DK229985A - LYMPHOKIN AND ITS MANUFACTURING AND USE - Google Patents

LYMPHOKIN AND ITS MANUFACTURING AND USE Download PDF

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Publication number
DK229985A
DK229985A DK229985A DK229985A DK229985A DK 229985 A DK229985 A DK 229985A DK 229985 A DK229985 A DK 229985A DK 229985 A DK229985 A DK 229985A DK 229985 A DK229985 A DK 229985A
Authority
DK
Denmark
Prior art keywords
human mif
monoclonal antibodies
derivatives
mif
human
Prior art date
Application number
DK229985A
Other languages
Danish (da)
Other versions
DK229985D0 (en
DK171646B1 (en
Inventor
Clemens Prof Sorg
Gerd Burmeister
Lajos Tarcsay
Walter Wiesendanger
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK229985D0 publication Critical patent/DK229985D0/en
Publication of DK229985A publication Critical patent/DK229985A/en
Application granted granted Critical
Publication of DK171646B1 publication Critical patent/DK171646B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The invention relates to purified human macrophage migration inhibitory factor (human MIF) and its individual proteins, to a process for the purification of human MIF and for the isolation of its individual proteins, to monoclonal antibodies against human MIF, derivatives thereof, processes for the preparation of these antibodies and derivatives thereof, hybridoma cell lines which produce these antibodies, processes for the preparation of said hybridoma cell lines, and to the use of the monoclonal antibodies and derivatives thereof for the qualitative and quantitative determination of human MIF in biological fluids and on cell surfaces, and to the use of the monoclonal antibodies for the purification of human MIF. Human MIF and monoclonal antibodies against human MIF are important for the diagnosis and therapy of immunoregulatory disorders and chronic inflammatory disorders.
DK229985A 1984-05-24 1985-05-23 Purified Human Macrophage Migration Inhibition Factor (Human MIF) and Its Single Proteins, Methods of Preparation thereof, Monoclonal Antibodies to Human MIF and Method of Preparation, Hybridoma Cell Lines Producing Monoclonal Antibodies to Human MIF, Their Use and Procedure for their Preparation pharmaceutical preparations containing purified human MIF or DK171646B1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH255784 1984-05-24
CH255784 1984-05-24
CH378684 1984-08-07
CH378684 1984-08-07
CH544684 1984-11-14
CH544684 1984-11-14
CH51285 1985-02-05
CH51285 1985-02-05

Publications (3)

Publication Number Publication Date
DK229985D0 DK229985D0 (en) 1985-05-23
DK229985A true DK229985A (en) 1985-11-25
DK171646B1 DK171646B1 (en) 1997-03-03

Family

ID=27427909

Family Applications (1)

Application Number Title Priority Date Filing Date
DK229985A DK171646B1 (en) 1984-05-24 1985-05-23 Purified Human Macrophage Migration Inhibition Factor (Human MIF) and Its Single Proteins, Methods of Preparation thereof, Monoclonal Antibodies to Human MIF and Method of Preparation, Hybridoma Cell Lines Producing Monoclonal Antibodies to Human MIF, Their Use and Procedure for their Preparation pharmaceutical preparations containing purified human MIF or

Country Status (8)

Country Link
EP (1) EP0162812B1 (en)
JP (3) JPH0672158B2 (en)
AT (1) ATE93869T1 (en)
DE (1) DE3587553D1 (en)
DK (1) DK171646B1 (en)
ES (3) ES8702950A1 (en)
IE (1) IE60450B1 (en)
IL (1) IL75280A0 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3789413T2 (en) * 1986-10-03 1994-07-28 Ciba Geigy Ag Lymphokine-like peptides.
GB8623850D0 (en) * 1986-10-03 1986-11-05 Ciba Geigy Ag Lymphokine related peptide
WO1990011301A1 (en) * 1989-03-17 1990-10-04 Genetics Institute, Inc. Human macrophage migration inhibitory factor
GB8915414D0 (en) * 1989-07-05 1989-08-23 Ciba Geigy Novel cytokines
US5107906A (en) * 1989-10-02 1992-04-28 Swenson Paul F System for fast-filling compressed natural gas powered vehicles
US5149544A (en) * 1989-11-13 1992-09-22 Research Corporation Technologies, Inc. Method of inhibiting progenitor cell proliferation
US6030615A (en) * 1993-05-17 2000-02-29 The Picower Institute For Medical Research Combination method for treating diseases caused by cytokine-mediated toxicity
CA2163211C (en) * 1993-05-17 2012-05-08 Richard J. Bucala Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity
US20030235584A1 (en) 2000-02-28 2003-12-25 Kloetzer William S. Method for preparing anti-MIF antibodies
DE10121255A1 (en) 2001-04-30 2002-11-07 Switch Biotech Ag Use of alpha 1-antichymotrypsin polypeptide or nucleic acids encoding the polypeptide, or of a cell expressing the polypeptide, or of antibody against the polypeptide, for diagnosing, treating or preventing poorly-healing wounds
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
CA2600175A1 (en) 2005-03-24 2006-03-20 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
CN100457895C (en) * 2006-05-24 2009-02-04 中国科学院生物物理研究所 Rat antihuman macrephage migration inhibiting factor monoclone antibody and its application
EP2748613B1 (en) * 2011-10-07 2021-05-05 Baxalta GmbH Oxmif as a diagnostic marker

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2755363C3 (en) * 1977-12-12 1983-12-01 R & Z Biologicals Beteiligungsgesellschaft mbH, 4050 Mönchengladbach Test method for diagnosing malignancies
US4299814A (en) * 1979-05-25 1981-11-10 Monsanto Company Radioimmunoassay of MIF
JPS5939832A (en) * 1982-08-28 1984-03-05 Ajinomoto Co Inc Monoclonal antibody and preparation and use thereof
DD230876A1 (en) * 1983-05-09 1985-12-11 Akad Wissenschaften Ddr PROCESS FOR OBTAINING MONOCLONAL ANTIBODY AGAINST HUMAN MIF

Also Published As

Publication number Publication date
ES543391A0 (en) 1987-01-16
JPH0780915B2 (en) 1995-08-30
DE3587553D1 (en) 1993-10-07
EP0162812A3 (en) 1988-04-20
DK229985D0 (en) 1985-05-23
JPH0770192A (en) 1995-03-14
ES8702950A1 (en) 1987-01-16
JPH06217789A (en) 1994-08-09
JPS60248617A (en) 1985-12-09
ES557072A0 (en) 1987-08-01
IE60450B1 (en) 1994-07-13
ES8801850A1 (en) 1987-08-01
JPH0672158B2 (en) 1994-09-14
ES8801852A1 (en) 1988-02-16
DK171646B1 (en) 1997-03-03
EP0162812A2 (en) 1985-11-27
ATE93869T1 (en) 1993-09-15
ES557071A0 (en) 1988-02-16
IL75280A0 (en) 1985-09-29
JPH07108915B2 (en) 1995-11-22
IE851295L (en) 1985-11-24
EP0162812B1 (en) 1993-09-01

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Legal Events

Date Code Title Description
ATS Application withdrawn
ATS Application withdrawn
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed