DK2223115T3 - Seprase as a marker for cancer - Google Patents

Seprase as a marker for cancer

Info

Publication number
DK2223115T3
DK2223115T3 DK08859952.7T DK08859952T DK2223115T3 DK 2223115 T3 DK2223115 T3 DK 2223115T3 DK 08859952 T DK08859952 T DK 08859952T DK 2223115 T3 DK2223115 T3 DK 2223115T3
Authority
DK
Denmark
Prior art keywords
cancer
seprase
types
assessment
specific
Prior art date
Application number
DK08859952.7T
Other languages
Danish (da)
Inventor
Wolfgang Rollinger
Johann Karl
Markus Roessler
Michael Tacke
Jarema Peter Kochan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07023897A external-priority patent/EP2071337A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2223115T3 publication Critical patent/DK2223115T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96411—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
DK08859952.7T 2007-12-10 2008-12-08 Seprase as a marker for cancer DK2223115T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07023897A EP2071337A1 (en) 2007-12-10 2007-12-10 Seprase as a marker for cancer
EP08015310 2008-08-29
PCT/EP2008/010385 WO2009074275A1 (en) 2007-12-10 2008-12-08 Seprase as a marker for cancer

Publications (1)

Publication Number Publication Date
DK2223115T3 true DK2223115T3 (en) 2011-12-12

Family

ID=40373548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08859952.7T DK2223115T3 (en) 2007-12-10 2008-12-08 Seprase as a marker for cancer

Country Status (15)

