DK2788354T3 - FUNCTIONALIZATION OF CAGE AMINIGANDS FOR METALLO-RADIOPHARMACEUTICAL AGENTS - Google Patents
FUNCTIONALIZATION OF CAGE AMINIGANDS FOR METALLO-RADIOPHARMACEUTICAL AGENTS Download PDFInfo
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- DK2788354T3 DK2788354T3 DK12856248.5T DK12856248T DK2788354T3 DK 2788354 T3 DK2788354 T3 DK 2788354T3 DK 12856248 T DK12856248 T DK 12856248T DK 2788354 T3 DK2788354 T3 DK 2788354T3
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- Prior art keywords
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- optionally substituted
- metal
- ligand
- moiety
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- 229950000688 phenothiazine Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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- 229960005190 phenylalanine Drugs 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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- 239000001294 propane Substances 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 239000012857 radioactive material Substances 0.000 description 1
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- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567255P | 2011-12-06 | 2011-12-06 | |
| PCT/AU2012/001483 WO2013082655A1 (en) | 2011-12-06 | 2012-12-06 | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2788354T3 true DK2788354T3 (en) | 2017-03-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12856248.5T DK2788354T3 (en) | 2011-12-06 | 2012-12-06 | FUNCTIONALIZATION OF CAGE AMINIGANDS FOR METALLO-RADIOPHARMACEUTICAL AGENTS |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9364570B2 (enExample) |
| EP (1) | EP2788354B1 (enExample) |
| JP (1) | JP6051227B2 (enExample) |
| AU (1) | AU2012350146B2 (enExample) |
| DK (1) | DK2788354T3 (enExample) |
| ES (1) | ES2617335T3 (enExample) |
| PT (1) | PT2788354T (enExample) |
| WO (1) | WO2013082655A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013082655A1 (en) | 2011-12-06 | 2013-06-13 | The University Of Melbourne | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
| WO2013181697A1 (en) * | 2012-06-05 | 2013-12-12 | The University Of Melbourne | Bicyclo[6.1.0]non-4-yne compounds suitable for use as linkers in biological applications |
| US9422286B2 (en) | 2014-01-27 | 2016-08-23 | Washington University | Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease |
| KR102368068B1 (ko) | 2015-08-24 | 2022-02-25 | 삼성전자주식회사 | 반도체 소자 제조용 조성물 및 이를 이용하는 반도체 소자의 제조 방법 |
| WO2021087568A1 (en) * | 2019-11-08 | 2021-05-14 | The University Of Queensland | Radiolabelled targeting ligands |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2712881T3 (es) | 2008-12-02 | 2019-05-16 | Univ Melbourne | Conjugados macrocíclicos que contienen nitrógeno como radiofármacos |
| WO2013082655A1 (en) | 2011-12-06 | 2013-06-13 | The University Of Melbourne | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
-
2012
- 2012-12-06 WO PCT/AU2012/001483 patent/WO2013082655A1/en not_active Ceased
- 2012-12-06 AU AU2012350146A patent/AU2012350146B2/en active Active
- 2012-12-06 EP EP12856248.5A patent/EP2788354B1/en active Active
- 2012-12-06 PT PT128562485T patent/PT2788354T/pt unknown
- 2012-12-06 ES ES12856248.5T patent/ES2617335T3/es active Active
- 2012-12-06 JP JP2014545037A patent/JP6051227B2/ja active Active
- 2012-12-06 US US14/363,242 patent/US9364570B2/en active Active
- 2012-12-06 DK DK12856248.5T patent/DK2788354T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2788354A4 (en) | 2015-06-17 |
| EP2788354A1 (en) | 2014-10-15 |
| US9364570B2 (en) | 2016-06-14 |
| EP2788354B1 (en) | 2016-11-30 |
| ES2617335T3 (es) | 2017-06-16 |
| JP6051227B2 (ja) | 2016-12-27 |
| US20150051392A1 (en) | 2015-02-19 |
| AU2012350146A1 (en) | 2014-07-03 |
| JP2015500246A (ja) | 2015-01-05 |
| WO2013082655A1 (en) | 2013-06-13 |
| PT2788354T (pt) | 2017-03-07 |
| AU2012350146B2 (en) | 2017-07-27 |
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