DK184786A - PHARMACEUTICAL PREPARATION WITH NIFEDIPINE AS ACTIVE SUBSTANCE AND ITS USE - Google Patents

PHARMACEUTICAL PREPARATION WITH NIFEDIPINE AS ACTIVE SUBSTANCE AND ITS USE Download PDF

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Publication number
DK184786A
DK184786A DK184786A DK184786A DK184786A DK 184786 A DK184786 A DK 184786A DK 184786 A DK184786 A DK 184786A DK 184786 A DK184786 A DK 184786A DK 184786 A DK184786 A DK 184786A
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DK
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Prior art keywords
nifedipine
weight
glycol
polyethylene
pharmaceutical preparation
Prior art date
Application number
DK184786A
Other languages
Danish (da)
Other versions
DK184786D0 (en
Inventor
Walter Burghart
Kurt Burghart
Original Assignee
Kuhlemann & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Kuhlemann & Co filed Critical Kuhlemann & Co
Publication of DK184786D0 publication Critical patent/DK184786D0/en
Publication of DK184786A publication Critical patent/DK184786A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The pharmaceutical preparation contains nifedipine as active agent and is conditioned as an aerosol by using a propelling gas or a spray. When using propelling gases, the preparation contains preferably from 2 to 5 % by weight of nifedipine, 25 to 40% by weight of polyethylene-glycol, 40 to 25% by weight of ethanol and 30 to 40% by weight, preferably 35% by weight of the propulsion agent, whereas in case of a spray, the preparation appropriately contains 19 mg of nifedipine, 70 to 100 mg of polyethylene-glycol, particularly a mixture of polyethylene-glycol 600 and polyethylene-glycol 400 in a ratio from 5:4 to 4:5, 30 to 40 mg of ethanol, 5 to 20 mg of water and optionally 2 to 5 mg of saccharine and 1 to 3 mg of flavouring agent like peppermint oil.
DK184786A 1984-08-23 1986-04-22 PHARMACEUTICAL PREPARATION WITH NIFEDIPINE AS ACTIVE SUBSTANCE AND ITS USE DK184786A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT270884 1984-08-23
PCT/AT1985/000027 WO1986001405A1 (en) 1984-08-23 1985-08-23 Pharmaceutical preparation and production process therefor

Publications (2)

Publication Number Publication Date
DK184786D0 DK184786D0 (en) 1986-04-22
DK184786A true DK184786A (en) 1986-04-22

Family

ID=3539047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK184786A DK184786A (en) 1984-08-23 1986-04-22 PHARMACEUTICAL PREPARATION WITH NIFEDIPINE AS ACTIVE SUBSTANCE AND ITS USE

Country Status (9)

Country Link
EP (2) EP0175671A1 (en)
JP (1) JPH0657655B2 (en)
AT (1) ATE64093T1 (en)
AU (1) AU584122B2 (en)
DE (1) DE3583135D1 (en)
DK (1) DK184786A (en)
FI (1) FI861695A0 (en)
HU (1) HU201242B (en)
WO (1) WO1986001405A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522550A1 (en) * 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab SPRAYABLE PHARMACEUTICAL PREPARATION FOR TOPICAL APPLICATION
DE3544692A1 (en) * 1985-12-18 1987-06-19 Bayer Ag DIHYDROPYRIDINE SPRAY, METHOD FOR THE PRODUCTION THEREOF AND ITS PHARMACEUTICAL USE
AU597049B2 (en) * 1986-03-10 1990-05-24 Kurt Burghart Pharmaceutical preparation containing nifedipine
DE3714402A1 (en) * 1987-04-30 1988-11-10 Kali Chemie Pharma Gmbh DRUG FORMULATION
HU199678B (en) * 1988-07-08 1990-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing aerosols containing nitroglicerol
AT391269B (en) * 1988-12-30 1990-09-10 Burghart Kurt PHARMACEUTICAL PREPARATION
TW247878B (en) * 1991-07-02 1995-05-21 Takeda Pharm Industry Co Ltd
US6123924A (en) * 1991-09-25 2000-09-26 Fisons Plc Pressurized aerosol inhalation compositions
IL103238A (en) 1991-09-25 1995-07-31 Fisons Plc Pressurised aerosol compositions
HU214582B (en) 1994-07-26 1998-04-28 EGIS Gyógyszergyár Rt. Spayable antihypertensive composition and process for it`s production
DE10142417A1 (en) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re drug
JP4644397B2 (en) * 2001-09-05 2011-03-02 信越化学工業株式会社 Method for producing pharmaceutical solid preparation containing poorly soluble drug
GB0215749D0 (en) * 2002-07-09 2002-08-14 3M Innovative Properties Co Medicinal suspension aerosol model systems

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632504A (en) * 1962-05-24
SU432703A3 (en) * 1971-08-24 1974-06-15 Фридрих Боссерт, Вульф Фатер, Курт Бауер
JPS5446837A (en) * 1977-09-19 1979-04-13 Kanebo Ltd Easily absorbable nifedipin composition, its preparation, and anti-stenocardia containing the same
DE2815578C2 (en) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen New pharmaceutical use of nimodipine
JPS5785316A (en) * 1980-11-14 1982-05-28 Kanebo Ltd Preparation of easily absorbable nifedipine preparation
DE3045914A1 (en) * 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen ANTIMYCOTIC AGENTS WITH HIGH ACTIVE SUBSTANCE RELEASE IN THE FORM OF ELASTIC LIQUID PLASTERS
JPS5846019A (en) * 1981-09-14 1983-03-17 Kanebo Ltd Nifedipine preparation with prolonged action
JPS58109412A (en) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk Nifedipine solid preparation
DE3307422A1 (en) † 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen LIQUID PREPARATIONS OF DIHYDROPYRIDINES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES

Also Published As

Publication number Publication date
EP0190292B2 (en) 1996-11-13
EP0175671A1 (en) 1986-03-26
EP0190292B1 (en) 1991-06-05
DK184786D0 (en) 1986-04-22
HU201242B (en) 1990-10-28
JPH0657655B2 (en) 1994-08-03
ATE64093T1 (en) 1991-06-15
FI861695A (en) 1986-04-22
FI861695A0 (en) 1986-04-22
HUT40757A (en) 1987-02-27
WO1986001405A1 (en) 1986-03-13
AU584122B2 (en) 1989-05-18
JPS62500031A (en) 1987-01-08
DE3583135D1 (en) 1991-07-11
AU4773285A (en) 1986-03-24
EP0190292A1 (en) 1986-08-13

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AHS Application shelved for other reasons than non-payment