeutics Llc Antibodies that bind cd277 and uses thereof
WO2020033926A2 (en) 2018-08-09 2020-02-13 Compass Therapeutics Llc Antibodies that bind cd277 and uses thereof
CN111417655A (en) 2018-08-28 2020-07-14 润俊(中国)有限公司 anti-CD3 antibody folate bioconjugates and uses thereof
JP2021535169A (en) 2018-09-03 2021-12-16 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Carboxamide and sulfonamide derivatives useful as TEAD modulators
FI3849614T3 (en) 2018-09-11 2024-02-08 Ambrx Inc Interleukin-2 polypeptide conjugates and their uses
WO2020053808A1 (en) 2018-09-12 2020-03-19 Georg Dewald Method of diagnosing vasoregulatory disorders
JP2022502037A (en) 2018-09-28 2022-01-11 マサチューセッツ インスティテュート オブ テクノロジー Immunomodulatory molecules localized to collagen and their methods
JP2022512636A (en) 2018-10-11 2022-02-07 アムジエン・インコーポレーテツド Downstream processing of bispecific antibody constructs
JP2022512746A (en) 2018-10-19 2022-02-07 アンブルックス,インコーポレイテッド Interleukin-10 polypeptide complex, its dimer, and their use
CA3122354A1 (en) 2018-12-17 2020-06-25 Tolremo Therapeutics Ag Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of cancer
MX2021008081A (en) 2019-01-04 2021-08-05 Resolve Therapeutics Llc Treatment of sjogren's disease with nuclease fusion proteins.
EP3908586B1 (en) 2019-01-11 2022-12-21 F. Hoffmann-La Roche AG Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof
US11680105B2 (en) 2019-01-17 2023-06-20 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
WO2020154032A1 (en) 2019-01-23 2020-07-30 Massachusetts Institute Of Technology Combination immunotherapy dosing regimen for immune checkpoint blockade
US11236157B2 (en) 2019-01-28 2022-02-01 Galderma Holding SA Treatment of skin lesions and pruritus in prurigo nodularis patients
BR112021015832A2 (en) 2019-02-12 2022-01-18 Ambrx Inc Compositions containing antibody-tlr agonist conjugates, methods and uses thereof
EP3941511A2 (en) 2019-03-20 2022-01-26 Massachusetts Institute of Technology Uses of amphiphiles in immune cell therapy and compositions therefor
EP3949989A4 (en) 2019-03-29 2022-12-14 Chugai Seiyaku Kabushiki Kaisha Anti il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function
US20220204608A1 (en) 2019-04-17 2022-06-30 Hiroshima University Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination
US20220193113A1 (en) 2019-05-31 2022-06-23 Osaka University Novel therapeutic agent for gastrointestinal cancer and method for screening for the same
EP4023230A4 (en) 2019-06-05 2023-11-15 Chugai Seiyaku Kabushiki Kaisha Antibody cleavage site-binding molecule
CR20220008A (en) 2019-06-10 2022-02-11 Chugai Pharmaceutical Co Ltd Anti-t cell antigen-binding molecule to be used in combination with cytokine inhibitor
TW202045711A (en) 2019-06-13 2020-12-16 美商安進公司 Automated biomass-based perfusion control in the manufacturing of biologics
EP3990491A1 (en) 2019-06-26 2022-05-04 Massachusetts Institute of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
CN114127125A (en) 2019-07-08 2022-03-01 安进公司 Multispecific thyroxin transporter immunoglobulin fusions
CN113950485A (en) 2019-07-10 2022-01-18 中外制药株式会社 Claudin-6 binding molecules and uses thereof
MX2022000988A (en) 2019-07-26 2022-05-03 Amgen Inc Anti-il13 antigen binding proteins.
EP4013788A1 (en) 2019-08-12 2022-06-22 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
MX2022001866A (en) 2019-08-13 2022-03-11 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells.
