DK2624832T3 - Hdac-inhibitorer til behandling af charcot-marie-tooths sygdom - Google Patents
Hdac-inhibitorer til behandling af charcot-marie-tooths sygdom Download PDFInfo
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- DK2624832T3 DK2624832T3 DK11767988.6T DK11767988T DK2624832T3 DK 2624832 T3 DK2624832 T3 DK 2624832T3 DK 11767988 T DK11767988 T DK 11767988T DK 2624832 T3 DK2624832 T3 DK 2624832T3
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Claims (5)
1. Selektiv HDAC6-inhibitor til anvendelse til behandling af Charcot-Marie-Tooths sygdom.
2. Inhibitor ifølge krav 1 til anvendelse til behandling af CMT-sygdommen ifølge krav 1, hvor Charcot-Marie-Tooths sygdom er aksonal CMT eller distal hereditær motorisk neuropati.
3. Inhibitor ifølge krav 1 til anvendelse til behandling af Charcot-Marie-Tooths sygdom ifølge krav 1, hvor CMT-sygdommen er kendetegnet ved mindst én mutation i HSPBl-genet eller - proteinet.
4. Inhibitor ifølge krav 1 til anvendelse til behandling af CMT-sygdommen ifølge krav 3, hvor mutationen i HSPBl-genet eller -proteinet er en mutation i alfa-crystallindomænet af HSPB1, især i rest S135, eller i den C-terminale hale, især i rest P182.
5. Inhibitor ifølge krav 1 til anvendelse til behandling af CMT-sygdommen ifølge krav 1, hvor den selektive HDAC6-inhibitor er valgt blandt tubacin og tubastatin A.
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| US40479610P | 2010-10-08 | 2010-10-08 | |
| PCT/EP2011/067438 WO2012045804A1 (en) | 2010-10-08 | 2011-10-06 | Hdac inhibitors to treat charcot-marie-tooth disease |
Publications (1)
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| DK2624832T3 true DK2624832T3 (da) | 2018-01-08 |
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| AU (1) | AU2011311531B2 (da) |
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| DK (1) | DK2624832T3 (da) |
| ES (1) | ES2647368T3 (da) |
| WO (1) | WO2012045804A1 (da) |
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| AU2011311531B2 (en) | 2010-10-08 | 2014-11-20 | Life Sciences Research Partners Vzw | HDAC inhibitors to treat Charcot-Marie-Tooth disease |
| WO2014072714A1 (en) | 2012-11-07 | 2014-05-15 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
| WO2014163380A1 (ko) * | 2013-04-02 | 2014-10-09 | 사회복지법인 삼성생명공익재단 | 샤르코-마리-투스 질환 치료제의 스크리닝 방법 및 이에 이용되는 자가분화운동신경세포 |
| WO2014163381A1 (ko) * | 2013-04-02 | 2014-10-09 | 사회복지법인 삼성생명공익재단 | Hsp27 변이(s135f) 매개의 샤르코-마리-투스 질환동물모델 |
| CN105283544B (zh) * | 2013-04-02 | 2019-10-18 | 三星生命公益财团 | 作为hsp27突变型(s135f)携带者的cmt病的动物模型 |
| KR20140120834A (ko) * | 2013-04-02 | 2014-10-14 | 주식회사 종근당 | 샤르코-마리-투스 질환 치료제의 스크리닝 방법 및 이에 이용되는 자가 분화 운동신경세포 |
| AU2014264370B2 (en) | 2013-05-10 | 2017-12-14 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| US20160158231A1 (en) * | 2014-12-05 | 2016-06-09 | Vib Vzw | Pyrimidine hydroxy amide compounds for treating peripheral neuropathy |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| WO2016126721A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | 3-aryl-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
| WO2018125799A2 (en) | 2016-12-29 | 2018-07-05 | Viamet Pharmaceuticals (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| AU2017387033B2 (en) | 2016-12-29 | 2024-02-01 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| WO2020018647A1 (en) * | 2018-07-17 | 2020-01-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating pacs1 and pacs2 syndromes |
