DK199885A - AMIDINO HYDRAZONS OF TETRALIN, CHROMON, THIOCHROMON AND TETRAHYDROQUINOLINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS - Google Patents

AMIDINO HYDRAZONS OF TETRALIN, CHROMON, THIOCHROMON AND TETRAHYDROQUINOLINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS Download PDF

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Publication number
DK199885A
DK199885A DK199885A DK199885A DK199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A DK 199885 A DK199885 A DK 199885A
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Prior art keywords
thiochromon
hydrazons
chromon
tetralin
amidino
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DK199885A
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Danish (da)
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DK199885D0 (en
Inventor
Hartmut Stegelmeier
Frank-Joachim Morich
Andreas Knorr
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Bayer Ag
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Publication of DK199885D0 publication Critical patent/DK199885D0/en
Publication of DK199885A publication Critical patent/DK199885A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms

Description

A betyder en binding, CR4R5, CR6R7-CR8R9, CR10R1;L-CR12R13--CR14R15, CR16=CR17 CO eller C=NOH, hvori r\ R2, R4-R·*·7 er ens eller forskellige og betyder hydrogen eller substituenter valgt blandt halogen, alkyl, alkoxy, alkylthio, alkyl-sulfinyl, cyano, hydroxy, nitro, mono-eller polyfluoralkyl, mono- eller polyfluoralkoxy, monoeller polyfluoralkylthio, amino, monoalkylaroino eller di-alkylamino eller betyder en aromatisk eller heteroaromatisk gruppe, som eventuelt er substitueret med 1-5 ens eller forskellige substituenter valgt blandt hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono- eller polyfluoralkyl, mono- eller polyfluoralkoxy, mono- eller polyfluoralkylthio, amino, monoalkyl-amino eller dialkylamino, R betyder hydrogen, alkyl, aryl, acyl eller alkansulfonyl, som eventuelt er substitueret med 1-5 ens eller forskellige substituenter valgt blandt hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono- eller polyfluoralkyl, mono- eller polyfluoralkoxy, mono- eller polyfluoralkylthio, amino, monoalkylamino eller dialkylamino, i form af isomere, isomerblandinger, racemater og optiske antipoder samt deres farmaceutisk uskadelige salte, er anvendelige i lægemidler, især lægemidler til påvirkning af kredsløbet.A means a bond, CR4R5, CR6R7-CR8R9, CR10R1; L-CR12R13 - CR14R15, CR16 = CR17 CO or C = NOH wherein r \ R2, R4-R · * · 7 are the same or different and mean hydrogen or substituents selected from halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono or polyfluoroalkyl, mono or polyfluoroalkoxy, mono or polyfluoroalkylthio, amino, monoalkylaroino or dialkylamino or means an aromatic or heteroaromatic group, optionally are substituted with 1 to 5 identical or different substituents selected from hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono or polyfluoroalkyl, mono- or polyfluoroalkoxy, mono- or polyfluoroalkylthio, amino, monoalkylamino or dialkylamino, R is hydrogen, alkyl, aryl, acyl or alkanesulfonyl optionally substituted with 1 to 5 same or different substituents selected from hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, cyano, hydroxy, nitro, mono or PO isofluoroalkyl, mono- or polyfluoroalkoxy, mono- or polyfluoroalkylthio, amino, monoalkylamino or dialkylamino, in the form of isomers, isomer blends, racemates and optical antibodies, and their pharmaceutically harmless salts, are useful in drugs, especially drugs for the influence of the circuit.

DK199885A 1984-05-05 1985-05-02 AMIDINO HYDRAZONS OF TETRALIN, CHROMON, THIOCHROMON AND TETRAHYDROQUINOLINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS DK199885A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843416695 DE3416695A1 (en) 1984-05-05 1984-05-05 AMIDINOHYDRAZONE OF TETRALINE, CHROMONE, THIOCHROMONE AND TRETRAHYDROQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
DE3416695 1984-05-05

Publications (2)

Publication Number Publication Date
DK199885D0 DK199885D0 (en) 1985-05-02
DK199885A true DK199885A (en) 1985-11-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK199885A DK199885A (en) 1984-05-05 1985-05-02 AMIDINO HYDRAZONS OF TETRALIN, CHROMON, THIOCHROMON AND TETRAHYDROQUINOLINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS

Country Status (11)

Country Link
EP (1) EP0163888A1 (en)
JP (1) JPS60239454A (en)
KR (1) KR850008672A (en)
AU (1) AU4200885A (en)
DE (1) DE3416695A1 (en)
DK (1) DK199885A (en)
ES (1) ES8607271A1 (en)
FI (1) FI851736L (en)
GR (1) GR851073B (en)
HU (1) HUT38609A (en)
ZA (1) ZA853328B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
HU197331B (en) * 1986-06-26 1989-03-28 Alkaloida Vegyeszeti Gyar Process for producing benzopiran derivatives, as well as insecticide and nematocide compositions comprising these compounds as active ingredient
JP2602037B2 (en) * 1987-10-31 1997-04-23 持田製薬株式会社 1-acyl-2,3-dihydro-4 (1H) -quinolinone-4-oxime derivatives, process for preparing the same, and pharmaceutical compositions containing diuretic, antihypertensive, anti-edema and ascites removal based on them
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
EP0543930A1 (en) * 1990-08-17 1993-06-02 E.I. Du Pont De Nemours And Company Arthropodicidal pyrazolines, pyrazolidines and hydrazines
FR2669927B1 (en) * 1990-11-29 1994-04-08 Adir Cie NOVEL GUANIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
KR20010041109A (en) * 1998-02-20 2001-05-15 다케다 야쿠힌 고교 가부시키가이샤 Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof
WO2000075115A1 (en) * 1999-06-03 2000-12-14 Takeda Chemical Industries, Ltd. Pernasal preparations
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
TWI472525B (en) 2008-12-05 2015-02-11 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493677A1 (en) * 1964-10-01 1969-06-19 Bayer Ag Process for the preparation of guanylhydrazones
FR2036989A1 (en) * 1969-04-28 1970-12-31 Anvar Amidino hydrazone antivirals
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.
DE2736064A1 (en) * 1977-08-10 1979-02-22 Bayer Ag Synergistic antimalarial compsn. contg. heterocyclic guanyl-hydrazone - and folic acid antagonist or glucose transport inhibitor

Also Published As

Publication number Publication date
ZA853328B (en) 1985-12-24
HUT38609A (en) 1986-06-30
FI851736A0 (en) 1985-05-02
FI851736L (en) 1985-11-06
KR850008672A (en) 1985-12-21
JPS60239454A (en) 1985-11-28
DK199885D0 (en) 1985-05-02
ES8607271A1 (en) 1986-05-16
GR851073B (en) 1985-11-25
DE3416695A1 (en) 1985-11-07
EP0163888A1 (en) 1985-12-11
AU4200885A (en) 1985-11-07
ES542615A0 (en) 1986-05-16

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