DK1948339T3 - Apparat til chromatografiske separationer - Google Patents

Apparat til chromatografiske separationer

Info

Publication number
DK1948339T3
DK1948339T3 DK06799508.4T DK06799508T DK1948339T3 DK 1948339 T3 DK1948339 T3 DK 1948339T3 DK 06799508 T DK06799508 T DK 06799508T DK 1948339 T3 DK1948339 T3 DK 1948339T3
Authority
DK
Denmark
Prior art keywords
branch
duct
valve
central duct
chromatographic separations
Prior art date
Application number
DK06799508.4T
Other languages
English (en)
Inventor
Marc Antonius Theodorus Bisschops
Jozef Anton Mari Pennings
Jacob Arthur Tijsterman
Original Assignee
Xendo Holding B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xendo Holding B V filed Critical Xendo Holding B V
Application granted granted Critical
Publication of DK1948339T3 publication Critical patent/DK1948339T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1842—Simulated moving beds characterized by apparatus features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G01N30/467—Flow patterns using more than one column with separation columns in parallel all columns being identical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1885—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/205—Diaphragm valves, e.g. deformed member closing the passage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK06799508.4T 2005-10-13 2006-10-13 Apparat til chromatografiske separationer DK1948339T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72641505P 2005-10-13 2005-10-13
EP05077342A EP1775001A1 (en) 2005-10-13 2005-10-13 Device for chromatographic separations
PCT/NL2006/000519 WO2007043874A1 (en) 2005-10-13 2006-10-13 Device for chromatographic separations

Publications (1)

Publication Number Publication Date
DK1948339T3 true DK1948339T3 (da) 2011-09-26

Family

ID=35783381

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06799508.4T DK1948339T3 (da) 2005-10-13 2006-10-13 Apparat til chromatografiske separationer

Country Status (10)

