DK2482841T4 - Sammensætninger og fremgangsmåder til at forbedre koagulationsfaktor-viii-funktion - Google Patents
Sammensætninger og fremgangsmåder til at forbedre koagulationsfaktor-viii-funktion Download PDFInfo
- Publication number
- DK2482841T4 DK2482841T4 DK10821393.5T DK10821393T DK2482841T4 DK 2482841 T4 DK2482841 T4 DK 2482841T4 DK 10821393 T DK10821393 T DK 10821393T DK 2482841 T4 DK2482841 T4 DK 2482841T4
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- methods
- factor viii
- coagulation factor
- viii function
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24817909P | 2009-10-02 | 2009-10-02 | |
| PCT/US2010/051285 WO2011041770A1 (en) | 2009-10-02 | 2010-10-04 | Compositions and methods for enhancing coagulation factor viii function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2482841T3 DK2482841T3 (da) | 2019-03-18 |
| DK2482841T4 true DK2482841T4 (da) | 2022-10-24 |
Family
ID=43826687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10821393.5T DK2482841T4 (da) | 2009-10-02 | 2010-10-04 | Sammensætninger og fremgangsmåder til at forbedre koagulationsfaktor-viii-funktion |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8816054B2 (da) |
| EP (1) | EP2482841B2 (da) |
| AU (1) | AU2010300292B2 (da) |
| CA (1) | CA2776503C (da) |
| DK (1) | DK2482841T4 (da) |
| ES (1) | ES2717902T5 (da) |
| PT (1) | PT2482841T (da) |
| WO (1) | WO2011041770A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013086125A2 (en) * | 2011-12-08 | 2013-06-13 | Bloodcenter Research Foundation | Method of inducing immune tolerance through targetted gene expression |
| US10023628B2 (en) | 2012-07-06 | 2018-07-17 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor VIII polypeptides and uses thereof |
| EP3180022B1 (en) * | 2014-08-13 | 2024-07-03 | The Children's Hospital of Philadelphia | An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders |
| US20190144524A1 (en) * | 2016-01-14 | 2019-05-16 | The Children's Hospital Of Philadelphia | Factor viii variants, nucleic acid sequences, and methods and uses for treatment of hemostasis disorders |
| AU2018338608A1 (en) | 2017-09-27 | 2020-04-09 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
| US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| IL312315A (en) | 2018-04-04 | 2024-06-01 | Sigilon Therapeutics Inc | Implantable particles and related methods |
| NZ769677A (en) | 2018-05-18 | 2024-07-05 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| WO2020168362A1 (en) | 2019-02-15 | 2020-08-20 | Crispr Therapeutics Ag | Gene editing for hemophilia a with improved factor viii expression |
| EP3736286A1 (en) | 2019-05-09 | 2020-11-11 | Biotest AG | Single chain factor viii molecule |
| WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
| WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910006424B1 (ko) † | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| US5451521A (en) † | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
| US5422260A (en) † | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
| EP0302925A4 (en) † | 1987-01-30 | 1989-04-24 | Biogen Nv | METHOD FOR PRODUCING FACTOR VIII IN LARGE QUANTITIES. |
| EP0294910B1 (en) † | 1987-06-12 | 1996-09-11 | Immuno Ag | Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| DE3720246A1 (de) † | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
| CA2264431A1 (en) * | 1998-03-05 | 1999-09-05 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
| DK1266006T3 (da) † | 2000-03-22 | 2006-01-16 | Octagene Gmbh | Fremstilling af rekombinante muteiner af blodkoagulationsfaktor VIII i humane cellelinier |
| WO2003100053A1 (en) † | 2002-05-22 | 2003-12-04 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of hemophilia a |
| US7041635B2 (en) † | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
-
2010
- 2010-10-04 EP EP10821393.5A patent/EP2482841B2/en active Active
- 2010-10-04 ES ES10821393T patent/ES2717902T5/es active Active
- 2010-10-04 DK DK10821393.5T patent/DK2482841T4/da active
- 2010-10-04 PT PT10821393T patent/PT2482841T/pt unknown
- 2010-10-04 AU AU2010300292A patent/AU2010300292B2/en active Active
- 2010-10-04 CA CA2776503A patent/CA2776503C/en active Active
- 2010-10-04 WO PCT/US2010/051285 patent/WO2011041770A1/en active Application Filing
-
2012
- 2012-04-02 US US13/437,486 patent/US8816054B2/en active Active
-
2014
- 2014-08-25 US US14/468,108 patent/US9670267B2/en active Active
-
2017
- 2017-06-05 US US15/614,532 patent/US10442850B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9670267B2 (en) | 2017-06-06 |
| WO2011041770A1 (en) | 2011-04-07 |
| PT2482841T (pt) | 2019-03-01 |
| EP2482841A1 (en) | 2012-08-08 |
| ES2717902T5 (es) | 2022-11-29 |
| EP2482841B2 (en) | 2022-09-28 |
| CA2776503C (en) | 2020-07-28 |
| US20170369554A1 (en) | 2017-12-28 |
| US8816054B2 (en) | 2014-08-26 |
| US20150056271A1 (en) | 2015-02-26 |
| AU2010300292B2 (en) | 2016-11-10 |
| ES2717902T3 (es) | 2019-06-26 |
| CA2776503A1 (en) | 2011-04-07 |
| DK2482841T3 (da) | 2019-03-18 |
| US20120308641A1 (en) | 2012-12-06 |
| EP2482841B1 (en) | 2018-11-21 |
| EP2482841A4 (en) | 2013-07-03 |
| AU2010300292A1 (en) | 2012-05-03 |
| US10442850B2 (en) | 2019-10-15 |
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