DK2329265T3 - Fremgangsmåder til screening, hvor der anvendes insekter med blodhjernebarriere - Google Patents

Fremgangsmåder til screening, hvor der anvendes insekter med blodhjernebarriere

Info

Publication number
DK2329265T3
DK2329265T3 DK09783096.2T DK09783096T DK2329265T3 DK 2329265 T3 DK2329265 T3 DK 2329265T3 DK 09783096 T DK09783096 T DK 09783096T DK 2329265 T3 DK2329265 T3 DK 2329265T3
Authority
DK
Denmark
Prior art keywords
insects
screening
blood
methods
brain barrier
Prior art date
Application number
DK09783096.2T
Other languages
English (en)
Inventor
Nielsen Peter Aadal
Gunnar Andersson
Original Assignee
Entomopharm Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entomopharm Aps filed Critical Entomopharm Aps
Application granted granted Critical
Publication of DK2329265T3 publication Critical patent/DK2329265T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK09783096.2T 2008-09-22 2009-09-16 Fremgangsmåder til screening, hvor der anvendes insekter med blodhjernebarriere DK2329265T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9880308P 2008-09-22 2008-09-22
PCT/EP2009/062023 WO2010031794A1 (en) 2008-09-22 2009-09-16 Screening methods employing insects with blood brain barrier

Publications (1)

Publication Number Publication Date
DK2329265T3 true DK2329265T3 (da) 2013-12-02

Family

ID=41328663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09783096.2T DK2329265T3 (da) 2008-09-22 2009-09-16 Fremgangsmåder til screening, hvor der anvendes insekter med blodhjernebarriere

Country Status (10)

Country Link
US (1) US9194864B2 (da)
EP (1) EP2329265B1 (da)
JP (1) JP5411937B2 (da)
CN (1) CN102159945B (da)
CA (1) CA2736844C (da)
DK (1) DK2329265T3 (da)
ES (1) ES2436731T3 (da)
PL (1) PL2329265T3 (da)
RU (1) RU2503004C2 (da)
WO (1) WO2010031794A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9194864B2 (en) 2008-09-22 2015-11-24 Entomopharm Aps Screening methods employing insects with blood brain barrier
US9097706B2 (en) 2009-08-12 2015-08-04 Entomopharm Aps Insect-based ex vivo model for testing blood-brain barrier penetration and method for exposing insect brain to chemical compounds
DK201000969A (en) * 2010-10-25 2012-04-26 Entomopharm Aps Insect-based ex vivo model for testing blood-brainbarrier penetration and method for exposinginsect brain to nanoparticles
DK177327B1 (da) * 2011-12-23 2013-01-14 Entomopharm Aps Optimeret insektbaseret ex vivo model til undersøgelse af blodhjernebarriere gennemtrængning og fremgangsmåde til eksponering af insekthjernen for kemiske forbindelser
DK177379B1 (da) * 2012-03-29 2013-02-25 Entomopharm Aps Insect-baseret model til undersøgelse af nanopartiklers virkning på blod-hjerne barrierens funktion og integritet
WO2016186559A1 (en) * 2015-05-18 2016-11-24 Quixolabs Ab Method for investigating blood-brain barrier properties and brain metabolism using insect brains
CN106353433B (zh) * 2016-10-13 2018-09-14 昆明赛诺制药股份有限公司 一种治疗乙型肝炎美洲大蠊提取物的检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007110C1 (ru) * 1990-04-16 1994-02-15 Гофман Виктор Робертович Способ определения проницаемости гематоэнцефалического барьера для нейротропных веществ
JP2958447B2 (ja) * 1997-03-11 1999-10-06 東京農工大学長 生体組織等の活動状態のイメージング法及びその利用法
US6057092A (en) * 1998-08-31 2000-05-02 Trellis Bioinformatics, Inc. Cellular transport detection method
AU2003225763A1 (en) 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
WO2004006854A2 (en) 2002-07-15 2004-01-22 Baylor College Of Medicine Method for identification of biologically active agents
US20050108779A1 (en) * 2003-10-21 2005-05-19 Envivo Pharmaceuticals, Inc. Transgenic flies expressing Abeta42-Italian
GB0403490D0 (en) * 2004-02-17 2004-03-24 Daniolabs Ltd Screening methods
US7332159B2 (en) 2004-09-30 2008-02-19 Board Of Regents Of The University Of Nebraska Method and composition for inhibiting reperfusion injury in the brain
JP4898126B2 (ja) * 2005-02-28 2012-03-14 中外製薬株式会社 Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物
CA2653456A1 (en) * 2006-05-24 2007-11-29 Richard Daneman Permeability of blood-brain barrier
US9194864B2 (en) 2008-09-22 2015-11-24 Entomopharm Aps Screening methods employing insects with blood brain barrier
US9097706B2 (en) 2009-08-12 2015-08-04 Entomopharm Aps Insect-based ex vivo model for testing blood-brain barrier penetration and method for exposing insect brain to chemical compounds

Also Published As

Publication number Publication date
CN102159945B (zh) 2015-01-07
RU2011112053A (ru) 2012-10-27
CA2736844C (en) 2014-06-17
US20110171682A1 (en) 2011-07-14
PL2329265T3 (pl) 2014-02-28
JP2012502293A (ja) 2012-01-26
JP5411937B2 (ja) 2014-02-12
RU2503004C2 (ru) 2013-12-27
EP2329265A1 (en) 2011-06-08
US9194864B2 (en) 2015-11-24
CA2736844A1 (en) 2010-03-25
ES2436731T3 (es) 2014-01-03
EP2329265B1 (en) 2013-09-11
CN102159945A (zh) 2011-08-17
WO2010031794A1 (en) 2010-03-25

Similar Documents

Publication Publication Date Title
BRPI0906962A2 (pt) Composto, e, composição farmacêutica
BRPI0906556A2 (pt) Composto, e, composição farmacêutica
DK2186966T3 (da) Facadekonstruktion
DK2340021T3 (da) Substituerede pyrrolidin-2-carboxamider
DK2260042T3 (da) Substituerede spirocykliske cyklohexan-derivater
DK2344471T3 (da) 7-piperidinalkyl-3,4-dihydroquinolon-derivat
BRPI0917681A2 (pt) Composto, e, composição farmacêutica
BRPI0921289A2 (pt) Combinações pesticidas
BRPI0911625A2 (pt) Métodos
BRPI0915562A2 (pt) tamis melhorado
DK2329265T3 (da) Fremgangsmåder til screening, hvor der anvendes insekter med blodhjernebarriere
BRPI0907825A2 (pt) Combinações pesticidas
BRPI0915442A2 (pt) tamis melhorado
BRPI0912118A2 (pt) composto, composição farmacêutica, e, intermediário sintético
BRPI0914182A2 (pt) composto, e, composição farmacêutica
BRPI0916990A2 (pt) Combinações inseticidas
DK2265778T3 (da) Muranker
DE112009001669A5 (de) Sektionaltor
FI20085902A0 (fi) Porrasrakenne
BRPI0922008A2 (pt) compostos e respectivos metodos de preparação
FI20080435A (fi) Pylväsrakenne
FI8611U1 (fi) Hirsirakenne
FI20085132A0 (fi) Hirsirakenne
FIU20070210U0 (fi) Karmikiinnike
FI20085607L (fi) Ovirakenne