DK310383A - 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler - Google Patents

14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler Download PDF

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Publication number
DK310383A
DK310383A DK310383A DK310383A DK310383A DK 310383 A DK310383 A DK 310383A DK 310383 A DK310383 A DK 310383A DK 310383 A DK310383 A DK 310383A DK 310383 A DK310383 A DK 310383A
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DK
Denmark
Prior art keywords
fluormorphinanes
medicines
procedures
preparing
Prior art date
Application number
DK310383A
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Danish (da)
English (en)
Other versions
DK310383D0 (da
Inventor
Venkat Rao Ganti
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK310383D0 publication Critical patent/DK310383D0/da
Publication of DK310383A publication Critical patent/DK310383A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK310383A 1982-07-06 1983-07-05 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler DK310383A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/395,597 US4451470A (en) 1982-07-06 1982-07-06 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans

Publications (2)

Publication Number Publication Date
DK310383D0 DK310383D0 (da) 1983-07-05
DK310383A true DK310383A (da) 1984-01-07

Family

ID=23563694

Family Applications (1)

Application Number Title Priority Date Filing Date
DK310383A DK310383A (da) 1982-07-06 1983-07-05 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler

Country Status (9)

Country Link
US (1) US4451470A (enExample)
EP (1) EP0098583A2 (enExample)
JP (1) JPS5921690A (enExample)
AU (1) AU1659483A (enExample)
DK (1) DK310383A (enExample)
ES (1) ES8505519A1 (enExample)
GR (1) GR79339B (enExample)
IL (1) IL69157A0 (enExample)
ZA (1) ZA834900B (enExample)

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US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4775759A (en) * 1984-11-27 1988-10-04 The United States Of America As Represented By The Department Of Health And Human Services Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT)
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
US5878750A (en) * 1996-11-14 1999-03-09 Clemens; Anton H. Method of treating the syndrome of coronary heart disease risk factors in humans
BR9813826A (pt) 1997-12-22 2000-10-10 Euro Celtique Sa Potencial de uso abusivo de administração oral de opióide analgésico
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
WO1999032119A1 (en) 1997-12-22 1999-07-01 Euro-Celtique, S.A. Opioid agonist/antagonist combinations
RU2138502C1 (ru) * 1999-03-29 1999-09-27 Закрытое акционерное общество "РМА-Фарм" Способ получения 17-циклопропилметил-6,14-эндо-этано-7-(2-гидрокси-3,3-диметилбут-2-ил)тетр агидро-17-норорипавина
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
KR20020071032A (ko) 2000-02-08 2002-09-11 유로-셀티크 소시에떼 아노뉨 오피오이드 효능제와 길항제를 함유하는 서방성 조성물
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
US6262062B1 (en) * 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6528520B2 (en) * 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
SI1416842T1 (sl) * 2001-07-18 2009-06-30 Euro Celtique Sa Farmacevtske kombinacije oksikodona in naloksona
CA2457361C (en) 2001-08-06 2008-11-04 Christopher Breder Opioid agonist formulations with releasable and sequestered antagonist
US20030157168A1 (en) * 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
DE20321531U1 (de) 2002-04-05 2007-11-22 Euro-Celtique S.A. Lagerstabiles pharmazeutisches Präparat, das Oxycodon und Naloxon umfaßt
AU2003270778B2 (en) * 2002-09-20 2009-10-08 Alpharma Pharmaceuticals, Llc Sequestering subunit and related compositions and methods
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) * 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20070191411A1 (en) * 2004-10-07 2007-08-16 Smith Richard A Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
MX2008013594A (es) * 2006-04-21 2009-01-16 Nektar Therapeutics Al Corp Reduccion estereoselectiva de una morfinona.
KR20150029762A (ko) * 2006-06-19 2015-03-18 알파마 파머슈티컬스 엘엘씨 약제학적 조성물
EP2724722B1 (en) 2006-10-20 2016-12-07 NeurEndo Pharma, LLC Method of restoring the incretin effect
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US7999105B2 (en) * 2008-02-29 2011-08-16 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
RU2478388C2 (ru) * 2008-07-07 2013-04-10 Еуро-Селтик С.А. Фармацевтическая композиция, содержащая опиоидный антагонист, для лечения задержки мочи
UY32487A (es) 2009-03-10 2010-06-30 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata comprendiendo oxicodona y naloxona
AU2010326676B2 (en) 2009-12-04 2013-03-14 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
KR101181000B1 (ko) * 2009-12-29 2012-09-07 엘지이노텍 주식회사 발광소자, 발광소자의 제조방법 및 발광소자 패키지
PL3446565T3 (pl) 2010-08-23 2024-04-02 Alkermes Pharma Ireland Limited Sposoby leczenia przyrostu masy ciała wywołanego lekami przeciwpsychotycznymi
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
NZ631018A (en) 2013-05-24 2017-12-22 Alkermes Pharma Ireland Ltd Morphan and morphinan analogues, and methods of use
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
US10034871B2 (en) 2014-11-07 2018-07-31 Regents Of The University Of Minnesota Salts and compositions useful for treating disease
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797223A (en) * 1957-06-25 Preparation of ix-bromocodeinone
CA913077A (en) * 1972-10-24 J. Pachter Irwin Process of preparing n-substituted 14-hydroxydihydronormorphines
US3137701A (en) * 1962-04-19 1964-06-16 Upjohn Co Process for the preparation of 6-deoxy-6-fluoromorphines, 6-deoxy-6-fluorocodeines, and related compounds
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3914265A (en) * 1972-12-11 1975-10-21 Du Pont Dialkylaminosulfur trifluorides as fluorinating agents
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone

Also Published As

Publication number Publication date
EP0098583A2 (en) 1984-01-18
ZA834900B (en) 1985-02-27
JPS5921690A (ja) 1984-02-03
GR79339B (enExample) 1984-10-22
IL69157A0 (en) 1983-11-30
AU1659483A (en) 1984-01-12
ES523863A0 (es) 1984-11-01
DK310383D0 (da) 1983-07-05
ES8505519A1 (es) 1984-11-01
US4451470A (en) 1984-05-29

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