DK2385992T3 - Berigelse og identificering af føtale celler i maternelt blod og ligand til en sådan anvendelse - Google Patents
Berigelse og identificering af føtale celler i maternelt blod og ligand til en sådan anvendelse Download PDFInfo
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- DK2385992T3 DK2385992T3 DK10701193T DK10701193T DK2385992T3 DK 2385992 T3 DK2385992 T3 DK 2385992T3 DK 10701193 T DK10701193 T DK 10701193T DK 10701193 T DK10701193 T DK 10701193T DK 2385992 T3 DK2385992 T3 DK 2385992T3
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (6)
1. Fremgangsmåde til detektion af en føtal celle, omfattende følgende trin a. der tilvejebringes en maternel blodprøve eller en fraktion deraf b. cellerne fikseres c. prøven bringes i kontakt med i. en hybridiseringsprobe, der er rettet mod en nukleinsyre, som omfatter mindst 10 bp af et gen, som udtrykkes differentielt i føtale celler fra en maternel blodprøve, hvor genet er TMEFF2, eller ii. en ligand, der er rettet mod et antigen, som kodes af et gen, som udtrykkes differentielt i føtale celler fra en maternel blodprøve, hvor genet er TMEFF2.
2. Fremgangsmåde ifølge krav 1, som desuden omfatter et trin, hvor der identificeres føtale celler i prøven, eller et trin, hvor føtale celler i prøven beriges.
3. Fremgangsmåde ifølge et hvilket som helst af kravene 1 og 2, hvor identificering omfatter detektion af tilstedeværelsen af liganden eller hybridiseringsproben på eller i de føtale celler.
4.
Fremgangsmåde
ifølge krav 2, hvor berigelse omfatter, at den materneile blodprøve bringes i kontakt med en ligand, der er rettet mod et celleoverfladeeksponeret antigen, som kodes af et gen, der er valgt fra gruppen bestående af tomoregulin, EDN1, AH NAK, CD 105, SYT 9, KMO, HMGA1, Mouse T, ACVR2B, CD141, CD135, CD142/F3, CD146, CD33, CD68, CD144, CD62E, GAP/GJA5, ITGA5, KCNK3/TASK-1, CNTFR, JAM-1, SDC4/Syndecan 4, ACVR2B, ACVR2A, CD44v6+CD44v4/5, STX1A, TEK/Tie2, CD171, NCAM/CD56, ALPP, ALPPL2 og MMP23A/MMP23B.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900020 | 2009-01-07 | ||
| DKPA200901084 | 2009-10-04 | ||
| PCT/DK2010/050002 WO2010078872A2 (en) | 2009-01-07 | 2010-01-07 | Enrichment and identification of fetal cells in maternal blood and ligands for such use |
Publications (1)
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| DK2385992T3 true DK2385992T3 (da) | 2015-04-07 |
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| DK10701193T DK2385992T3 (da) | 2009-01-07 | 2010-01-07 | Berigelse og identificering af føtale celler i maternelt blod og ligand til en sådan anvendelse |
| DK14199993.8T DK2857527T3 (da) | 2009-01-07 | 2010-01-07 | Berigelse og identificering af føtale celler i maternelt blod og ligander til en sådan anvendelse |
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| DK14199993.8T DK2857527T3 (da) | 2009-01-07 | 2010-01-07 | Berigelse og identificering af føtale celler i maternelt blod og ligander til en sådan anvendelse |
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| EP (4) | EP2385992B1 (da) |
| DK (2) | DK2385992T3 (da) |
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| HR (2) | HRP20150274T1 (da) |
| PL (2) | PL2385992T3 (da) |
| PT (2) | PT2385992E (da) |
| WO (1) | WO2010078872A2 (da) |