| WO2020081737A1 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Compositions and methods for inducing intestinal stem cell regeneration |
| CA3156060A1 (en) | 2019-09-27 | 2021-04-01 | Takeda Pharmaceutical Company Limited | 2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS |
| EP4326263A1 (en) | 2021-04-23 | 2024-02-28 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for use in the treatment of dilated cardiomyopathy |
| TW202308619A (zh) | 2021-05-04 | 2023-03-01 | 美商特納亞治療股份有限公司 | 用於治療代謝疾病和hfpef的hdac6抑制劑 |
| WO2022251871A1 (en) * | 2021-05-27 | 2022-12-01 | The Brigham And Women's Hospital, Inc. | Small molecule inhibitors of formation of neutrophil-derived extracellular traps (netosis) and uses thereof |
| WO2023288110A1 (en) * | 2021-07-15 | 2023-01-19 | The United States Government As Represented By The Department Of Veterans Affairs | Romidepsin as a therapeutic agent for nerve-injury induced neuropathic pain and spasticity |
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| CA2632078C (en) * | 2002-03-04 | 2012-08-14 | Sloan-Kettering Institute For Cancer Research | Methods of inducing terminal differentiation |
| US20070129290A1 (en) * | 2005-11-18 | 2007-06-07 | Or Yat S | Metabolite derivatives of the HDAC inhibitor FK228 |
| EP2015741A4 (en) * | 2006-05-04 | 2009-12-23 | Merck & Co Inc | HISTONE DESACETYLASE INHIBITORS FOR THE TREATMENT OF NEURODEGENERATION |
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| US7737175B2 (en) * | 2007-06-01 | 2010-06-15 | Duke University | Methods and compositions for regulating HDAC4 activity |
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| CA2701115A1 (en) | 2007-10-04 | 2009-04-09 | Merck Sharp & Dohme Corp. | N-hydroxy-naphthalene dicarboxamide and n-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors |
| EP2065038A1 (en) * | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
| EP2293845A1 (en) | 2008-05-22 | 2011-03-16 | Karus Therapeutics Limited | Depsipeptides and their therapeutic use |
| GB0809329D0 (en) | 2008-05-22 | 2008-07-02 | Karus Therapeutics Ltd | Depsipeptides and their therapeutic use |
| ES2428817T3 (es) | 2008-05-22 | 2013-11-11 | Karus Therapeutics Limited | Depsipéptidos y su uso terapéutico |
| CA2750086C (en) | 2009-01-28 | 2018-01-02 | Karus Therapeutics Limited | Scriptaid isosteres and their use in therapy |
| GB0905970D0 (en) | 2009-04-06 | 2009-05-20 | Karus Therapeutics Ltd | Depsipeptides and their therapeutic use |
| HUE030679T2 (en) | 2010-01-22 | 2017-05-29 | Acetylon Pharmaceuticals Inc | Reverse amide compounds as protein deacetylase inhibitors and methods of use |
| AU2011311531B2 (en) | 2010-10-08 | 2014-11-20 | Life Sciences Research Partners Vzw | HDAC inhibitors to treat Charcot-Marie-Tooth disease |
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2011
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- 2011-10-06 EP EP11767988.6A patent/EP2624832B1/en active Active
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| CA2812855A1 (en) | 2012-04-12 |
| AU2011311531A1 (en) | 2013-04-11 |
| US9238028B2 (en) | 2016-01-19 |
| CA2812855C (en) | 2017-12-19 |
| AU2011311531B2 (en) | 2014-11-20 |
| US20140329849A1 (en) | 2014-11-06 |
| US20130227717A1 (en) | 2013-08-29 |
| US20160000766A1 (en) | 2016-01-07 |
| WO2012045804A1 (en) | 2012-04-12 |
| EP2624832A1 (en) | 2013-08-14 |
| ES2647368T3 (es) | 2017-12-21 |
| EP2624832B1 (en) | 2017-09-27 |
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