Country Link
US (2) US7846335B2 (da)
EP (2) EP1775001A1 (da)
JP (1) JP4837740B2 (da)
CN (1) CN101340960B (da)
AT (1) ATE511901T1 (da)
AU (1) AU2006300050B2 (da)
DK (1) DK1948339T3 (da)
ES (1) ES2370052T3 (da)
PL (1) PL1948339T3 (da)
WO (1) WO2007043874A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1775001A1 (en) * 2005-10-13 2007-04-18 Xendo Holding B.V. Device for chromatographic separations
US9012212B2 (en) 2007-04-17 2015-04-21 Xendo Holding B.V. Method and device for continuous membrane adsorption
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
EP2486571A1 (en) 2009-10-08 2012-08-15 GE Healthcare UK Limited Chromatography components
CN102190704B (zh) * 2010-03-17 2014-04-02 中国科学院过程工程研究所 蛋白层析系统
BRMU9101903Y1 (pt) * 2011-09-30 2018-12-04 Universidade Estadual De Campinas - Unicamp dispositivo para extração em fase sólida tipo "manifold" com câmara de vácuo, válvulas para controle por vácuo e válvulas adaptadas para controle por bomba peristáltica
EP2578286A1 (en) 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
EP2656892A1 (en) * 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US9404900B2 (en) 2012-12-21 2016-08-02 Thermo Finnigan Llc System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis
TWI591339B (zh) 2013-05-02 2017-07-11 羅門哈斯公司 偵測燃料標記物之分析方法
JP6540705B2 (ja) 2013-12-19 2019-07-10 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 生物学的液体処理システムのための遠隔操作弁
GB201401010D0 (en) * 2014-01-21 2014-03-05 Nat Nuclear Lab Ltd Improved separation apparatus and method
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
US20150369781A1 (en) * 2014-06-06 2015-12-24 The Penn State Research Foundation Mems flow control chip for gas chromatography
CN107106929B (zh) * 2014-12-31 2020-06-09 通用电气健康护理生物科学股份公司 用于模拟移动床层析的阀歧管
EP3429717B1 (fr) * 2015-03-18 2020-05-06 François Parmentier Procédé de séparation chromatographique énergetiquement économe
EP3037513A1 (de) * 2015-05-13 2016-06-29 Bayer Technology Services GmbH Verfahren zur kontinuierlichen elution eines produktes von chromatographiesäulen
PT3101660T (pt) * 2015-06-05 2017-09-18 Ion Beam Appl Sa Processo de produção de gálio-68 através de irradiação de um alvo em solução
CN105203675B (zh) * 2015-08-18 2017-03-01 苏州赛谱仪器有限公司 连续进样层析装置
GB201703258D0 (en) * 2017-02-28 2017-04-12 Ge Healthcare Bio Sciences Ab Parallel separation and washing
EP3381529A1 (fr) 2017-03-29 2018-10-03 EMD Millipore Corporation Installation de traitement de liquide biologique
EP3381530A1 (fr) 2017-03-29 2018-10-03 EMD Millipore Corporation Installation de traitement de liquide biologique
JP6790963B2 (ja) * 2017-03-30 2020-11-25 株式会社島津製作所 液体クロマトグラフ
GB201715399D0 (en) 2017-09-22 2017-11-08 Ge Healthcare Bio Sciences Ab Valve unit for a chromatography apparatus
TW202005694A (zh) * 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
US10905999B2 (en) * 2018-10-05 2021-02-02 Battelle Energy Alliance, Llc Methods for separating isotopes from a sample of fission products
GB201820691D0 (en) * 2018-12-19 2019-01-30 Ge Healthcare Bio Sciences Ab Device for distributing a flow
FR3116000B1 (fr) 2020-11-10 2023-06-02 Novasep Process Assemblage de modules fluidiques
US20230266282A1 (en) 2022-02-18 2023-08-24 Sartorius Stedim North America Inc. Valve switching cassette for selectively interconnecting components of a bioprocess installation
US20230277958A1 (en) 2022-03-04 2023-09-07 Sartorius Stedim Chromatography Systems Ltd. Method for operating a chromatography setup
US20230294016A1 (en) 2022-03-21 2023-09-21 Sartorius Stedim North America Inc. Valve switching system for selectively interconnecting components of a bioprocess installation
US11879561B2 (en) * 2022-05-20 2024-01-23 Sartorius Stedim Chromatography Systems Ltd. Valve setup for SMB chromatography
US20240068996A1 (en) 2022-08-26 2024-02-29 Sartorius Stedim North America Inc. Valve switching system for selectively interconnecting components of a bioprocess installation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201922A (en) * 1962-02-07 1965-08-24 Beckman Instruments Inc Chromatographic method
US3922223A (en) * 1974-03-25 1975-11-25 Us Navy Multiple chromatographic column system
DE2806123C2 (de) * 1978-02-14 1985-02-21 Siemens AG, 1000 Berlin und 8000 München Umschalteinrichtung mit einem Verzweigungsstück zwischen zwei gaschromatographischen Trennsäulen
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
DE3717456C1 (de) * 1987-05-23 1988-07-21 Eberhard Gerstel Gaschromatograph und Verfahren zur gaschromatographischen Trennung
US4848722A (en) 1987-12-11 1989-07-18 Integrated Fluidics, Inc. Valve with flexible sheet member
JP2834225B2 (ja) 1989-10-20 1998-12-09 オルガノ株式会社 擬似移動層式クロマト分離装置
US5176359A (en) 1991-05-20 1993-01-05 Photovac International, Inc. Fluid control valve arrangement
US5203368A (en) 1992-07-29 1993-04-20 Protein Technologies Inc. Matrix of valves
US5470464A (en) 1994-04-06 1995-11-28 Uop Small scale simulated moving bed separation apparatus and process
US5465748A (en) 1994-05-24 1995-11-14 Millipore Corporation Sanitizable slider diaphragm valve
GB9419888D0 (en) * 1994-10-03 1994-11-16 Davis John Apparatus and techiques for separation
FR2750886B1 (fr) * 1996-07-11 1998-09-25 Inst Francais Du Petrole Dispositif de rincage dans une unite d'adsorption en lit mobile simule et son utilisation
FR2751888B1 (fr) * 1996-07-31 1998-09-11 Inst Francais Du Petrole Dispositif et procede de rincage en lit mobile simule comportant au moins deux lignes de distribution de fluides
US6063284A (en) 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
CA2272562A1 (en) 1997-09-22 1999-04-01 Organo Corporation Chromatographic separation process and separator
JP3478325B2 (ja) * 1997-12-25 2003-12-15 オルガノ株式会社 クロマト分離方法
JP3453516B2 (ja) 1998-05-29 2003-10-06 オルガノ株式会社 クロマト分離方法
FR2782657B1 (fr) * 1998-09-02 2000-09-29 Inst Francais Du Petrole Systeme distributeur-collecteur de fluides et son procede
FR2794836B1 (fr) * 1999-06-09 2001-08-03 Inst Francais Du Petrole Vanne rotative amelioree
US6544413B1 (en) 1999-11-02 2003-04-08 Daicel Chemical Industries, Ltd. Simulated moving bed device
WO2001086283A2 (en) * 2000-05-11 2001-11-15 Ontogen Corporation Apparatus and method for multiple channel high throughput purification
JP4879392B2 (ja) 2000-11-09 2012-02-22 日本錬水株式会社 クロマト分離方法
JP2002153702A (ja) 2000-11-21 2002-05-28 Japan Organo Co Ltd トコトリエノ−ルのクロマト分取法
US6427526B1 (en) * 2001-02-27 2002-08-06 Isco, Inc. Liquid chromatographic method and system
FR2833499B1 (fr) * 2001-12-19 2004-08-20 Inst Francais Du Petrole Dispositif d'injection d'un fluide devie dans un procede de separation en lit mobile simule
US6712963B2 (en) * 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
US9283521B2 (en) * 2002-06-14 2016-03-15 Parker-Hannifin Corporation Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications
FR2867089B1 (fr) * 2004-03-03 2006-06-09 Bionisis Sa Installation de separation de composants dans plusieurs voies paralleles
JP2008139022A (ja) 2005-03-23 2008-06-19 Daicel Chem Ind Ltd ブロックバルブ及びそれを有する擬似移動床式クロマトグラフィー分離装置
US7544293B2 (en) * 2005-09-26 2009-06-09 Semba Inc. Valve and process for interrupted continuous flow chromatography
EP1775001A1 (en) * 2005-10-13 2007-04-18 Xendo Holding B.V. Device for chromatographic separations
FR2913345B1 (fr) * 2007-03-09 2010-06-11 Inst Francais Du Petrole Procede et dispositif de separation en lit mobile simule a nombre de vannes et volume de lignes reduits
US9012212B2 (en) * 2007-04-17 2015-04-21 Xendo Holding B.V. Method and device for continuous membrane adsorption