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| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| HRP20171468T1 (hr) * | 2010-11-09 | 2017-12-15 | Arcedi Biotech Aps | Obogaćivanje i identificiranje fetalnih stanica u majčinskoj krvi, te ligandi namijenjenu u tu svrhu |
| WO2014067528A1 (en) * | 2012-10-29 | 2014-05-08 | Arcedi Biotech Aps | Improved enrichment and detection of rare blood cells |
| US20150082145A1 (en) * | 2013-09-17 | 2015-03-19 | Amazon Technologies, Inc. | Approaches for three-dimensional object display |
| US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
| US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
| CA3044033A1 (en) | 2016-11-15 | 2018-05-24 | Quest Diagnostics Investments Llc | Methods for detecting cystic fibrosis mutations using mitra tip extraction |
| CN108088997B (zh) * | 2016-11-21 | 2020-03-17 | 同济大学 | 利用细胞表面分子标志物鉴定人类原态多能性的方法 |
| WO2018191194A1 (en) * | 2017-04-14 | 2018-10-18 | Rarecyte, Inc. | Enrichment and identification of fetal material |
| IL308999B2 (en) | 2019-06-07 | 2026-02-01 | Arcedi Biotech Aps | Isolation of fetal cells using FACS |
| EP4284911A4 (en) | 2021-01-27 | 2025-01-08 | BioFluidica, Inc. | High efficiency capture of fetal cells from maternal samples |
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| US5641628A (en) | 1989-11-13 | 1997-06-24 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
| GB0009179D0 (en) * | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Non-invasive prenatal diagnosis |
| KR101104655B1 (ko) * | 2002-03-08 | 2012-01-13 | 애보트 바이오테라퓨틱스 코포레이션 | 암 항원 ｔｍｅｆｆ２ 에 대한 항체 및 이의 용도 |
| US20050181429A1 (en) * | 2003-04-03 | 2005-08-18 | Monaliza Medical Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| US20040197832A1 (en) * | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| CA2601735C (en) * | 2005-03-18 | 2015-10-06 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring of trisomy 21 |
| CA2651367A1 (en) * | 2005-05-11 | 2006-11-16 | Genetic Technologies Limited | Methods of enriching fetal cells |
| DE602006017878D1 (de) * | 2005-12-08 | 2010-12-09 | Fcmb Aps | Nachweis fötaler zellen aus mütterlichem blut |
| GB0616045D0 (en) * | 2006-08-11 | 2006-09-20 | Univ Bristol | Blood cell separation |
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- 2010-01-07 PT PT14199993T patent/PT2857527T/pt unknown
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2019
- 2019-01-11 HR HRP20190076TT patent/HRP20190076T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2385992B1 (en) | 2014-12-31 |
| PL2857527T3 (pl) | 2019-05-31 |
| HRP20190076T1 (hr) | 2019-03-08 |
| PL2385992T3 (pl) | 2015-06-30 |
| US20120003643A1 (en) | 2012-01-05 |
| HRP20150274T1 (hr) | 2015-05-08 |
| PT2857527T (pt) | 2019-02-19 |
| EP3470534C0 (en) | 2024-03-20 |
| WO2010078872A3 (en) | 2010-09-16 |
| EP3470534A1 (en) | 2019-04-17 |
| HK1208883A1 (en) | 2016-03-18 |
| EP2634268A2 (en) | 2013-09-04 |
| WO2010078872A2 (en) | 2010-07-15 |
| EP2857527B1 (en) | 2018-11-14 |
| EP2857527A2 (en) | 2015-04-08 |
| PT2385992E (pt) | 2015-04-16 |
| ES2708558T3 (es) | 2019-04-10 |
| ES2985983T3 (es) | 2024-11-08 |
| EP2385992A2 (en) | 2011-11-16 |
| ES2533861T3 (es) | 2015-04-15 |
| EP2634268A3 (en) | 2013-12-25 |
| EP2857527A3 (en) | 2015-07-29 |
| DK2857527T3 (da) | 2019-02-25 |
| EP3470534B1 (en) | 2024-03-20 |
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