DK2220049T3 - Fremgangsmåde til fremstilling af precursorer for L-3,4-dihydroxy-[18F]fluorphenylalanin og 2-[18F]fluor-L-tyrosin og alfa-methylerede derivater deraf og precursorerne - Google Patents
Fremgangsmåde til fremstilling af precursorer for L-3,4-dihydroxy-[18F]fluorphenylalanin og 2-[18F]fluor-L-tyrosin og alfa-methylerede derivater deraf og precursorerneInfo
- Publication number
- DK2220049T3 DK2220049T3 DK08857332.4T DK08857332T DK2220049T3 DK 2220049 T3 DK2220049 T3 DK 2220049T3 DK 08857332 T DK08857332 T DK 08857332T DK 2220049 T3 DK2220049 T3 DK 2220049T3
- Authority
- DK
- Denmark
- Prior art keywords
- tert
- butyl
- precursors
- methyl
- fluorophenylalanine
- Prior art date
Links
- 229960004441 tyrosine Drugs 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title 2
- JMDCRDOIPYCSCH-RPDRGXCHSA-N (2S)-3-(3,4-dihydroxyphenyl)-2-(fluoranylamino)propanoic acid Chemical compound [18F]N[C@H](C(=O)O)CC1=CC=C(O)C(O)=C1 JMDCRDOIPYCSCH-RPDRGXCHSA-N 0.000 title 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UGLRFIAZTBSXED-NBFOKTCDSA-N 1-[(2s)-2-tert-butyl-3,5-dimethyl-4-oxoimidazolidin-1-yl]-2-phenylethane-1,2-dione Chemical compound CC(C)(C)[C@H]1N(C)C(=O)C(C)N1C(=O)C(=O)C1=CC=CC=C1 UGLRFIAZTBSXED-NBFOKTCDSA-N 0.000 abstract 1
- LLDGSSJMFWHLBM-HNNXBMFYSA-N 1-[(2s)-2-tert-butyl-3-methyl-4-oxoimidazolidin-1-yl]-2-phenylethane-1,2-dione Chemical compound C1C(=O)N(C)[C@H](C(C)(C)C)N1C(=O)C(=O)C1=CC=CC=C1 LLDGSSJMFWHLBM-HNNXBMFYSA-N 0.000 abstract 1
- -1 L-3,4-dihydroxy-6-[18F]fluorophenylalanine compound Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- XRBCNJHOLYADDH-JTQLQIEISA-N tert-butyl (2s)-2-tert-butyl-5-methoxy-2,4-dihydroimidazole-3-carboxylate Chemical compound COC1=N[C@H](C(C)(C)C)N(C(=O)OC(C)(C)C)C1 XRBCNJHOLYADDH-JTQLQIEISA-N 0.000 abstract 1
- PVQFEORWMIYROR-KOLCDFICSA-N tert-butyl (2s,5r)-2-tert-butyl-3,5-dimethyl-4-oxoimidazolidine-1-carboxylate Chemical compound C[C@H]1N(C(=O)OC(C)(C)C)[C@@H](C(C)(C)C)N(C)C1=O PVQFEORWMIYROR-KOLCDFICSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007059313A DE102007059313A1 (de) | 2007-12-07 | 2007-12-07 | Verfahren zur Herstellung von Vorläufern für L-3,4-Dihydroxy-6-[18F]fluor-phenylalanin und 2-[18F]Fluor-L-tyrosin und deren α-methylierten Derivaten, Vorläufer, sowie Verfahren zur Herstellung von L-3,4-Dihydroxy-6-[18F]fluor-phenylalanin und 2-[18F]Fluor-L-tyrosin und deren α-methylierten Derivaten aus dem Vorläufer |
| PCT/DE2008/001930 WO2009071049A2 (de) | 2007-12-07 | 2008-11-21 | VERFAHREN ZUR HERSTELLUNG VON VORLÄUFERN FÜR L-3,4-DIHYDROXY-6-[18F]FLUOR-PHENYLALANIN UND 2-[18F]FLUOR-L-TYROSIN UND DEREN α-METHYLIERTEN DERIVATEN, VORLÄUFER, SOWIE VERFAHREN ZUR HERSTELLUNG VON L-3,4 DIHYDROXY-6-[18F]FLUOR-PHENYLALANIN UND 2-[18F]FLUOR-L-TYROSIN UND DEREN α-METHYLIERTEN DERIVATEN AUS DEM VORLÄUFER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2220049T3 true DK2220049T3 (da) | 2011-10-24 |
Family
ID=40679782
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08857332.4T DK2220049T3 (da) | 2007-12-07 | 2008-11-21 | Fremgangsmåde til fremstilling af precursorer for L-3,4-dihydroxy-[18F]fluorphenylalanin og 2-[18F]fluor-L-tyrosin og alfa-methylerede derivater deraf og precursorerne |
