DK2536691T3 - Bifunktionelt chelatdannende middel - Google Patents
Bifunktionelt chelatdannende middel Download PDFInfo
- Publication number
- DK2536691T3 DK2536691T3 DK11744221.0T DK11744221T DK2536691T3 DK 2536691 T3 DK2536691 T3 DK 2536691T3 DK 11744221 T DK11744221 T DK 11744221T DK 2536691 T3 DK2536691 T3 DK 2536691T3
- Authority
- DK
- Denmark
- Prior art keywords
- nmr
- mhz
- mmol
- complexes
- dedpa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
Claims (10)
1. Bifunktionelt chelatdannende middel eller farmaceutisk acceptabelt salt deraf, der har en formel (la):
hvor: (a) Q1 og Q2 er hver H og Q4 er
eller (b) en af Q1 og Q2 er
og den anden af Q1 og Q2 er
eller H, og Q4 er H; og hvor: hver R6 er NO2, NH2, isothiocyanato, semicarbazido, thiosemicarbazido, malei-mido, bromacetamido eller carboxyl; n er 0 eller 1; og z er 1,2 eller 3.
2. Bifunktionelt chelatdannende middel eller farmaceutisk acceptabelt salt deraf ifølge krav 1, hvilket chelatdannende middel er:
3. Bifunktionelt chelatdannende middel eller farmaceutisk acceptabelt salt deraf, der er valgt fra gruppen, som består af:
4. Konjugat af et bifunktionelt chelatdannende middel eller farmaceutisk acceptabelt salt deraf, som er defineret i et hvilket som helst af kravene 1 til 3 med en bærer, der omfatter en biotargeting molekyldel, en lipofil gruppe eller en biosensor.
5. Konjugatet ifølge krav 4, hvor bæreren omfatter en biotargeting molekyldel.
6. Konjugatet ifølge krav 5, hvor biotargeting-molekyldelen er et protein, antistof, antistoffragment, hormon, peptid, vækstfaktor, antigen eller hapten.
7. Kompleks, der omfatter det bifunktionelle chelatdannende middel eller farmaceutisk acceptabelt salt deraf, som defineret i et hvilket som helst af kravene 1 til 3, eller konjugatet som er defineret i et hvilket som helst af kravene 4 til 6 og en ion af en stabil eller radioaktiv form af et metal, der er valgt blandt en gruppe, som består af Ga, In, TI, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Sc, Y, Ti, Zr, Cr, Mn, Tc, Re, Fe, Ru, Co, Rh, Ir, Ni, Pd, Pt, Cu, Zn, Cd, Hg, Al, Ge, Sn, Pb, Sb, Bi, Te, Po, Mg, Ca, Sr, Ba, Ra, Ac, Th og U.
8. Komplekset ifølge krav 7, hvor ionen er en ion af et radioaktivt metal, der er udvalgt fra gruppen, som består af 66Ga, 67Ga, 68Ga, 111ln, 201TI, 142Pr, 149Pm, 153Sm, 153Gd, 159Gd, 166Ho, 175Yb, 177Lu, 47Sc, 90Y, 89Zr, 51Cr, 99mTc, 188Re, 186Re, 57Co, 101mRh, 62Cu, 64Cu, 67Cu, 117mSn, 203Pb, 212Pb, 212Bi, 223Ra og 225Ac.