WO2021055329A1 (en) 2019-09-16 2021-03-25 Surface Oncology, Inc. Anti-cd39 antibody compositions and methods
AU2020353672A1 (en) 2019-09-25 2022-03-31 Surface Oncology, LLC Anti-IL-27 antibodies and uses thereof
WO2021064141A1 (en) 2019-10-02 2021-04-08 Tolremo Therapeutics Ag Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b
JP7395723B2 (en) 2019-10-02 2023-12-11 トルレモ・セラピューティクス・アクチェンゲゼルシャフト Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
WO2021070885A1 (en) 2019-10-11 2021-04-15 中外製薬株式会社 Pharmaceutical composition which can be used for prevention and/or treatment of acquired hemophilia a, and product comprising said pharmaceutical composition
IL292153A (en) 2019-10-16 2022-06-01 Cemm Forschungszentrum Fur Molekulare Medizin Gmbh Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof
WO2021074418A1 (en) 2019-10-16 2021-04-22 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Carbazole-type cullin ring ubiquitin ligase compounds and uses thereof
US20220378817A1 (en) 2019-10-23 2022-12-01 Checkmate Pharmaceuticals, Inc. Synthetic rig-i-like receptor agonists
US11459389B2 (en) 2019-10-24 2022-10-04 Massachusetts Institute Of Technology Monoclonal antibodies that bind human CD161
AU2020371784A1 (en) 2019-10-24 2022-06-02 Minotaur Therapeutics, Inc. Chimeric cytokine modified antibodies and methods of use thereof
CA3155989A1 (en) 2019-11-13 2021-05-20 Jason Robert ZBIEG Therapeutic compounds and methods of use
CA3156683A1 (en) 2019-11-13 2021-05-20 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
AU2020386151B2 (en) 2019-11-19 2023-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel compounds for the diagnosis, treatment and prevention of diseases associated with the aggregation of alpha-synuclein
JP2023507115A (en) 2019-12-17 2023-02-21 アムジエン・インコーポレーテツド Dual interleukin-2/TNF receptor agonist for use in therapy
CA3160204A1 (en) 2020-01-06 2021-07-15 Vaccinex, Inc. Anti-ccr8 antibodies and uses thereof
WO2021173889A1 (en) 2020-02-26 2021-09-02 Ambrx, Inc. Uses of anti-cd3 antibody folate bioconjugates
AU2021233909A1 (en) 2020-03-11 2022-09-29 Ambrx, Inc. Interleukin-2 polypeptide conjugates and methods of use thereof
KR20220155338A (en) 2020-03-19 2022-11-22 암젠 인크 Antibodies to mucin 17 and uses thereof
JP2023106635A (en) 2020-04-17 2023-08-02 中外製薬株式会社 Bispecific antigen binding molecules and compositions related thereto, uses, kits and methods for producing compositions
WO2021221783A1 (en) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
WO2021221782A1 (en) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Chimeric antigen receptor-targeting ligands and uses thereof
US20230235036A1 (en) 2020-06-05 2023-07-27 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Acvr1 (alk2) receptor inhibition to treat neurological diseases
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
CR20230014A (en) 2020-06-19 2023-02-17 Chugai Pharmaceutical Co Ltd Anti-t cell antigen-binding molecule for use in combination with angiogenesis inhibitor
BR112022026045A2 (en) 2020-06-25 2023-01-17 Tolremo Therapeutics Ag HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT, IMPROVEMENT OR PREVENTION OF FIBROTIC DISEASE
EP4171614A1 (en) 2020-06-29 2023-05-03 Resolve Therapeutics, LLC Treatment of sjogren's syndrome with nuclease fusion proteins
EP3939578A1 (en) 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease
US11787775B2 (en) 2020-07-24 2023-10-17 Genentech, Inc. Therapeutic compounds and methods of use
IL300225A (en) 2020-07-31 2023-03-01 Chugai Pharmaceutical Co Ltd Pharmaceutical composition including cell expressing chimeric receptor
