WO2012071096A3 - Arid1a and ppp2r1a mutations in cancer - Google Patents
Arid1a and ppp2r1a mutations in cancer Download PDFInfo
- Publication number
- WO2012071096A3 WO2012071096A3 PCT/US2011/050487 US2011050487W WO2012071096A3 WO 2012071096 A3 WO2012071096 A3 WO 2012071096A3 US 2011050487 W US2011050487 W US 2011050487W WO 2012071096 A3 WO2012071096 A3 WO 2012071096A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- ppp2r1a
- arid1a
- diagnosis
- mutations
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
Two genes, ARID1A (AT-rich interactive domain-containing protein 1A) and PPP2R1A (protein-phosphatase 2, regulatory subunit 1, alpha), can be used in methods which are useful for detecting cancer, diagnosing cancer, contributing to a diagnosis of cancer, confirming a diagnosis of cancer, identifying appropriate treatments for cancer, monitoring treatment of cancer, and evaluating treatment protocols for cancer, including ovarian clear cell carcinoma, breast cancer, colon cancer, gastric cancer, lung cancer, medulloblastoma, pancreatic cancer, and prostate cancer.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/819,933 US9982304B2 (en) | 2010-09-03 | 2011-09-06 | ARID1A and PPP2R1A mutations in cancer |
US15/987,235 US20180327863A1 (en) | 2010-09-03 | 2018-05-23 | Arid1a and ppp2r1a mutations in cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37987510P | 2010-09-03 | 2010-09-03 | |
US61/379,875 | 2010-09-03 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/819,933 A-371-Of-International US9982304B2 (en) | 2010-09-03 | 2011-09-06 | ARID1A and PPP2R1A mutations in cancer |
US15/987,235 Division US20180327863A1 (en) | 2010-09-03 | 2018-05-23 | Arid1a and ppp2r1a mutations in cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012071096A2 WO2012071096A2 (en) | 2012-05-31 |
WO2012071096A3 true WO2012071096A3 (en) | 2012-08-16 |
Family
ID=46146345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/050487 WO2012071096A2 (en) | 2010-09-03 | 2011-09-06 | Arid1a and ppp2r1a mutations in cancer |
Country Status (2)
Country | Link |
---|---|
US (2) | US9982304B2 (en) |
WO (1) | WO2012071096A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6351182B2 (en) * | 2012-10-15 | 2018-07-04 | エピザイム,インコーポレイティド | How to treat cancer |
ES2674928T3 (en) * | 2012-11-05 | 2018-07-05 | Gmdx Co Pty Ltd | Methods to determine the cause of somatic mutagenesis |
US10815522B2 (en) | 2015-02-20 | 2020-10-27 | The Johns Hopkins University | Genomic alterations in the tumor and circulation of pancreatic cancer patients |
MX2018002344A (en) | 2015-08-24 | 2018-07-06 | Epizyme Inc | Method for treating cancer. |
CN108504637A (en) * | 2017-07-10 | 2018-09-07 | 复旦大学附属肿瘤医院 | Chinese's clear cell carcinoma of ovary cell line |
CN114555802A (en) * | 2019-07-31 | 2022-05-27 | 铂赛基因组学公司 | Single cell analysis |
WO2021173960A1 (en) * | 2020-02-28 | 2021-09-02 | The Wistar Institute Of Anatomy And Biology | Treatment of carm1-overexpressing and/or arid1a mutant cancers with ire-1/xbp-1 inhibitors |
US20230176059A1 (en) * | 2020-05-01 | 2023-06-08 | Mayo Foundation For Medical Education And Research | Methods and materials for treating endometrial cancer |
WO2022020359A1 (en) * | 2020-07-24 | 2022-01-27 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating high grade subtypes of uterine cancer |
WO2022056457A1 (en) * | 2020-09-14 | 2022-03-17 | The Johns Hopkins University | Methods and compositions for prognosing glioblastoma or breast cancer |
CN116019916A (en) * | 2021-10-27 | 2023-04-28 | 蚌埠医学院第一附属医院 | Application of non-small cell lung cancer target ARID1A and inhibitor thereof in preparation of lung cancer treatment drugs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
US5965377A (en) | 1997-03-24 | 1999-10-12 | Baystate Medical Center | Method for determining the presence of mutated BRCA protein |
DK2245199T3 (en) * | 2008-02-01 | 2014-02-03 | Gen Hospital Corp | APPLICATION OF MICROVESCIES IN DIAGNOSTICATION, PROGRAMMING AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS |
-
2011
- 2011-09-06 WO PCT/US2011/050487 patent/WO2012071096A2/en active Application Filing
- 2011-09-06 US US13/819,933 patent/US9982304B2/en active Active
-
2018
- 2018-05-23 US US15/987,235 patent/US20180327863A1/en not_active Abandoned
Non-Patent Citations (6)
Title |
---|
CALIN, G. A. ET AL.: "Low frequency of alterations of the a(PPP2R1A) and b(PPP2RIB) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms", ONCOGENE, vol. 19, 24 February 2000 (2000-02-24), pages 1191 - 1195 * |
HUNG, J. ET AL.: "Genomic and functional evidence for an ARID1A tumor suppressor role", GENES, CHROMOSOMES & CANCER, vol. 46, 10 May 2007 (2007-05-10), pages 745 - 750 * |
JONES, S. ET AL.: "Frequent mutations of chromatin remodeling gene ARIDIA in ovarian clear cell carcinoma", SCIENCE, vol. 330, no. 6001, 8 October 2010 (2010-10-08), pages 228 - 231 * |
MAEDA, D. ET AL.: "Clinicopathological significance of loss of ARID1A immunoreactivity in ovarian clear cell carcinoma", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, vol. 11, 13 December 2010 (2010-12-13), pages 5120 - 5128 * |
MCCONECHY, M. K. ET AL.: "Subtype-specific mutation of PPP2RIA in endometrial and ovarian carcinomas", JOURNAL OF PATHOLOGY, vol. 223, April 2011 (2011-04-01), pages 567 - 573 * |
WIEGAND, K. C. ET AL.: "ARIDIA mutations in endometriosis associated ovarian carcinomas", NEW ENGLAND JOURNAL OF MEDICINE, vol. 363, no. 16, 14 October 2010 (2010-10-14), pages 1532 - 1543 * |
Also Published As
Publication number | Publication date |
---|---|
US20180327863A1 (en) | 2018-11-15 |
US9982304B2 (en) | 2018-05-29 |
US20130210900A1 (en) | 2013-08-15 |
WO2012071096A2 (en) | 2012-05-31 |
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