DK238585A - PEPTIDES AND PREPARATION THEREOF - Google Patents

PEPTIDES AND PREPARATION THEREOF Download PDF

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Publication number
DK238585A
DK238585A DK238585A DK238585A DK238585A DK 238585 A DK238585 A DK 238585A DK 238585 A DK238585 A DK 238585A DK 238585 A DK238585 A DK 238585A DK 238585 A DK238585 A DK 238585A
Authority
DK
Denmark
Prior art keywords
chain
terminal end
human insulin
bridging
insulin
Prior art date
Application number
DK238585A
Other languages
Danish (da)
Other versions
DK157938B (en
DK157938C (en
DK238585D0 (en
Inventor
Jan Markussen
Niels Fiil
Gustav Ammerer
Mogens Trier Hansen
Lars Thim
Kjeld Norris
Hans Ole Voigt
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK266584A external-priority patent/DK266584D0/en
Priority claimed from DK58285A external-priority patent/DK58285D0/en
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK238585A priority Critical patent/DK157938C/en
Publication of DK238585D0 publication Critical patent/DK238585D0/en
Publication of DK238585A publication Critical patent/DK238585A/en
Publication of DK157938B publication Critical patent/DK157938B/en
Application granted granted Critical
Publication of DK157938C publication Critical patent/DK157938C/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Human insulin precursors containing the peptide chain B(1- 29)-A(1-21) of human insulin and derivatives thereof having a bridging chain which links the C-terminal end of the B(1-29) chain to the N-terminal end of the A(1-21) chain are prepared by culturing a yeast strain which has been transformed with a replicatable expression medium which is able to express a DNA sequence which encodes the insulin precursor. The bridging chain is preferably relatively short and preferably contains from 2 to 8 acid residues. The bridging chain must not contain two adjacent basic amino acid residues (Lys or Arg) and has a Lys or Arg connected to the N-terminal end of the A(1-21) chain. Human insulin is prepared from the insulin precursors by means of in vitro conversion.
DK238585A 1984-05-30 1985-05-29 DNA SEQUENCE FOR INSULIN PRECURSORS, VECTORS CONTAINING THIS SEQUENCE, YEAR TRANSFORMED WITH THESE VECTORS, AND A PROCEDURE FOR PREPARING INSULIN PRECURSORS AND A PROCEDURE FOR PREPARING THEM. DK157938C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK238585A DK157938C (en) 1984-05-30 1985-05-29 DNA SEQUENCE FOR INSULIN PRECURSORS, VECTORS CONTAINING THIS SEQUENCE, YEAR TRANSFORMED WITH THESE VECTORS, AND A PROCEDURE FOR PREPARING INSULIN PRECURSORS AND A PROCEDURE FOR PREPARING THEM.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK266584A DK266584D0 (en) 1984-05-30 1984-05-30 DNA SEQUENCE CODING A BIOSYNTHETIC INSULIN PRECURSOR AND PROCEDURE FOR MANUFACTURING THE INSULIN PRECURSOR
DK266584 1984-05-30
DK58285 1985-02-08
DK58285A DK58285D0 (en) 1984-05-30 1985-02-08 PEPTIDES AND MANUFACTURING AND USING THEREOF
DK238585A DK157938C (en) 1984-05-30 1985-05-29 DNA SEQUENCE FOR INSULIN PRECURSORS, VECTORS CONTAINING THIS SEQUENCE, YEAR TRANSFORMED WITH THESE VECTORS, AND A PROCEDURE FOR PREPARING INSULIN PRECURSORS AND A PROCEDURE FOR PREPARING THEM.
DK238585 1985-05-29

Publications (4)

Publication Number Publication Date
DK238585D0 DK238585D0 (en) 1985-05-29
DK238585A true DK238585A (en) 1985-12-01
DK157938B DK157938B (en) 1990-03-05
DK157938C DK157938C (en) 1990-08-27

Family

ID=27220795

Family Applications (1)

Application Number Title Priority Date Filing Date
DK238585A DK157938C (en) 1984-05-30 1985-05-29 DNA SEQUENCE FOR INSULIN PRECURSORS, VECTORS CONTAINING THIS SEQUENCE, YEAR TRANSFORMED WITH THESE VECTORS, AND A PROCEDURE FOR PREPARING INSULIN PRECURSORS AND A PROCEDURE FOR PREPARING THEM.

Country Status (1)

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DK (1) DK157938C (en)

Also Published As

Publication number Publication date
DK157938B (en) 1990-03-05
DK157938C (en) 1990-08-27
DK238585D0 (en) 1985-05-29

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