Country Link
US (1) US8980573B2 (en)
EP (1) EP2223115B1 (en)
JP (1) JP5563988B2 (en)
KR (1) KR101202220B1 (en)
CN (1) CN101896818B (en)
AT (1) ATE524740T1 (en)
AU (1) AU2008335855B2 (en)
BR (1) BRPI0820793A2 (en)
CA (1) CA2706115A1 (en)
DK (1) DK2223115T3 (en)
ES (1) ES2372442T3 (en)
HK (1) HK1150884A1 (en)
MX (1) MX2010004671A (en)
PL (1) PL2223115T3 (en)
WO (1) WO2009074275A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8213005B2 (en) 2003-07-22 2012-07-03 King Saud University Method for discriminating between benign and malignant prostate tumors
CN102138074B (en) * 2008-07-03 2014-08-13 霍夫曼-拉罗奇有限公司 ASC as a marker for lung cancer
ES2592386T3 (en) 2009-12-20 2016-11-29 Astute Medical, Inc. Methods and compositions for the diagnosis and prognosis of renal injury and renal insufficiency
PT2666872T (en) 2010-02-05 2016-07-08 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2815356A1 (en) * 2010-10-20 2012-04-26 Rush University Medical Center Lung cancer tests
WO2012123299A1 (en) * 2011-03-11 2012-09-20 Roche Diagnostics Gmbh Asc as marker for chronic obstructive pulmonary disease (copd)
EP2684049A1 (en) * 2011-03-11 2014-01-15 Roche Diagniostics GmbH Seprase as marker for chronic obstructive pulmonary disease (copd)
CN102435748B (en) * 2011-11-25 2014-07-16 广东药学院 Double-antibody sandwich enzymelinked immunosorbent detection kit and preparation method thereof
ES2933570T3 (en) 2011-12-08 2023-02-10 Astute Medical Inc Methods and compositions for the diagnosis and prognosis of kidney injury and kidney failure
AU2013284448B2 (en) 2012-06-27 2019-04-18 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
WO2014072465A1 (en) 2012-11-09 2014-05-15 Roche Diagnostics Gmbh In vitro capture and analysis of circulating tumor cells
CN110596385A (en) * 2012-11-30 2019-12-20 迪森德克斯公司 Methods for assessing the presence or risk of a colon tumor
EP3734280B8 (en) 2013-01-17 2022-08-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9753037B2 (en) 2013-03-15 2017-09-05 Rush University Medical Center Biomarker panel for detecting lung cancer
CN103267852B (en) * 2013-05-15 2015-03-25 中国医学科学院北京协和医院 Application of fibroblast activation protein (FAP) alpha to preparation of pancreatic cancer prognosis kit
KR101619122B1 (en) 2013-08-14 2016-05-10 연세대학교 산학협력단 Screening method for enhancing the sensitization of colorectal cancer cell death by demethylation-induced ASC expression
US10365281B2 (en) 2013-12-09 2019-07-30 Rush University Medical Center Biomarkers of rapid progression in advanced non-small cell lung cancer
PL230661B1 (en) * 2014-01-29 2018-11-30 Centrum Onkologii Inst Im Marii Sklodowskiej Curie Oddzial W Gliwicach Profile of blood protein markers as the test for detecting lung cancer
EP2916134B1 (en) 2014-03-05 2017-08-16 Roche Diagnostics GmbH Use of Seprase for differential diagnosis of acute dyspnea
WO2016094425A1 (en) 2014-12-08 2016-06-16 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
WO2016146174A1 (en) * 2015-03-17 2016-09-22 Biontech Ag Compositions and methods for diagnosis and treatment of cancer
US9689874B2 (en) 2015-04-10 2017-06-27 Applied Proteomics, Inc. Protein biomarker panels for detecting colorectal cancer and advanced adenoma
JP2018035137A (en) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ Novel anti-fibroblast activated protein (FAP) binding agent and use thereof
WO2018020530A1 (en) * 2016-07-25 2018-02-01 静岡県 Diagnostic biomarker for extrahepatic bile duct cancer, intrahepatic bile duct cancer or gallbladder cancer
WO2018111989A1 (en) 2016-12-14 2018-06-21 Purdue Research Foundation Fibroblast activation protein (fap)-targeted imaging and therapy
DE102017010455A1 (en) * 2017-06-13 2018-12-13 Forschungszentrum Jülich GmbH Method for detecting aggregates of biotherapeutic substances in a sample
BR112020004391A2 (en) * 2017-09-05 2020-09-08 Oncotag Diagnostics Co., Ltd. pancreatic cancer diagnostic method, composition, kit, method to improve sensitivity and specificity in a pancreatic cancer cytodiagnosis or biopsy and use
WO2022007283A1 (en) * 2020-07-08 2022-01-13 深圳霁因生物医药转化研究院 Kit and method for diagnosing disease associated with abnormal fap expression, and computer readable storage medium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953639A1 (en) * 1998-04-30 1999-11-03 Boehringer Ingelheim International GmbH FAPalpha-specific antibody with improved producibility
AU2004286307A1 (en) * 2003-10-31 2005-05-12 Vitatex, Inc. Blood test prototypes and methods for the detection of circulating tumor and endothelial cells
WO2007001420A2 (en) * 2004-10-22 2007-01-04 Genencor International, Inc. Isolating human antibodies
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
JP5270369B2 (en) * 2005-12-19 2013-08-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ Soft protease inhibitor and its pro-soft type

Also Published As

Publication number Publication date
AU2008335855B2 (en) 2012-08-30
EP2223115B1 (en) 2011-09-14
AU2008335855A1 (en) 2009-06-18
ATE524740T1 (en) 2011-09-15
US20100240081A1 (en) 2010-09-23
KR20100091212A (en) 2010-08-18
ES2372442T3 (en) 2012-01-19
CA2706115A1 (en) 2009-06-18
CN101896818A (en) 2010-11-24
EP2223115A1 (en) 2010-09-01
CN101896818B (en) 2016-01-20
HK1150884A1 (en) 2012-01-13
JP2011506941A (en) 2011-03-03
KR101202220B1 (en) 2012-11-16
WO2009074275A1 (en) 2009-06-18
PL2223115T3 (en) 2012-02-29
US8980573B2 (en) 2015-03-17
JP5563988B2 (en) 2014-07-30
BRPI0820793A2 (en) 2015-06-16
MX2010004671A (en) 2010-05-27

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