DK200401791A - Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition - Google Patents

Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition Download PDF

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Publication number
DK200401791A
DK200401791A DK200401791A DKPA200401791A DK200401791A DK 200401791 A DK200401791 A DK 200401791A DK 200401791 A DK200401791 A DK 200401791A DK PA200401791 A DKPA200401791 A DK PA200401791A DK 200401791 A DK200401791 A DK 200401791A
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DK
Denmark
Prior art keywords
composition
active agent
preparation
pharmacologically active
systemic administration
Prior art date
Application number
DK200401791A
Other languages
Danish (da)
Inventor
Hoffmann Hans-Rainer
Kissel Thomas
Schrank Henriette
Original Assignee
Lohmann Therapie Syst Lts
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK198505029A external-priority patent/DK175774B1/en
Application filed by Lohmann Therapie Syst Lts, Novartis Ag filed Critical Lohmann Therapie Syst Lts
Priority to DK200401791A priority Critical patent/DK175981B1/en
Publication of DK200401791A publication Critical patent/DK200401791A/en
Application granted granted Critical
Publication of DK175981B1 publication Critical patent/DK175981B1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

PATENTKRAV 1. Farmaceutisk præparat til transdermal systemisk administration af et farmakologisk aktivt middel, kendetegnet ved, at det indeholder tizanidin som et aktivt middel i et reservoir, der omfatter en hydrofil polymer. 2. Præparat ifølge krav 1, kendetegnet ved, at polymeren er en polyacrylatpolymer. 3. Præparat ifølge krav 1, kendetegnet ved, at polymeren er en polyacrylatpolymer indeholdende kationiske funktionelle grupper. 4. Præparat ifølge et hvilket som helst af kravene 1-3, kendetegnet ved, at polymeren er en acrylat/methacrylatpolymer 5. Præparat ifølge et hvilket som helst af kravene 1-4, kendetegnet ved, at polymeren indeholder trimethylaminoethylestergrupper. 6. Præparat ifølge et hvilket som helst af kravene 1-5, kendetegnet ved, at det er i form af et klæbende plaster eller lap omfattende a) et dæklag, c) et lægemiddelreservoir omfattende 1-10 lag af en homogen dispersion af partikler af aktivt middel eller en opløsning af aktivt middel i en polymermatrix, og d) et klæbende lag, idet reservoiret c) er anbragt mellem lagene a) og d). 7. Fremgangsmåde til fremstilling af et farmaceutisk præparat til transdermal administration, kendetegnet ved, at man dispergerer a) tizanidin. i en polyacrylatpolymer indeholdende kationiske funktionelle grupper eller b) dispergerer tizanidin i en hydrofil polymer, og eventuelt påfører et klæbende lag.A pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent, characterized in that it contains tizanidine as an active agent in a reservoir comprising a hydrophilic polymer. Composition according to claim 1, characterized in that the polymer is a polyacrylate polymer. Composition according to claim 1, characterized in that the polymer is a polyacrylate polymer containing cationic functional groups. Composition according to any one of claims 1-3, characterized in that the polymer is an acrylate / methacrylate polymer 5. Composition according to any one of claims 1-4, characterized in that the polymer contains trimethylaminoethyl ester groups. Composition according to any one of claims 1-5, characterized in that it is in the form of an adhesive patch or patch comprising a) a cover layer, c) a drug reservoir comprising 1-10 layers of a homogeneous dispersion of particles of active agent or solution of active agent in a polymer matrix, and d) an adhesive layer, the reservoir c) being arranged between layers a) and d). Process for the preparation of a pharmaceutical composition for transdermal administration, characterized in that a) tizanidine is dispersed. in a polyacrylate polymer containing cationic functional groups or b) dispersing tizanidine in a hydrophilic polymer and optionally applying an adhesive layer.

DK200401791A 1984-03-01 2004-11-18 Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition DK175981B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401791A DK175981B1 (en) 1984-03-01 2004-11-18 Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH100884 1984-03-01
CH100884 1984-03-01
CH175384 1984-04-06
CH175384 1984-04-06
DK502985 1985-10-31
DK198505029A DK175774B1 (en) 1984-03-01 1985-10-31 Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent, process for its preparation and use of ketotifen for the manufacture of a drug
DK200401791 2004-11-18
DK200401791A DK175981B1 (en) 1984-03-01 2004-11-18 Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition

Publications (2)

Publication Number Publication Date
DK200401791A true DK200401791A (en) 2004-11-18
DK175981B1 DK175981B1 (en) 2005-10-24

Family

ID=32685610

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198703245A DK175236B1 (en) 1984-03-01 1987-06-25 Pharmaceutical compsns. for trans:dermal admin.
DK200401791A DK175981B1 (en) 1984-03-01 2004-11-18 Pharmaceutical composition for transdermal systemic administration of a pharmacologically active agent containing tizanidine and method of preparation of the composition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK198703245A DK175236B1 (en) 1984-03-01 1987-06-25 Pharmaceutical compsns. for trans:dermal admin.

Country Status (1)

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DK (2) DK175236B1 (en)

Also Published As

Publication number Publication date
DK324587D0 (en) 1987-06-25
DK175981B1 (en) 2005-10-24
DK175236B1 (en) 2004-07-19
DK324587A (en) 1987-06-25

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