DK2635293T3 - Skin ulcer preparations and methods for their use - Google Patents
Skin ulcer preparations and methods for their use Download PDFInfo
- Publication number
- DK2635293T3 DK2635293T3 DK10859369.0T DK10859369T DK2635293T3 DK 2635293 T3 DK2635293 T3 DK 2635293T3 DK 10859369 T DK10859369 T DK 10859369T DK 2635293 T3 DK2635293 T3 DK 2635293T3
- Authority
- DK
- Denmark
- Prior art keywords
- wound
- wound healing
- polypeptide
- composition
- hsp90a
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title abstract description 13
- 206010040943 Skin Ulcer Diseases 0.000 title 1
- 231100000019 skin ulcer Toxicity 0.000 title 1
- 206010052428 Wound Diseases 0.000 claims abstract description 52
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 52
- 230000029663 wound healing Effects 0.000 claims abstract description 36
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 27
- 229920001184 polypeptide Polymers 0.000 claims abstract description 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 26
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 239000006071 cream Substances 0.000 claims abstract description 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 12
- 239000002674 ointment Substances 0.000 claims abstract description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 239000006185 dispersion Substances 0.000 claims abstract description 3
- 239000000499 gel Substances 0.000 claims abstract description 3
- 239000006210 lotion Substances 0.000 claims abstract description 3
- 239000006072 paste Substances 0.000 claims abstract description 3
- 239000007921 spray Substances 0.000 claims abstract description 3
- 239000000725 suspension Substances 0.000 claims abstract description 3
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 claims description 22
- 206010072170 Skin wound Diseases 0.000 claims description 9
- 230000035876 healing Effects 0.000 claims description 8
- -1 conditioner Substances 0.000 claims description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 230000005012 migration Effects 0.000 description 8
- 238000013508 migration Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 6
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 5
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 108010081589 Becaplermin Proteins 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 230000004899 motility Effects 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000012292 cell migration Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 description 2
- 101150109894 TGFA gene Proteins 0.000 description 2
- 206010053692 Wound complication Diseases 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000035752 proliferative phase Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- XOIQMTLWECTKJL-HXPDMXKUSA-M sodium;(3r,4s)-4-[(2s,5r,7s,8r,9s)-2-[(2r,5s)-5-ethyl-5-[(2r,3s,5r)-5-[(2s,3s,5r,6r)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate Chemical compound [Na+].C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)C(C)C([O-])=O)O2 XOIQMTLWECTKJL-HXPDMXKUSA-M 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 108091006112 ATPases Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 102100024321 Alkaline phosphatase, placental type Human genes 0.000 description 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 description 1
- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 208000003790 Foot Ulcer Diseases 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- 101150031823 HSP70 gene Proteins 0.000 description 1
- 101000823116 Homo sapiens Alpha-1-antitrypsin Proteins 0.000 description 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 description 1
- 208000005230 Leg Ulcer Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 101710202113 Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000011717 athymic nude mouse Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940112869 bone morphogenetic protein Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000006041 cell recruitment Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 101150052825 dnaK gene Proteins 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 102000051631 human SERPINA1 Human genes 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000029774 keratinocyte migration Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 108010031345 placental alkaline phosphatase Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 229940116157 regranex Drugs 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/055319 WO2012060832A1 (en) | 2010-11-03 | 2010-11-03 | Skin wound healing compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2635293T3 true DK2635293T3 (en) | 2018-06-14 |
Family