| DK11001114.5T DK2336114T3 (da) | 2007-12-07 | 2008-11-21 | Fremgangsmåde til syntese af l-3,4 dihydroxy-6-[18f]fluor-phenylalanin og 2-[18f]fluor-l-tyrosin og deres alfa-methylerede derivater startende fra en precursor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11001114.5T DK2336114T3 (da) | 2007-12-07 | 2008-11-21 | Fremgangsmåde til syntese af l-3,4 dihydroxy-6-[18f]fluor-phenylalanin og 2-[18f]fluor-l-tyrosin og deres alfa-methylerede derivater startende fra en precursor |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100261913A1 (enExample) |
| EP (2) | EP2336114B1 (enExample) |
| JP (1) | JP5680418B2 (enExample) |
| CN (1) | CN101889002A (enExample) |
| AT (1) | ATE519745T1 (enExample) |
| DE (1) | DE102007059313A1 (enExample) |
| DK (2) | DK2220049T3 (enExample) |
| ES (1) | ES2420629T3 (enExample) |
| WO (1) | WO2009071049A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2821383B1 (en) * | 2013-07-02 | 2017-08-30 | Trasis S.A. | Stabilization of radiosynthetic intermediates |
| WO2015152128A1 (ja) * | 2014-03-31 | 2015-10-08 | 長瀬産業株式会社 | アミノ酸前駆体、アミノ酸およびその製造方法、ならびに該アミノ酸を用いたｐｅｔ診断用トレーサー |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886814A (en) * | 1986-03-13 | 1989-12-12 | Dr. Karl Thomas Gmbh | Substituted thiazoles and oxazoles and 2-hydroxy-morpholines |
| DE3901550A1 (de) * | 1989-01-20 | 1990-07-26 | Basf Ag | Neue tetrahydroindazole mit phenyletherstruktur |
| DE10346228B4 (de) * | 2003-09-25 | 2009-04-09 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren |
-
2007
- 2007-12-07 DE DE102007059313A patent/DE102007059313A1/de not_active Withdrawn
-
2008
- 2008-11-21 DK DK08857332.4T patent/DK2220049T3/da active
- 2008-11-21 AT AT08857332T patent/ATE519745T1/de active
- 2008-11-21 EP EP11001114.5A patent/EP2336114B1/de not_active Not-in-force
- 2008-11-21 CN CN2008801192567A patent/CN101889002A/zh active Pending
- 2008-11-21 ES ES11001114T patent/ES2420629T3/es active Active
- 2008-11-21 US US12/734,936 patent/US20100261913A1/en not_active Abandoned
- 2008-11-21 JP JP2010536317A patent/JP5680418B2/ja active Active
- 2008-11-21 EP EP08857332A patent/EP2220049B1/de not_active Not-in-force
- 2008-11-21 WO PCT/DE2008/001930 patent/WO2009071049A2/de not_active Ceased
- 2008-11-21 DK DK11001114.5T patent/DK2336114T3/da active
-
2012
- 2012-11-06 US US13/669,997 patent/US20130060063A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2220049B1 (de) | 2011-08-10 |
| ES2420629T3 (es) | 2013-08-26 |
| US20100261913A1 (en) | 2010-10-14 |
| ATE519745T1 (de) | 2011-08-15 |
| CN101889002A (zh) | 2010-11-17 |
| US20130060063A1 (en) | 2013-03-07 |
| JP5680418B2 (ja) | 2015-03-04 |
| EP2220049A2 (de) | 2010-08-25 |
| DE102007059313A1 (de) | 2009-06-18 |
| EP2336114A1 (de) | 2011-06-22 |
| JP2011505392A (ja) | 2011-02-24 |
| WO2009071049A3 (de) | 2009-09-17 |
| EP2336114B1 (de) | 2013-04-17 |
| DK2336114T3 (da) | 2013-07-29 |
| WO2009071049A2 (de) | 2009-06-11 |
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