DK3538510T3 - PROCEDURE FOR THE MANUFACTURE OF MONO-PROTECTED ALFA, OMEGA DIAMINO ALKANES - Google Patents

PROCEDURE FOR THE MANUFACTURE OF MONO-PROTECTED ALFA, OMEGA DIAMINO ALKANES Download PDF

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Publication number
DK3538510T3
DK3538510T3 DK17792089.9T DK17792089T DK3538510T3 DK 3538510 T3 DK3538510 T3 DK 3538510T3 DK 17792089 T DK17792089 T DK 17792089T DK 3538510 T3 DK3538510 T3 DK 3538510T3
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DK
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Prior art keywords
alfa
mono
protected
procedure
manufacture
Prior art date
Application number
DK17792089.9T
Other languages
Danish (da)
Inventor
Wiro Michael Petrus Bernardus Menge
Original Assignee
Byondis Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Byondis Bv filed Critical Byondis Bv
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Publication of DK3538510T3 publication Critical patent/DK3538510T3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • C07C281/04Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052Val-amino acid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK17792089.9T 2016-11-14 2017-11-03 PROCEDURE FOR THE MANUFACTURE OF MONO-PROTECTED ALFA, OMEGA DIAMINO ALKANES DK3538510T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16198696 2016-11-14
PCT/EP2017/078132 WO2018086993A1 (en) 2016-11-14 2017-11-03 PROCESS FOR THE PREPARATION OF MONO-PROTECTED alpha,omega-DIAMINO ALKANES

Publications (1)

Publication Number Publication Date
DK3538510T3 true DK3538510T3 (en) 2021-03-01

Family

ID=57442444

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17792089.9T DK3538510T3 (en) 2016-11-14 2017-11-03 PROCEDURE FOR THE MANUFACTURE OF MONO-PROTECTED ALFA, OMEGA DIAMINO ALKANES

Country Status (8)

Country Link
US (1) US10815194B2 (en)
EP (1) EP3538510B1 (en)
KR (1) KR102614466B1 (en)
CN (1) CN109963833B (en)
DK (1) DK3538510T3 (en)
ES (1) ES2853999T3 (en)
RU (1) RU2747400C2 (en)
WO (1) WO2018086993A1 (en)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU503508A3 (en) * 1973-12-21 1976-02-15 К.Х.Берингер Зон (Фирма) The method of obtaining-bis / -oxy-aryl ethyl diaminoalkanes
JP2001512441A (en) * 1997-02-07 2001-08-21 ザ スクリップス リサーチ インスティテュート Convergent synthesis of combinatorial libraries
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US20030060632A1 (en) * 1999-09-29 2003-03-27 Lain-Yen Hu Calcium channel blockers
WO2009138985A2 (en) 2008-05-15 2009-11-19 Luxembourg Bio Technologies Ltd. Coupling agents for the synthesis of polypeptides and polynucleotides
PL2433940T3 (en) * 2009-04-28 2015-03-31 Chugai Pharmaceutical Co Ltd Spiroimidazolone derivative
PL3056203T3 (en) 2010-04-21 2018-06-29 Syntarga B.V. Conjugates of cc-1065 analogs and bifunctional linkers
JPWO2013051632A1 (en) * 2011-10-04 2015-03-30 武田薬品工業株式会社 Nitrogen-containing fused heterocyclic compounds
EP2628721A1 (en) * 2012-02-20 2013-08-21 LEK Pharmaceuticals d.d. Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
ES2644870T3 (en) * 2012-06-18 2017-11-30 Geistlich Pharma Ag Oxathiazine derivatives as antibacterial and anticancer agents
IN2015MN00421A (en) * 2012-08-27 2015-09-04 Lupin Ltd
CA2947238A1 (en) 2014-05-22 2015-11-26 Synthon Biopharmaceuticals B.V. Site-specific conjugation of linker drugs to antibodies and resulting adcs

Also Published As

Publication number Publication date
EP3538510B1 (en) 2021-01-06
EP3538510A1 (en) 2019-09-18
US20200010408A1 (en) 2020-01-09
KR102614466B1 (en) 2023-12-14
WO2018086993A1 (en) 2018-05-17
US10815194B2 (en) 2020-10-27
ES2853999T3 (en) 2021-09-20
RU2019118296A (en) 2020-12-14
CN109963833A (en) 2019-07-02
KR20190086715A (en) 2019-07-23
RU2019118296A3 (en) 2021-03-09
RU2747400C2 (en) 2021-05-04
CN109963833B (en) 2022-02-22

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