ID=46024739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10859369.0T DK2635293T3 (en) | 2010-11-03 | 2010-11-03 | Skin ulcer preparations and methods for their use |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2635293B1 (enExample) |
| JP (1) | JP5815725B2 (enExample) |
| CN (1) | CN103458914B (enExample) |
| CA (1) | CA2816818C (enExample) |
| DK (1) | DK2635293T3 (enExample) |
| WO (1) | WO2012060832A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207118B2 (en) | 2009-07-17 | 2012-06-26 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
| KR102143557B1 (ko) * | 2013-08-09 | 2020-08-12 | 주식회사 리제론 | 인간 열 활성화 단백질 90a의 절편을 유효성분으로 포함하는 피부상태 개선용 조성물 |
| US9468654B1 (en) | 2014-04-02 | 2016-10-18 | Ali Razavi | Drug delivery compositions and methods |
| US20180201662A1 (en) * | 2016-11-30 | 2018-07-19 | Industrial Technology Research Institute | Peptide for promoting cell migration and/or skin wound healing, pharmaceutical composition containing the same, and application thereof |
| CN107446018B (zh) * | 2017-08-07 | 2020-07-17 | 温州千瑞生物科技有限公司 | 促进伤口愈合的肽及其应用 |
| WO2022178005A1 (en) | 2021-02-17 | 2022-08-25 | Oxion Dental, Llc | Stabilized active oxygen-generating antiseptic compositions, irrigation solutions, and articles |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5183805A (en) * | 1990-08-13 | 1993-02-02 | Board Of Regents, The University Of Texas System | Bioactive egf peptides for promotion of tissue regeneration and cancer therapy |
| US6475490B1 (en) * | 1998-10-19 | 2002-11-05 | Fordham University | Compositions and methods for promoting tissue repair using heat shock proteins |
| US7081240B1 (en) | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
| TWI305778B (en) * | 2001-12-03 | 2009-02-01 | Nishida Teruo | Peptides of an expressing unit for igf-i minimal activity and their pharmaceutical use |
| US20070098735A1 (en) * | 2005-10-29 | 2007-05-03 | Chandawarkar Rajiv Y | Methods for the Elimination of Pathogens and Other Particulate Agents |
| KR101020658B1 (ko) * | 2006-01-23 | 2011-03-09 | 주식회사 이매진 | 신규한 펩타이드 및 이의 용도 |
| US8022037B2 (en) * | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
-
2010
- 2010-11-03 JP JP2013537646A patent/JP5815725B2/ja active Active
- 2010-11-03 EP EP10859369.0A patent/EP2635293B1/en active Active
- 2010-11-03 WO PCT/US2010/055319 patent/WO2012060832A1/en not_active Ceased
- 2010-11-03 CN CN201080070970.9A patent/CN103458914B/zh active Active
- 2010-11-03 CA CA2816818A patent/CA2816818C/en active Active
- 2010-11-03 DK DK10859369.0T patent/DK2635293T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103458914B (zh) | 2015-11-25 |
| JP5815725B2 (ja) | 2015-11-17 |
| EP2635293A4 (en) | 2014-04-02 |
| JP2013542954A (ja) | 2013-11-28 |
| CN103458914A (zh) | 2013-12-18 |
| CA2816818C (en) | 2019-01-22 |
| CA2816818A1 (en) | 2012-05-10 |
| WO2012060832A1 (en) | 2012-05-10 |
| EP2635293B1 (en) | 2018-04-04 |
| EP2635293A1 (en) | 2013-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8455443B2 (en) | Methods of use of skin wound healing compositions | |
| US8022037B2 (en) | Skin wound healing compositions and methods of use thereof | |
| DK2635293T3 (en) | Skin ulcer preparations and methods for their use | |
| EP1303284B1 (en) | Compositions and methods for the treatment of skin damage | |
| EP1579221A2 (de) | Verwendungen von hmgb, hmgn, hmga proteinen | |
| JP6348126B2 (ja) | 創傷治癒を促進する生物活性短鎖ペプチド | |
| JP7026050B2 (ja) | 慢性創傷を治療するための組成物及び方法 | |
| CA2724308C (en) | Method of promoting wound healing | |
| Zhong et al. | Combination therapy of negative pressure wound therapy and antibiotic‐loaded bone cement for accelerating diabetic foot ulcer healing: A prospective randomised controlled trial | |
| Ramineni et al. | Effects of epidermal growth factor-loaded mucoadhesive films on wounded oral tissue rafts | |
| CN106822093B (zh) | 组合物用于制备血管新生异常的药物的用途 | |
| US10980863B2 (en) | Composition and methods for treating ischemic wounds and inflammatory conditions | |
| Yamani et al. | Evaluation the Effect of Formulation made of Talh Honey, Whey Protein and Collagen on Acute Excisional Skin Wound Healing in Wistar Male Rat. | |
| TWI602565B (zh) | 組合物用於製備調控血管新生之藥物的用途 | |
| KR20250141164A (ko) | 피부 질환 치료를 위한 펩타이드 | |
| Abdel Gawad et al. | Effect of the use of the human amniotic membrane in healing of surgically induced skin defects in rabbits (histopathological study) | |
| EP1694343A1 (en) | Compositions and methods for the treatment of skin damage | |
| TW201735917A (zh) | 組合物用於製備調控血管新生之藥物的用途 | |
| Cheng et al. | A facilely fabricated in vivo hypertrophic scar model through continuous gradient elastic tension | |
| CN105561292A (zh) | 皮肤伤口愈合组合物及其使用方法 | |
| CA3192177A1 (en) | Compositions and methods for treating wounds | |
| HK1237254B (zh) | 组合物用於制备血管新生异常的药物的用途 | |
| AU2013204203A1 (en) | Method of promoting wound healing |