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Polysaccharides And Polysaccharide Derivatives
(AREA)
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Low-molecular heparin is prepared by the batchwise enzymatic depolymerization of heparin with the aid of heparinase, where heparin is depolymerized to the required weight-average molecular weight by depolymerizing it to the corresponding number-average molecular weight. The process makes it possible to depolymerize heparin to the required weight-average molecular weight by measuring the increase in the UV absorption (preferably at 230-235 nm) at δA235 and terminating the depolymerization when δA235 reaches the calculated value that corresponds to the required number-average molecular weight Mn.
DK217187A1986-04-301987-04-29
METHOD FOR MANUFACTURING THE LMW HEPARIN
DK156402C
(en)