DK230890A - DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM - Google Patents
DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM Download PDFInfo
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- DK230890A DK230890A DK230890A DK230890A DK230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A DK 230890 A DK230890 A DK 230890A
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- DK
- Denmark
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- toxin
- analogue
- dna
- pasteurella
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
A vaccine for immunising an animal against diseases caused by micro-organisms which produce an osteolytic toxin, with the vaccine comprising an immunologically effective quantity of a recombinant, immunogenic, detoxified Pasteurella multocida toxin or a recombinant, immunogenic, detoxified Pasteurella multocida toxin analogue, which vaccine is characterised in that it is encoded by a nucleotide sequence which encodes a Pasteurella multocida toxin or a Pasteurella multocida toxin analogue and which is inserted in an expression vector which is able to replicate in a suitable host microorganism in which the sequence can be expressed. The toxin which is produced, or the toxin analogue which is produced, is subject, where appropriate, to post-transcriptional modifications in order to obtain the detoxified toxin or the detoxified toxin analogue. Alternatively, the nucleotide sequence is modified before being inserted into the expression vector in order to obtain a toxin or the toxin analogue in a detoxified form. The use of a monoclonal antibody against Pasteurella multocida toxin or toxin analogue, a labelled DNA sequence which is homologous with a DNA sequence which encodes a toxin or a toxin analogue, and the toxin or the toxin analogue as such as diagnostic agents, are also described.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK230890A DK169749B1 (en) | 1988-04-12 | 1990-09-24 | A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK199588A DK199588D0 (en) | 1988-04-12 | 1988-04-12 | VACCINE |
DK199588 | 1988-04-12 | ||
DK8900084 | 1989-04-11 | ||
PCT/DK1989/000084 WO1989009617A1 (en) | 1988-04-12 | 1989-04-11 | A pasteurella vaccine |
DK230890 | 1990-09-24 | ||
DK230890A DK169749B1 (en) | 1988-04-12 | 1990-09-24 | A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine |
Publications (3)
Publication Number | Publication Date |
---|---|
DK230890A true DK230890A (en) | 1990-09-24 |
DK230890D0 DK230890D0 (en) | 1990-09-24 |
DK169749B1 DK169749B1 (en) | 1995-02-13 |
Family
ID=26066268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK230890A DK169749B1 (en) | 1988-04-12 | 1990-09-24 | A DNA fragment which encodes a Pasteurella multocida toxin, or an immunogenic subsequence or analogue thereof, an expression vector which comprises the DNA fragment, a process for preparing a Pasteurella multocida toxin, and the use of a Pasteurella multocida toxin sequence or toxin sequence analogue for producing a vaccine |
Country Status (1)
Country | Link |
---|---|
DK (1) | DK169749B1 (en) |
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1990
- 1990-09-24 DK DK230890A patent/DK169749B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK169749B1 (en) | 1995-02-13 |
DK230890D0 (en) | 1990-09-24 |
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DK230890A (en) | DNA DNA DNA DNA CODES, CODES FOR A PASTURELY MULTOCIDE-TOXIN, OR ANALOGUAL OR ANALOGY, , VACCINE CONTAINING A PASTEURELLA-MULTOCIDA TOXIN DERIVATIVE, USING PASTEURELLA MULTOCIDA-T MM |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |