DK2556055T3 - Ship-hæmmere og anvendelser deraf - Google Patents
Ship-hæmmere og anvendelser deraf Download PDFInfo
- Publication number
- DK2556055T3 DK2556055T3 DK11766857.4T DK11766857T DK2556055T3 DK 2556055 T3 DK2556055 T3 DK 2556055T3 DK 11766857 T DK11766857 T DK 11766857T DK 2556055 T3 DK2556055 T3 DK 2556055T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- ship inhibitors
- ship
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0007—Androstane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32237810P | 2010-04-09 | 2010-04-09 | |
| PCT/US2011/031930 WO2011127465A2 (en) | 2010-04-09 | 2011-04-11 | Ship inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2556055T3 true DK2556055T3 (da) | 2019-08-19 |
Family
ID=44763588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11766857.4T DK2556055T3 (da) | 2010-04-09 | 2011-04-11 | Ship-hæmmere og anvendelser deraf |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9447139B2 (da) |
| EP (2) | EP3581563B1 (da) |
| DK (1) | DK2556055T3 (da) |
| ES (1) | ES2742213T3 (da) |
| WO (1) | WO2011127465A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2742213T3 (es) | 2010-04-09 | 2020-02-13 | The Research Foundation Of The State Univ Of New York | Inhibidores de SHIP y uso de los mismos |
| CN104072564B (zh) * | 2013-03-28 | 2016-08-17 | 广州市赛普特医药科技股份有限公司 | 2β,3α,5α-三羟基-雄甾-6-酮及其制备方法与用途 |
| AU2014284360B9 (en) * | 2013-07-01 | 2019-10-24 | The Research Foundation For The State University Of New York | Ship inhibition to combat obesity |
| DK3157529T3 (da) | 2014-06-17 | 2021-11-08 | Univ New York State Res Found | Ship-hæmning til at inducere aktivering af naturlige dræberceller |
| US10736877B2 (en) | 2015-12-31 | 2020-08-11 | Syracuse University | Tryptamine-based ship inhibitors for the treatment of cancer |
| EP3542160A4 (en) * | 2016-11-16 | 2020-06-24 | Ichor, LLC. | INHIBITORS OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE FOR TREATING CARDIOVASCULAR AND LUNG DISEASES |
| US20210186989A1 (en) | 2018-06-06 | 2021-06-24 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Enhanced trained immunity in myeloid cells by ship-1 inhibition |
| CA3107823A1 (en) * | 2018-07-31 | 2020-02-06 | The Research Foundation For The State University Of New York | Methods of activating microglial cells |
| CN112315964B (zh) * | 2020-12-07 | 2024-01-26 | 中国医科大学附属盛京医院 | 环戊基菲啶苯类化合物在制备tln1蛋白抑制剂中的应用 |
| CN114716499B (zh) * | 2022-04-24 | 2023-05-23 | 浙江工商大学 | 生物甾醇胍基化修饰的胆酸螯合剂及制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU36147A1 (da) | 1957-09-27 | |||
| GB1033520A (en) * | 1962-03-30 | 1966-06-22 | Sterling Drug Inc | 3-amino steroids |
| CS126738B5 (da) * | 1965-08-31 | 1968-03-15 | ||
| BE702699A (da) | 1967-08-16 | 1968-01-15 | ||
| CA2275683A1 (en) | 1996-12-20 | 1998-07-02 | Frederik Christian Gronvald | Meiosis regulating compounds |
| AU2003284140A1 (en) | 2002-10-11 | 2004-05-04 | Isis Pharmaceuticals, Inc. | Method for inhibiting angiogenesis with ship-1 inhibitors |
| CA2517893C (fr) | 2003-03-11 | 2012-05-15 | Trophos | Application a titre de medicaments de derives de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation |
| JP2008504329A (ja) | 2004-06-29 | 2008-02-14 | ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用 |
| AU2007327761A1 (en) | 2006-12-08 | 2008-06-12 | Jado Technologies Gmbh | Cholesterylamines for the treatment and prevention of infectious diseases |
| WO2010045199A2 (en) | 2008-10-13 | 2010-04-22 | University Of South Florida | Method of modulating ship activity |
| US8101605B2 (en) | 2009-12-04 | 2012-01-24 | Aquinox Pharmaceuticals Inc. | SHIP1 modulators and methods related thereto |
| ES2742213T3 (es) | 2010-04-09 | 2020-02-13 | The Research Foundation Of The State Univ Of New York | Inhibidores de SHIP y uso de los mismos |
| AU2014284360B9 (en) | 2013-07-01 | 2019-10-24 | The Research Foundation For The State University Of New York | Ship inhibition to combat obesity |
-
2011
- 2011-04-11 ES ES11766857T patent/ES2742213T3/es active Active
- 2011-04-11 DK DK11766857.4T patent/DK2556055T3/da active
- 2011-04-11 EP EP19189158.9A patent/EP3581563B1/en active Active
- 2011-04-11 WO PCT/US2011/031930 patent/WO2011127465A2/en active Application Filing
- 2011-04-11 US US13/640,162 patent/US9447139B2/en active Active
- 2011-04-11 EP EP11766857.4A patent/EP2556055B1/en active Active
-
2016
- 2016-09-19 US US15/269,209 patent/US11319336B2/en active Active
-
2021
- 2021-12-03 US US17/542,090 patent/US20220162254A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3581563C0 (en) | 2023-06-28 |
| EP3581563A1 (en) | 2019-12-18 |
| WO2011127465A3 (en) | 2012-03-15 |
| US9447139B2 (en) | 2016-09-20 |
| US11319336B2 (en) | 2022-05-03 |
| EP2556055A2 (en) | 2013-02-13 |
| EP2556055A4 (en) | 2014-02-19 |
| EP3581563B1 (en) | 2023-06-28 |
| WO2011127465A2 (en) | 2011-10-13 |
| US20220162254A1 (en) | 2022-05-26 |
| US20170051006A1 (en) | 2017-02-23 |
| US20130102577A1 (en) | 2013-04-25 |
| EP2556055B1 (en) | 2019-07-31 |
| ES2742213T3 (es) | 2020-02-13 |
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