9. Komplekset ifølge krav 7, hvor ionen er en ion af en stabil eller radioaktiv form af metallet Ga eller In.
10. Komplekset ifølge krav 8, hvor ionen er en ion af det radioaktive metal 66Ga, 67Ga, 68Ga eller 111ln.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30625610P | 2010-02-19 | 2010-02-19 | |
| US39473910P | 2010-10-19 | 2010-10-19 | |
| PCT/CA2011/000187 WO2011100829A1 (en) | 2010-02-19 | 2011-02-18 | Bifunctional chelating agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2536691T3 true DK2536691T3 (da) | 2018-02-19 |
Family
ID=44482427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11744221.0T DK2536691T3 (da) | 2010-02-19 | 2011-02-18 | Bifunktionelt chelatdannende middel |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8772446B2 (da) |
| EP (2) | EP2536691B1 (da) |
| JP (1) | JP5856982B2 (da) |
| DK (1) | DK2536691T3 (da) |
| ES (1) | ES2962520T3 (da) |
| NO (1) | NO2536691T3 (da) |
| WO (1) | WO2011100829A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150297761A1 (en) * | 2012-11-12 | 2015-10-22 | The General Hospital Corporation | Peptidic structures incorporating an amino acid metal complex and applications in magnetic resonance imaging |
| DE102013113156A1 (de) | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
| CN104152520B (zh) * | 2014-07-30 | 2017-01-18 | 华南理工大学 | 一种具有抗肿瘤活性的核桃多肽‑锌螯合物的制备方法 |
| JP7523883B2 (ja) * | 2015-08-13 | 2024-07-29 | ザ ジェネラル ホスピタル コーポレイション | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| CN106496110B (zh) * | 2016-09-05 | 2019-04-23 | 郑州大学 | 金属β-内酰胺酶抑制剂开链吡啶羧酸衍生物及其制备方法 |
| KR101851979B1 (ko) * | 2017-03-23 | 2018-06-07 | (주) 에프엔지리서치 | 중금속 및 포름알데히드 제거능을 가지는 세제 조성물 |
| JP2024125438A (ja) * | 2021-08-03 | 2024-09-19 | 住友化学株式会社 | 放射性金属錯体及びその製造方法、並びに放射性金属捕捉剤 |
| CN116041257B (zh) * | 2023-02-02 | 2024-10-15 | 杭州谱康医学科技有限公司 | 金属螯合配体及其制备方法、应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
| US5220000A (en) * | 1992-01-23 | 1993-06-15 | Spyros Theodoropulos | Bifunctional-bis-quinolinols, and their metal chelates |
| FR2890657B1 (fr) * | 2005-09-15 | 2007-11-09 | Commissariat Energie Atomique | Procede d'obtention de complexes de lanthanides hautement luminescents. |
| FR2896501B1 (fr) | 2006-01-20 | 2008-04-25 | Commissariat Energie Atomique | Nouveaux ligands et complexes de lanthanides, et leur utilisation en tant qu'agents de contraste |
-
2011
- 2011-02-18 US US13/030,766 patent/US8772446B2/en active Active
- 2011-02-18 WO PCT/CA2011/000187 patent/WO2011100829A1/en active Application Filing
- 2011-02-18 ES ES17200176T patent/ES2962520T3/es active Active
- 2011-02-18 NO NO11744221A patent/NO2536691T3/no unknown
- 2011-02-18 JP JP2012553161A patent/JP5856982B2/ja active Active
- 2011-02-18 EP EP11744221.0A patent/EP2536691B1/en active Active
- 2011-02-18 DK DK11744221.0T patent/DK2536691T3/da active
- 2011-02-18 EP EP17200176.0A patent/EP3318555B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013519692A (ja) | 2013-05-30 |
| NO2536691T3 (da) | 2018-04-21 |
| EP3318555C0 (en) | 2023-08-16 |
| EP2536691A4 (en) | 2013-08-14 |
| WO2011100829A8 (en) | 2011-10-27 |
| EP2536691B1 (en) | 2017-11-22 |
| JP5856982B2 (ja) | 2016-02-10 |
| ES2962520T3 (es) | 2024-03-19 |
| EP2536691A1 (en) | 2012-12-26 |
| US8772446B2 (en) | 2014-07-08 |
| WO2011100829A1 (en) | 2011-08-25 |
| EP3318555B1 (en) | 2023-08-16 |
| US20110313130A1 (en) | 2011-12-22 |
| EP3318555A1 (en) | 2018-05-09 |
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