DK217087A - PREPARATION OF LMW HEPARIN - Google Patents
PREPARATION OF LMW HEPARINInfo
- Publication number
- DK217087A DK217087A DK217087A DK217087A DK217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A
- Authority
- DK
- Denmark
- Prior art keywords
- heparin
- molecular weight
- lmw
- lmw heparin
- polydispersity
- Prior art date
Links
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for producing low molecular weight heparin (LMW heparin) by enzymically depolymerizing heparin with heparinase, with heparin being continuously added to a depolymerization zone, the depolymerized LMW heparin being subjected to ultrafiltration, the retentate being circulated to the depolymerization zone and the LMW heparin being recovered from the filtrate. The process makes it possible to produce LMW heparin of a desired molecular weight and low polydispersity within narrow limits by continuously or frequently measuring the molecular weight and polydispersity of the LMW heparin product and correcting the process parameters of the depolymerization reaction in order to counteract deviations in the molecular weight and the polydispersity from the desired values. <IMAGE>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK217087A DK162108C (en) | 1986-04-30 | 1987-04-29 | METHOD FOR MANUFACTURING THE LMW HEPARIN |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK196886A DK196886D0 (en) | 1986-04-30 | 1986-04-30 | PREPARATION OF POLYSACCHARIDES |
DK196886 | 1986-04-30 | ||
DK217087 | 1987-04-29 | ||
DK217087A DK162108C (en) | 1986-04-30 | 1987-04-29 | METHOD FOR MANUFACTURING THE LMW HEPARIN |
Publications (4)
Publication Number | Publication Date |
---|---|
DK217087D0 DK217087D0 (en) | 1987-04-29 |
DK217087A true DK217087A (en) | 1987-10-31 |
DK162108B DK162108B (en) | 1991-09-16 |
DK162108C DK162108C (en) | 1992-02-24 |
Family
ID=26066235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK217087A DK162108C (en) | 1986-04-30 | 1987-04-29 | METHOD FOR MANUFACTURING THE LMW HEPARIN |
Country Status (1)
Country | Link |
---|---|
DK (1) | DK162108C (en) |
-
1987
- 1987-04-29 DK DK217087A patent/DK162108C/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK162108C (en) | 1992-02-24 |
DK162108B (en) | 1991-09-16 |
DK217087D0 (en) | 1987-04-29 |
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