WO2022023292A2 (en) 2020-07-31 2022-02-03 Friedrich-Alexander-Universität Erlangen-Nürnberg Corona virus spike protein-targeting antibodies and use thereof
AU2021327396A1 (en) 2020-08-20 2023-03-23 Ambrx, Inc. Antibody-TLR agonist conjugates, methods and uses thereof
EP3964497A1 (en) 2020-09-04 2022-03-09 Friedrich-Alexander-Universität Erlangen-Nürnberg Substituted vicinal diamine compounds and their use in the treatment, amelioration or prevention of pain
BR112023005853A2 (en) 2020-10-02 2023-05-02 Genentech Inc PROCESS FOR PREPARING A COMPOUND OF FORMULA I, COMPOUNDS, PROCESSES FOR PREPARING COMPOUND 1, CRYSTALLINE FORM, PHARMACEUTICAL COMPOSITION, PROCESS FOR PREPARING THE CRYSTALLINE FORM OF COMPOUND I AND METHOD FOR TREATMENT OF A NEURODEGENERATIVE CONDITION
WO2022087274A1 (en) 2020-10-21 2022-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies that neutralize type-i interferon (ifn) activity
AU2021374839A1 (en) 2020-11-06 2023-06-08 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
CN117321076A (en) 2021-02-19 2023-12-29 美国卫生及公众服务部代表 Single domain antibodies neutralizing SARS-CoV-2
TW202302143A (en) 2021-03-12 2023-01-16 日商中外製藥股份有限公司 Pharmaceutical composition for treatment or prevention of myasthenia gravis
WO2022212899A1 (en) 2021-04-03 2022-10-06 Ambrx, Inc. Anti-her2 antibody-drug conjugates and uses thereof
CN117355512A (en) 2021-04-07 2024-01-05 托雷莫治疗股份公司 Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
WO2022232321A1 (en) 2021-04-28 2022-11-03 Minotaur Therapeutics, Inc. Humanized chimeric bovine antibodies and methods of use
EP4334358A1 (en) 2021-05-06 2024-03-13 Amgen Research (Munich) GmbH Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
JP2024516970A (en) 2021-05-07 2024-04-18 サーフィス オンコロジー, エルエルシー Anti-IL-27 antibodies and uses thereof
AU2022272740A1 (en) 2021-05-14 2023-11-02 Claris Biotherapeutics, Inc. Compositions of growth factor for the treatment of eye disease
WO2023028077A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. Sodium channel inhibitors and methods of designing same
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
US20230242652A1 (en) 2021-08-30 2023-08-03 Galderma Holding S.A. Treatments for atopic dermatitis
AR126971A1 (en) 2021-09-03 2023-12-06 Univ Of Bern COMPOSITIONS AND METHODS FOR TREATING LONG QT SYNDROME
CA3233696A1 (en) 2021-11-03 2023-05-11 Joachim Koch Bispecific cd16a binders
WO2023079493A1 (en) 2021-11-03 2023-05-11 Affimed Gmbh Bispecific cd16a binders
WO2023097195A1 (en) 2021-11-24 2023-06-01 Genentech, Inc. Therapeutic indazole compounds and methods of use in the treatment of cancer
US20230364031A1 (en) 2022-04-19 2023-11-16 Garth Cooper Treatment of brain copper disorders
WO2023203172A1 (en) 2022-04-20 2023-10-26 Proxygen Gmbh Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof
WO2023218027A1 (en) 2022-05-12 2023-11-16 Amgen Research (Munich) Gmbh Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
US20240026001A1 (en) 2022-05-25 2024-01-25 Surface Oncology, Inc. Use of anti-il-27 antibodies
US20240025987A1 (en) 2022-05-25 2024-01-25 Surface Oncology, Inc. Use of anti-il-27 antibodies
WO2024050526A1 (en) 2022-09-02 2024-03-07 Biomarin Pharmaceutical Inc. Compositions and methods for treating long qt syndrome
WO2024047497A1 (en) 2022-09-02 2024-03-07 Galderma Holding SA Treatments for prurigo nodularis
WO2024059675A2 (en) 2022-09-14 2024-03-21 Amgen Inc. Bispecific molecule stabilizing composition
WO2024076995A1 (en) 2022-10-03 2024-04-11 Insigna Inc. Compositions for non-surgical prevention of boar taint and aggressive behavior

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