DK2841402T3 - Markerede quinoxalinderivater som multimodale radiofarmaceutiske midler og deres prækursorer - Google Patents

Markerede quinoxalinderivater som multimodale radiofarmaceutiske midler og deres prækursorer Download PDF

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Publication number
DK2841402T3
DK2841402T3 DK13725814.1T DK13725814T DK2841402T3 DK 2841402 T3 DK2841402 T3 DK 2841402T3 DK 13725814 T DK13725814 T DK 13725814T DK 2841402 T3 DK2841402 T3 DK 2841402T3
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DK
Denmark
Prior art keywords
precursors
marked
pharmaceutical agents
radio pharmaceutical
multimodal
Prior art date
Application number
DK13725814.1T
Other languages
English (en)
Inventor
Jean-Michel Chezal
Philippe Auzeloux
Jean-Claude Madelmont
Elisabeth Miot-Noirault
Aurélie Maisonial
Latifa Rbah-Vidal
Emilie Billaud
Aurélien Vidal
Janine Papon
Original Assignee
Inst Nat De La Santé Et De La Rech Medicale
Univ D'auvergne Clermont I
Laboratoires Cyclopharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat De La Santé Et De La Rech Medicale, Univ D'auvergne Clermont I, Laboratoires Cyclopharma filed Critical Inst Nat De La Santé Et De La Rech Medicale
Application granted granted Critical
Publication of DK2841402T3 publication Critical patent/DK2841402T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22Tin compounds
    • C07F7/2208Compounds having tin linked only to carbon, hydrogen and/or halogen
DK13725814.1T 2012-04-24 2013-04-19 Markerede quinoxalinderivater som multimodale radiofarmaceutiske midler og deres prækursorer DK2841402T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12165413.1A EP2657213A1 (en) 2012-04-24 2012-04-24 Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors
PCT/IB2013/053106 WO2013160808A1 (en) 2012-04-24 2013-04-19 Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors

Publications (1)

Publication Number Publication Date
DK2841402T3 true DK2841402T3 (da) 2017-02-20

Family

ID=48536968

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13725814.1T DK2841402T3 (da) 2012-04-24 2013-04-19 Markerede quinoxalinderivater som multimodale radiofarmaceutiske midler og deres prækursorer

Country Status (8)

Country Link
US (1) US20150079000A1 (da)
EP (2) EP2657213A1 (da)
AU (1) AU2013254326B2 (da)
DK (1) DK2841402T3 (da)
ES (1) ES2616793T3 (da)
HK (1) HK1207852A1 (da)
IL (1) IL235122A (da)
WO (1) WO2013160808A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014112747A1 (de) * 2014-09-04 2016-03-10 Eberhard Karls Universität Tübingen Medizinische Fakultät Verwendung eines Quinoxalinderivats in einem bildgebenden Verfahren
WO2020202726A1 (ja) * 2019-03-29 2020-10-08 国立研究開発法人量子科学技術研究開発機構 放射性標識化合物の製造方法、製造装置、放射性標識化合物及び放射性同位体製造装置
GB202108605D0 (en) * 2021-06-16 2021-07-28 Ge Healthcare Uk Ltd Effect of water content

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2642972B1 (fr) 1989-02-14 1994-08-05 Inst Nat Sante Rech Med Agents pour le diagnostic et le traitement des melanomes, derives halogenes aromatiques utilisables comme de tels agents et leur preparation
US5911970A (en) 1993-05-06 1999-06-15 Research Corporation Technologies, Inc. Methods for cancer imaging and therapy using benzamine compounds
DE102004011720B4 (de) 2004-03-10 2008-04-03 Bayer Schering Pharma Aktiengesellschaft Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie
GB0428012D0 (en) * 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
AU2006261917A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
EP2085390A1 (en) * 2008-01-31 2009-08-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors

Also Published As

Publication number Publication date
IL235122A (en) 2017-01-31
EP2841402B1 (en) 2016-11-30
AU2013254326B2 (en) 2017-02-02
ES2616793T3 (es) 2017-06-14
WO2013160808A1 (en) 2013-10-31
EP2841402A1 (en) 2015-03-04
AU2013254326A1 (en) 2014-10-30
US20150079000A1 (en) 2015-03-19
HK1207852A1 (en) 2016-02-12
EP2657213A1 (en) 2013-10-30

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