DK3102571T3 - Substituted pyrimidines useful as EGFR-T790M kinase inhibitors - Google Patents

Substituted pyrimidines useful as EGFR-T790M kinase inhibitors Download PDF

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Publication number
DK3102571T3
DK3102571T3 DK15746902.4T DK15746902T DK3102571T3 DK 3102571 T3 DK3102571 T3 DK 3102571T3 DK 15746902 T DK15746902 T DK 15746902T DK 3102571 T3 DK3102571 T3 DK 3102571T3
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Prior art keywords
cancer
compound
disorder
pharmaceutical composition
mmol
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Application number
DK15746902.4T
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Danish (da)
English (en)
Inventor
Dawei Zhang
Original Assignee
Jiangsu Medolution Ltd
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Application filed by Jiangsu Medolution Ltd filed Critical Jiangsu Medolution Ltd
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Publication of DK3102571T3 publication Critical patent/DK3102571T3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15746902.4T 2014-02-04 2015-02-03 Substituted pyrimidines useful as EGFR-T790M kinase inhibitors DK3102571T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461965584P 2014-02-04 2014-02-04
PCT/CN2015/072179 WO2015117547A1 (en) 2014-02-04 2015-02-03 Substituted pyrimidines useful as egfr-t790m kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3102571T3 true DK3102571T3 (en) 2018-05-07

Family

ID=53777338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15746902.4T DK3102571T3 (en) 2014-02-04 2015-02-03 Substituted pyrimidines useful as EGFR-T790M kinase inhibitors

Country Status (8)

Country Link
US (1) US10167264B2 (de)
EP (1) EP3102571B1 (de)
JP (1) JP6257787B2 (de)
CN (1) CN105980377B (de)
DK (1) DK3102571T3 (de)
ES (1) ES2667847T3 (de)
NO (1) NO2718543T3 (de)
WO (1) WO2015117547A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106554318A (zh) * 2015-09-25 2017-04-05 正大天晴药业集团股份有限公司 氘代二苯基氨基嘧啶化合物
CN106554347B (zh) * 2015-09-25 2020-10-30 浙江博生医药有限公司 Egfr激酶抑制剂及其制备方法和应用
CN105461640B (zh) * 2015-12-02 2017-11-21 芷威（上海）化学科技有限公司 一种酪氨酸激酶抑制剂的制备方法
CN106146406A (zh) * 2016-02-23 2016-11-23 深圳市塔吉瑞生物医药有限公司 一种取代的二氨基嘧啶类化合物及包含该化合物的组合物及其用途
CN107344925B (zh) * 2016-05-04 2022-11-11 正大天晴药业集团股份有限公司 氘代二苯基氨基-三氟甲基嘧啶化合物
CN107088196A (zh) * 2017-02-27 2017-08-25 王涛 一种治疗骨质疏松症的药物组合物
US20220267294A1 (en) * 2019-06-20 2022-08-25 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of src tyrosine kinase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101705158B1 (ko) * 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
JP5957460B2 (ja) * 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 複素環式化合物またはその使用
EP2802568A1 (de) * 2012-01-13 2014-11-19 Acea Biosciences, Inc. Heterocyclische verbindungen und ihr verwendung als antikrebsmittel
WO2013138495A1 (en) 2012-03-15 2013-09-19 Celgene Avilomics Research, Inc. Solid forms of an epidermal growth factor receptor kinase inhibitor
CN104284584B (zh) * 2012-03-15 2019-06-04 西建卡尔有限责任公司 表皮生长因子受体激酶抑制剂的盐

Also Published As

Publication number Publication date
EP3102571B1 (de) 2018-04-04
EP3102571A1 (de) 2016-12-14
JP6257787B2 (ja) 2018-01-10
CN105980377B (zh) 2018-07-03
JP2017505319A (ja) 2017-02-16
US10167264B2 (en) 2019-01-01
ES2667847T3 (es) 2018-05-14
NO2718543T3 (de) 2018-01-06
CN105980377A (zh) 2016-09-28
WO2015117547A1 (en) 2015-08-13
EP3102571A4 (de) 2016-12-14
US20170008856A1 (en) 2017-01-12

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