DK3209673T4 - Mixtures of human milk oligosaccharides - Google Patents

Mixtures of human milk oligosaccharides Download PDF

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Publication number
DK3209673T4
DK3209673T4 DK15852675.6T DK15852675T DK3209673T4 DK 3209673 T4 DK3209673 T4 DK 3209673T4 DK 15852675 T DK15852675 T DK 15852675T DK 3209673 T4 DK3209673 T4 DK 3209673T4
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DK
Denmark
Prior art keywords
mixtures
human milk
milk oligosaccharides
oligosaccharides
human
Prior art date
Application number
DK15852675.6T
Other languages
English (en)
Other versions
DK3209673T3 (en
Inventor
Elise Champion
Gyula Dekany
Bruce Mcconnell
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55760374&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3209673(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glycom As filed Critical Glycom As
Application granted granted Critical
Publication of DK3209673T3 publication Critical patent/DK3209673T3/da
Publication of DK3209673T4 publication Critical patent/DK3209673T4/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01065—3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (2.4.1.65), i.e. alpha-1-3 fucosyltransferase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK15852675.6T 2014-10-24 2015-10-23 Mixtures of human milk oligosaccharides DK3209673T4 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP14190374 2014-10-24
EP15155450 2015-02-17
EP15155457 2015-02-17
EP15155460 2015-02-17
EP15155454 2015-02-17
EP15163045 2015-04-09
EP15163044 2015-04-09
EP15163047 2015-04-09
PCT/IB2015/058198 WO2016063262A1 (en) 2014-10-24 2015-10-23 MIXTURES OF HMOs

Publications (2)

Publication Number Publication Date
DK3209673T3 DK3209673T3 (en) 2020-11-02
DK3209673T4 true DK3209673T4 (da) 2023-10-02

Family

ID=55760374

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15852675.6T DK3209673T4 (da) 2014-10-24 2015-10-23 Mixtures of human milk oligosaccharides

Country Status (7)

Country Link
US (2) US10314852B2 (da)
EP (1) EP3209673B2 (da)
CN (1) CN107108677B (da)
DK (1) DK3209673T4 (da)
ES (1) ES2824679T5 (da)
PL (1) PL3209673T5 (da)
WO (1) WO2016063262A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10314852B2 (en) * 2014-10-24 2019-06-11 Glycom A/S Mixtures of HMOs
US11179405B2 (en) * 2016-09-07 2021-11-23 Societe Des Produits Nestle S.A. Nutritional compositions for infants and/or young children comprising oligosaccharides
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
WO2019003133A1 (en) 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
BR112020010843A2 (pt) * 2017-11-30 2020-11-10 Glycom A/S oligossacarídeos do leite humano e composições sintéticas desses para modulação da microbiota
BR112022016589A2 (pt) * 2019-12-06 2022-10-11 Glycom As Composição que compreende 2?-fl e dfl para uso em um método para reduzir a dor
EP4093876A1 (en) * 2020-01-23 2022-11-30 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in hmo production
EP4192970A1 (en) * 2020-08-10 2023-06-14 Inbiose N.V. Production of alpha-1,3 glycosylated form of fuc-a1,2-gal-r
CN117858693A (zh) * 2021-08-24 2024-04-09 帝斯曼知识产权资产管理有限公司 至少一种人乳低聚糖的新颖用途
EP4418878A1 (en) 2021-10-18 2024-08-28 DSM IP Assets B.V. A method for providing an amorphous hmo product by drying
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
WO2024042235A1 (en) 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos
WO2024110667A1 (en) 2022-11-25 2024-05-30 Dsm Ip Assets B.V. Two-strain system for producing oligosaccharides

Family Cites Families (32)

