DK230890A - DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM - Google Patents

DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM Download PDF

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Publication number
DK230890A
DK230890A DK230890A DK230890A DK230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A
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DK
Denmark
Prior art keywords
toxin
analogue
dna
pasteurella
codes
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Application number
DK230890A
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Danish (da)
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DK169749B1 (en
DK230890D0 (en
Inventor
Niels Taekker Foged
Svend Petersen
Original Assignee
Nordisk Droge & Kemikalie
Statens Veterinaere Serumlabor
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Priority claimed from DK199588A external-priority patent/DK199588D0/en
Application filed by Nordisk Droge & Kemikalie, Statens Veterinaere Serumlabor filed Critical Nordisk Droge & Kemikalie
Priority to DK230890A priority Critical patent/DK169749B1/en
Publication of DK230890A publication Critical patent/DK230890A/en
Publication of DK230890D0 publication Critical patent/DK230890D0/en
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Publication of DK169749B1 publication Critical patent/DK169749B1/en

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  • Peptides Or Proteins (AREA)

Abstract

A vaccine for immunising an animal against diseases caused by micro-organisms which produce an osteolytic toxin, with the vaccine comprising an immunologically effective quantity of a recombinant, immunogenic, detoxified Pasteurella multocida toxin or a recombinant, immunogenic, detoxified Pasteurella multocida toxin analogue, which vaccine is characterised in that it is encoded by a nucleotide sequence which encodes a Pasteurella multocida toxin or a Pasteurella multocida toxin analogue and which is inserted in an expression vector which is able to replicate in a suitable host microorganism in which the sequence can be expressed. The toxin which is produced, or the toxin analogue which is produced, is subject, where appropriate, to post-transcriptional modifications in order to obtain the detoxified toxin or the detoxified toxin analogue. Alternatively, the nucleotide sequence is modified before being inserted into the expression vector in order to obtain a toxin or the toxin analogue in a detoxified form. The use of a monoclonal antibody against Pasteurella multocida toxin or toxin analogue, a labelled DNA sequence which is homologous with a DNA sequence which encodes a toxin or a toxin analogue, and the toxin or the toxin analogue as such as diagnostic agents, are also described.
DK230890A 1988-04-12 1990-09-24 A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine DK169749B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK230890A DK169749B1 (en) 1988-04-12 1990-09-24 A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK199588A DK199588D0 (en) 1988-04-12 1988-04-12 VACCINE
DK199588 1988-04-12
DK8900084 1989-04-11
PCT/DK1989/000084 WO1989009617A1 (en) 1988-04-12 1989-04-11 A pasteurella vaccine
DK230890 1990-09-24
DK230890A DK169749B1 (en) 1988-04-12 1990-09-24 A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine

Publications (3)

Publication Number Publication Date
DK230890A true DK230890A (en) 1990-09-24
DK230890D0 DK230890D0 (en) 1990-09-24
DK169749B1 DK169749B1 (en) 1995-02-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK230890A DK169749B1 (en) 1988-04-12 1990-09-24 A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine

Country Status (1)

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DK (1) DK169749B1 (en)

Also Published As

Publication number Publication date
DK169749B1 (en) 1995-02-13
DK230890D0 (en) 1990-09-24

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DK230890A (en) DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM

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B1 Patent granted (law 1993)
PUP Patent expired