Also Published As

Publication number Publication date
US8828234B2 (en) 2014-09-09
EP1948339A1 (en) 2008-07-30
US20110108485A1 (en) 2011-05-12
AU2006300050B2 (en) 2010-07-15
ES2370052T3 (es) 2011-12-12
EP1775001A1 (en) 2007-04-18
ATE511901T1 (de) 2011-06-15
US20090218286A1 (en) 2009-09-03
EP1948339B1 (en) 2011-06-08
AU2006300050A1 (en) 2007-04-19
PL1948339T3 (pl) 2011-12-30
CN101340960A (zh) 2009-01-07
CN101340960B (zh) 2011-03-30
WO2007043874A1 (en) 2007-04-19
JP2009511900A (ja) 2009-03-19
US7846335B2 (en) 2010-12-07
JP4837740B2 (ja) 2011-12-14

Similar Documents

Publication Publication Date Title
DK1948339T3 (da) Apparat til chromatografiske separationer
WO2008115074A3 (en) Subsea installation and method for separation of liquid and gas
DK1620196T3 (da) Fremgangsmåde og apparat til kontinuerlig blanding af to strömninger
WO2007038417A3 (en) Novel valve and process for interrupted continuous flow chromatography
GB2440244B (en) Axial chromatography colums and method
SG145668A1 (en) Method and apparatus for controlling gas flow to a processing chamber
SG145663A1 (en) Method and apparatus for controlling gas flow to a processing chamber
SG145669A1 (en) Method and apparatus for controlling gas flow to a processing chamber
ATE424923T1 (de) Modulares mikrofluidiksystem
WO2012006610A3 (en) A gas pressurized separation column and process to generate a high pressure product gas
WO2008008597A3 (en) Reactor system with interstage product removal
WO2009050367A3 (fr) Dispositif de separation liquide/gaz horizontal et procede de separation, notamment des phases liquide et gazeuse d'un petrole brut
WO2009001101A3 (en) Sample plate
FR2926813B1 (fr) Procede de separation du propane et du propylene mettant en oeuvre une colonne a distiller et une unite de separation par membrane
ATE494946T1 (de) Vorrichtung zum mischen mit niedrigem druckverlust und verfahren zum mischen von zwei gasen/dämpfen
EA200870286A1 (ru) Аппарат и способ разделения смеси текучих сред на фракции
WO2008121229A3 (en) Method and apparatus for concentrating molecules
WO2006084065A3 (en) Simulated moving bed adsorptive separation process for handling multiple feedstocks
WO2009092784A3 (en) Apparatus and method for distributing a plurality of fluid flows through a plurality of chambers, particularly for carrying out adsorption processes.
DK1982734T3 (da) Fremgangsmåde og apparat til væskerensning
DE60302163D1 (de) Kontinuierliches hochleistungs-reaktion/trennverfahren in einer fest-flüssig kontaktvorrichtung
MY152787A (en) Method of bypassing a pipeline in a multiple pipeline system
JP2018502302A (ja) 疑似移動床クロマトグラフィー用弁マニホールド
DK1494827T3 (da) Apparat til plastisk deformation af arbejdsstykker
ATE486210T1 (de) System zur ausrichtung eines rückgeführten verbrennungsgasstroms