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Publication number Priority date Publication date Assignee Title
JPH0686684A (ja) 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
DE19701382A1 (de) * 1997-01-16 1998-07-23 Nutricia Nv Kohlenhydratmischung
US6045854A (en) 1997-03-31 2000-04-04 Abbott Laboraties Nutritional formulations containing oligosaccharides
FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
WO2005055944A2 (en) 2003-12-05 2005-06-23 Cincinnati Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
MY148510A (en) 2006-03-09 2013-04-30 Centre Nat Rech Scient Method for producing sialylated oligosaccharides
WO2008033520A2 (en) * 2006-09-15 2008-03-20 The Regents Of The University Of California Bifidobacterial gene sequences and their use
KR101218893B1 (ko) 2009-03-05 2013-01-09 닛산 지도우샤 가부시키가이샤 쌍극형 2차 전지 및 그 제조 방법
US9012625B2 (en) 2009-04-07 2015-04-21 Glycom A/S Method for the synthesis of a trisaccharide
EP2536736B1 (en) 2010-02-19 2017-08-16 Glycom A/S Production of 6'-o-sialyllactose and intermediates
US8993740B2 (en) 2010-02-19 2015-03-31 Glycom A/S Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine
SG10201707519PA (en) 2010-12-31 2017-10-30 Abbott Lab Neutral human milk oligosaccharides to promote growth of beneficial bacteria
CA3098403C (en) * 2011-02-16 2022-05-10 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
EP2522232A1 (en) * 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
KR20140036227A (ko) 2011-05-13 2014-03-25 글리콤 에이/에스 모유 올리고사카라이드(hmo) 또는 그의 전구체의 생성 방법
US20140323705A1 (en) 2011-05-13 2014-10-30 Markus Hederos Manufacture of lacto-n-tetraose
CA2835989A1 (en) 2011-05-13 2012-11-22 Glycom A/S Diversification of human milk oligosaccharides (hmos) or precursors thereof
US9567361B2 (en) 2011-05-13 2017-02-14 Glycosyn LLC Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics
JP5834484B2 (ja) * 2011-05-13 2015-12-24 味の素株式会社 フコシル化されたＧａｌ−Ｇｌｃまたはその誘導体の製造方法
NL2007268C2 (en) 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
EP2760875A4 (en) 2011-09-30 2015-08-26 Glycom As SYNTHESIS OF HMO NUCLEAR STRUCTURES
WO2013091660A1 (en) 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
EP2828275B1 (en) 2012-03-20 2017-03-01 Glycom A/S Synthesis of the trisaccharide 3-o-fucosyllactose and intermediates thereof
CN104507483A (zh) 2012-04-13 2015-04-08 波士顿学院理事会 益生元组合物及使用方法
EP2656862A1 (en) 2012-04-24 2013-10-30 The Procter & Gamble Company Substrate comprising one or more human milk oligosaccharides and disposable absorbent article comprising the substrate
US9896470B2 (en) * 2012-06-14 2018-02-20 Glycom A/S Enhancing the stability and purity and increasing the bioavailability of human milk oligosaccharides or precursors or blends thereof
WO2013190530A1 (en) 2012-06-22 2013-12-27 Glycom A/S Modified galactooligosaccharides
US20150320780A1 (en) 2012-12-14 2015-11-12 Glycom A/S Mixture of fucosylate lactoses
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
WO2015071403A1 (en) * 2013-11-15 2015-05-21 Nestec S.A. Compositions for use in the prevention or treatment of necrotizing enterocolitis in infants and young children
US10314852B2 (en) * 2014-10-24 2019-06-11 Glycom A/S Mixtures of HMOs
CN115364113A (zh) * 2014-10-29 2022-11-22 格礼卡姆股份公司 合成组合物以及用于治疗肠易激综合症的方法

Also Published As

Publication number Publication date
WO2016063262A1 (en) 2016-04-28
EP3209673B2 (en) 2023-07-26
PL3209673T5 (pl) 2023-10-23
US10946032B2 (en) 2021-03-16
CN107108677A (zh) 2017-08-29
US10314852B2 (en) 2019-06-11
PL3209673T3 (pl) 2021-01-25
ES2824679T3 (es) 2021-05-13
DK3209673T3 (en) 2020-11-02
EP3209673A1 (en) 2017-08-30
ES2824679T5 (es) 2023-12-11
US20170312298A1 (en) 2017-11-02
US20190290667A1 (en) 2019-09-26
EP3209673A4 (en) 2018-06-13
CN107108677B (zh) 2020-08-07
EP3209673B1 (en) 2020-08-19

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